ES8308358A1 - Un procedimiento para la preparacion de una serie de nuevos derivados del compuesto ml-236b - Google Patents

Un procedimiento para la preparacion de una serie de nuevos derivados del compuesto ml-236b

Info

Publication number
ES8308358A1
ES8308358A1 ES514185A ES514185A ES8308358A1 ES 8308358 A1 ES8308358 A1 ES 8308358A1 ES 514185 A ES514185 A ES 514185A ES 514185 A ES514185 A ES 514185A ES 8308358 A1 ES8308358 A1 ES 8308358A1
Authority
ES
Spain
Prior art keywords
lactone
microorganism
compound
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514185A
Other languages
English (en)
Other versions
ES514185A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES8308358A1 publication Critical patent/ES8308358A1/es
Publication of ES514185A0 publication Critical patent/ES514185A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Steering-Linkage Mechanisms And Four-Wheel Steering (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE UNA SERIE DE NUEVOS DERIVADOS DEL COMPUESTO ML-236 B. CONSISTE EN ALCOXILAR ENZIMATICAMENTE UN COMPUESTO ML-236 B SELECCIONADO DE ENTRE EL GRUPO FORMADO POR LACTONA ML-236 B, ACIDO ML-236 B CARBOXILICO Y SALES Y ESTERES DE DICHO ACIDO; SI ES NECESARIO, EL PRODUCTO OBTENIDO PUEDE SALIFICARSE O ESTERIFICARSE. LA ETOXILACION ENZIMATICA SE REALIZA PONIENDO EN CONTACTO EL COMPUESTO ML-236 B CON UN MICROORGANISMO DEL GENERO SYNCEPHALASTRUM, ABSIDIA O CUNNIN GHAMELLA, CONCRETAMENTE PUEDE EMPLEARSE SYNCEPHALASTRUM RACEMOSUM IFO-48N O 4828; ABSIDIA COERULEO IFO-4423 O CUNNINGHAMELLA ECHINULATA IFO-4445.
ES514185A 1981-07-21 1982-07-20 Un procedimiento para la preparacion de una serie de nuevos derivados del compuesto ml-236b Granted ES514185A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56114038A JPS5815968A (ja) 1981-07-21 1981-07-21 Ｍｌ−２３６ｂ誘導体およびその製法

Publications (2)

Publication Number Publication Date
ES8308358A1 true ES8308358A1 (es) 1983-08-16
ES514185A0 ES514185A0 (es) 1983-08-16

Family

ID=14627469

Family Applications (1)

Application Number Title Priority Date Filing Date
ES514185A Granted ES514185A0 (es) 1981-07-21 1982-07-20 Un procedimiento para la preparacion de una serie de nuevos derivados del compuesto ml-236b

Country Status (12)

Country Link
US (1) US4447626A (es)
EP (1) EP0070649B1 (es)
JP (1) JPS5815968A (es)
KR (1) KR880001354B1 (es)
AT (1) ATE39487T1 (es)
AU (1) AU547968B2 (es)
CA (1) CA1185199A (es)
DE (1) DE3279304D1 (es)
DK (1) DK159397C (es)
ES (1) ES514185A0 (es)
FI (1) FI75186C (es)
IE (1) IE54747B1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4611081A (en) * 1985-07-05 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
USRE33033E (en) * 1985-07-05 1989-08-22 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
US4841074A (en) * 1987-12-11 1989-06-20 Merck & Co., Inc. Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors
JP2792600B2 (ja) * 1989-04-14 1998-09-03 旭電化工業株式会社 メバロン酸生産菌
EP0409399B1 (en) * 1989-06-09 1996-03-13 Merck & Co. Inc. 3-keto HMG-COA reductase inhibitors
KR100186758B1 (ko) * 1996-08-09 1999-04-01 영진약품공업 주식회사 프라바스타틴(pravastatin)전구체의제조방법
IN191580B (es) 1999-12-17 2003-12-06 Ranbaxy Lab Ltd

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (es) * 1974-06-07 1981-03-18
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b

Also Published As

Publication number Publication date
EP0070649A2 (en) 1983-01-26
DK325782A (da) 1983-01-22
KR880001354B1 (ko) 1988-07-28
CA1185199A (en) 1985-04-09
JPS5815968A (ja) 1983-01-29
DK159397B (da) 1990-10-08
FI822567L (fi) 1983-01-22
KR840000519A (ko) 1984-02-25
IE54747B1 (en) 1990-01-31
FI75186C (fi) 1988-05-09
DK159397C (da) 1991-03-25
FI822567A0 (fi) 1982-07-20
JPS6355502B2 (es) 1988-11-02
DE3279304D1 (en) 1989-02-02
EP0070649B1 (en) 1988-12-28
US4447626A (en) 1984-05-08
AU8592682A (en) 1983-01-27
FI75186B (fi) 1988-01-29
ES514185A0 (es) 1983-08-16
IE821738L (en) 1983-01-21
ATE39487T1 (de) 1989-01-15
AU547968B2 (en) 1985-11-14
EP0070649A3 (en) 1984-04-04

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