ES481549A1 - Un procedimiento para la producicion de un derivado de feni-letanolamina. - Google Patents
Un procedimiento para la producicion de un derivado de feni-letanolamina.Info
- Publication number
- ES481549A1 ES481549A1 ES481549A ES481549A ES481549A1 ES 481549 A1 ES481549 A1 ES 481549A1 ES 481549 A ES481549 A ES 481549A ES 481549 A ES481549 A ES 481549A ES 481549 A1 ES481549 A1 ES 481549A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- substituent
- arylthio
- aryloxy
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para la producción de un derivado de feniletanolamina representado por la fórmula: **(Fórmula-01)** donde R representa un átomo de hidrógeno, un átomo de halógeno, un grupo hidroxilo, un grupo alquilo inferior un grupo alcoxi inferior, un grupo alquiltio inferior, un grupo amino, un grupo acilamino inferior, un grupo aluilsulfonilo inferior o un grupo alquilsulfonilamino inferior. R1m R2, R3 y R4, que pueden ser iguales o diferentes, representan cada uno de ellos un átomo de hidrógeno o un grupo alquilo inferior; R5 representa un grupo arilo que pueden contener sustituyentes, un grupo benzodioxano cíclico que puede contener sustituyentes, un grupo ariloxi que puede contener sustituyentes o un grupo ariltio que puede contener sustituyentes; sin embargo, R5 es un grupo benzodioxano cíclico que puede contener sustituyentes, un grupo ariloxi que puede contener sustituyentes o un grupo ariltio que puede contener sustituyentes cuando R es un grupo hidroxilo y n representa 0 o unnúmero entero de 1 a 3; cuyo procedimiento consiste en hacer reacción un compuesto de fórmula: **(Fórmula-02)** donde Y es hidroxi, X es halógeno ó Y y X tomados juntos forman un puente epóxido, con una amina de fórmula. **(Fórmula-03)** donde R3, R4, R5 y n tienen el significado dado anteriormente.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12203477A JPS5473751A (en) | 1977-10-12 | 1977-10-12 | Phenyl ethanolamine derivatives and their preparation |
JP12843677A JPS5463048A (en) | 1977-10-26 | 1977-10-26 | Novel phenyl ethanolamine derivatives and their preparation |
JP15535277A JPS5495544A (en) | 1977-12-23 | 1977-12-23 | Phenylethanolamine derivative and its preparation |
JP7496478A JPS552639A (en) | 1978-06-21 | 1978-06-21 | Phenylethanolamine derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES481549A1 true ES481549A1 (es) | 1980-04-01 |
Family
ID=27465764
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES474149A Expired ES474149A1 (es) | 1977-10-12 | 1978-10-11 | Un procedimiento para la produccion de un derivado de feni- letanolamina |
ES481549A Expired ES481549A1 (es) | 1977-10-12 | 1979-06-13 | Un procedimiento para la producicion de un derivado de feni-letanolamina. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES474149A Expired ES474149A1 (es) | 1977-10-12 | 1978-10-11 | Un procedimiento para la produccion de un derivado de feni- letanolamina |
Country Status (16)
Country | Link |
---|---|
US (1) | US4217305A (es) |
AT (1) | AT363457B (es) |
AU (1) | AU526715B2 (es) |
CA (1) | CA1147342A (es) |
CH (1) | CH639948A5 (es) |
DE (1) | DE2843016A1 (es) |
DK (1) | DK168484B1 (es) |
ES (2) | ES474149A1 (es) |
FR (1) | FR2405931A1 (es) |
GB (1) | GB2006772B (es) |
GR (1) | GR65337B (es) |
IT (1) | IT1160853B (es) |
NO (1) | NO147148C (es) |
PT (1) | PT68624A (es) |
SE (1) | SE448232B (es) |
SU (2) | SU982537A3 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55124742A (en) * | 1979-03-20 | 1980-09-26 | Kyowa Hakko Kogyo Co Ltd | Novel aminoalcohol derivative |
