ES2261657T3 - Derivados de hidrazida del acido pirrolidin-2-carboxilico para uso como inhibidores de metaloproteasa. - Google Patents

Derivados de hidrazida del acido pirrolidin-2-carboxilico para uso como inhibidores de metaloproteasa.

Info

Publication number
ES2261657T3
ES2261657T3 ES02719751T ES02719751T ES2261657T3 ES 2261657 T3 ES2261657 T3 ES 2261657T3 ES 02719751 T ES02719751 T ES 02719751T ES 02719751 T ES02719751 T ES 02719751T ES 2261657 T3 ES2261657 T3 ES 2261657T3
Authority
ES
Spain
Prior art keywords
methyl
trifluomethyl
bis
tolyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02719751T
Other languages
English (en)
Spanish (es)
Inventor
Susanne Buser
Anthony P. D. W. Ford
Torsten Hoffmann
Barbara Lenz
Andrew John Sleight
Pierre Vankan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2261657T3 publication Critical patent/ES2261657T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES02719751T 2001-04-23 2002-02-02 Derivados de hidrazida del acido pirrolidin-2-carboxilico para uso como inhibidores de metaloproteasa. Expired - Lifetime ES2261657T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01109853 2001-04-23
EP01109853 2001-04-23

Publications (1)

Publication Number Publication Date
ES2261657T3 true ES2261657T3 (es) 2006-11-16

Family

ID=8177209

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02719751T Expired - Lifetime ES2261657T3 (es) 2001-04-23 2002-02-02 Derivados de hidrazida del acido pirrolidin-2-carboxilico para uso como inhibidores de metaloproteasa.

Country Status (17)

