BRPI1007867B8 - anticorpo recombinante ou fragmento de ligação ao antígeno do mesmo, composição farmacêutica e kit compreendendo o referido anticorpo, métodos de detecção de antígeno de troponina i em uma amostra de teste e métodos in vitro de diagnóstico de síndrome coronariana aguda ou infarto do miocárdio em um paciente - Google Patents
anticorpo recombinante ou fragmento de ligação ao antígeno do mesmo, composição farmacêutica e kit compreendendo o referido anticorpo, métodos de detecção de antígeno de troponina i em uma amostra de teste e métodos in vitro de diagnóstico de síndrome coronariana aguda ou infarto do miocárdio em um pacienteInfo
- Publication number
- BRPI1007867B8 BRPI1007867B8 BRPI1007867A BRPI1007867A BRPI1007867B8 BR PI1007867 B8 BRPI1007867 B8 BR PI1007867B8 BR PI1007867 A BRPI1007867 A BR PI1007867A BR PI1007867 A BRPI1007867 A BR PI1007867A BR PI1007867 B8 BRPI1007867 B8 BR PI1007867B8
- Authority
- BR
- Brazil
- Prior art keywords
- antigen
- methods
- antibody
- patient
- myocardial infarction
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4716—Muscle proteins, e.g. myosin, actin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/391,937 US8030026B2 (en) | 2009-02-24 | 2009-02-24 | Antibodies to troponin I and methods of use thereof |
US12/391,937 | 2009-02-24 | ||
PCT/US2010/024979 WO2010099079A1 (en) | 2009-02-24 | 2010-02-23 | Antibodies to troponin i and methods of use thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI1007867A2 BRPI1007867A2 (pt) | 2018-03-06 |
BRPI1007867B1 BRPI1007867B1 (pt) | 2021-01-26 |
BRPI1007867B8 true BRPI1007867B8 (pt) | 2021-05-25 |
Family
ID=42102721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI1007867A BRPI1007867B8 (pt) | 2009-02-24 | 2010-02-23 | anticorpo recombinante ou fragmento de ligação ao antígeno do mesmo, composição farmacêutica e kit compreendendo o referido anticorpo, métodos de detecção de antígeno de troponina i em uma amostra de teste e métodos in vitro de diagnóstico de síndrome coronariana aguda ou infarto do miocárdio em um paciente |
Country Status (9)
Country | Link |
---|---|
US (4) | US8030026B2 (pt) |
EP (2) | EP2853540A1 (pt) |
JP (3) | JP6055593B2 (pt) |
CN (1) | CN102421795B (pt) |
BR (1) | BRPI1007867B8 (pt) |
CA (1) | CA2753541C (pt) |
ES (1) | ES2525799T3 (pt) |
MX (2) | MX2011008938A (pt) |
WO (1) | WO2010099079A1 (pt) |
Families Citing this family (26)
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US8030026B2 (en) * | 2009-02-24 | 2011-10-04 | Abbott Laboratories | Antibodies to troponin I and methods of use thereof |
WO2012088290A2 (en) * | 2010-12-22 | 2012-06-28 | Abbott Laboratories | Tri-variable domain binding proteins and uses thereof |
WO2013084371A1 (ja) * | 2011-12-06 | 2013-06-13 | パナソニック株式会社 | ヒト心筋由来トロポニンiに特異的にかつ速やかに結合できる組み換えタンパク質 |
US8603759B2 (en) | 2011-12-06 | 2013-12-10 | Panasonic Corporation | Recombinant protein capable of binding specifically and quickly to troponin I derived from human myocardium |
US8663933B2 (en) * | 2011-12-16 | 2014-03-04 | Panasonic Corporation | Recombinant protein capable of binding specifically and quickly to troponin I derived from human myocardium |
US8603760B2 (en) * | 2011-12-20 | 2013-12-10 | Panasonic Corporation | Recombinant protein capable of binding specifically and quickly to troponin I derived from human myocardium |
WO2013175678A1 (ja) * | 2012-05-24 | 2013-11-28 | パナソニック株式会社 | ヒト心筋由来トロポニンiに特異的にかつ速やかに結合できる変異体タンパク質 |
US20160116472A1 (en) * | 2013-02-04 | 2016-04-28 | The General Hospital Corporation | Biomarkers for stroke diagnosis |
US9371374B2 (en) | 2013-03-14 | 2016-06-21 | Abbott Laboratories | HCV core lipid binding domain monoclonal antibodies |
CN105209616A (zh) | 2013-03-14 | 2015-12-30 | 雅培制药有限公司 | 用于改进的抗体检测的hcv ns3重组抗原及其突变体 |
CA2906421C (en) | 2013-03-14 | 2022-08-16 | George J. Dawson | Hcv antigen-antibody combination assay and methods and compositions for use therein |
WO2014192202A1 (ja) * | 2013-05-29 | 2014-12-04 | パナソニックヘルスケア株式会社 | ヒト心筋由来トロポニンiに特異的にかつ速やかに結合できる組み換えタンパク質 |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
US20190025328A1 (en) | 2015-10-27 | 2019-01-24 | Abbott Laboratories | Troponin i and soluble urokinase receptor detection for determining the risk of cardiovascular disease |
EP4310502A3 (en) | 2016-03-31 | 2024-03-27 | Abbott Laboratories | Decision tree based systems and methods for estimating the risk of acute coronary syndrome |
