ES8303334A1 - Procedimiento para la obtencion de acidos 1-carboxi-(alca- noil o aralcancil)-indolin-2-carboxilicos - Google Patents

Procedimiento para la obtencion de acidos 1-carboxi-(alca- noil o aralcancil)-indolin-2-carboxilicos

Info

Publication number
ES8303334A1
ES8303334A1 ES506571A ES506571A ES8303334A1 ES 8303334 A1 ES8303334 A1 ES 8303334A1 ES 506571 A ES506571 A ES 506571A ES 506571 A ES506571 A ES 506571A ES 8303334 A1 ES8303334 A1 ES 8303334A1
Authority
ES
Spain
Prior art keywords
carboxylic acids
derivatives
carboxyalkanoylindolin
compounds
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506571A
Other languages
English (en)
Other versions
ES506571A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES506571A0 publication Critical patent/ES506571A0/es
Publication of ES8303334A1 publication Critical patent/ES8303334A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS 1-CARBOXI-(ALCANOIL O ARALCANOIL)-INDOLIN-2-CARBOXILICOS, DE FORMULA GENERAL (I), DONDE PH SIGNIFICA 1,2-FENILENO INSUSTITUIDO O 1,2-FENILENO SUSTITUIDO POR UNO HASTA TRES SUSTITUYENTES, IGUALES O DIFERENTES; RO SIGNIFICA H O HPH; R , R Y R E SIGNIFICAN HIDROGENO O ALQUILO INFERIOR; Y N ES UN NUMERO ENTERO DE 1 HASTA 10, Y SUS SALES. CONSISTE EN CONDENSAR UN COMPUESTO DE FORMULA (II) O SUS DERIVADOS DE ACIDO O DE AMINO, CON DERIVADOS FUNCIONALES REACTIVOS DE UN COMPUESTO DE FORMULA (III), DONDE RH, RO, R , R , R Y N TIENEN LOS SIGNIFICADOS YA INDICADOS. DE APLICACION EN PREPARADOS FARMACEUTICOS POR SUS EFECTOS ANTIHIPERTENSIVOS.
ES506571A 1980-10-27 1981-10-26 Procedimiento para la obtencion de acidos 1-carboxi-(alca- noil o aralcancil)-indolin-2-carboxilicos Expired ES8303334A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20070680A 1980-10-27 1980-10-27
US06/235,294 US4374847A (en) 1980-10-27 1981-02-17 1-Carboxyalkanoylindoline-2-carboxylic acids

Publications (2)

Publication Number Publication Date
ES506571A0 ES506571A0 (es) 1983-02-01
ES8303334A1 true ES8303334A1 (es) 1983-02-01

Family

ID=26896021

Family Applications (2)

Application Number Title Priority Date Filing Date
ES506571A Expired ES8303334A1 (es) 1980-10-27 1981-10-26 Procedimiento para la obtencion de acidos 1-carboxi-(alca- noil o aralcancil)-indolin-2-carboxilicos
ES516561A Granted ES516561A0 (es) 1980-10-27 1982-10-15 Procedimiento para la obtencion de acidos 1-carboxi-(alcanoil o aralcanoil)-indolin-2-carboxilicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES516561A Granted ES516561A0 (es) 1980-10-27 1982-10-15 Procedimiento para la obtencion de acidos 1-carboxi-(alcanoil o aralcanoil)-indolin-2-carboxilicos.

Country Status (22)

Country Link
US (1) US4374847A (es)
EP (1) EP0050850B1 (es)
KR (1) KR890000662B1 (es)
AT (1) ATE26705T1 (es)
AU (1) AU546726B2 (es)
CA (1) CA1172257A (es)
CY (1) CY1380A (es)
DD (1) DD201887A5 (es)
DE (1) DE3176125D1 (es)
DK (1) DK154978C (es)
ES (2) ES8303334A1 (es)
FI (1) FI813349L (es)
GB (1) GB2085880B (es)
GR (1) GR74690B (es)
HK (1) HK84687A (es)
HU (1) HU185151B (es)
IE (1) IE51688B1 (es)
IL (1) IL64111A (es)
MY (1) MY8700568A (es)
NO (1) NO156979C (es)
NZ (1) NZ198750A (es)
PT (1) PT73879B (es)

Families Citing this family (63)

