AR049177A1 - Polipeptidos y conjugados de interferon-alfa - Google Patents
Polipeptidos y conjugados de interferon-alfaInfo
- Publication number
- AR049177A1 AR049177A1 ARP050102059A ARP050102059A AR049177A1 AR 049177 A1 AR049177 A1 AR 049177A1 AR P050102059 A ARP050102059 A AR P050102059A AR P050102059 A ARP050102059 A AR P050102059A AR 049177 A1 AR049177 A1 AR 049177A1
- Authority
- AR
- Argentina
- Prior art keywords
- polypeptides
- conjugates
- nucleic acids
- interferon
- alfa
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Polipéptidos y conjugados de interferon-alfa, y ácidos nucleicos que codifican los polipéptidos. También se incluyen composiciones que comprenden estos polipéptidos, conjugados y ácidos nucleicos; células que contienen o expresan los polipéptidos, los conjugados y los ácidos nucleicos; métodos para preparar los polipéptidos, los conjugados y los ácidos nucleicos; y métodos para usar los polipéptidos, los conjugados y los ácidos nucleicos. Reivindicacion 1: Un polipéptido aislado o recombinante caracterizado porque comprende una secuencia que (a) difiere en entre 1 y 16 posiciones de aminoácidos de SEQ ID No. 1, y (b) comprende una o más sustituciones respecto de SEQ ID No. 1 seleccionadas del grupo que consiste en F48A/L; V51P; F55A; F65A; F68P; L111A; y V114P; donde el polipéptido presenta actividad antiviral.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57250404P | 2004-05-19 | 2004-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR049177A1 true AR049177A1 (es) | 2006-07-05 |
Family
ID=35428915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050102059A AR049177A1 (es) | 2004-05-19 | 2005-05-19 | Polipeptidos y conjugados de interferon-alfa |
Country Status (14)
Country | Link |
---|---|
US (9) | US7318918B2 (es) |
EP (1) | EP1753779A2 (es) |
JP (1) | JP2008507298A (es) |
CN (1) | CN101115769A (es) |
AR (1) | AR049177A1 (es) |
AU (1) | AU2005245918A1 (es) |
BR (1) | BRPI0511196A (es) |
CA (1) | CA2566247A1 (es) |
IL (1) | IL178470A0 (es) |
MX (1) | MXPA06013412A (es) |
NO (1) | NO20065084L (es) |
RU (1) | RU2006145020A (es) |
TW (1) | TW200611910A (es) |
WO (1) | WO2005113592A2 (es) |
Families Citing this family (28)
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JP2002537762A (ja) | 1999-01-05 | 2002-11-12 | トラスティーズ オブ ボストン ユニバーシティ | 改良型核酸クローニング |
US20040005673A1 (en) | 2001-06-29 | 2004-01-08 | Kevin Jarrell | System for manipulating nucleic acids |
WO2002008408A2 (en) * | 2000-07-21 | 2002-01-31 | Trustees Of Boston University | Modular vector systems |
US7435562B2 (en) * | 2000-07-21 | 2008-10-14 | Modular Genetics, Inc. | Modular vector systems |
WO2005112586A2 (en) * | 2004-05-12 | 2005-12-01 | Fusionone, Inc. | Advanced contact identification system |
CA2590245A1 (en) | 2004-11-11 | 2006-05-18 | Modular Genetics, Inc. | Ladder assembly and system for generating diversity |
MY167668A (en) * | 2005-03-09 | 2018-09-21 | Superlab Far East Ltd | Uses of recombinant super-compound interferons |
JP2008545393A (ja) | 2005-05-18 | 2008-12-18 | マキシジェン, インコーポレイテッド | 進歩したインターフェロンαポリペプチド |
AR078117A1 (es) * | 2006-06-20 | 2011-10-19 | Protech Pharma S A | Una muteina recombinante del interferon alfa humano glicosilado, un gen que codifica para dicha muteina, un metodo de produccion de dicho gen, un metodo para obtener una celula eucariota productora de dicha muteina, un metodo para producir dicha muteina, un procedimiento para purificar dicha muteina |
WO2008008808A2 (en) * | 2006-07-11 | 2008-01-17 | Modular Genetics Inc. | Methods of introducing targeted diversity into nucleic acid molecules |
US20100009908A1 (en) * | 2006-07-25 | 2010-01-14 | Nozomu Nishi | Galectin 9-Polymer Conjugates |
US7808342B2 (en) * | 2006-10-02 | 2010-10-05 | Skyworks Solutions, Inc. | Harmonic phase tuning filter for RF switches |