Country Link
US (1) US20030004157A1 (de)
EP (1) EP1385577B1 (de)
JP (1) JP4146730B2 (de)
KR (1) KR100599134B1 (de)
CN (1) CN100398106C (de)
AR (1) AR035935A1 (de)
AT (1) ATE323531T1 (de)
AU (1) AU2002250876B2 (de)
BR (1) BR0209151A (de)
CA (1) CA2444395C (de)
DE (1) DE60210760T2 (de)
DK (1) DK1385577T3 (de)
ES (1) ES2261657T3 (de)
MX (1) MXPA03009720A (de)
PT (1) PT1385577E (de)
WO (1) WO2002085458A2 (de)
ZA (1) ZA200308110B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002259147A1 (en) * 2001-05-08 2002-11-18 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
US6849624B2 (en) * 2001-07-31 2005-02-01 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted amides
CN100562320C (zh) * 2003-01-31 2009-11-25 弗·哈夫曼-拉罗切有限公司 2-(3,5-二-三氟甲基-苯基)-N-[6-(1,1-二氧代-1λ6-硫代吗啉-4-基)-4-(4-氟-2-甲基-苯基)-吡啶-3-基]-N-甲基-异丁酰胺的新晶体变体
CN1852712B (zh) * 2003-07-03 2010-06-09 弗·哈夫曼-拉罗切有限公司 用于治疗精神***症的双重nk1/nk3拮抗剂
ES2246687B2 (es) * 2004-02-11 2006-11-16 Miguel Muñoz Saez Utilizacion de antagonistas no peptidicos de receptores nk1 para la produccion de apoptosis en celulas tumorales.
JP4580426B2 (ja) 2004-07-06 2010-11-10 エフ．ホフマン−ラ ロシュ アーゲー Ｎｋ−１受容体拮抗薬の合成において中間体として使用されるカルボキサミド誘導体の製造方法
US20060030600A1 (en) * 2004-08-06 2006-02-09 Patrick Schnider Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia
MX2007009571A (es) 2005-02-25 2007-09-21 Hoffmann La Roche Tabletas con dispersion mejorada de la sustancia del farmaco.
ZA200803887B (en) 2005-11-08 2009-12-30 Vertex Pharma Heterocyclic modulators of ATP-Binding Cassette transporters
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
CA2676357A1 (en) 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
NZ581259A (en) 2007-05-09 2012-07-27 Vertex Pharma Modulators of cystic fibrosis transmembrane conductance regulator
CA2986286C (en) 2007-12-07 2019-04-23 Vertex Pharmaceuticals Incorporated Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
EP2639223B1 (de) 2007-12-07 2017-03-29 Vertex Pharmaceuticals Incorporated Verfahren zur Herstellung von Cycloalkylcarboxamidopyridinbenzoesäuren
JP5523352B2 (ja) 2008-02-28 2014-06-18 バーテックス ファーマシューティカルズ インコーポレイテッド Ｃｆｔｒ修飾因子としてのへテロアリール誘導体
GB0808747D0 (en) 2008-05-14 2008-06-18 Glaxo Wellcome Mfg Pte Ltd Novel compounds
MX2011009700A (es) 2009-03-17 2011-12-08 Daiichi Sankyo Co Ltd Derivado de amida.
WO2010119347A1 (en) * 2009-04-14 2010-10-21 Helsinn Healthcare S.A. Netupitant for use in treating bladder dysfunction
US20120196901A1 (en) * 2009-10-29 2012-08-02 Merck Sharp & Dohme Corp. Tertiary amide orexin receptor antagonists
CA2795804C (en) 2010-04-07 2021-10-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof
AU2014347644B2 (en) 2013-11-08 2018-06-14 Kissei Pharmaceutical Co., Ltd. Carboxymethyl piperidine derivative
CN105848657B (zh) 2013-11-12 2020-05-22 沃泰克斯药物股份有限公司 制备用于治疗cftr介导的疾病的药物组合物的方法
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
DK3221692T3 (da) 2014-11-18 2021-08-23 Vertex Pharma Fremgangsmåde til udførsel af tests med høj kapacitet ved hjælp af højtryksvæskekromatografi
US11801244B2 (en) * 2018-02-02 2023-10-31 Eustralis Pharmaceuticals Limited Parenteral formulations and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6175013B1 (en) * 1994-06-10 2001-01-16 Eli Lilly And Company Imidazolinyl tachykinin receptor antagonists
FR2729951B1 (fr) * 1995-01-30 1997-04-18 Sanofi Sa Nouveaux composes heterocycliques, procede pour leur preparation et compositions pharmaceutiques en contenant
WO1999007681A1 (en) * 1997-08-06 1999-02-18 Eli Lilly And Company 2-acylaminopropanamines as tachykinin receptor antagonists
WO1999007677A1 (en) * 1997-08-06 1999-02-18 Eli Lilly And Company 2-acylaminopropanamines as tachykinin receptor antagonists
JPH11322748A (ja) * 1998-03-19 1999-11-24 Takeda Chem Ind Ltd 複素環化合物、その製造法および用途
SI1035115T1 (en) * 1999-02-24 2005-02-28 F. Hoffmann-La Roche Ag 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists
WO2000067742A2 (en) * 1999-05-05 2000-11-16 Warner-Lambert Company Use of gaba analogues for the modulation of substance p
PL205207B1 (pl) * 2000-07-14 2010-03-31 Hoffmann La Roche N-tlenki pochodnych 4-fenylopirydyny środek leczniczy, sposób wytwarzania tych N-tlenków i ich zastosowanie
US6849624B2 (en) * 2001-07-31 2005-02-01 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted amides

Also Published As

Publication number Publication date
BR0209151A (pt) 2004-07-13
EP1385577A2 (de) 2004-02-04
EP1385577B1 (de) 2006-04-19
JP2004529931A (ja) 2004-09-30
MXPA03009720A (es) 2004-01-29
CN100398106C (zh) 2008-07-02
AR035935A1 (es) 2004-07-28
PT1385577E (pt) 2006-08-31
ZA200308110B (en) 2005-03-30
CN1503684A (zh) 2004-06-09
AU2002250876B2 (en) 2005-03-03
CA2444395C (en) 2010-12-21
US20030004157A1 (en) 2003-01-02
WO2002085458A3 (en) 2003-10-30
WO2002085458A2 (en) 2002-10-31
JP4146730B2 (ja) 2008-09-10
KR20040007503A (ko) 2004-01-24
DE60210760D1 (de) 2006-05-24
DE60210760T2 (de) 2006-11-23
DK1385577T3 (da) 2006-08-21
KR100599134B1 (ko) 2006-07-12
CA2444395A1 (en) 2002-10-31
ATE323531T1 (de) 2006-05-15

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