ES8401086A1 - Procedimiento para la obtencion de imidazotiadiazolalquencarboxilamidas. - Google Patents
Procedimiento para la obtencion de imidazotiadiazolalquencarboxilamidas.Info
- Publication number
- ES8401086A1 ES8401086A1 ES520398A ES520398A ES8401086A1 ES 8401086 A1 ES8401086 A1 ES 8401086A1 ES 520398 A ES520398 A ES 520398A ES 520398 A ES520398 A ES 520398A ES 8401086 A1 ES8401086 A1 ES 8401086A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- imidazothiadiazolealkene
- medicines
- carboxylic
- acid amides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Lubricants (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE IMIDAZOTIADIAZOLALQUEN CARBOXILAMIDAS.CONSISTE EN: A) LA REACCION, ENTRE -20 Y 110JC, DE COMPUESTOS DE FORMULA (II) CON OTROS DE FORMULA (III), EN PRESENCIA DE BASES FUERTES Y EN DISOLVENTES ORGANICOS INERTES, DONDO SI R8 F CH3 Y X F O, SE OBTIENEN ALQUENCARBOXILAMIDAS DE FORMULA (I) CON R2 F H; O B) LA REACCION DE (I), CON AGENTES DE ACILACION (IV) EN UN DISOLVENTE ORGANICO INERTE EN PRESENCIA DE UNA BASE ORGANICA; O C) LA REACCION, ENTRE 20 Y 200JC, DE COMPUESTOS (II) CON DERIVADOS DE ACETAMIDA (V), EN PRESENCIA DE CATALIZADORES ACIDOS O BASICOS Y DE DISOLVENTES ORGANICOSINERTES; O D) ACIDOS ALQUENCARBOXILICOS (VI) SE AMIDAN CON AMINAS (VII), ENTRE 20 Y 150JC. EL RADICAL R1 ES HIDROGENO, ARILO O UN RESTO HIDROCARBURO ALIFATICO Y OTROS; R2 ES HIDROGENO O EL RESTO CXR8, DONDE R8 ES IGUAL QUE R1 Y X ES OXIGENO, AZUFRE Y OTROS; R4 ES HIDROGENO, TRIFLUORMETILO O ALQUILO; R3 ES IGUAL QUE R1 O ES FURILO, TIENILO U OTROS; R5 ES HIDROGENO, ALQUILO Y OTROS; Y R6 YR7 SON IGUALES QUE R1 O FORMAN CON UN ATOMO DE NITROGENO UN ANILLO DE C 3 A 8.DE USO FARMACOLOGICO COMO ANTIHIPERTENSIVOS, DIURETICOS Y URICOSURICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823208437 DE3208437A1 (de) | 1982-03-09 | 1982-03-09 | Imidazothiadiazolalkencarbonsaeureamide, neue zwischenprodukte zu ihrer herstellung, ihre herstellung und ihre verwendung in arzneimitteln |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES520398A0 ES520398A0 (es) | 1983-12-01 |
| ES8401086A1 true ES8401086A1 (es) | 1983-12-01 |
Family
ID=6157723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES520398A Expired ES8401086A1 (es) | 1982-03-09 | 1983-03-08 | Procedimiento para la obtencion de imidazotiadiazolalquencarboxilamidas. |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US4585873A (es) |
| EP (1) | EP0088323B1 (es) |
| JP (1) | JPS58162593A (es) |
| AT (1) | ATE26984T1 (es) |
| AU (1) | AU1193483A (es) |
| CA (1) | CA1215710A (es) |
| DE (2) | DE3208437A1 (es) |
| DK (1) | DK113283A (es) |
| ES (1) | ES8401086A1 (es) |
| GR (1) | GR77427B (es) |
| NO (1) | NO830611L (es) |
| ZA (1) | ZA831574B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005010215A1 (de) * | 2005-03-05 | 2006-09-07 | Bayer Cropscience Ag | Heterobicyclische Acrylamide |
