ES8401016A1 - Un metodo para la preparacion de un peptido inhibidor de la renina. - Google Patents
Un metodo para la preparacion de un peptido inhibidor de la renina.Info
- Publication number
- ES8401016A1 ES8401016A1 ES516294A ES516294A ES8401016A1 ES 8401016 A1 ES8401016 A1 ES 8401016A1 ES 516294 A ES516294 A ES 516294A ES 516294 A ES516294 A ES 516294A ES 8401016 A1 ES8401016 A1 ES 8401016A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- renin
- peptides
- inhibitory peptides
- absent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE PEPTIDOS INHIBIDORES DE LA RENINA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A, B, D, E, R, R, R, R Y R PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN EL TRATAMIENTO DEL ESTER O AMIDA DESEADOS DEL AMINOACIDO C-TERMINAL (AA,I) CON EL PROXIMO AMINOACIDO ADYACENTE (AA,II), EN PRESENCIA DE UN AGENTE DE CONDENSACION. DESPROTECCION DEL DIPEPTIDO FORMADO Y TRATAMIENTO CON UN GRUPO PROTECTOR, EN PRESENCIA DE UN AGENTE DE CONDENSACION. DESPROTECCION DEL TRIPEPTIDO ASI FORMADO Y FORMACION DE UN PENTAPEPTIDO HASTAUN NONAPEPTIDO. DESPROTECCION DE ESTOS Y TRATAMIENTO CON COMPUESTOS QUE CONTIENEN GRUPO ACTIVANTE DEL CARBOXILO.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE HIPERTENSION E HIPERALDOSTERONISMO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30985581A | 1981-10-08 | 1981-10-08 | |
US31255881A | 1981-10-19 | 1981-10-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8401016A1 true ES8401016A1 (es) | 1983-11-16 |
ES516294A0 ES516294A0 (es) | 1983-11-16 |
Family
ID=26977061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES516294A Granted ES516294A0 (es) | 1981-10-08 | 1982-10-07 | Un metodo para la preparacion de un peptido inhibidor de la renina. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0077028B1 (es) |
CA (1) | CA1258748A (es) |
DE (1) | DE3275094D1 (es) |
DK (1) | DK444682A (es) |
ES (1) | ES516294A0 (es) |
GR (1) | GR77713B (es) |
PT (1) | PT75653B (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0104041B1 (en) * | 1982-09-15 | 1988-07-27 | Aktiebolaget Hässle | Enzyme inhibitors |
US4650661A (en) * | 1982-09-15 | 1987-03-17 | Aktiebolaget Hassle | Enzyme inhibitors |
US4595677A (en) * | 1982-12-03 | 1986-06-17 | Ciba-Geigy Corporation | Substituted tetrapeptides |
GB2135773B (en) * | 1983-01-31 | 1985-12-04 | Boots Celltech Diagnostics | Enzyme inhibitor labelled immunoassay |
US4613676A (en) * | 1983-11-23 | 1986-09-23 | Ciba-Geigy Corporation | Substituted 5-amino-4-hydroxyvaleryl derivatives |
CA1254699A (en) * | 1984-03-12 | 1989-05-23 | Jasjit S. Bindra | Renin inhibitors containing statine or derivatives thereof |
US4665052A (en) * | 1984-03-27 | 1987-05-12 | Merck & Co., Inc. | Renin inhibitors containing homophe8 and a C-terminal amide cycle |
US4668663A (en) * | 1984-03-27 | 1987-05-26 | Merck & Co., Inc. | Renin inhibitors containing homophe8 |
EP0156318A3 (en) * | 1984-03-27 | 1988-07-06 | Merck & Co. Inc. | C-terminal amide cyclic renin inhibitors containing peptide isosteres |
US4636491A (en) * | 1984-03-27 | 1987-01-13 | Merck & Co., Inc. | Renin inhibitory peptides having improved solubility |
US4661473A (en) * | 1984-03-27 | 1987-04-28 | Merck & Co., Inc. | Renin inhibitors containing peptide isosteres |
US4663310A (en) * | 1984-04-04 | 1987-05-05 | Merck & Co., Inc. | Renin inhibitors containing 2-substituted statine |
DE3418491A1 (de) * | 1984-05-18 | 1985-11-21 | Merck Patent Gmbh, 6100 Darmstadt | Diaminosaeurederivate |
FR2564844A1 (fr) * | 1984-05-25 | 1985-11-29 | Sanofi Sa | Nouveaux peptides derives de la statine, procede d'obtention et compositions pharmaceutiques les contenant |
EP0163237A3 (en) * | 1984-05-29 | 1988-04-27 | Merck & Co. Inc. | Di- and tri-peptidal renin inhibitors |
US4645759A (en) * | 1984-06-22 | 1987-02-24 | Abbott Laboratories | Renin inhibiting compounds |
US4652551A (en) * | 1984-06-22 | 1987-03-24 | Abbott Laboratories | Renin inhibiting compounds |
US4880781A (en) * | 1984-08-06 | 1989-11-14 | The Upjohn Company | Renin inhibitory peptides containing an N-alkyl-histidine moiety |
DK356085A (da) * | 1984-08-06 | 1986-02-07 | Upjohn Co | Reninhaemmende peptid eller et farmaceutisk acceptabelt syreadditionssalt deraf |
DE3438545A1 (de) * | 1984-10-20 | 1986-04-24 | Merck Patent Gmbh, 6100 Darmstadt | Peptide |
