ES8401753A1 - Un procedimiento para la preparacion de un peptido inhibidor de la renina. - Google Patents
Un procedimiento para la preparacion de un peptido inhibidor de la renina.Info
- Publication number
- ES8401753A1 ES8401753A1 ES517994A ES517994A ES8401753A1 ES 8401753 A1 ES8401753 A1 ES 8401753A1 ES 517994 A ES517994 A ES 517994A ES 517994 A ES517994 A ES 517994A ES 8401753 A1 ES8401753 A1 ES 8401753A1
- Authority
- ES
- Spain
- Prior art keywords
- phe
- deletion
- inhibitory peptides
- renin inhibitory
- renin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE UN PEPTIDO INHIBIDOR DE LA RENINA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A, B, D, E, R1, R2, R3, R4 PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE ESTER O AMIDA ADECUADOS DEL AMINOACIDO C-TERMINAL (AAI) CON EL PROXIMO AMINOACIDO ADYACENTE (AAII) DEL PEPTIDO, EN PRESENCIA DE UN AGENTE CONDENSANTE, Y CON EL GRUPO AMINO DEL AMINOACIDO PROTEGIDO. DESPROTECCION DEL DIPEPTIDO FORMADO. TRATAMIENTO CON (AAIII) Y PROSECUCION DE LA SECUENCIA HASTA LA FORMACION DEL PEPTIDO DESEADO.ESTOSPEPTIDOS TIENEN APLICACIONES PARA EL TRATAMIENTO DE DIVERSAS FORMAS DE HIPERTENSION E HIPERALDOSTERONISMO ASOCIADAS A LA REN
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32916681A | 1981-12-10 | 1981-12-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES517994A0 ES517994A0 (es) | 1984-01-01 |
ES8401753A1 true ES8401753A1 (es) | 1984-01-01 |
Family
ID=23284161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES517994A Expired ES8401753A1 (es) | 1981-12-10 | 1982-12-07 | Un procedimiento para la preparacion de un peptido inhibidor de la renina. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0081783B2 (es) |
JP (1) | JPS58105949A (es) |
AT (1) | ATE13892T1 (es) |
AU (1) | AU9111082A (es) |
CA (1) | CA1245217A (es) |
DE (1) | DE3264326D1 (es) |
DK (1) | DK546882A (es) |
ES (1) | ES8401753A1 (es) |
GR (1) | GR77077B (es) |
IE (1) | IE54375B1 (es) |
PT (1) | PT75972B (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0104041B1 (en) * | 1982-09-15 | 1988-07-27 | Aktiebolaget Hässle | Enzyme inhibitors |
US4650661A (en) * | 1982-09-15 | 1987-03-17 | Aktiebolaget Hassle | Enzyme inhibitors |
US4595677A (en) * | 1982-12-03 | 1986-06-17 | Ciba-Geigy Corporation | Substituted tetrapeptides |
DE3381565D1 (de) * | 1982-12-27 | 1990-06-21 | Merck & Co Inc | Reninhemmende tripeptide. |
AU573735B2 (en) * | 1983-02-07 | 1988-06-23 | Aktiebolaget Hassle | Peptide analogue enzyme inhibitors |
US4485099A (en) * | 1983-06-15 | 1984-11-27 | Merck & Co., Inc. | Renin inhibitors containing a C-terminal amide cycle |
US4613676A (en) * | 1983-11-23 | 1986-09-23 | Ciba-Geigy Corporation | Substituted 5-amino-4-hydroxyvaleryl derivatives |
EP0144290A3 (de) * | 1983-12-01 | 1987-05-27 | Ciba-Geigy Ag | Substituierte Aethylendiaminderivate |
JPS60163899A (ja) * | 1984-02-03 | 1985-08-26 | Sankyo Co Ltd | レニン阻害ペプチド類 |
CA1254699A (en) * | 1984-03-12 | 1989-05-23 | Jasjit S. Bindra | Renin inhibitors containing statine or derivatives thereof |
