ES8300729A1 - Un procedimiento para la produccion de un derivado de pripe-razina. - Google Patents

Un procedimiento para la produccion de un derivado de pripe-razina.

Info

Publication number
ES8300729A1
ES8300729A1 ES503502A ES503502A ES8300729A1 ES 8300729 A1 ES8300729 A1 ES 8300729A1 ES 503502 A ES503502 A ES 503502A ES 503502 A ES503502 A ES 503502A ES 8300729 A1 ES8300729 A1 ES 8300729A1
Authority
ES
Spain
Prior art keywords
composition containing
piperazine derivative
group
analgesic composition
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503502A
Other languages
English (en)
Other versions
ES503502A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP8978280A external-priority patent/JPS5714585A/ja
Priority claimed from JP56069689A external-priority patent/JPS57185272A/ja
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of ES8300729A1 publication Critical patent/ES8300729A1/es
Publication of ES503502A0 publication Critical patent/ES503502A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIPERAZINA DE FORMULA (I), EN LA QUE R ES CICLOPROPILMETILO, ISOPROPILO O ALILO; R ES FENILO SUSTITUIDO CON HALOGENO O TRIFLUORMETILO. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA R X CON UN COMPUESTO DE FORMULA (II), EN LAS QUE R Y R SON LOS MISMOS QUE EN LA FORMULA (I) Y X ES UN ATOMO DE HALOGENO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PESENCIA DE UNA BASE COMO ACEPTOR DE ACIDO, A UNA TEMPERATURA ENTRE LA AMBIENTE Y LA DE EBULLICION DEL DISOLVENTE. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANALGESICA.
ES503502A 1980-06-30 1981-06-29 Un procedimiento para la produccion de un derivado de pripe-razina. Granted ES503502A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8978280A JPS5714585A (en) 1980-06-30 1980-06-30 1-cycloalkylmethylpiperazine derivative
JP56069689A JPS57185272A (en) 1981-05-08 1981-05-08 Piperazine derivative

Publications (2)

Publication Number Publication Date
ES8300729A1 true ES8300729A1 (es) 1982-11-01
ES503502A0 ES503502A0 (es) 1982-11-01

Family

ID=26410857

Family Applications (2)

Application Number Title Priority Date Filing Date
ES503502A Granted ES503502A0 (es) 1980-06-30 1981-06-29 Un procedimiento para la produccion de un derivado de pripe-razina.
ES512562A Granted ES512562A0 (es) 1980-06-30 1982-05-26 Un procedimiento para la produccion de un derivado de piperazina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES512562A Granted ES512562A0 (es) 1980-06-30 1982-05-26 Un procedimiento para la produccion de un derivado de piperazina.

Country Status (11)

Country Link
US (1) US4518712A (es)
KR (1) KR850000216B1 (es)
AU (1) AU524157B2 (es)
CA (1) CA1203239A (es)
CH (1) CH649995A5 (es)
DE (1) DE3125471C2 (es)
ES (2) ES503502A0 (es)
FR (1) FR2493315A1 (es)
GB (1) GB2078746B (es)
IT (1) IT1171335B (es)
NL (1) NL191307C (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3306964A1 (de) * 1983-02-28 1984-09-06 Boehringer Ingelheim KG, 6507 Ingelheim Neues n-arylpiperazin und verfahren zu seiner herstellung
FR2635105B1 (fr) * 1988-08-03 1991-01-25 Synthelabo Derives de piperazine et leur procede de preparation
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
SE9904723D0 (sv) * 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission II
SE9904724D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission I
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
DE10161644A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh N,N'-disubstituierte Piperazin-Verbindungen
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
AR047759A1 (es) * 2003-09-26 2006-02-22 Vertex Pharma Derivados de fenil - piperazina como moduladores de receptores muscarnicos
US7851629B2 (en) 2004-06-08 2010-12-14 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
DE602005017784D1 (de) 2004-06-08 2009-12-31 Nsab, Filial Af Neurosearch Sweden Ab Neue disubstituierte phenylpiperidine als modulatoren der dopamin- und serotoninneurotransmission
CN101056854B (zh) 2004-10-13 2013-06-05 Nsab神经研究瑞典公司分公司 合成4-(3-甲磺酰基苯基)-1-n-丙基-哌啶的方法
SE529246C2 (sv) 2005-10-13 2007-06-12 Neurosearch Sweden Ab Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
EP2014656A3 (en) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
US9012476B2 (en) 2011-12-08 2015-04-21 IVAX International GmbH Hydrobromide salt of pridopidine
CN104470585A (zh) 2012-04-04 2015-03-25 爱华克斯国际有限公司 用于联合疗法的药物组合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2830056A (en) * 1958-04-08 Chj oh
US3037024A (en) * 1962-05-29 Chjchj
US3402039A (en) * 1966-12-05 1968-09-17 Dow Chemical Co Piperazinium salts as plant stunting agents
US3394137A (en) * 1966-12-05 1968-07-23 Dow Chemical Co Nu-pentachlorophenyl piperazine derivatives
US3506666A (en) * 1966-12-05 1970-04-14 Dow Chemical Co 1-methyl-1-(substituted)-4-(pentachloro-phenyl)piperazinium salts
FR2201084B1 (es) * 1972-09-29 1975-10-31 Bouchara Emile
GB1554897A (en) * 1976-12-10 1979-10-31 Beecham Group Ltd (substituted phenyl) - piperazines and their use in pharmaceutical compositions
GB1560271A (en) * 1977-01-14 1980-02-06 Joullie International Sa Therapeutically useful m-trifluoromethylphenylpiperazine derivatives

Also Published As

Publication number Publication date
ES8305344A1 (es) 1983-04-01
GB2078746A (en) 1982-01-13
KR830006255A (ko) 1983-09-20
FR2493315B1 (es) 1984-11-09
AU7231081A (en) 1982-03-04
ES512562A0 (es) 1983-04-01
NL191307B (nl) 1994-12-16
US4518712A (en) 1985-05-21
GB2078746B (en) 1984-01-18
CA1203239A (en) 1986-04-15
DE3125471A1 (de) 1982-03-18
IT8148772A0 (it) 1981-06-26
AU524157B2 (en) 1982-09-02
ES503502A0 (es) 1982-11-01
KR850000216B1 (ko) 1985-03-06
CH649995A5 (de) 1985-06-28
FR2493315A1 (fr) 1982-05-07
IT1171335B (it) 1987-06-10
NL8103131A (nl) 1982-01-18
NL191307C (nl) 1995-05-16
DE3125471C2 (de) 1985-07-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001