ES2506116T3 - Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo - Google Patents
Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo Download PDFInfo
- Publication number
- ES2506116T3 ES2506116T3 ES09749849.7T ES09749849T ES2506116T3 ES 2506116 T3 ES2506116 T3 ES 2506116T3 ES 09749849 T ES09749849 T ES 09749849T ES 2506116 T3 ES2506116 T3 ES 2506116T3
- Authority
- ES
- Spain
- Prior art keywords
- trem
- sepsis
- subject
- sample
- prognosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/26—Infectious diseases, e.g. generalised sepsis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Método para la predicción, pronóstico y/o diagnóstico de septicemia, septicemia grave, choque septicémico, o MODS en un sujeto de prueba que comprende: (a) medir el nivel de transcrito de receptor similar a TREM-1 soluble (sTLT1) y TREM-1 en una muestra de sangre o suero extraída de dicho sujeto de prueba, y (b) comparar dicho nivel de transcrito de receptor similar a TREM-1 soluble (sTLT1) y TREM-1 con un nivel de referencia de transcrito de receptor similar a TREM-1 soluble (sTLT1) y TREM-1 obtenido de una muestra de un sujeto sano, en la que (c) un nivel de expresión reducida de sTLT-1 y una expresión aumentada de TREM-1 en la muestra del sujeto de prueba en comparación con los de una muestra de un sujeto sano o sin septicemia indica que el sujeto de prueba tiene o corre el riesgo de tener septicemia, septicemia grave, choque septicémico o MODS.
Description
Claims (1)
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imagen1 imagen2
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08156837 | 2008-05-23 | ||
EP08156837 | 2008-05-23 | ||
PCT/EP2009/056094 WO2009141359A1 (en) | 2008-05-23 | 2009-05-19 | New biomarker for diagnosis, prediction and/or prognosis of sepsis and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2506116T3 true ES2506116T3 (es) | 2014-10-13 |
Family
ID=40897625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09749849.7T Active ES2506116T3 (es) | 2008-05-23 | 2009-05-19 | Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo |
Country Status (5)
Country | Link |
---|---|
US (1) | US8697370B2 (es) |
EP (2) | EP2796878A1 (es) |
CA (1) | CA2721742A1 (es) |
ES (1) | ES2506116T3 (es) |
WO (1) | WO2009141359A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8981061B2 (en) | 2001-03-20 | 2015-03-17 | Novo Nordisk A/S | Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
GB0426146D0 (en) | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
WO2010132370A2 (en) * | 2009-05-11 | 2010-11-18 | Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Soluble tlt-1 for the treatment and diagnosis of sepsis |
US20120089421A1 (en) * | 2010-10-08 | 2012-04-12 | Cerner Innovation, Inc. | Multi-site clinical decision support for sepsis |
WO2012136548A1 (en) | 2011-04-04 | 2012-10-11 | Universiteit Gent | Biomarkers for acute kidney injury |
RU2463606C1 (ru) * | 2011-08-17 | 2012-10-10 | Учреждение Российской академии медицинских наук Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний Сибирского отделения Российской академии медицинских наук (УРАМН НИИ КПССЗ СО РАМН) | Способ ранней диагностики осложненного системного воспалительного ответа у пациентов, оперированных в условиях искусственного кровообращения |
WO2013119869A1 (en) * | 2012-02-07 | 2013-08-15 | Children's Hospital Medical Center | A multi-biomarker-based outcome risk stratification model for adult septic shock |
US9238841B2 (en) | 2012-02-07 | 2016-01-19 | Children's Hospital Medical Center | Multi-biomarker-based outcome risk stratification model for pediatric septic shock |
CN108802385B (zh) | 2012-02-09 | 2022-02-08 | 米密德诊断学有限公司 | 用于诊断感染的标记和决定因素和其使用方法 |
US9000127B2 (en) | 2012-02-15 | 2015-04-07 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
EP2814842B1 (en) | 2012-02-15 | 2018-08-22 | Novo Nordisk A/S | Antibodies that bind peptidoglycan recognition protein 1 |
CA2893158A1 (en) * | 2012-11-30 | 2014-06-05 | Applied Proteomics, Inc. | Method for evaluation of presence of or risk of colon tumors |
CA2915611A1 (en) * | 2013-06-28 | 2014-12-31 | Acumen Research Laboratories Pte. Ltd. | Sepsis biomarkers and uses thereof |
EP3030576A4 (en) * | 2013-08-07 | 2017-04-05 | University Of Rochester | Method of diagnosing sepsis or sepsis risk |
EP3074536B1 (en) | 2013-11-25 | 2019-06-19 | Children's Hospital Medical Center | Temporal pediatric sepsis biomarker risk model |
KR101569334B1 (ko) | 2013-12-20 | 2015-11-17 | 경북대학교 산학협력단 | 래프틀린을 함유하는 패혈증 진단용 바이오마커 조성물 및 이를 이용한 진단방법 |