US4665052A (en) * | 1984-03-27 | 1987-05-12 | Merck & Co., Inc. | Renin inhibitors containing homophe8 and a C-terminal amide cycle |
US4636491A (en) * | 1984-03-27 | 1987-01-13 | Merck & Co., Inc. | Renin inhibitory peptides having improved solubility |
US4661473A (en) * | 1984-03-27 | 1987-04-28 | Merck & Co., Inc. | Renin inhibitors containing peptide isosteres |
US4663310A (en) * | 1984-04-04 | 1987-05-05 | Merck & Co., Inc. | Renin inhibitors containing 2-substituted statine |
DE3418491A1 (de) * | 1984-05-18 | 1985-11-21 | Merck Patent Gmbh, 6100 Darmstadt | Diaminosaeurederivate |
FR2564844A1 (fr) * | 1984-05-25 | 1985-11-29 | Sanofi Sa | Nouveaux peptides derives de la statine, procede d'obtention et compositions pharmaceutiques les contenant |
EP0163237A3 (en) * | 1984-05-29 | 1988-04-27 | Merck & Co. Inc. | Di- and tri-peptidal renin inhibitors |
US4880781A (en) * | 1984-08-06 | 1989-11-14 | The Upjohn Company | Renin inhibitory peptides containing an N-alkyl-histidine moiety |
DE3438545A1 (de) * | 1984-10-20 | 1986-04-24 | Merck Patent Gmbh, 6100 Darmstadt | Peptide |
EP0181110A3 (en) * | 1984-10-22 | 1988-05-11 | Kissei Pharmaceutical Co. Ltd. | Histidine derivatives as renin inhibitors |
EP0184855A3 (en) * | 1984-12-14 | 1989-05-03 | Abbott Laboratories | Resin inhibiting compounds |
FR2577226B1 (fr) * | 1985-02-12 | 1990-06-15 | Sanofi Sa | Analogues de pepstatine inhibiteurs de la renine et des proteases acides |
CA1286846C (en) * | 1985-02-12 | 1991-07-23 | Catherine Cazaubon | Peptide derivatives which inhibit renin and acid proteases |
FR2585708B1 (fr) * | 1985-07-31 | 1989-07-07 | Sanofi Sa | Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique |
PT82077B (fr) * | 1985-02-26 | 1987-09-25 | Sanofi Sa | Procede pour l'obtention des derives aminoalcools peptidiques inhibiteurs de la renine et des proteases acides |
DE3512128A1 (de) | 1985-04-03 | 1986-10-09 | Merck Patent Gmbh, 6100 Darmstadt | Peptide |
EP0218688B1 (en) | 1985-04-19 | 1990-09-12 | The Upjohn Company | Dihalo-statine substituted renin inhibitors |
US4882420A (en) * | 1985-04-19 | 1989-11-21 | The Upjohn Company | Dihalo-statine substituted renin inhibitors |
US4657931A (en) * | 1985-05-15 | 1987-04-14 | G. D. Searle & Co. | N-(acyldipeptidyl)-aminoglycols |
EP0206807A3 (en) * | 1985-06-28 | 1988-01-20 | Kissei Pharmaceutical Co. Ltd. | Novel amino acid derivatives |
CA1290097C (en) * | 1985-07-24 | 1991-10-01 | Merck & Co., Inc. | Peptide enzyme inhibitors |
US4729985A (en) * | 1985-08-09 | 1988-03-08 | Pfizer Inc. | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues |
US4853463A (en) * | 1985-09-04 | 1989-08-01 | Kissei Pharmaceutical Co., Ltd. | Amino acid derivatives |
HU200473B (en) * | 1985-11-01 | 1990-06-28 | Pfizer | Process for producing polypeptides containing difluorocyclostatine and pharmaceutical compositions comprising same |
DE3540495A1 (de) * | 1985-11-15 | 1987-05-21 | Merck Patent Gmbh | Aminosaeurederivate |
