ES417078A1 - D-6-methyl-2,8-disubstituted ergolines - Google Patents

D-6-methyl-2,8-disubstituted ergolines

Info

Publication number
ES417078A1
ES417078A1 ES417078A ES417078A ES417078A1 ES 417078 A1 ES417078 A1 ES 417078A1 ES 417078 A ES417078 A ES 417078A ES 417078 A ES417078 A ES 417078A ES 417078 A1 ES417078 A1 ES 417078A1
Authority
ES
Spain
Prior art keywords
methyl
substituted
pharmaceutically acceptable
acceptable acids
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES417078A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES417078A1 publication Critical patent/ES417078A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A procedure for the preparation of a new 2-substituted and 8-substituted D-6-methyl-ergoline of formula I: **(See formula)** where X is halogen, and R is CH2-CN or (see formula) and its salts formed with pharmaceutically acceptable acids, the process of which is characterized by halogenating D-6-methyl-8-cyanomethylergoline or D-6-methyl-8-carboxamidomethylergoline and then, if desired, forming salts with pharmaceutically acceptable acids. (Machine-translation by Google Translate, not legally binding)
ES417078A 1972-07-21 1973-07-20 D-6-methyl-2,8-disubstituted ergolines Expired ES417078A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27390272A 1972-07-21 1972-07-21

Publications (1)

Publication Number Publication Date
ES417078A1 true ES417078A1 (en) 1976-05-01

Family

ID=23045910

Family Applications (5)

Application Number Title Priority Date Filing Date
ES417078A Expired ES417078A1 (en) 1972-07-21 1973-07-20 D-6-methyl-2,8-disubstituted ergolines
ES442887A Expired ES442887A1 (en) 1972-07-21 1975-11-21 D-6-methyl-2,8-disubstituted ergolines
ES442886A Expired ES442886A1 (en) 1972-07-21 1975-11-21 D-6-methyl-2,8-disubstituted ergolines
ES442885A Expired ES442885A1 (en) 1972-07-21 1975-11-21 D-6-methyl-2,8-disubstituted ergolines
ES446789A Expired ES446789A1 (en) 1972-07-21 1976-04-07 D-6-methyl-2,8-disubstituted ergolines

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES442887A Expired ES442887A1 (en) 1972-07-21 1975-11-21 D-6-methyl-2,8-disubstituted ergolines
ES442886A Expired ES442886A1 (en) 1972-07-21 1975-11-21 D-6-methyl-2,8-disubstituted ergolines
ES442885A Expired ES442885A1 (en) 1972-07-21 1975-11-21 D-6-methyl-2,8-disubstituted ergolines
ES446789A Expired ES446789A1 (en) 1972-07-21 1976-04-07 D-6-methyl-2,8-disubstituted ergolines

Country Status (24)

Country Link
JP (2) JPS576431B2 (en)
AR (3) AR206772A1 (en)
AT (1) AT331425B (en)
BE (1) BE802531A (en)
BG (3) BG22400A3 (en)
CA (1) CA1006159A (en)
CH (5) CH578564A5 (en)
CS (1) CS208164B2 (en)
DD (1) DD107690A5 (en)
DE (2) DE2335750C3 (en)
DK (1) DK140986B (en)
ES (5) ES417078A1 (en)
FR (1) FR2193606B1 (en)
GB (1) GB1423065A (en)
HU (1) HU167274B (en)
IE (1) IE37936B1 (en)
IL (3) IL48288A (en)
NL (1) NL7309969A (en)
PH (1) PH11229A (en)
RO (2) RO63792A (en)
SE (3) SE393111B (en)
SU (3) SU645581A3 (en)
YU (1) YU36953B (en)
ZA (1) ZA734627B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1517973A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
US3968111A (en) * 1974-12-06 1976-07-06 Eli Lilly And Company 8,8-Disubstituted-6-methylergolines and related compounds
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
AU526764B2 (en) * 1978-09-08 1983-01-27 Farmitalia Carlo Erba S.P.A. Ergoline derivatives
ATE107647T1 (en) * 1984-04-09 1994-07-15 Schering Ag 2-SUBSTITUTED ERGOLINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DE3620293A1 (en) * 1986-06-16 1987-12-17 Schering Ag 1 AND / OR 2 SUBSTITUTED ERGOL DERIVATIVES
JPH0596382U (en) * 1992-05-28 1993-12-27 イビデン株式会社 Door unit

Also Published As

Publication number Publication date
RO63792A (en) 1978-12-15
SU645581A3 (en) 1979-01-30
SE7611467L (en) 1976-10-15
CH578563A5 (en) 1976-08-13
RO71305A (en) 1982-03-24
NL7309969A (en) 1974-01-23
IE37936B1 (en) 1977-11-23
IE37936L (en) 1974-01-21
CH581135A5 (en) 1976-10-29
SE410459B (en) 1979-10-15
PH11229A (en) 1977-10-28
BG22400A3 (en) 1977-02-20
ES446789A1 (en) 1977-06-01
AU5792673A (en) 1975-01-16
SU584780A3 (en) 1977-12-15
ES442887A1 (en) 1977-05-16
HU167274B (en) 1975-09-27
ES442885A1 (en) 1977-04-16
SE7611466L (en) 1976-10-15
IL48288A (en) 1976-06-30
DK140986C (en) 1980-07-21
FR2193606A1 (en) 1974-02-22
JPS5781487A (en) 1982-05-21
BG21410A3 (en) 1976-05-20
DE2335750A1 (en) 1974-02-14
DK140986B (en) 1979-12-17
CA1006159A (en) 1977-03-01
CH580626A5 (en) 1976-10-15
SE393111B (en) 1977-05-02
BE802531A (en) 1974-01-21
CS208164B2 (en) 1981-08-31
ATA643473A (en) 1975-11-15
JPS5813541B2 (en) 1983-03-14
GB1423065A (en) 1976-01-28
CH578564A5 (en) 1976-08-13
SU575029A3 (en) 1977-09-30
AT331425B (en) 1976-08-25
DE2365974A1 (en) 1977-03-24
FR2193606B1 (en) 1977-07-15
AR206887A1 (en) 1976-08-31
JPS576431B2 (en) 1982-02-04
ES442886A1 (en) 1977-04-16
ZA734627B (en) 1974-06-26
JPS4985099A (en) 1974-08-15
CH580625A5 (en) 1976-10-15
BG21411A3 (en) 1976-05-20
DE2335750C3 (en) 1978-10-19
DD107690A5 (en) 1974-08-12
IL42730A0 (en) 1973-10-25
YU36953B (en) 1984-08-31
YU194573A (en) 1982-06-18
AR206772A1 (en) 1976-08-23
SE410603B (en) 1979-10-22
AR210072A1 (en) 1977-06-30
IL42730A (en) 1976-06-30
IL48288A0 (en) 1975-12-31
DE2335750B2 (en) 1978-02-23

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