US10260111B1 (en) | 2014-01-20 | 2019-04-16 | Brett Eric Etchebarne | Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample |
SG11201700250WA (en) | 2014-07-17 | 2017-02-27 | Novo Nordisk As | Site directed mutagenesis of trem-1 antibodies for decreasing viscosity |
CA2954601C (en) | 2014-08-14 | 2023-04-18 | Memed Diagnostics Ltd. | Computational analysis of biological data using manifold and a hyperplane |
US10761093B2 (en) | 2014-10-09 | 2020-09-01 | Texas Tech University System | Microdevice for cell separation utilizing activation phenotype |
WO2016059636A1 (en) | 2014-10-14 | 2016-04-21 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof |
WO2016092554A1 (en) * | 2014-12-11 | 2016-06-16 | Memed Diagnostics Ltd. | Marker combinations for diagnosing infections and methods of use thereof |
JP2018517892A (ja) | 2015-04-10 | 2018-07-05 | アプライド プロテオミクス,インク. | 結腸直腸癌と進行腺腫を検知するためのタンパク質バイオマーカーパネル |
US10261068B2 (en) | 2015-06-04 | 2019-04-16 | Children's Hospital Medical Center | Persevere-II: redefining the pediatric sepsis biomarker risk model with septic shock phenotype |
CA2989381A1 (en) | 2015-07-15 | 2017-01-19 | Universiteit Gent | Probes and a methylation in situ hybridization assay |
EP3423590A4 (en) | 2016-03-03 | 2020-02-26 | Memed Diagnostics Ltd. | DETERMINANTS OF RNA TO DIFFERENTIATE BACTERIAL VIRAL INFECTIONS |
EP4141448A1 (en) | 2016-07-10 | 2023-03-01 | MeMed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
EP4184167A1 (en) | 2016-07-10 | 2023-05-24 | MeMed Diagnostics Ltd. | Early diagnosis of infections |
US11385241B2 (en) | 2016-09-29 | 2022-07-12 | Memed Diagnostics Ltd. | Methods of prognosis and treatment |
WO2018060999A1 (en) | 2016-09-29 | 2018-04-05 | Memed Diagnostics Ltd. | Methods of risk assessment and disease classification |
GB201616557D0 (en) * | 2016-09-29 | 2016-11-16 | Secretary Of State For Health The | Assay for distinguishing between sepsis and systemic inflammatory response syndrome |
US10209260B2 (en) | 2017-07-05 | 2019-02-19 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
JP2021519594A (ja) | 2018-04-02 | 2021-08-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 抗trem−1抗体およびその使用 |
US11154240B2 (en) | 2019-04-02 | 2021-10-26 | Kpn Innovations Llc | Methods and systems for utilizing diagnostics for informed vibrant constitutional guidance |
WO2021123249A1 (en) * | 2019-12-20 | 2021-06-24 | Gerencia Regional de Salud de Castilla y León | In vitro method for the differential diagnosis between septic shock and non-septic shock patients |
US11289206B2 (en) | 2020-06-02 | 2022-03-29 | Kpn Innovations, Llc. | Artificial intelligence methods and systems for constitutional analysis using objective functions |
US11211158B1 (en) | 2020-08-31 | 2021-12-28 | Kpn Innovations, Llc. | System and method for representing an arranged list of provider aliment possibilities |
WO2023087016A1 (en) * | 2021-11-15 | 2023-05-19 | Ascendo Biotechnology, Inc. | Methods to reverse treml1-induced immune suppression |
CN117491284B (zh) * | 2023-11-03 | 2024-05-07 | 上海长征医院 | 一种基于微流控技术的脓毒症即时检测设备 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458539B1 (en) | 1993-09-17 | 2002-10-01 | Somalogic, Inc. | Photoselection of nucleic acid ligands |
US6329145B1 (en) | 1999-02-09 | 2001-12-11 | Gilead Science, Inc. | Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligand |
US20040180409A1 (en) | 2003-03-16 | 2004-09-16 | Mcvicar Daniel | TLT-1, a novel platelet-associated receptor and uses therefor |
GB0401730D0 (en) | 2004-01-27 | 2004-03-03 | Bioxell Spa | Diagnosis method |
AU2006299417A1 (en) | 2005-10-03 | 2007-04-12 | Biosite Incorporated | Methods and compositions for diagnosis and/or prognosis in Systemic Inflammatory Response Syndromes |
-
2009
- 2009-05-19 EP EP14177586.6A patent/EP2796878A1/en not_active Withdrawn
- 2009-05-19 EP EP09749849.7A patent/EP2300829B1/en not_active Not-in-force
- 2009-05-19 WO PCT/EP2009/056094 patent/WO2009141359A1/en active Application Filing
- 2009-05-19 CA CA2721742A patent/CA2721742A1/en not_active Abandoned
- 2009-05-19 ES ES09749849.7T patent/ES2506116T3/es active Active
- 2009-05-19 US US12/990,841 patent/US8697370B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20110059858A1 (en) | 2011-03-10 |
EP2300829A1 (en) | 2011-03-30 |
US8697370B2 (en) | 2014-04-15 |
WO2009141359A1 (en) | 2009-11-26 |
EP2796878A1 (en) | 2014-10-29 |
CA2721742A1 (en) | 2009-11-26 |
EP2300829B1 (en) | 2014-07-23 |
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