ES8504775A1 - Un metodo de preparar compuestos de diaminopirimidina - Google Patents

Un metodo de preparar compuestos de diaminopirimidina

Info

Publication number
ES8504775A1
ES8504775A1 ES531004A ES531004A ES8504775A1 ES 8504775 A1 ES8504775 A1 ES 8504775A1 ES 531004 A ES531004 A ES 531004A ES 531004 A ES531004 A ES 531004A ES 8504775 A1 ES8504775 A1 ES 8504775A1
Authority
ES
Spain
Prior art keywords
diaminopyrimidines
production
pyrimidinediamine
piperazinyl
antibacterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531004A
Other languages
English (en)
Other versions
ES531004A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES531004A0 publication Critical patent/ES531004A0/es
Publication of ES8504775A1 publication Critical patent/ES8504775A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE PREPARAR COMPUESTOS DE DIAMINOPIRIMIDINA.COMPRENDE: A) HACER REACCIONAR UN DERIVADO DE 5-BROMOURACILO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), PARA PRODUCIR UN COMPUESTO DE FORMULA (IV); Y B) CLORAR Y AMINAR A (IV) PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: R1, H O ALCOHILO DE C 1 A 6; R2 Y R3, H O METILO; Y R4, R5, H, HAL, NITRO, CIANO Y OTROS.
ES531004A 1982-09-09 1984-03-27 Un metodo de preparar compuestos de diaminopirimidina Expired ES8504775A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41640482A 1982-09-09 1982-09-09
US06/520,653 US4532240A (en) 1982-09-09 1983-08-09 Diaminopyrimidines

Publications (2)

Publication Number Publication Date
ES531004A0 ES531004A0 (es) 1985-05-01
ES8504775A1 true ES8504775A1 (es) 1985-05-01

Family

ID=27023342

Family Applications (2)

Application Number Title Priority Date Filing Date
ES525490A Expired ES8502989A1 (es) 1982-09-09 1983-09-08 Un metodo de preparar compuestos de diaminopirimidina
ES531004A Expired ES8504775A1 (es) 1982-09-09 1984-03-27 Un metodo de preparar compuestos de diaminopirimidina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES525490A Expired ES8502989A1 (es) 1982-09-09 1983-09-08 Un metodo de preparar compuestos de diaminopirimidina

Country Status (9)

Country Link
US (1) US4532240A (es)
EP (1) EP0103464B1 (es)
AU (2) AU560971B2 (es)
CA (1) CA1251447A (es)
DE (1) DE3378469D1 (es)
DK (1) DK158310C (es)
ES (2) ES8502989A1 (es)
GR (1) GR79058B (es)
IE (1) IE56148B1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE35053E (en) * 1985-09-12 1995-10-10 The Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
US5099019A (en) * 1985-09-12 1992-03-24 Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
LU86695A1 (fr) * 1986-12-01 1988-07-14 Oreal Nouveaux derives de piperazinyl-1 pyrimidine,leur preparation et leur application en therapeutique et cosmetique
HUT64323A (en) * 1992-06-09 1993-12-28 Richter Gedeon Vegyeszet Process for production new piperazinyl-bis(alkyl-amino)-pyrimidine derivatives
WO1994019327A1 (de) * 1993-02-26 1994-09-01 Max-Delbrück-Centrum für Molekulare Medizin Nukleoside, ihre herstellung und ihre verwendung als therapeutikum und als baustein für synthetische oligonukleotide
DE4320570C2 (de) * 1993-02-26 2002-07-11 Max Delbrueck Centrum Verfahren zur Herstellung von C-Nukleosiden und C-Nukleosid-Analoga, neue C-Nukleoside und C-Nukleosid-Analoga sowie deren Verwendung
GB9801392D0 (en) * 1998-01-22 1998-03-18 Smithkline Beecham Plc Novel compounds
AU2076299A (en) 1998-01-30 1999-08-16 Meiji Seika Kaisha Ltd. Phenylpiperazine derivatives as integrin alphavbeta3 antagonists
US20040006042A1 (en) * 1998-08-13 2004-01-08 Berry David Allen Diaminopyrimidines and combination therapies effective for treatment of P-glycoprotein positive cancers
WO2000009131A1 (en) * 1998-08-13 2000-02-24 Warner-Lambert Company Diaminopyrimidines and combination therapies effective for treatment of p-glycoprotein positive cancers
IL158941A0 (en) 2001-05-22 2004-05-12 Neurogen Corp Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
GB0412072D0 (en) * 2004-05-28 2004-06-30 Syngenta Participations Ag Chemical compounds
BR112018015924A2 (pt) 2016-02-05 2018-12-26 Vyera Pharmaceuticals Llc composições e métodos para tratar infecções
US20200270233A1 (en) * 2017-08-07 2020-08-27 Vyera Pharmaceuticais LLC Dhfr inhibitors, compositions, and methods related thereto

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US416404A (en) 1889-12-03 Automatic lath-feeder for paper-carriers
BE485737A (es) * 1947-11-12
US2748125A (en) * 1954-04-26 1956-05-29 American Cyanamid Co 1-substituted-4-sulfamylpiperazine and method of preparing the same
AT340933B (de) * 1973-08-20 1978-01-10 Thomae Gmbh Dr K Verfahren zur herstellung neuer pyrimidinderivate und ihrer saureadditionssalze
US4166852A (en) * 1974-08-09 1979-09-04 Produits Chimiques Ugine Kuhlmann Piperazino-pyrimidines and their use as spasmolytic agents
US4287338A (en) * 1980-03-10 1981-09-01 The Upjohn Company Sulfooxy-pyrimidinium, -pyridinium, and -triazinium hydroxide inner salts
US4351832A (en) * 1980-04-18 1982-09-28 American Home Products Corporation 2-(Piperazinyl)-4-pyrimidinamines

Also Published As

Publication number Publication date
AU560971B2 (en) 1987-04-30
ES531004A0 (es) 1985-05-01
EP0103464A2 (en) 1984-03-21
ES525490A0 (es) 1985-02-01
DK407383D0 (da) 1983-09-08
IE831920L (en) 1984-03-09
EP0103464B1 (en) 1988-11-17
DE3378469D1 (en) 1988-12-22
DK158310B (da) 1990-04-30
US4532240A (en) 1985-07-30
ES8502989A1 (es) 1985-02-01
DK158310C (da) 1990-10-15
DK407383A (da) 1984-03-10
EP0103464A3 (en) 1985-07-03
AU568997B2 (en) 1988-01-14
CA1251447A (en) 1989-03-21
AU1869983A (en) 1984-03-15
IE56148B1 (en) 1991-05-08
AU6878787A (en) 1987-05-14
GR79058B (es) 1984-10-02

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040216