ES2129073T3 - Derivados del acido 4-fenilcarbamoil-3-isoxazol-carboxilico con actividad antiinflamatoria. - Google Patents
Derivados del acido 4-fenilcarbamoil-3-isoxazol-carboxilico con actividad antiinflamatoria.Info
- Publication number
- ES2129073T3 ES2129073T3 ES93401114T ES93401114T ES2129073T3 ES 2129073 T3 ES2129073 T3 ES 2129073T3 ES 93401114 T ES93401114 T ES 93401114T ES 93401114 T ES93401114 T ES 93401114T ES 2129073 T3 ES2129073 T3 ES 2129073T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- ncx3
- fenilcarbamoil
- carboxilico
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/80—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Abstract
COMPUESTO DE FORMULA (I); EN LA CUAL: R1 REPRESENTA UN ATOMO DE HIDROGENO O UNA AGRUPACION ALQUILO QUE COMPORTA DE 1 A 3 ATOMOS DE CARBONO; R2 REPRESENTA UNA AGRUPACION ALQUILO QUE COMPORTA DE 1 A 3 ATOMOS DE CARBONO O UNA AGRUPACION CILCOALQUILO QUE COMPORTA DE 3 A 6 ATOMOS DE CARBONO; R3 REPRESENTA UNA AGRUPACION COOH O UNA AGRUPACION -COOR6 EN LA CUAL R6 REPRESENTA UNA AGRUPACION ALQUILO QUE COMPORTA DE 1 A 3 ATOMOS DE CARBONO; R4 REPRESENTA UN ATOMO DE HALOGENO, UNA AGRUPACION NITRILO, UNA AGRUPACION NITRO, UNA AGRUPACION -5CH3, UNA AGRUPACION ALQUILCARBONILO EN C1 A 6, UNA AGRUPACION CICLOALQUILCARBONILO EN C3-6, UNA AGRUPACION -CX3, UNA AGRUPACION -WCX3, UNA AGRUPACION -(CH2)NCX3, UNA AGRUPACION (CX2)NCX3, UNA AGRUPACION -W(CX2)NCX3 O UNA AGRUPACION -W(CH2)NCX3, EN LOS CUALES X REPRESENTA UN ATOMO DE HALOGENO, W REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE, Y N REPRESENTA 1, 2 O 3; Y R5 REPRESENTA UN ATOMO DE HIDROGENO, UNA AGRUPACION ALQUILO QUE COMPORTA DE 1 A 3 ATOMOS DE CARBONO O UNA AGRUPACION CICLOALQUILO QUE COMPORTA 3 A 6 ATOMOS DE CARBONO. SUS SALES DE ADICION DE BASE PRESENTAN UNA ACTIVIDAD ANTIINFLAMATORIA. SE DESCRIBE SU PROCESO DE PREPARACION, LAS COMPOSICIONES QUE LOS CONTIENEN Y SU UTILIZACION COMO MEDICAMENTO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929209330A GB9209330D0 (en) | 1992-04-30 | 1992-04-30 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2129073T3 true ES2129073T3 (es) | 1999-06-01 |
Family
ID=10714782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93401114T Expired - Lifetime ES2129073T3 (es) | 1992-04-30 | 1993-04-29 | Derivados del acido 4-fenilcarbamoil-3-isoxazol-carboxilico con actividad antiinflamatoria. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5371099A (es) |
EP (1) | EP0573318B1 (es) |
JP (1) | JP3642797B2 (es) |
AT (1) | ATE178059T1 (es) |
DE (1) | DE69324066T2 (es) |
DK (1) | DK0573318T3 (es) |
ES (1) | ES2129073T3 (es) |
GB (1) | GB9209330D0 (es) |
GR (1) | GR3030234T3 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4214010A1 (de) * | 1992-04-29 | 1993-11-04 | Basf Ag | Isoxazolcarbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung |
CA2117413C (en) * | 1993-07-30 | 2006-11-21 | Neil Geach | Herbicidal isoxazole-4-yl-methanone derivatives |
GB9320299D0 (en) * | 1993-10-01 | 1993-11-17 | Roussel Lab Ltd | Isoxazole derivatives |
US6331555B1 (en) | 1995-06-01 | 2001-12-18 | University Of California | Treatment of platelet derived growth factor related disorders such as cancers |
MY119279A (en) * | 1996-04-23 | 2005-04-30 | Minerals Tech Inc | Polyolefin film, compositions and resins useable therefor and related making method |
US6316479B1 (en) | 1997-05-19 | 2001-11-13 | Sugen, Inc. | Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders |
ATE207065T1 (de) | 1997-08-08 | 2001-11-15 | Aventis Pharma Gmbh | Kristallform von n-(4-trifluormethylphenyl)-5- methylisoxazol-4-carbonsäureamid |
US7071355B2 (en) | 2002-12-23 | 2006-07-04 | 4 Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
US7365094B2 (en) | 2002-12-23 | 2008-04-29 | 4Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
AU2003300530A1 (en) * | 2002-12-23 | 2004-07-14 | 4Sc Ag | Dhodh-inhibitors and method for their identification |
WO2015077535A2 (en) | 2013-11-22 | 2015-05-28 | Genzyme Corporation | Novel methods for treating neurodegenerative diseases |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE12435C (de) * | L. A. enzinger in Worms a. Rh | Isobarometrischer Abfüll-Apparat für gashaltige Flüssigkeiten | ||
NL186239B (nl) * | 1975-06-05 | Hoechst Ag | Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze. | |
DE2854438A1 (de) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | Isoxazolderivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende mittel und ihre verwendung |
US4935434A (en) * | 1988-01-26 | 1990-06-19 | Bristol-Myers Company | Antiarthritic isoxazole-4-carboxamides |
US5001124A (en) * | 1990-02-02 | 1991-03-19 | Syntex (U.S.A.) Inc. | 4-isoxazolecarboxamide derivatives |
-
1992
- 1992-04-30 GB GB929209330A patent/GB9209330D0/en active Pending
-
1993
- 1993-04-28 JP JP12309893A patent/JP3642797B2/ja not_active Expired - Lifetime
- 1993-04-28 US US08/054,893 patent/US5371099A/en not_active Expired - Lifetime
- 1993-04-29 ES ES93401114T patent/ES2129073T3/es not_active Expired - Lifetime
- 1993-04-29 DE DE69324066T patent/DE69324066T2/de not_active Expired - Lifetime
- 1993-04-29 AT AT93401114T patent/ATE178059T1/de active
- 1993-04-29 EP EP93401114A patent/EP0573318B1/fr not_active Expired - Lifetime
- 1993-04-29 DK DK93401114T patent/DK0573318T3/da active
-
1999
- 1999-05-14 GR GR990401322T patent/GR3030234T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69324066T2 (de) | 1999-10-14 |
US5371099A (en) | 1994-12-06 |
JP3642797B2 (ja) | 2005-04-27 |
JPH0649047A (ja) | 1994-02-22 |
GR3030234T3 (en) | 1999-08-31 |
EP0573318A1 (fr) | 1993-12-08 |
EP0573318B1 (fr) | 1999-03-24 |
DE69324066D1 (de) | 1999-04-29 |
ATE178059T1 (de) | 1999-04-15 |
DK0573318T3 (da) | 1999-10-11 |
GB9209330D0 (en) | 1992-06-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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