JPS55118428A - Biochemical resolution - Google Patents
Biochemical resolutionInfo
- Publication number
- JPS55118428A JPS55118428A JP2556879A JP2556879A JPS55118428A JP S55118428 A JPS55118428 A JP S55118428A JP 2556879 A JP2556879 A JP 2556879A JP 2556879 A JP2556879 A JP 2556879A JP S55118428 A JPS55118428 A JP S55118428A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- esters
- genus
- useful
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain an optically-active secondary alcohol useful as an intermediate of medicines, agricultural chemicals, etc., by the biochemical resolution which comprises the asymmetric hydrolysis of an organic carboxylic acid ester of a specific secondary alcohol with esterase produced by a specific microorganism.
CONSTITUTION: Esterase produced by microorganism belonging to Candida genus, Rhodotorula genus and/or Brevibacterium genus is separated from said bacterial cells or their cultured product, and allowed to act with esters of formula I (R1 and R2 are different alkyl or alkenyl; R3 is H, or substituted or unsubstituted alkyl or alkenyl) or their mixture, whereby alcohols of formula II rich in one optical isomer and esters of formula III rich in the other optical isomer are obtained. The method is widely applicable to the asymmetric hydrolysis of esters of formula I, and optically- active substances of formula II which are useful in the syntheses of various useful natural organic compounds are obtained in higher optical yield than that of conventional method.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2556879A JPS55118428A (en) | 1979-03-07 | 1979-03-07 | Biochemical resolution |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2556879A JPS55118428A (en) | 1979-03-07 | 1979-03-07 | Biochemical resolution |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55118428A true JPS55118428A (en) | 1980-09-11 |
Family
ID=12169522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2556879A Pending JPS55118428A (en) | 1979-03-07 | 1979-03-07 | Biochemical resolution |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55118428A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01257484A (en) * | 1987-12-14 | 1989-10-13 | Idemitsu Kosan Co Ltd | Production of optically active secondary alcohol |
US5187094A (en) * | 1989-09-06 | 1993-02-16 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Method for the preparation of optically active 3-hydroxypyrrolidine derivatives |
US5637500A (en) * | 1990-08-13 | 1997-06-10 | Suntory Limited | Process for preparing optically active alpha-hydroxyalkene derivatives |
-
1979
- 1979-03-07 JP JP2556879A patent/JPS55118428A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01257484A (en) * | 1987-12-14 | 1989-10-13 | Idemitsu Kosan Co Ltd | Production of optically active secondary alcohol |
US5187094A (en) * | 1989-09-06 | 1993-02-16 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Method for the preparation of optically active 3-hydroxypyrrolidine derivatives |
US5637500A (en) * | 1990-08-13 | 1997-06-10 | Suntory Limited | Process for preparing optically active alpha-hydroxyalkene derivatives |
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