ES8502992A1 - Procedimiento para la preparacion de un (tio)-eter de 2-metil-liserg-8-ilo - Google Patents
Procedimiento para la preparacion de un (tio)-eter de 2-metil-liserg-8-iloInfo
- Publication number
- ES8502992A1 ES8502992A1 ES524815A ES524815A ES8502992A1 ES 8502992 A1 ES8502992 A1 ES 8502992A1 ES 524815 A ES524815 A ES 524815A ES 524815 A ES524815 A ES 524815A ES 8502992 A1 ES8502992 A1 ES 8502992A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- agents
- ergot alkaloids
- phenyl
- lysergyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE UN (TIO)-ETER DE 2-METIL-LISERG-8-ILO.COMPRENDE REEMPLAZAR EL GRUPO Y EN UN DERIVADO 8-CH2Y CORRESPONDIENTE EN EL QUE Y ES UN GRUPO SUSCEPTIBLE DE SER ELIMINADO, TAL COMO UN COMPUESTO DE FORMULA (II), POR UN RADICAL ETER O TIOETER, TAL COMO UN GRUPO DE FORMULA (III) Y RECUPERAR EL COMPUESTO DE FORMULA (I) EN FORMA DE UNA SAL DE ADICION DEL MISMO, EN LA QUE X SIQNIFICA O O S; R1 SIGNIFICA H, ALQUILO C 1 A 4 O FENILO; R2 SIGNIFICA ALQUILO C 1 A 3 Y R3 SIGNIFICA FENILO O PIRIDILO, SIS SUSTITUIR O LLEVANDO CADA UNO, UNO, DOS O TRES SUSTITUYENTES ELEGIDOS ENTRE UN NUMERO ATOMICO DE 9 A 35, ALQUILO C 1 A 4 Y ALCOXI C 1 A 4, O REPRESENTA ALQUILO C 1 A 4 Y SALES DE ADICION DE ACIDOS DE LOS COMPUESTOS. LA REACCION SE REALIZA A TEMPERATURA ENTRE 50 Y 100JC Y EN UNA ATMOSFERA DE UN GAS INERTE COMO NITROGENO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH4772/82A CH649998A5 (de) | 1982-08-09 | 1982-08-09 | Ergolinderivate, ein verfahren zu ihrer herstellung und heilmittel, enthaltend diese ergolinderivate als wirkstoff. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES524815A0 ES524815A0 (es) | 1985-02-01 |
| ES8502992A1 true ES8502992A1 (es) | 1985-02-01 |
Family
ID=4282273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES524815A Expired ES8502992A1 (es) | 1982-08-09 | 1983-08-08 | Procedimiento para la preparacion de un (tio)-eter de 2-metil-liserg-8-ilo |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS5948480A (es) |
| AT (1) | AT383125B (es) |
| AU (1) | AU563736B2 (es) |
| BE (1) | BE897473A (es) |
| CA (1) | CA1215972A (es) |
| CH (1) | CH649998A5 (es) |
| DE (1) | DE3327705A1 (es) |
| DK (1) | DK361983A (es) |
| ES (1) | ES8502992A1 (es) |
| FI (1) | FI73679C (es) |
| FR (1) | FR2531433B1 (es) |
| GB (1) | GB2125041B (es) |
| GR (1) | GR78923B (es) |
| HU (1) | HU187600B (es) |
| IL (1) | IL69450A (es) |
| IT (1) | IT1168961B (es) |
| MY (1) | MY8700166A (es) |
| NL (1) | NL8302776A (es) |
| NZ (1) | NZ205181A (es) |
| PH (1) | PH20385A (es) |
| PT (1) | PT77168B (es) |
| SE (1) | SE8304315L (es) |
| ZA (1) | ZA835850B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675322A (en) * | 1984-12-10 | 1987-06-23 | Eli Lilly And Company | 1-Substituted-6-n-propyl-8β-methylthio-methylergolines |
| HU193782B (en) * | 1985-06-21 | 1987-11-30 | Richter Gedeon Vegyeszet | Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof |
| FR2589734B1 (fr) * | 1985-11-13 | 1988-09-02 | Roussel Uclaf | Utilisation de derives de l'ergoline a l'obtention d'un medicament a visee geriatrique |
| US4798834A (en) * | 1987-08-31 | 1989-01-17 | Eli Lilly And Company | Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement |
| DE3913756A1 (de) * | 1989-04-21 | 1990-10-25 | Schering Ag | 8(beta)-substituierte ergoline, verfahren zu ihrer herstellung und ihre verwendung |