US4206125A (en) * | 1979-05-04 | 1980-06-03 | Richardson-Merrell Inc. | 5-[2-[(2,3-Dihydro-1,4-benzodioxan-2-ylmethyl)amino]-1-hydroxyethyl]-2-hydroxybenzoic acid derivatives |
DD157796A5 (de) * | 1979-12-04 | 1982-12-08 | Ciba Geigy Ag | Verfahren zur herstellung neuer derivate des 2-amino-aethanols |
JPS56110665A (en) * | 1980-02-08 | 1981-09-01 | Yamanouchi Pharmaceut Co Ltd | Sulfamoyl-substituted phenetylamine derivative and its preparation |
US4558156A (en) * | 1980-02-08 | 1985-12-10 | Yamanouchi Pharmaceutical Co., Ltd. | Sulfamoyl-substituted phenethylamine derivatives |
US5391825A (en) * | 1980-02-08 | 1995-02-21 | Yamanouchi Pharmaceutical Co., Ltd. | Sulfamoyl substituted phenethylamine intermediates |
DE3128117A1 (de) * | 1980-07-29 | 1982-03-11 | Yamanouchi Pharmaceutical Co., Ltd., Tokyo | Neue phenyl-aethylaminderivate, verfahren zu ihrer herstellung |
CA1219865A (en) * | 1982-05-14 | 1987-03-31 | Leo Alig | Aziridine phenethanolamine derivatives |
PT78388B (en) * | 1983-04-12 | 1986-09-15 | Smithkline Beckman Corp | Dopamine-beta-hydroxylase inhibitors |
JPS6051106A (ja) * | 1983-08-31 | 1985-03-22 | Yamanouchi Pharmaceut Co Ltd | 塩酸アモスラロ−ル持続性製剤 |
EP0162404B1 (en) * | 1984-05-15 | 1988-08-24 | Seitetsu Kagaku Co., Ltd. | Process for preparing 2-alkyl-5-haloacetylbenzenesulfonamide |
US4678855A (en) * | 1985-10-09 | 1987-07-07 | Merck & Co., Inc. | Substituted benzenesulfonamides |
JPS62114952A (ja) * | 1985-11-13 | 1987-05-26 | Yamanouchi Pharmaceut Co Ltd | 置換フエネチルアミン誘導体の製造法 |
DE3880628T2 (de) * | 1987-11-13 | 1993-08-05 | Glaxo Group Ltd | Phenethanolamin-derivate. |
ES2137260T3 (es) * | 1992-05-22 | 1999-12-16 | Senju Pharma Co | Composicion farmaceutica para uso en el tratamiento del glaucoma. |
FR2737494B1 (fr) * | 1995-08-04 | 1997-08-29 | Synthelabo | Derives de benzenesulfonamide, leur preparation et leur application en therapeutique |
ES2208772T3 (es) * | 1996-01-10 | 2004-06-16 | Asahi Kasei Kabushiki Kaisha | Nuevos compuestos triciclicos y compuestos farmaceuticos que contienen los mismos. |
MXPA00010805A (es) * | 1998-05-06 | 2002-05-08 | Univ Duke | Metodo para el tratamiento de sindromes de la vejiga y del tracto urinario inferior. |
FR2791675B1 (fr) * | 1999-03-30 | 2001-05-04 | Synthelabo | Derives de n-[2-(4-aminophenyl) ethyl] -2,3-dihydro-1,4- benzodioxinne-2-methanamine, leur preparation et leur application en therapeutique |
US6835853B2 (en) * | 2001-10-31 | 2004-12-28 | Synthon Bv | Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith |
ES2362998T3 (es) | 2002-08-19 | 2011-07-18 | Pfizer Inc. | Terapia de combinación para enfermedades hiperproliferativas. |
JP4901474B2 (ja) | 2003-05-30 | 2012-03-21 | ランバクシー ラボラトリーズ リミテッド | 置換ピロール誘導体 |
KR100596373B1 (ko) | 2003-12-09 | 2006-07-04 | 씨제이 주식회사 | 광학적으로 순수한 펜에틸 아민 유도체의 제조방법 |
ES2328384T3 (es) * | 2004-11-23 | 2009-11-12 | Warner-Lambert Company Llc | Derivados del acido 7-(2h-pirazol-3-il)-3,5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de la lipidemia. |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
AU2006313430B2 (en) | 2005-11-08 | 2012-09-06 | Ranbaxy Laboratories Limited | Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
WO2007131804A1 (en) | 2006-05-17 | 2007-11-22 | Synthon B.V. | Tablet composition with a prolonged release of tamsulosin |
CN101663262B (zh) | 2006-12-01 | 2014-03-26 | 百时美施贵宝公司 | 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物 |
US8465770B2 (en) * | 2008-12-24 | 2013-06-18 | Synthon Bv | Low dose controlled release tablet |
