ES8201521A1 - Un procedimiento para la preparacion de nuevos derivados de acido propanoico - Google Patents

Un procedimiento para la preparacion de nuevos derivados de acido propanoico

Info

Publication number
ES8201521A1
ES8201521A1 ES499292A ES499292A ES8201521A1 ES 8201521 A1 ES8201521 A1 ES 8201521A1 ES 499292 A ES499292 A ES 499292A ES 499292 A ES499292 A ES 499292A ES 8201521 A1 ES8201521 A1 ES 8201521A1
Authority
ES
Spain
Prior art keywords
methylpropionic acid
derivatives
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499292A
Other languages
English (en)
Other versions
ES499292A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schiapparelli Farmaceutici SpA
Original Assignee
Schiapparelli Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schiapparelli Farmaceutici SpA filed Critical Schiapparelli Farmaceutici SpA
Publication of ES8201521A1 publication Critical patent/ES8201521A1/es
Publication of ES499292A0 publication Critical patent/ES499292A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDO PROPANOICO, DE FORMULA (I), EN LA QUE R PUEDE SER HIDROGENO O RADICAL ALQUILO DE UNO A OCHO ATOMOS DE CARBONO. CONSISTE EN LA REACCION DE 4-(2,4-DIFLUORO-FENIL)-FENOL, DE FORMULA (II), CON UN EXCESO DE 70-90 EQUIVALENTES MOLARES DE ACETONA, EN PRESENCIA DE UN AGENTE ALCALINO, TAL COMO HIDROXIDO DE UN METAL ALCALINO O ALCALINOTERREO, A LA TEMPERATURA DE EBULLICION. SE AÑADE UN LIGERO EXCESO MOLAR DE CLOROFORMO Y SE CALIENTA A REFLUJO, DESPUES DE LO CUAL SE SEPARA EL DISOLVENTE POR DESTILACION. EL ACIDO ASI OBTENIDO SE PUEDE ESTERIFICAR CON UN ALCANOL DE UNO A OCHO ATOMOS DE CARBONO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS ACTIVIDADES HIPOLIPIDEMICA E HIPOCOLESTEROLEMICA.
ES499292A 1980-02-12 1981-02-10 Un procedimiento para la preparacion de nuevos derivados de acido propanoico Granted ES499292A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03334/80A IT1141655B (it) 1980-02-12 1980-02-12 Nuovi derivati dell'acido propanoico ad attivita' ipolipidemica e ipocolesterolemica

Publications (2)

Publication Number Publication Date
ES8201521A1 true ES8201521A1 (es) 1982-01-01
ES499292A0 ES499292A0 (es) 1982-01-01

Family

ID=11105179

Family Applications (1)

Application Number Title Priority Date Filing Date
ES499292A Granted ES499292A0 (es) 1980-02-12 1981-02-10 Un procedimiento para la preparacion de nuevos derivados de acido propanoico

Country Status (5)

Country Link
EP (1) EP0033980A1 (es)
JP (1) JPS56127330A (es)
DK (1) DK57381A (es)
ES (1) ES499292A0 (es)
IT (1) IT1141655B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1195295B (it) * 1981-11-24 1988-10-12 Ausonia Farma Srl Nuovi composti ad atitivita' antiinfiammatoria e analgesica,processo per la loro preparazione e relative composizioni farmaceutiche
IT1211135B (it) * 1981-11-24 1989-09-29 Ausonia Farma Srl Composti ad attivita'analgesica e antiinfiammatoria, processo per la loro preparazione e relative composizioni farmaceutiche.
IN160141B (es) * 1983-05-09 1987-06-27 Council Scient Ind Res
FR2598146B1 (fr) * 1986-04-30 1989-01-20 Rech Ind Nouveau procede de preparation de fibrates.
FR2602228A1 (en) * 1986-07-30 1988-02-05 Kirkiacharian Serge New phenoxyisobutyric acids, their derivatives and processes for producing them

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1121722A (en) * 1966-03-31 1968-07-31 Ici Ltd New carboxylic acid derivatives

Also Published As

Publication number Publication date
EP0033980A1 (de) 1981-08-19
IT8003334A0 (it) 1980-02-12
ES499292A0 (es) 1982-01-01
IT1141655B (it) 1986-10-08
JPS56127330A (en) 1981-10-06
DK57381A (da) 1981-08-13

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