ES2051814T3 - Proceso de preparacion de compuestos para la induccion de la produccion de citocinas in vivo e in vitro. - Google Patents

Proceso de preparacion de compuestos para la induccion de la produccion de citocinas in vivo e in vitro.

Info

Publication number
ES2051814T3
ES2051814T3 ES88116788T ES88116788T ES2051814T3 ES 2051814 T3 ES2051814 T3 ES 2051814T3 ES 88116788 T ES88116788 T ES 88116788T ES 88116788 T ES88116788 T ES 88116788T ES 2051814 T3 ES2051814 T3 ES 2051814T3
Authority
ES
Spain
Prior art keywords
carbons
carbon atoms
compounds
production
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88116788T
Other languages
English (en)
Inventor
Michael Albeck
Benjamin Sredni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2051814T3 publication Critical patent/ES2051814T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D329/00—Heterocyclic compounds containing rings having oxygen and selenium or oxygen and tellurium atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D517/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D517/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms in which the condensed system contains two hetero rings
    • C07D517/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN COMPUESTO DE FORMULA(I) EN LA QUE Q ES TE O SE; T ES 1 O 0; U ES 1 O 0, LOS RADICALES R A R9 SON IGUALES O DIFERENTES Y SE SELECCIONAN DE H, OH, HALOGENO, CARBOXI, ACILO, AMIDO, CIANO, ALQUILO O ALCOXI DE 1 A 5 C (QUE PUEDEN ESTAR DIVERSAMENTE SUSTITUIDOS); Y X ES HALOGENO. AUNQUE SE DESCRIBE LA SAL POTASICA, LA INVENCION INCLUYE OTRAS SALES FARMACEUTICAMENTE ACEPTABLES, EN UN METODO PARA ESTIMULAR LA PRODUCCION DE LINFOQUINA POR ADMINISTRACION A UN HUESPED DE UNA CANTIDAD EFECTIVA DE UN COMPUESTO DE DICHA CLASE, ASI COMO TAMBIEN PARA EL TRATAMIENTO DE SINDROMES DE INMUNODEFICIENCIA ADQUIRIDA. TAMBIEN SE REFIERE LA INVENCION A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS CITADOS COMPUESTOS Y A UN PROCESO PARA SU PREPARACION PONIENDO EN CONTACTO ALQUILENGLICOL CON TETRACLORURO DE TELURIO EN PRESENCIA DE UN HALURO DE POTASIO O AMONIO, A TEMPERATURA ALTA.
ES88116788T 1987-10-09 1988-10-10 Proceso de preparacion de compuestos para la induccion de la produccion de citocinas in vivo e in vitro. Expired - Lifetime ES2051814T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/107,131 US4962207A (en) 1985-09-30 1987-10-09 Organic derivatives of tellurium and selenium

Publications (1)

Publication Number Publication Date
ES2051814T3 true ES2051814T3 (es) 1994-07-01

Family

ID=22315021

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88116788T Expired - Lifetime ES2051814T3 (es) 1987-10-09 1988-10-10 Proceso de preparacion de compuestos para la induccion de la produccion de citocinas in vivo e in vitro.

Country Status (6)

Country Link
US (1) US4962207A (es)
EP (1) EP0311138B1 (es)
JP (1) JP2749596B2 (es)
AT (1) ATE104292T1 (es)
DE (1) DE3889057T2 (es)
ES (1) ES2051814T3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946437A (en) * 1988-12-02 1990-08-07 Bar-Ilan University Method for the stimulation of bone marrow cells
JPH10510812A (ja) * 1994-12-15 1998-10-20 ベーカー ノートン ファーマスーティカルズ、インコーポレーテッド タクサン化合物およびテルルおよび／またはセレン化合物の併用により腫瘍の発育を減少させるための方法および組成物
US6482311B1 (en) 2000-08-01 2002-11-19 Tda Research, Inc. Methods for suppression of filamentous coke formation
US7045150B2 (en) * 2001-07-31 2006-05-16 Tellus Biotech Ltd. Tellurium containing nutrient formulation and process for enhancing the cumulative weight gain or feed efficacy in poultry
EP1694313A4 (en) * 2003-12-18 2010-11-17 Biomas Ltd TELLURIUM DERIVATIVES FOR THE PREVENTION AND TREATMENT OF NEURODEEGENERATIVE PROCESSES
JP4903057B2 (ja) * 2004-01-22 2012-03-21 バイオマス リミテッド いぼをテルル化合物により治療するための治療法および医薬組成物
US7709524B2 (en) * 2004-09-17 2010-05-04 Biomas Ltd. Use of tellurium compounds for inhibition of interleukin-converting enzyme
US20080260770A1 (en) * 2004-09-17 2008-10-23 Biomas Ltd. Use of Tellurium Compounds as Adjuvants
US8703753B2 (en) * 2005-09-15 2014-04-22 Biomas Ltd. Use of tellurium compounds for the treatment of actinic keratosis
WO2009066300A2 (en) * 2007-11-23 2009-05-28 Biomas Ltd. Methods and compositions for inhibiting integrins using tellurium-containing compounds
EP2442817A1 (en) 2009-06-16 2012-04-25 Biomas Ltd. Tellurium-containing compounds for treating viral infections
US11304976B2 (en) 2015-02-18 2022-04-19 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11318163B2 (en) 2015-02-18 2022-05-03 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11497767B2 (en) 2015-02-18 2022-11-15 Enlivex Therapeutics R&D Ltd Combination immune therapy and cytokine control therapy for cancer treatment
CN109069539A (zh) 2016-02-18 2018-12-21 恩立夫克治疗有限责任公司 用于癌症治疗的联合免疫疗法和细胞因子控制疗法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239846A (en) * 1978-04-10 1980-12-16 Eastman Kodak Company Tellurium (IV) compounds and compositions
US4508662A (en) * 1983-03-24 1985-04-02 The United States Of America As Represented By The Secretary Of The Air Force Pentafluorotelluriumoxide fluorocarbons
US4761490A (en) * 1985-03-15 1988-08-02 Bar-Ilan University Organic derivatives of tellurium and selenium and their use to stimulate cytokine production

Also Published As

Publication number Publication date
JP2749596B2 (ja) 1998-05-13
ATE104292T1 (de) 1994-04-15
JPH01238580A (ja) 1989-09-22
US4962207A (en) 1990-10-09
EP0311138A2 (en) 1989-04-12
DE3889057D1 (de) 1994-05-19
EP0311138A3 (en) 1990-07-18
DE3889057T2 (de) 1994-08-11
EP0311138B1 (en) 1994-04-13

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