ES276465A1 - Procedure for preparing derivatives of 19-nor-testosterone (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparing derivatives of 19-nor-testosterone (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES276465A1
ES276465A1 ES276465A ES276465A ES276465A1 ES 276465 A1 ES276465 A1 ES 276465A1 ES 276465 A ES276465 A ES 276465A ES 276465 A ES276465 A ES 276465A ES 276465 A1 ES276465 A1 ES 276465A1
Authority
ES
Spain
Prior art keywords
testosterone
2alpha
17beta
lower alkyl
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES276465A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR858794A external-priority patent/FR1368721A/en
Priority claimed from FR870687A external-priority patent/FR1457M/en
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES276465A1 publication Critical patent/ES276465A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

Process for the preparation of 9alpha-lOalpha-epoxy 2alpha-lower alkyl 19-nor testosterone, of its esters and ethers, characterized in that it is cyclized by means of a basic function agent, a 17beta-hydroxy or 17beta-acyloxy; , 5-dry 3,5-dioxo-2-lower alkyl Δ 9-premiere in a 3-oxo 17beta-hydroxy or 17beta-acyloxy 2-lower alkyl Δ 4,9-estradiene corresponding, separates 2alpha and 2beta epimers , the 2alpha epimer is subjected to the action of a peracid, a 9alpha, 10alpha-epoxy-2alpha-lower alkyl-19-nor-testosterone is obtained, free or esterified, and is transformed, if necessary, into the desired functional derivative. (Machine-translation by Google Translate, not legally binding)
ES276465A 1961-04-14 1962-04-13 Procedure for preparing derivatives of 19-nor-testosterone (Machine-translation by Google Translate, not legally binding) Expired ES276465A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR858794A FR1368721A (en) 1961-04-14 1961-04-14 19-nor testosterone derivatives and method of preparation
FR870687A FR1457M (en) 1961-08-11 1961-08-11 New drug in particular for the treatment of hypophyseal follicle stimulating hyperactivity.

Publications (1)

Publication Number Publication Date
ES276465A1 true ES276465A1 (en) 1962-06-16

Family

ID=26190113

Family Applications (1)

Application Number Title Priority Date Filing Date
ES276465A Expired ES276465A1 (en) 1961-04-14 1962-04-13 Procedure for preparing derivatives of 19-nor-testosterone (Machine-translation by Google Translate, not legally binding)

Country Status (4)

Country Link
BE (1) BE616293A (en)
CH (1) CH409944A (en)
ES (1) ES276465A1 (en)
GB (1) GB974525A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0220296D0 (en) * 2002-08-31 2002-10-09 Bone Paul A Cotainer
TW200611909A (en) * 2004-08-04 2006-04-16 Akzo Nobel Nv Process for the preparation 2-substituted-derivatives of estrone and estradiol
TW200613316A (en) 2004-08-26 2006-05-01 Akzo Nobel Nv Process for the preparation of estrone and/or estradiol-derivates

Also Published As

Publication number Publication date
GB974525A (en) 1964-11-04
BE616293A (en) 1962-10-11
CH409944A (en) 1966-03-31

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