GB955613A - New steroid compounds and processes - Google Patents

New steroid compounds and processes

Info

Publication number
GB955613A
GB955613A GB4717062A GB4717062A GB955613A GB 955613 A GB955613 A GB 955613A GB 4717062 A GB4717062 A GB 4717062A GB 4717062 A GB4717062 A GB 4717062A GB 955613 A GB955613 A GB 955613A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
methylpregna
trione
dione
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4717062A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB955613A publication Critical patent/GB955613A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 4-bromo-17a -hydroxy-16a -methylpregna-3, 11, 20-trione, 17a -hydroxy-16a -methylpregna-4-ene-3, 11, 20-trione, 17a -hydroxy-16a -methylpregna-4, 9(11)-diene-3, 20-dione and processes for the preparation thereof by oxidizing 3a , 17a -dihydroxy-16a -methylpregna-11, 20-dione to form the 3-keto derivative which is then brominated to form 4-bromo-17a -hydroxy-16a -methyl-pregna-3, 11, 20-trione which is then dehydrobrominated to form 17a -hydroxy-16a -methyl-pregna-4, ene-3, 11, 20-trione, ketalising the said 17a -hydroxy-16a -methylpregn-4-ene-3, 11, 20-trione, reducing the 3, 20-diketal at the 11-position to yield the corresponding 3, 20-diketal of 11b , 17a -dihydroxy-16a -methylpregn-4-ene-3, 20-dione, followed by dehydration thereof to yield the corresponding 3, 20-diketal of 17a -hydroxy-16a -methyl-pregna-4, 9(11)-diene-3, 20-dione and hydrolyzing the latter to yield 17a -hydroxy-16a -methylpregna-4, 9(11)-diene-3, 20-dione. Specifications 471,762 and 934,702 are referred to.
GB4717062A 1960-03-16 1961-03-08 New steroid compounds and processes Expired GB955613A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR821557A FR1259501A (en) 1960-03-16 1960-03-16 Improvements made to the preparation of derivatives of pregnane 9alpha-halo 16 alpha-methylated

Publications (1)

Publication Number Publication Date
GB955613A true GB955613A (en) 1964-04-15

Family

ID=8727263

Family Applications (3)

Application Number Title Priority Date Filing Date
GB4717062A Expired GB955613A (en) 1960-03-16 1961-03-08 New steroid compounds and processes
GB852561A Expired GB955612A (en) 1960-03-16 1961-03-08 New steroid compounds, processes for their preparation and conversion into compounds of utility in the production of substituted corticosteroids
GB4717162A Expired GB955614A (en) 1960-03-16 1961-03-08 New steroid compound and processes

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB852561A Expired GB955612A (en) 1960-03-16 1961-03-08 New steroid compounds, processes for their preparation and conversion into compounds of utility in the production of substituted corticosteroids
GB4717162A Expired GB955614A (en) 1960-03-16 1961-03-08 New steroid compound and processes

Country Status (5)

Country Link
BE (1) BE601375A (en)
CH (1) CH395080A (en)
ES (1) ES265581A1 (en)
FR (1) FR1259501A (en)
GB (3) GB955613A (en)

Also Published As

Publication number Publication date
CH395080A (en) 1965-07-15
GB955614A (en) 1964-04-15
BE601375A (en) 1961-09-15
FR1259501A (en) 1961-04-28
ES265581A1 (en) 1961-07-01
GB955612A (en) 1964-04-15

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