ES2536974T3 - Péptidos de epítopos del receptor de EGF y usos de los mismos - Google Patents
Péptidos de epítopos del receptor de EGF y usos de los mismos Download PDFInfo
- Publication number
- ES2536974T3 ES2536974T3 ES05723258.9T ES05723258T ES2536974T3 ES 2536974 T3 ES2536974 T3 ES 2536974T3 ES 05723258 T ES05723258 T ES 05723258T ES 2536974 T3 ES2536974 T3 ES 2536974T3
- Authority
- ES
- Spain
- Prior art keywords
- egf receptor
- epitope peptides
- receptor epitope
- seq
- nos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000001301 EGF receptor Human genes 0.000 title 1
- 108060006698 EGF receptor Proteins 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Un péptido aislado que consiste en la secuencia seleccionada entre el grupo que consiste en: (i) la secuencia expuesta en una cualquiera de las SEQ ID NOs: 1-10; y (ii) una variante o mutante de la secuencia expuesta en una cualquiera de las SEQ ID NOs: 1-10, en la que un aminoácido se ha sustituido por un aminoácido conservativo o no conservativo.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54660204P | 2004-02-20 | 2004-02-20 | |
US546602P | 2004-02-20 | ||
US58462304P | 2004-07-01 | 2004-07-01 | |
US584623P | 2004-07-01 | ||
PCT/US2005/005155 WO2005081854A2 (en) | 2004-02-20 | 2005-02-18 | Egf receptor epitope peptides and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2536974T3 true ES2536974T3 (es) | 2015-06-01 |
Family
ID=34915579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES05723258.9T Active ES2536974T3 (es) | 2004-02-20 | 2005-02-18 | Péptidos de epítopos del receptor de EGF y usos de los mismos |
Country Status (8)
Country | Link |
---|---|
US (2) | US7767792B2 (es) |
EP (2) | EP1722808B1 (es) |
JP (2) | JP2008501308A (es) |
KR (2) | KR101270443B1 (es) |
AU (2) | AU2005216082B8 (es) |
CA (1) | CA2556632C (es) |
ES (1) | ES2536974T3 (es) |
WO (1) | WO2005081854A2 (es) |
Families Citing this family (58)
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ES2334494T5 (es) | 2001-05-11 | 2013-05-29 | Ludwig Institute For Cancer Research Ltd. | Proteínas de unión específicas y usos de las mismas |
DK1399484T3 (da) * | 2001-06-28 | 2010-11-08 | Domantis Ltd | Dobbelt-specifik ligand og anvendelse af denne |
US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
DK1517921T3 (da) * | 2002-06-28 | 2006-10-09 | Domantis Ltd | Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf |
US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
EP1578801A2 (en) * | 2002-12-27 | 2005-09-28 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
US7767792B2 (en) * | 2004-02-20 | 2010-08-03 | Ludwig Institute For Cancer Research Ltd. | Antibodies to EGF receptor epitope peptides |
US20070009972A1 (en) * | 2005-02-16 | 2007-01-11 | Ginger Chao | Epidermal growth factor receptor polypeptides and antibodies |
ZA200803759B (en) * | 2005-11-02 | 2009-10-28 | Univ Duke | Concurrent chemotherapy and immunotherapy |
BRPI0619225A2 (pt) * | 2005-12-01 | 2017-11-07 | Domantis Ltd | monômero de anticorpo de domínio, ligando, ácidos nucleicos isolado e recombinante, vetor, célula hospedeira, método para produzir um monômero de dab de ligando, composição farmacêutica, dispositivo de liberação de medicamento, uso de um monômero de anticorpo de domínio, e, método para tratar uma doença inflamatória, artrite ou doença respiratória |
EP2163563A1 (en) * | 2006-03-31 | 2010-03-17 | Massachusetts Institute of Technology | Treatment of tumors expressing mutant EGF receptors |
WO2008033495A2 (en) * | 2006-09-15 | 2008-03-20 | Life Science Pharmaceuticals | Method for detecting and treating skin disorders |
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EP2147397A4 (en) * | 2007-04-23 | 2013-08-21 | Univ Ramot | SYSTEM, METHOD AND COMPUTER READABLE MEDIUM FOR PROVIDING AN OUTPUT IMAGE |
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WO2009023266A1 (en) * | 2007-08-14 | 2009-02-19 | Ludwig Institute For Cancer Research | Generation of antibodies to cell-surface receptors and cancer-associated proteins including egfr family members |
EP2188311B1 (en) | 2007-08-14 | 2016-10-05 | Ludwig Institute for Cancer Research Ltd. | Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof |
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WO2009149094A2 (en) * | 2008-06-02 | 2009-12-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cytotoxic t cell defined egfr peptide and an optimized derivative peptide |
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US8741287B2 (en) * | 2008-06-18 | 2014-06-03 | Abbott Laboratories | PlGF-1 assay and kits and components thereof |
WO2010077643A1 (en) * | 2008-12-08 | 2010-07-08 | Tegopharm Corporation | Masking ligands for reversible inhibition of multivalent compounds |
US8895702B2 (en) | 2008-12-08 | 2014-11-25 | City Of Hope | Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies |
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WO2010096838A2 (en) * | 2009-02-23 | 2010-08-26 | Cytomx Therapeutics, Llc | Proproteins and methods of use thereof |
KR101477762B1 (ko) * | 2009-09-22 | 2014-12-30 | 상하이 캔서 인스티튜트 | 특이성 결합 단백질 및 용도 |
CN102127147B (zh) * | 2010-01-20 | 2014-07-02 | 上海市肿瘤研究所 | 表皮生长因子受体模拟表位肽及其应用 |
CN103539840B (zh) * | 2010-01-20 | 2015-04-01 | 上海市肿瘤研究所 | 表皮生长因子受体模拟表位肽及其应用 |
JP2013534515A (ja) | 2010-06-01 | 2013-09-05 | モナシュ ユニバーシティ | プロセシングされていない受容体型チロシンキナーゼc−METに対する抗体 |
WO2012024659A2 (en) | 2010-08-20 | 2012-02-23 | Massachusetts Institute Of Technology | Antibody-based constructs directed against tyrosine kinase receptors |
EP2699268A2 (de) | 2011-04-21 | 2014-02-26 | Seattle Genetics, Inc. | Neue binder-wirkstoff konjugate (adcs) und ihre verwendung |
IN2014DN08778A (es) * | 2012-03-27 | 2015-05-22 | Green Cross Corp | |
JP6103832B2 (ja) | 2012-06-25 | 2017-03-29 | Hoya株式会社 | Egfr結合性ペプチド |
CN106163568B (zh) | 2013-12-23 | 2021-03-23 | 拜耳制药股份公司 | 含纺锤体驱动蛋白(ksp)的抗体药物偶联物(adc) |
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US20190099475A1 (en) | 2015-04-08 | 2019-04-04 | Nantomics, Llc | Cancer neoepitopes |
CN108513593A (zh) | 2015-04-23 | 2018-09-07 | 南托米克斯有限责任公司 | 癌症新表位 |
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MX2009009782A (es) | 2007-03-15 | 2010-09-10 | Ludwig Inst Cancer Res | Metodo de tratamiento que utiliza anticuerpos egfr e inhibidores de src y formulaciones relacionadas. |
EP2188311B1 (en) | 2007-08-14 | 2016-10-05 | Ludwig Institute for Cancer Research Ltd. | Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof |
US20110076232A1 (en) | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
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2005
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- 2005-02-18 ES ES05723258.9T patent/ES2536974T3/es active Active
- 2005-02-18 EP EP05723258.9A patent/EP1722808B1/en active Active
- 2005-02-18 CA CA2556632A patent/CA2556632C/en active Active
- 2005-02-18 WO PCT/US2005/005155 patent/WO2005081854A2/en active Application Filing
- 2005-02-18 KR KR1020127010335A patent/KR101270443B1/ko active IP Right Grant
- 2005-02-18 AU AU2005216082A patent/AU2005216082B8/en active Active
- 2005-02-18 KR KR1020067019405A patent/KR101280267B1/ko active IP Right Grant
- 2005-02-18 JP JP2006554221A patent/JP2008501308A/ja active Pending
- 2005-02-18 EP EP12164335A patent/EP2514763A1/en not_active Withdrawn
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2010
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- 2010-09-20 AU AU2010224335A patent/AU2010224335B2/en active Active
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Also Published As
Publication number | Publication date |
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KR20070031871A (ko) | 2007-03-20 |
CA2556632C (en) | 2016-10-11 |
KR20120050530A (ko) | 2012-05-18 |
KR101280267B1 (ko) | 2013-07-15 |
WO2005081854A3 (en) | 2006-01-05 |
JP2012102109A (ja) | 2012-05-31 |
AU2005216082B2 (en) | 2010-10-14 |
WO2005081854A2 (en) | 2005-09-09 |
JP2008501308A (ja) | 2008-01-24 |
EP1722808A2 (en) | 2006-11-22 |
JP6045147B2 (ja) | 2016-12-14 |
EP1722808A4 (en) | 2009-08-19 |
KR101270443B1 (ko) | 2013-05-31 |
AU2010224335A1 (en) | 2010-10-14 |
EP2514763A1 (en) | 2012-10-24 |
AU2005216082A1 (en) | 2005-09-09 |
US7767792B2 (en) | 2010-08-03 |
AU2010224335B2 (en) | 2012-04-05 |
AU2005216082B8 (en) | 2010-11-18 |
EP1722808B1 (en) | 2015-04-08 |
US20100322937A1 (en) | 2010-12-23 |
US20050255555A1 (en) | 2005-11-17 |
CA2556632A1 (en) | 2005-09-09 |
US8652473B2 (en) | 2014-02-18 |
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