EP0181110A3 (en) * | 1984-10-22 | 1988-05-11 | Kissei Pharmaceutical Co. Ltd. | Histidine derivatives as renin inhibitors |
DE3512128A1 (de) * | 1985-04-03 | 1986-10-09 | Merck Patent Gmbh, 6100 Darmstadt | Peptide |
US4882420A (en) * | 1985-04-19 | 1989-11-21 | The Upjohn Company | Dihalo-statine substituted renin inhibitors |
EP0218688B1 (en) | 1985-04-19 | 1990-09-12 | The Upjohn Company | Dihalo-statine substituted renin inhibitors |
EP0206807A3 (en) * | 1985-06-28 | 1988-01-20 | Kissei Pharmaceutical Co. Ltd. | Novel amino acid derivatives |
US4729985A (en) * | 1985-08-09 | 1988-03-08 | Pfizer Inc. | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues |
US4992562A (en) * | 1985-08-09 | 1991-02-12 | Pfizer Inc. | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues |
US4853463A (en) * | 1985-09-04 | 1989-08-01 | Kissei Pharmaceutical Co., Ltd. | Amino acid derivatives |
DE3538749A1 (de) * | 1985-10-31 | 1987-05-07 | Merck Patent Gmbh | Peptide |
US4894437A (en) * | 1985-11-15 | 1990-01-16 | The Upjohn Company | Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties |
DE3540495A1 (de) * | 1985-11-15 | 1987-05-21 | Merck Patent Gmbh | Aminosaeurederivate |
CA1309555C (en) * | 1986-02-27 | 1992-10-27 | Suvit Thaisrivongs | Inhibiting peptides having a dihydroxyethylene isostere transitionstate insert |
US4705846A (en) * | 1986-03-27 | 1987-11-10 | The Upjohn Company | Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert |
JPS6322081A (ja) * | 1986-07-11 | 1988-01-29 | Kissei Pharmaceut Co Ltd | 新規なアミノ酸誘導体 |
DE3626130A1 (de) * | 1986-08-01 | 1988-02-11 | Merck Patent Gmbh | Aminosaeurederivate |
US4743584A (en) * | 1986-10-07 | 1988-05-10 | Merck & Co., Inc. | C-terminal amide cyclic renin inhibitors containing peptide isosteres |
DE3640535A1 (de) * | 1986-11-27 | 1988-06-01 | Merck Patent Gmbh | Peptide |
DE3724197A1 (de) * | 1987-07-22 | 1989-02-02 | Merck Patent Gmbh | Verfahren zur reduktion von ketonen |
DE3840289A1 (de) * | 1988-11-30 | 1990-05-31 | Merck Patent Gmbh | Aminosaeurederivate |
US5674979A (en) * | 1989-02-10 | 1997-10-07 | Schramm; Wolfgang | Agent for inhibiting symmetrical proteins, in particular enzymes |
WO1990009191A1 (de) * | 1989-02-10 | 1990-08-23 | Wolfgang Schramm | Mittel zur hemmung von symmetrischen proteinen, insbesondere von enzymen |
US5212157A (en) * | 1989-06-06 | 1993-05-18 | Bio-Mega, Inc. | Enzyme inhibitors |
US5126326A (en) * | 1989-06-06 | 1992-06-30 | Bio-Mega, Inc. | Enzyme inhibiting peptide derivatives |
DE4014421A1 (de) * | 1990-05-05 | 1991-11-07 | Merck Patent Gmbh | Aminosaeurederivate |
US5278326A (en) * | 1991-03-18 | 1994-01-11 | Warner-Lambert Company | Substituted beta-ketoamide ACAT inhibitors |
WO2012107153A1 (de) | 2011-02-08 | 2012-08-16 | Merck Patent Gmbh | Aminostatin-derivate zur behandlung von arthrose |
CN104507957B (zh) | 2012-07-24 | 2018-12-25 | 默克专利股份有限公司 | 用于治疗关节病的羟基他汀衍生物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3873681A (en) | 1972-02-16 | 1975-03-25 | Lilly Co Eli | Determination of increased amounts of renin in body fluids |
DE2506601C3 (de) * | 1974-02-28 | 1980-12-11 | Sanraku-Ocean Co., Ltd., Tokio | Tetrapeptide und Verfahren zu ihrer Herstellung |
FR2399409A1 (fr) | 1977-08-04 | 1979-03-02 | Anvar | Nouveaux derives de la pepstatine, leur preparation et les compositions pharmaceutiques qui les contiennent |
-
1982
- 1982-10-05 CA CA000412839A patent/CA1258748A/en not_active Expired
- 1982-10-06 GR GR69461A patent/GR77713B/el unknown
- 1982-10-07 ES ES516294A patent/ES516294A0/es active Granted
- 1982-10-07 EP EP19820109271 patent/EP0077028B1/en not_active Expired
- 1982-10-07 PT PT7565382A patent/PT75653B/pt unknown
- 1982-10-07 DK DK444682A patent/DK444682A/da not_active Application Discontinuation
- 1982-10-07 DE DE8282109271T patent/DE3275094D1/de not_active Expired
Also Published As
Publication number | Publication date |
---|---|
PT75653B (en) | 1985-12-09 |
EP0077028A2 (en) | 1983-04-20 |
EP0077028A3 (en) | 1984-03-21 |
DK444682A (da) | 1983-04-09 |
CA1258748A (en) | 1989-08-22 |
PT75653A (en) | 1982-11-01 |
DE3275094D1 (en) | 1987-02-19 |
EP0077028B1 (en) | 1987-01-14 |
ES516294A0 (es) | 1983-11-16 |
GR77713B (es) | 1984-09-25 |
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