BG103947A - Derivatives of 9-oxymerythromycin - Google Patents

Derivatives of 9-oxymerythromycin

Info

Publication number
BG103947A
BG103947A BG103947A BG10394799A BG103947A BG 103947 A BG103947 A BG 103947A BG 103947 A BG103947 A BG 103947A BG 10394799 A BG10394799 A BG 10394799A BG 103947 A BG103947 A BG 103947A
Authority
BG
Bulgaria
Prior art keywords
oxymerythromycin
derivatives
compounds
methods
relates
Prior art date
Application number
BG103947A
Other languages
Bulgarian (bg)
Inventor
Yong- Jin WU
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of BG103947A publication Critical patent/BG103947A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Abstract

The invention relates to compounds or their pharmaceutically acceptable salts with the formula where R1, R2, R6 and X have the meanings listed in the description. The invention also relates to pharmaceutical compositions containing the compounds, to methods for their application for the treatment of bacterial protozoal infections, as well as to methods for their preparation. 14 claims
BG103947A 1997-06-11 1999-12-03 Derivatives of 9-oxymerythromycin BG103947A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934997P 1997-06-11 1997-06-11
PCT/IB1998/000741 WO1998056800A1 (en) 1997-06-11 1998-05-15 9-oxime erythromycin derivatives

Publications (1)

Publication Number Publication Date
BG103947A true BG103947A (en) 2000-07-31

Family

ID=21959341

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103947A BG103947A (en) 1997-06-11 1999-12-03 Derivatives of 9-oxymerythromycin

Country Status (31)

Country Link
EP (1) EP0988308A1 (en)
JP (1) JP2000513026A (en)
KR (1) KR20010013660A (en)
CN (1) CN1259135A (en)
AP (1) AP9801253A0 (en)
AR (1) AR012244A1 (en)
AU (1) AU7226798A (en)
BG (1) BG103947A (en)
BR (1) BR9810021A (en)
CA (1) CA2293335A1 (en)
CO (1) CO4940506A1 (en)
CZ (1) CZ9904388A3 (en)
EA (1) EA199901016A1 (en)
GT (1) GT199800074A (en)
HN (1) HN1998000073A (en)
HR (1) HRP980316A2 (en)
HU (1) HUP0002252A3 (en)
ID (1) ID24529A (en)
IL (1) IL132767A0 (en)
IS (1) IS5251A (en)
MA (1) MA26505A1 (en)
NO (1) NO996108L (en)
OA (1) OA11225A (en)
PA (1) PA8451801A1 (en)
PE (1) PE79899A1 (en)
PL (1) PL337606A1 (en)
TN (1) TNSN98083A1 (en)
TR (1) TR199902995T2 (en)
TW (1) TW448174B (en)
WO (1) WO1998056800A1 (en)
ZA (1) ZA985018B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000159A (en) * 1997-10-29 1999-02-09 Monsanto Co DERIVATIVES OF 9- AMINO - 3 CETO ERITROMICINA
AU5299499A (en) * 1998-09-22 2000-04-10 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (en) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
US6258785B1 (en) 1998-12-02 2001-07-10 Pfizer Inc. Crystalline 9-E-(O-methyl)oxime of 11, 12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyloxy)-6-O-methyl-12,11-(iminocarbonyl-(2-(3-(4-(3-pyridinyl)1H-imadazol-1-yl)propyl)hydrazono))-3-oxoerythromycin
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
US6284732B1 (en) * 1998-12-18 2001-09-04 Bio-Rad Laboratories, Inc. Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases
ES2272273T3 (en) * 1999-04-16 2007-05-01 Kosan Biosciences, Inc. MACROLID ANTI-INFECTIVE AGENTS.
AP2001002302A0 (en) 1999-05-24 2001-10-25 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
WO2000075156A1 (en) * 1999-06-07 2000-12-14 Abbott Laboratories 6-o-carbamate ketolide derivatives
ID27331A (en) * 1999-09-29 2001-03-29 Pfizer Prod Inc MAKING ANTIBIOTIC-ANTIBIOTIC KETOLIDA CARBAMATE
EP1114826A3 (en) * 1999-12-29 2001-10-31 Pfizer Products Inc. Novel antibacterial and prokinetic macrolides
EP1439186A3 (en) * 1999-12-29 2004-11-03 Pfizer Products Inc. Intermediates for novel antibacterial and prokinetic macrolides
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
US6403776B1 (en) 2000-07-05 2002-06-11 Pfizer Inc. Synthesis of carbamate ketolide antibiotics
WO2003090761A1 (en) * 2002-04-25 2003-11-06 Abbott Laboratories 9-oxime macrolide antibacterials
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
WO2004080391A2 (en) * 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
EP1723159B1 (en) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Macrocyclic compounds and methods of making and using the same
CN101917850B (en) 2007-10-25 2016-01-13 森普拉制药公司 The preparation method of macrolide antibacterial agents
WO2010048601A1 (en) 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2011032052A1 (en) 2009-09-10 2011-03-17 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
CN102146085B (en) * 2010-02-09 2014-03-26 北京理工大学 9-oxime-ether ketolide derivative, and preparation method and medical composite thereof
KR20180101643A (en) 2010-03-22 2018-09-12 셈프라 파마슈티컬스, 인크. Crystalline forms of a macrolide, and uses therefor
BR112012029586A2 (en) 2010-05-20 2016-08-02 Cempra Pharmaceuticals Inc processes for preparing macrolides and ketolides and intermediates thereof
JP6042334B2 (en) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド Hydrogen bond forming fluoroketolides for disease treatment
RU2658050C2 (en) 2012-03-27 2018-06-19 Семпра Фармасьютикалз, Инк. Parenteral formulations for administering macrolide antibiotics
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
KR20160020403A (en) 2013-03-15 2016-02-23 셈프라 파마슈티컬스, 인크. Convergent processes for preparing macrolide antibacterial agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (en) * 1994-04-08 1997-01-10 Roussel Uclaf New erythromycin derivatives, their preparation process and their use as drugs.

Also Published As

Publication number Publication date
CO4940506A1 (en) 2000-07-24
TW448174B (en) 2001-08-01
HN1998000073A (en) 1999-01-08
WO1998056800A1 (en) 1998-12-17
HRP980316A2 (en) 1999-04-30
CZ9904388A3 (en) 2002-10-16
JP2000513026A (en) 2000-10-03
IL132767A0 (en) 2001-03-19
AU7226798A (en) 1998-12-30
HUP0002252A2 (en) 2000-12-28
NO996108L (en) 2000-02-10
EP0988308A1 (en) 2000-03-29
MA26505A1 (en) 2004-12-20
BR9810021A (en) 2000-09-19
HUP0002252A3 (en) 2002-01-28
PL337606A1 (en) 2000-08-28
EA199901016A1 (en) 2000-06-26
TNSN98083A1 (en) 2005-03-15
AR012244A1 (en) 2000-09-27
OA11225A (en) 2003-07-17
ZA985018B (en) 1999-12-10
GT199800074A (en) 1999-11-27
AP9801253A0 (en) 1999-12-04
CA2293335A1 (en) 1998-12-17
KR20010013660A (en) 2001-02-26
PE79899A1 (en) 1999-08-25
NO996108D0 (en) 1999-12-10
ID24529A (en) 2000-07-20
IS5251A (en) 1999-11-16
CN1259135A (en) 2000-07-05
TR199902995T2 (en) 2000-02-21
PA8451801A1 (en) 2000-05-24

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