| US8563550B2 (en) | 2007-09-27 | 2013-10-22 | Centro Nacional De Investigaciones Oncologicas (Cnio) | Imidazolothiadiazoles for use as protein kinase inhibitors |
| DK2414369T3 (en) | 2009-04-02 | 2015-09-21 | Fundacion Ct Nac Investigaciones Oncologicas Carlos Iii | Imidazo [2,1-b] [1,3,4] thiadiazole derivatives |
| US9173887B2 (en) | 2010-12-22 | 2015-11-03 | Abbvie Inc. | Hepatitis C inhibitors and uses thereof |
| CN114787167B (zh) | 2019-10-21 | 2024-06-21 | 诺华股份有限公司 | 用于治疗寄生虫病的化合物及组合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3946031A (en) * | 1973-10-04 | 1976-03-23 | Syntex Inc. | 2-Substituted-1,2,4-thiadiazolo-[2,3-a]-benzimidazoles |
| DE2823686A1 (de) * | 1978-05-31 | 1979-12-06 | Bayer Ag | Imidazo eckige klammer auf 2.1-b eckige klammer zu eckige klammer auf 1.3.4 eckige klammer zu -thiadiazole |
| NO811630L (no) * | 1980-05-29 | 1981-11-30 | Bayer Ag | Imidazoazolalkensyreamider, nye mellomprodukter for deres fremstilling, deres fremstilling og deres anvendelse som legemiddel |
-
1982
- 1982-03-09 DE DE19823208437 patent/DE3208437A1/de not_active Withdrawn
-
1983
- 1983-02-22 NO NO830611A patent/NO830611L/no unknown
- 1983-02-22 US US06/468,737 patent/US4585873A/en not_active Expired - Fee Related
- 1983-02-28 DE DE8383101929T patent/DE3371339D1/de not_active Expired
- 1983-02-28 EP EP83101929A patent/EP0088323B1/de not_active Expired
- 1983-02-28 AT AT83101929T patent/ATE26984T1/de active
- 1983-03-01 AU AU11934/83A patent/AU1193483A/en not_active Abandoned
- 1983-03-04 JP JP58034671A patent/JPS58162593A/ja active Pending
- 1983-03-07 CA CA000423009A patent/CA1215710A/en not_active Expired
- 1983-03-07 GR GR70699A patent/GR77427B/el unknown
- 1983-03-08 ZA ZA831574A patent/ZA831574B/xx unknown
- 1983-03-08 DK DK113283A patent/DK113283A/da not_active Application Discontinuation
- 1983-03-08 ES ES520398A patent/ES8401086A1/es not_active Expired
-
1985
- 1985-10-21 US US06/789,689 patent/US4657905A/en not_active Expired - Fee Related
-
1986
- 1986-07-01 US US06/880,752 patent/US4703125A/en not_active Expired - Fee Related
- 1986-07-11 US US06/884,561 patent/US4709031A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO830611L (no) | 1983-09-12 |
| US4703125A (en) | 1987-10-27 |
| JPS58162593A (ja) | 1983-09-27 |
| US4585873A (en) | 1986-04-29 |
| ATE26984T1 (de) | 1987-05-15 |
| DE3208437A1 (de) | 1983-09-15 |
| DK113283D0 (da) | 1983-03-08 |
| US4709031A (en) | 1987-11-24 |
| DE3371339D1 (en) | 1987-06-11 |
| ES520398A0 (es) | 1983-12-01 |
| ZA831574B (en) | 1983-12-28 |
| EP0088323A3 (en) | 1984-08-01 |
| CA1215710A (en) | 1986-12-23 |
| AU1193483A (en) | 1983-09-15 |
| EP0088323B1 (de) | 1987-05-06 |
| DK113283A (da) | 1983-09-10 |
| US4657905A (en) | 1987-04-14 |
| EP0088323A2 (de) | 1983-09-14 |
| GR77427B (es) | 1984-09-14 |
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