US4894437A (en) * | 1985-11-15 | 1990-01-16 | The Upjohn Company | Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties |
DE3601248A1 (de) * | 1986-01-17 | 1987-07-23 | Hoechst Ag | Substituierte 4-amino-3-hydroxybuttersaeure-derivate, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung |
DE3628650A1 (de) * | 1986-03-12 | 1987-09-24 | Bayer Ag | Renininhibitoren, verfahren zur herstellung und ihre verwendung |
US4705846A (en) * | 1986-03-27 | 1987-11-10 | The Upjohn Company | Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert |
EP0244083A3 (en) * | 1986-04-01 | 1989-11-15 | Kissei Pharmaceutical Co. Ltd. | Amino acid derivatives |
DE3619508A1 (de) * | 1986-06-10 | 1987-12-17 | Merck Patent Gmbh | Aminosaeurederivate |
JPS6322081A (ja) * | 1986-07-11 | 1988-01-29 | Kissei Pharmaceut Co Ltd | 新規なアミノ酸誘導体 |
DE3626130A1 (de) * | 1986-08-01 | 1988-02-11 | Merck Patent Gmbh | Aminosaeurederivate |
DE3640535A1 (de) * | 1986-11-27 | 1988-06-01 | Merck Patent Gmbh | Peptide |
CH676988A5 (es) * | 1987-01-21 | 1991-03-28 | Sandoz Ag | |
US5378691A (en) * | 1988-04-14 | 1995-01-03 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Amino acid derivatives |
DE3840289A1 (de) * | 1988-11-30 | 1990-05-31 | Merck Patent Gmbh | Aminosaeurederivate |
US5049548A (en) * | 1989-03-03 | 1991-09-17 | Merck & Co., Inc. | Renin-inhibitory di-, tri-, and tetrapeptides |
EP2113510A1 (en) * | 2008-04-30 | 2009-11-04 | Freie Universität Berlin | Pepstatin A derivatives |
PL3185908T3 (pl) * | 2014-08-28 | 2020-09-07 | Pfizer Inc. | Łączniki modulujące stabilność do stosowania z koniugatami przeciwciało-lek |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2506601C3 (de) * | 1974-02-28 | 1980-12-11 | Sanraku-Ocean Co., Ltd., Tokio | Tetrapeptide und Verfahren zu ihrer Herstellung |
-
1982
- 1982-12-01 CA CA000416760A patent/CA1245217A/en not_active Expired
- 1982-12-03 AU AU91110/82A patent/AU9111082A/en not_active Abandoned
- 1982-12-06 DE DE8282111259T patent/DE3264326D1/de not_active Expired
- 1982-12-06 AT AT82111259T patent/ATE13892T1/de active
- 1982-12-06 EP EP82111259A patent/EP0081783B2/en not_active Expired
- 1982-12-07 ES ES517994A patent/ES8401753A1/es not_active Expired
- 1982-12-09 IE IE2924/82A patent/IE54375B1/en unknown
- 1982-12-09 GR GR70032A patent/GR77077B/el unknown
- 1982-12-09 DK DK546882A patent/DK546882A/da unknown
- 1982-12-10 PT PT75972A patent/PT75972B/pt unknown
- 1982-12-10 JP JP57215681A patent/JPS58105949A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PT75972B (en) | 1985-12-20 |
PT75972A (en) | 1983-01-01 |
IE822924L (en) | 1983-06-10 |
DE3264326D1 (en) | 1985-07-25 |
EP0081783B2 (en) | 1989-02-08 |
ES517994A0 (es) | 1984-01-01 |
EP0081783B1 (en) | 1985-06-19 |
AU9111082A (en) | 1983-06-16 |
IE54375B1 (en) | 1989-09-13 |
ATE13892T1 (de) | 1985-07-15 |
JPS58105949A (ja) | 1983-06-24 |
EP0081783A1 (en) | 1983-06-22 |
DK546882A (da) | 1983-06-11 |
GR77077B (es) | 1984-09-06 |
CA1245217A (en) | 1988-11-22 |
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