| DE10212564B4 (de) * | 2002-03-12 | 2007-04-19 | Neurobiotec Gmbh | 1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE41533B1 (en) * | 1974-03-14 | 1980-01-30 | Sandoz Ltd | Thiomethyl ergolene derivatives |
| US3901894A (en) * | 1974-06-06 | 1975-08-26 | Lilly Co Eli | 8-thiomethylergolines |
| US3959288A (en) * | 1974-12-13 | 1976-05-25 | Eli Lilly And Company | 8-Oxymethylergolines and process therefor |
| US4166182A (en) * | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
| US4382940A (en) * | 1979-12-06 | 1983-05-10 | Farmitalia Carlo Erba S.P.A. | Ercoline derivatives and therapeutic compositions having CNS affecting activity |
-
1982
- 1982-08-09 CH CH4772/82A patent/CH649998A5/de not_active IP Right Cessation
-
1983
- 1983-08-01 DE DE19833327705 patent/DE3327705A1/de not_active Withdrawn
- 1983-08-02 FI FI832789A patent/FI73679C/fi not_active IP Right Cessation
- 1983-08-04 FR FR8313018A patent/FR2531433B1/fr not_active Expired
- 1983-08-05 BE BE1/10847A patent/BE897473A/fr not_active IP Right Cessation
- 1983-08-05 GB GB08321222A patent/GB2125041B/en not_active Expired
- 1983-08-05 NL NL8302776A patent/NL8302776A/nl not_active Application Discontinuation
- 1983-08-08 SE SE8304315A patent/SE8304315L/xx not_active Application Discontinuation
- 1983-08-08 IL IL69450A patent/IL69450A/xx unknown
- 1983-08-08 HU HU832798A patent/HU187600B/hu unknown
- 1983-08-08 DK DK361983A patent/DK361983A/da unknown
- 1983-08-08 PT PT77168A patent/PT77168B/pt unknown
- 1983-08-08 ES ES524815A patent/ES8502992A1/es not_active Expired
- 1983-08-08 CA CA000434064A patent/CA1215972A/en not_active Expired
- 1983-08-08 NZ NZ205181A patent/NZ205181A/en unknown
- 1983-08-08 GR GR72165A patent/GR78923B/el unknown
- 1983-08-08 AU AU17672/83A patent/AU563736B2/en not_active Expired - Fee Related
- 1983-08-08 JP JP58144843A patent/JPS5948480A/ja active Pending
- 1983-08-08 AT AT0286383A patent/AT383125B/de not_active IP Right Cessation
- 1983-08-09 ZA ZA835850A patent/ZA835850B/xx unknown
- 1983-08-09 PH PH29378A patent/PH20385A/en unknown
- 1983-08-09 IT IT22490/83A patent/IT1168961B/it active
-
1987
- 1987-12-30 MY MY166/87A patent/MY8700166A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE897473A (fr) | 1984-02-06 |
| DE3327705A1 (de) | 1984-02-09 |
| DK361983A (da) | 1984-02-10 |
| DK361983D0 (da) | 1983-08-08 |
| AU1767283A (en) | 1984-02-16 |
| FI73679B (fi) | 1987-07-31 |
| IT8322490A0 (it) | 1983-08-09 |
| ZA835850B (en) | 1985-03-27 |
| SE8304315L (sv) | 1984-02-10 |
| CH649998A5 (de) | 1985-06-28 |
| IT1168961B (it) | 1987-05-20 |
| IL69450A0 (en) | 1983-11-30 |
| HU187600B (en) | 1986-01-28 |
| PT77168A (en) | 1983-09-01 |
| FI832789A (fi) | 1984-02-10 |
| MY8700166A (en) | 1987-12-31 |
| PH20385A (en) | 1986-12-08 |
| ES524815A0 (es) | 1985-02-01 |
| ATA286383A (de) | 1986-10-15 |
| SE8304315D0 (sv) | 1983-08-08 |
| CA1215972A (en) | 1986-12-30 |
| NZ205181A (en) | 1986-07-11 |
| FR2531433B1 (fr) | 1985-10-18 |
| FI832789A0 (fi) | 1983-08-02 |
| GB2125041B (en) | 1986-04-23 |
| FI73679C (fi) | 1987-11-09 |
| GR78923B (es) | 1984-10-02 |
| GB8321222D0 (en) | 1983-09-07 |
| FR2531433A1 (fr) | 1984-02-10 |
| NL8302776A (nl) | 1984-03-01 |
| AU563736B2 (en) | 1987-07-23 |
| JPS5948480A (ja) | 1984-03-19 |
| IL69450A (en) | 1986-10-31 |
| GB2125041A (en) | 1984-02-29 |
| AT383125B (de) | 1987-05-25 |
| PT77168B (en) | 1986-03-27 |
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