US11535673B2 (en) | 2007-04-05 | 2022-12-27 | President and Fellows of Harvard CoHege | Chimeric activators: quantitatively designed protein therapeutics and uses thereof |
US7625555B2 (en) | 2007-06-18 | 2009-12-01 | Novagen Holding Corporation | Recombinant human interferon-like proteins |
WO2009006579A1 (en) * | 2007-07-05 | 2009-01-08 | Pharmaessentia Corp. | Peptide-polymer conjugates |
WO2009046080A1 (en) | 2007-10-01 | 2009-04-09 | Pharmaessentia Corp. | N-terminal modified interferon-alpha |
CA2711375C (en) | 2008-01-18 | 2019-04-16 | F. Hoffmann-La Roche Ag | Purification of not-glycosylated polypeptides |
US7954022B2 (en) * | 2008-01-30 | 2011-05-31 | Alcatel-Lucent Usa Inc. | Apparatus and method for controlling dynamic modification of a scan path |
KR20110086705A (ko) * | 2008-11-17 | 2011-07-29 | 제넨테크, 인크. | 생리학적 조건 하에 거대분자의 응집을 감소시키는 방법 및 제제 |
US8940501B2 (en) | 2009-01-30 | 2015-01-27 | Whitehead Institute For Biomedical Research | Methods for ligation and uses thereof |
SG195192A1 (en) | 2011-06-02 | 2013-12-30 | Hanmi Science Co Ltd | Non-peptidyl polymer-insulin multimer and method for producing the same |
WO2013003555A1 (en) | 2011-06-28 | 2013-01-03 | Whitehead Institute For Biomedical Research | Using sortases to install click chemistry handles for protein ligation |
CN102358897B (zh) * | 2011-10-31 | 2013-02-13 | 北京三元基因工程有限公司 | 重组人寡腺苷酸合成酶-1的制备方法 |
US10308697B2 (en) | 2014-04-30 | 2019-06-04 | President And Fellows Of Harvard College | Fusion proteins for treating cancer and related methods |
EP3006045B3 (en) * | 2014-10-07 | 2021-03-17 | Cyprumed GmbH | Pharmaceutical formulations for the oral delivery of peptide or protein drugs |
US10525137B2 (en) | 2015-12-30 | 2020-01-07 | Genentech, Inc. | Formulations with reduced degradation of polysorbate |
RU2650755C1 (ru) * | 2017-05-24 | 2018-04-17 | Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России (ФГБУ "ГНЦ Институт иммунологии" ФМБА России) | Способ очистки лекарственного средства пролонгированного действия на основе рекомбинантного аналога интерферона альфа-17 для лечения вирусного гепатита С |
IL294901A (en) * | 2020-01-24 | 2022-09-01 | Alkermes Pharma Ireland Ltd | Methods for purification |
Family Cites Families (29)
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US6610830B1 (en) * | 1980-07-01 | 2003-08-26 | Hoffman-La Roche Inc. | Microbial production of mature human leukocyte interferons |
ES506955A0 (es) | 1980-11-10 | 1983-02-01 | Genentech Inc | Un procedimiento para producir un polipeptido antiviral. |
US4414150A (en) * | 1980-11-10 | 1983-11-08 | Genentech, Inc. | Hybrid human leukocyte interferons |
IT1167610B (it) | 1982-01-19 | 1987-05-13 | Cetus Corp | Interfreron ibrido multiclasse, composizione farmaceutica che lo contiene e procedimento di produzione |
US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
JPS60152058A (ja) * | 1984-01-20 | 1985-08-10 | Toshiba Corp | 半導体記憶装置 |
ATE78262T1 (de) * | 1985-06-11 | 1992-08-15 | Ciba Geigy Ag | Hybrid-interferone. |
US4695626A (en) * | 1986-07-29 | 1987-09-22 | Pfizer Inc. | 1-aza-4,5-dithiabicyclo [4.2.0] oct-2-en-8-one-2 carboxylate esters |
SG52537A1 (en) | 1990-10-17 | 1998-09-28 | Amgen Inc | Methods and compositions for the treatment of cell proliferation disorders |
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US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
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TW517067B (en) * | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
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BR122013003013B8 (pt) | 1999-01-14 | 2021-07-06 | Bolder Biotechnology Inc | proteína isolada monopeguilada do hormônio do crescimento e método para sua obtenção |