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DE3300316A1 (de) * 1983-01-07 1984-07-12 Hoechst Ag, 6230 Frankfurt Disubstituierte prolinderivate, verfahren zu ihrer herstellung und ihre verwendung
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US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
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DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
US4614806A (en) * 1983-12-23 1986-09-30 American Home Products Corporation Process for the asymmetric synthesis of chiral indoline-2-carboxylic acids
US4644081A (en) * 1985-02-11 1987-02-17 American Home Products Corporation Process for the asymmetric synthesis of chiral indoline-2-carboxylic acids
US4727183A (en) * 1983-12-23 1988-02-23 American Home Products Corporation Process for the asymmetric synthesis of chiral α-hydroxy-2-nitrobenzenepropanoic acid
US4585879A (en) * 1983-12-23 1986-04-29 American Home Products Corporation Process for preparing indoline-2-carboxylic acids via alpha-hydroxy-2-nitrobenzenepropanoic acid
US4785118A (en) * 1983-12-23 1988-11-15 American Home Products Corporation Process for preparing indoline-2-carboxylic acids via alpha-hydroxy-2-nitrobenzenepropanoic acid
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US4697016A (en) * 1984-10-26 1987-09-29 Ciba-Geigy Corporation Intermediates for the preparation of a carboxylic acid
US4595766A (en) * 1984-10-26 1986-06-17 Ciba-Geigy Corporation Process for the preparation of an indoline carboxylic acid
US4645857A (en) * 1985-02-11 1987-02-24 American Home Products Corporation Process for preparing indoline-2-carboxylic acids via α-hydroxy-2-nitrobenzenepropanoic acid
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
KR880001848B1 (ko) * 1985-07-04 1988-09-22 재단법인 한국화학연구소 인돌린 유도체의 제조방법
DE3536687A1 (de) * 1985-10-15 1987-04-16 Hoechst Ag Verfahren zur behandlung von atherosklerose, thrombose und der peripheren gefaesskrankheit
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5166212A (en) * 1985-12-06 1992-11-24 Ciba-Geigy Corporation Certain n-substituted butyramide derivatives
EP0225292A3 (en) * 1985-12-06 1988-11-30 Ciba-Geigy Ag Certain n-substituted butyramide derivatives
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
EP0254032A3 (en) * 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
EP0566157A1 (en) 1986-06-20 1993-10-20 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
DD284030A5 (de) 1988-11-24 1990-10-31 Hoechst Ag,De Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
AU6880291A (en) * 1989-11-21 1991-06-13 Schering Corporation Carboxyalkylcarbonyl aminoacid endopeptidase inhibitors
US5407960A (en) * 1989-12-22 1995-04-18 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
US5075302A (en) * 1990-03-09 1991-12-24 Schering Corporation Mercaptoacyl aminolactam endopeptidase inhibitors
US5173506A (en) * 1990-08-16 1992-12-22 Schering Corporation N-(mercaptoalkyl)ureas and carbamates
TW197945B (es) * 1990-11-27 1993-01-11 Hoechst Ag
TW258739B (es) * 1992-04-04 1995-10-01 Hoechst Ag
EP0739898B1 (de) * 1995-03-13 2001-09-26 Aventis Pharma Deutschland GmbH Phosphonomonoesternnukleinsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
WO1997011936A1 (en) * 1995-09-28 1997-04-03 Merck & Co., Inc. Preparation of carboxyalkyl derivatives
DE59706273D1 (de) 1996-03-20 2002-03-21 Hoechst Ag Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DE19612067A1 (de) * 1996-03-27 1997-10-02 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de) * 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
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EP1615885A1 (en) * 2003-04-15 2006-01-18 Warner-Lambert Company LLC B -fused bicyclic proline derivatives and their use for treating arthritic conditions

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Also Published As

Publication number Publication date
HK84687A (en) 1987-11-20
KR830007551A (ko) 1983-10-21
US4374847A (en) 1983-02-22
DE3176125D1 (en) 1987-05-27
DK154978B (da) 1989-01-16
IE51688B1 (en) 1987-02-04
MY8700568A (en) 1987-12-31
ES8401027A1 (es) 1983-12-01
DK154978C (da) 1989-06-12
NO156979B (no) 1987-09-21
CA1172257A (en) 1984-08-07
EP0050850B1 (de) 1987-04-22
IL64111A (en) 1984-10-31
ATE26705T1 (de) 1987-05-15
FI813349L (fi) 1982-04-28
EP0050850A1 (de) 1982-05-05
GR74690B (es) 1984-07-03
GB2085880A (en) 1982-05-06
KR890000662B1 (ko) 1989-03-22
NZ198750A (en) 1984-05-31
NO813615L (no) 1982-04-28
CY1380A (en) 1987-08-07
ES516561A0 (es) 1983-12-01
DD201887A5 (de) 1983-08-17
NO156979C (no) 1987-12-30
ES506571A0 (es) 1983-02-01
GB2085880B (en) 1984-05-31
PT73879A (de) 1981-11-01
AU546726B2 (en) 1985-09-19
IL64111A0 (es) 1982-01-31
DK470481A (da) 1982-04-28
PT73879B (de) 1983-10-25
AU7682381A (en) 1982-05-06
HU185151B (en) 1984-12-28

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