EP3730944B1 (en) | 2016-04-13 | 2021-12-29 | Abbott Laboratories | Cardiac troponin i detection during pregnancy for cardiovascular disease identification and risk assessment |
US20170363620A1 (en) | 2016-06-17 | 2017-12-21 | Abbott Laboratories | BIOMARKERS TO PREDICT NEW ONSET HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF) |
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US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
BR112020017941A2 (pt) * | 2018-03-14 | 2021-02-17 | F. Hoffmann-La Roche Ag | anticorpos, moléculas de ácido nucleico, vetor, composição e método de determinação da troponina t cardíaca humana |
WO2019213624A1 (en) * | 2018-05-04 | 2019-11-07 | The Regents Of The University Of California | Spiked primers for enrichment of pathogen nucleic acids among background of nucleic acids |
CN111018980B (zh) * | 2018-10-10 | 2021-12-03 | 东莞市朋志生物科技有限公司 | 一种抗人心肌肌钙蛋白i的抗体及其应用 |
CN111018976B (zh) * | 2018-10-10 | 2022-04-01 | 东莞市朋志生物科技有限公司 | 一种抗人心肌肌钙蛋白i的重组抗体 |
WO2024044288A1 (en) | 2022-08-26 | 2024-02-29 | Abbott Laboratories | Use of cardiac troponin and galectin-3 to differentiate myocardial infarction type i and type ii |
WO2024102383A1 (en) | 2022-11-10 | 2024-05-16 | Abbott Laboratories | Methods of identifying macrotroponin in biological samples |
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CN1644685A (zh) * | 2004-12-23 | 2005-07-27 | 复旦大学 | 抗人心肌肌钙蛋白i单克隆抗体及其应用 |
CN1982337A (zh) * | 2005-12-14 | 2007-06-20 | 中国医学科学院放射医学研究所 | 抗人心肌肌钙蛋白i合成多肽抗体及其制备方法与应用 |
EP2014302A1 (en) | 2007-07-12 | 2009-01-14 | Institut Curie | An antibody specific for the Tn antigen for the treatment of cancer |
JP5470817B2 (ja) | 2008-03-10 | 2014-04-16 | 日産自動車株式会社 | 電池用電極およびこれを用いた電池、並びにその製造方法 |
US8030026B2 (en) * | 2009-02-24 | 2011-10-04 | Abbott Laboratories | Antibodies to troponin I and methods of use thereof |
JP6136279B2 (ja) | 2013-01-15 | 2017-05-31 | 株式会社ジェイテクト | 転がり軸受装置 |
TWI503850B (zh) | 2013-03-22 | 2015-10-11 | Polytronics Technology Corp | 過電流保護元件 |
TWI510996B (zh) | 2013-10-03 | 2015-12-01 | Acer Inc | 控制觸控面板的方法以及使用該方法的可攜式電腦 |
US9816280B1 (en) | 2016-11-02 | 2017-11-14 | Matthew Reitnauer | Portable floor |
-
2009
- 2009-02-24 US US12/391,937 patent/US8030026B2/en not_active Ceased
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2010
- 2010-02-23 EP EP14190758.4A patent/EP2853540A1/en not_active Withdrawn
- 2010-02-23 MX MX2011008938A patent/MX2011008938A/es active IP Right Grant
- 2010-02-23 WO PCT/US2010/024979 patent/WO2010099079A1/en active Application Filing
- 2010-02-23 EP EP10704731.8A patent/EP2401292B1/en active Active
- 2010-02-23 MX MX2015001161A patent/MX359949B/es unknown
- 2010-02-23 CA CA2753541A patent/CA2753541C/en active Active
- 2010-02-23 JP JP2011551284A patent/JP6055593B2/ja active Active
- 2010-02-23 ES ES10704731.8T patent/ES2525799T3/es active Active
- 2010-02-23 US US13/319,657 patent/US20120076803A1/en not_active Abandoned
- 2010-02-23 CN CN201080017906.4A patent/CN102421795B/zh active Active
- 2010-02-23 BR BRPI1007867A patent/BRPI1007867B8/pt active IP Right Grant
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2013
- 2013-09-24 US US14/035,420 patent/USRE45763E1/en active Active
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2014
- 2014-09-05 US US14/461,082 patent/US20150024457A1/en not_active Abandoned
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2015
- 2015-09-11 JP JP2015179220A patent/JP6199935B2/ja active Active
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2017
- 2017-08-24 JP JP2017161049A patent/JP2018038392A/ja active Pending
Also Published As
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JP2016039804A (ja) | 2016-03-24 |
BRPI1007867A2 (pt) | 2018-03-06 |
BRPI1007867B1 (pt) | 2021-01-26 |
MX2011008938A (es) | 2012-04-02 |
CN102421795A (zh) | 2012-04-18 |
JP2012518418A (ja) | 2012-08-16 |
US8030026B2 (en) | 2011-10-04 |
USRE45763E1 (en) | 2015-10-20 |
JP6199935B2 (ja) | 2017-09-20 |
EP2853540A1 (en) | 2015-04-01 |
US20150024457A1 (en) | 2015-01-22 |
US20100216720A1 (en) | 2010-08-26 |
ES2525799T3 (es) | 2014-12-30 |
CA2753541C (en) | 2018-07-17 |
CN102421795B (zh) | 2015-11-25 |
MX359949B (es) | 2018-10-17 |
JP2018038392A (ja) | 2018-03-15 |
EP2401292B1 (en) | 2014-10-29 |
US20120076803A1 (en) | 2012-03-29 |
EP2401292A1 (en) | 2012-01-04 |
JP6055593B2 (ja) | 2016-12-27 |
WO2010099079A1 (en) | 2010-09-02 |
CA2753541A1 (en) | 2010-09-02 |
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