WO2000052153A2 (en) * | 1999-03-02 | 2000-09-08 | Maxygen, Inc. | Method to identify ligands for orphan receptors |
DK1187852T3 (da) | 1999-05-19 | 2007-11-26 | Merck Patent Gmbh | Ekspression og eksport af interferon-alpha-proteiner som Fc-fusionsproteiner |
US20040002474A1 (en) * | 1999-10-07 | 2004-01-01 | Maxygen Inc. | IFN-alpha homologues |
EP1238082A2 (en) | 1999-10-07 | 2002-09-11 | Maxygen, Inc. | Ifn-alpha homologues |
CA2390292A1 (en) * | 1999-11-12 | 2001-05-25 | Maxygen Holdings Ltd. | Interferon gamma conjugates |
EP1284987B1 (en) | 2000-05-16 | 2007-07-18 | Bolder Biotechnology, Inc. | Methods for refolding proteins containing free cysteine residues |
AU2002223350A1 (en) | 2000-12-01 | 2002-06-11 | Eleanor N. Fish | Cytokine receptor binding peptides |
KR100459105B1 (ko) | 2001-02-15 | 2004-12-03 | 선바이오(주) | 변형된 인터페론-알파 2a 및 2b, 그리고 이들과 PEG유도체와의 배합체 |
AU2003293668A1 (en) | 2002-11-15 | 2004-06-15 | F. Hoffmann-La Roche Ag | Positional isomers of peg ifn alpha 2a |
CA2504267A1 (en) | 2002-11-18 | 2004-06-03 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
-
2005
- 2005-05-18 MX MXPA06013412A patent/MXPA06013412A/es unknown
- 2005-05-18 TW TW094116107A patent/TW200611910A/zh unknown
- 2005-05-18 CN CNA2005800241473A patent/CN101115769A/zh active Pending
- 2005-05-18 RU RU2006145020/04A patent/RU2006145020A/ru unknown
- 2005-05-18 WO PCT/US2005/017471 patent/WO2005113592A2/en active Application Filing
- 2005-05-18 AU AU2005245918A patent/AU2005245918A1/en not_active Abandoned
- 2005-05-18 JP JP2007527427A patent/JP2008507298A/ja active Pending
- 2005-05-18 CA CA002566247A patent/CA2566247A1/en not_active Abandoned
- 2005-05-18 EP EP05751765A patent/EP1753779A2/en not_active Withdrawn
- 2005-05-18 US US11/132,722 patent/US7318918B2/en not_active Expired - Fee Related
- 2005-05-18 BR BRPI0511196-0A patent/BRPI0511196A/pt not_active Application Discontinuation
- 2005-05-19 AR ARP050102059A patent/AR049177A1/es unknown
-
2006
- 2006-09-13 US US11/531,570 patent/US20070020734A1/en not_active Abandoned
- 2006-09-13 US US11/531,531 patent/US7531630B2/en not_active Expired - Fee Related
- 2006-09-13 US US11/531,557 patent/US7531324B2/en not_active Expired - Fee Related
- 2006-09-14 US US11/532,024 patent/US20070225204A1/en not_active Abandoned
- 2006-09-14 US US11/532,045 patent/US20070225205A1/en not_active Abandoned
- 2006-10-05 IL IL178470A patent/IL178470A0/en unknown
- 2006-11-03 NO NO20065084A patent/NO20065084L/no unknown
-
2007
- 2007-05-04 US US11/744,424 patent/US7541436B2/en not_active Expired - Fee Related
- 2007-08-14 US US11/838,730 patent/US7541163B2/en not_active Expired - Fee Related
- 2007-08-15 US US11/839,493 patent/US7537755B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL178470A0 (en) | 2007-02-11 |
US20070225205A1 (en) | 2007-09-27 |
US20080031853A1 (en) | 2008-02-07 |
US7541436B2 (en) | 2009-06-02 |
BRPI0511196A (pt) | 2007-12-04 |
TW200611910A (en) | 2006-04-16 |
AU2005245918A1 (en) | 2005-12-01 |
US20080076710A1 (en) | 2008-03-27 |
CN101115769A (zh) | 2008-01-30 |
US20070225204A1 (en) | 2007-09-27 |
MXPA06013412A (es) | 2007-01-23 |
NO20065084L (no) | 2006-12-01 |
US7541163B2 (en) | 2009-06-02 |
US20070025966A1 (en) | 2007-02-01 |
US7537755B2 (en) | 2009-05-26 |
RU2006145020A (ru) | 2008-06-27 |
US20080171363A1 (en) | 2008-07-17 |
US20070020734A1 (en) | 2007-01-25 |
US7318918B2 (en) | 2008-01-15 |
WO2005113592A2 (en) | 2005-12-01 |
EP1753779A2 (en) | 2007-02-21 |
WO2005113592A3 (en) | 2006-04-06 |
US7531630B2 (en) | 2009-05-12 |
US20070020235A1 (en) | 2007-01-25 |
US20050266465A1 (en) | 2005-12-01 |
US7531324B2 (en) | 2009-05-12 |
JP2008507298A (ja) | 2008-03-13 |
CA2566247A1 (en) | 2005-12-01 |
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