CN102050766B (zh) * | 2009-11-03 | 2013-08-07 | 安徽省新星药物开发有限责任公司 | 一种盐酸氨磺洛尔的合成方法 |
EP2986599A1 (en) | 2013-04-17 | 2016-02-24 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
CA3125765A1 (en) | 2019-01-18 | 2020-07-23 | Astrazeneca Ab | Pcsk9 inhibitors and methods of use thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3701808A (en) * | 1967-12-21 | 1972-10-31 | Allen & Hanburys Ltd | Phenylethanolamines |
GB1266058A (es) | 1969-07-08 | 1972-03-08 | ||
GB1321701A (en) | 1969-10-01 | 1973-06-27 | Continental Pharma | Amino-alcohols their salts and process for prepairing the same |
US3711545A (en) * | 1971-02-23 | 1973-01-16 | Smith Kline French Lab | Alpha-aminoalkyl-4-hydroxy-3-sulfamoylaminobenzyl alcohols |
DE2115926C3 (de) * | 1971-04-01 | 1978-05-03 | C.H. Boehringer Sohn, 6507 Ingelheim | 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel |
US4034112A (en) * | 1973-06-22 | 1977-07-05 | Imperial Chemical Industries Limited | Ethanolamine derivatives having β-adrenergic blocking activity |
US3860647A (en) * | 1973-08-20 | 1975-01-14 | Smithkline Corp | {60 -Aminomethyl-4-hydroxy-3-sulfamyl-benzyl alcohols and 4-hydroxy-3-sulfamyl phenethylamines |
DK31578A (da) * | 1977-02-03 | 1978-08-04 | Allen & Hanburys Ltd | Fremgangsmaade til fremstilling af benzenderivater |
GB1593651A (en) * | 1977-02-03 | 1981-07-22 | Allen & Hanburys Ltd | Amides |
-
1978
- 1978-09-22 CA CA000311934A patent/CA1147342A/en not_active Expired
- 1978-09-25 GR GR57301A patent/GR65337B/el unknown
- 1978-09-27 US US05/946,192 patent/US4217305A/en not_active Expired - Lifetime
- 1978-10-02 CH CH1021878A patent/CH639948A5/de not_active IP Right Cessation
- 1978-10-03 DE DE19782843016 patent/DE2843016A1/de active Granted
- 1978-10-06 PT PT68624A patent/PT68624A/pt unknown
- 1978-10-09 FR FR7828743A patent/FR2405931A1/fr active Granted
- 1978-10-11 DK DK452178A patent/DK168484B1/da active
- 1978-10-11 AT AT0731778A patent/AT363457B/de not_active IP Right Cessation
- 1978-10-11 IT IT69350/78A patent/IT1160853B/it active
- 1978-10-11 SU SU782673556A patent/SU982537A3/ru active
- 1978-10-11 NO NO783442A patent/NO147148C/no unknown
- 1978-10-11 SE SE7810613A patent/SE448232B/sv not_active IP Right Cessation
- 1978-10-11 ES ES474149A patent/ES474149A1/es not_active Expired
- 1978-10-12 AU AU40642/78A patent/AU526715B2/en not_active Expired
- 1978-10-12 GB GB7840390A patent/GB2006772B/en not_active Expired
-
1979
- 1979-06-13 ES ES481549A patent/ES481549A1/es not_active Expired
- 1979-10-18 SU SU792835396A patent/SU932982A3/ru active
Also Published As
Publication number | Publication date |
---|---|
ES474149A1 (es) | 1979-10-16 |
CA1147342A (en) | 1983-05-31 |
GB2006772A (en) | 1979-05-10 |
NO783442L (no) | 1979-04-18 |
SE7810613L (sv) | 1979-04-13 |
SU982537A3 (ru) | 1982-12-15 |
FR2405931A1 (fr) | 1979-05-11 |
DK452178A (da) | 1979-04-13 |
NO147148B (no) | 1982-11-01 |
US4217305A (en) | 1980-08-12 |
SU932982A3 (ru) | 1982-05-30 |
ATA731778A (de) | 1981-01-15 |
GR65337B (en) | 1980-08-18 |
FR2405931B1 (es) | 1982-11-19 |
DE2843016A1 (de) | 1979-04-26 |
CH639948A5 (de) | 1983-12-15 |
AT363457B (de) | 1981-08-10 |
IT7869350A0 (it) | 1978-10-11 |
AU4064278A (en) | 1980-04-17 |
PT68624A (en) | 1978-11-01 |
SE448232B (sv) | 1987-02-02 |
IT1160853B (it) | 1987-03-11 |
DE2843016C2 (es) | 1988-10-13 |
NO147148C (no) | 1983-02-09 |
AU526715B2 (en) | 1983-01-27 |
DK168484B1 (da) | 1994-04-05 |
GB2006772B (en) | 1982-02-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000301 |