ES2240856T3 - 6h- dibenzo (c,h) cromen0s sustituidos, como agentes estrogenicos. - Google Patents

6h- dibenzo (c,h) cromen0s sustituidos, como agentes estrogenicos.

Info

Publication number: ES2240856T3
Authority: ES; Spain
Prior art keywords: compound; carbon atoms; dibenzo; chromene; formula
Prior art date: 2001-12-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES02805117T

Other languages

English (en)

Spanish (es)

Inventor

Richard Eric Mewshaw

Richard James Edsall

Stephen Todd Cohn

Heather Anne Harris

James Carl Keith, Jr.

Leo Massillamoney Albert

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wyeth LLC

Original Assignee

Wyeth LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-13

Filing date

2002-12-12

Publication date

2005-10-16

2002-12-12 Application filed by Wyeth LLC filed Critical Wyeth LLC

2005-10-16 Application granted granted Critical

2005-10-16 Publication of ES2240856T3 publication Critical patent/ES2240856T3/es

2022-12-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Cardiology (AREA)
Dermatology (AREA)
Hematology (AREA)
Obesity (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Toxicology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Communicable Diseases (AREA)
Emergency Medicine (AREA)

ES02805117T 2001-12-13 2002-12-12 6h- dibenzo (c,h) cromen0s sustituidos, como agentes estrogenicos. Expired - Lifetime ES2240856T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US34144101P	2001-12-13	2001-12-13
US341441P		2001-12-13

Publications (1)

Publication Number	Publication Date
ES2240856T3 true ES2240856T3 (es)	2005-10-16

Family

ID=23337586

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES02805117T Expired - Lifetime ES2240856T3 (es)	2001-12-13	2002-12-12	6h- dibenzo (c,h) cromen0s sustituidos, como agentes estrogenicos.

Country Status (16)

Country	Link
US (1)	US6723747B2 (fr)
EP (1)	EP1453820B1 (fr)
JP (1)	JP2005538925A (fr)
CN (1)	CN100429210C (fr)
AR (1)	AR037814A1 (fr)
AT (1)	ATE296818T1 (fr)
AU (1)	AU2002357184A1 (fr)
BR (1)	BR0214918A (fr)
CA (1)	CA2470105C (fr)
DE (1)	DE60204482T2 (fr)
ES (1)	ES2240856T3 (fr)
HK (1)	HK1069171A1 (fr)
MX (1)	MXPA04005630A (fr)
PT (1)	PT1453820E (fr)
TW (1)	TW200301107A (fr)
WO (1)	WO2003051863A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005014586A1 (fr)	2003-08-08	2005-02-17	Arpida Ag	Nouveau procede de preparation de 2h-chromenes
US7157492B2 (en) *	2004-02-26	2007-01-02	Wyeth	Dibenzo chromene derivatives and their use as ERβ selective ligands
JP2008505095A (ja) *	2004-07-01	2008-02-21	ワイス	エストロゲンリガンドとしての四環式化合物
CN101052641A (zh)	2004-09-07	2007-10-10	惠氏公司	6H－[1]苯并吡喃并[4,3－b]喹啉及其作为***药物的用途
RU2007120254A (ru) *	2004-12-17	2009-01-27	Вайет (Us)	Новые способы применения агонистов эстрогена бета
RU2007128819A (ru) *	2005-02-16	2009-03-27	Вайет (Us)	Применение селективных агонистов бета-рецепторов эстрогена для лучевой или химиотерапии, вызываемой мукозитом или лучевым циститом
CA2641116A1 (fr) *	2006-02-14	2007-08-23	Wyeth	Preparations pharmaceutiques aqueuses de ligands selectifs d'er.beta.
US9623021B2 (en) *	2007-01-22	2017-04-18	Gtx, Inc.	Nuclear receptor binding agents
CN101641013B (zh)	2007-01-22	2014-07-30	Gtx公司	核受体结合剂
US9604931B2 (en)	2007-01-22	2017-03-28	Gtx, Inc.	Nuclear receptor binding agents
MX2009008121A (es) *	2007-01-31	2009-08-12	Wyeth Corp	Uso de ligados selectivos de receptores de estrogeno beta para tratar lesiones de pulmon agudas.
CN108774207B (zh) *	2018-07-30	2021-12-17	苏州大学张家港工业技术研究院	环戊二烯并[c]色烯化合物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5688810A (en)	1994-12-22	1997-11-18	Ligand Pharmaceuticals Incorporated	Steroid receptor modulator compounds and methods
BR9510486A (pt) *	1994-12-22	1998-06-02	Ligand Pharm Inc	Compostos moduladores de receptores de esteróide e métodos
TR200201762T2 (tr)	1999-04-16	2002-10-21	Astrazeneca Ab	B östrojen reseptörü ligandları.

2002
- 2002-12-10 TW TW091135700A patent/TW200301107A/zh unknown
- 2002-12-11 US US10/317,163 patent/US6723747B2/en not_active Expired - Fee Related
- 2002-12-12 CA CA2470105A patent/CA2470105C/fr not_active Expired - Fee Related
- 2002-12-12 ES ES02805117T patent/ES2240856T3/es not_active Expired - Lifetime
- 2002-12-12 AU AU2002357184A patent/AU2002357184A1/en not_active Abandoned
- 2002-12-12 AR ARP020104830A patent/AR037814A1/es not_active Application Discontinuation
- 2002-12-12 DE DE60204482T patent/DE60204482T2/de not_active Expired - Lifetime
- 2002-12-12 PT PT02805117T patent/PT1453820E/pt unknown
- 2002-12-12 CN CNB028248791A patent/CN100429210C/zh not_active Expired - Fee Related
- 2002-12-12 MX MXPA04005630A patent/MXPA04005630A/es active IP Right Grant
- 2002-12-12 JP JP2003552747A patent/JP2005538925A/ja not_active Ceased
- 2002-12-12 BR BRPI0214918-4A patent/BR0214918A/pt not_active IP Right Cessation
- 2002-12-12 AT AT02805117T patent/ATE296818T1/de not_active IP Right Cessation
- 2002-12-12 WO PCT/US2002/039802 patent/WO2003051863A1/fr active IP Right Grant
- 2002-12-12 EP EP02805117A patent/EP1453820B1/fr not_active Expired - Lifetime
2005
- 2005-02-28 HK HK05101682A patent/HK1069171A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2470105C (fr)	2010-07-27
DE60204482T2 (de)	2005-10-27
CN100429210C (zh)	2008-10-29
EP1453820B1 (fr)	2005-06-01
CN1602307A (zh)	2005-03-30
TW200301107A (en)	2003-07-01
MXPA04005630A (es)	2004-12-06
US20030176491A1 (en)	2003-09-18
ATE296818T1 (de)	2005-06-15
AR037814A1 (es)	2004-12-09
HK1069171A1 (en)	2005-05-13
BR0214918A (pt)	2006-05-30
WO2003051863A1 (fr)	2003-06-26
US6723747B2 (en)	2004-04-20
DE60204482D1 (de)	2005-07-07
PT1453820E (pt)	2005-09-30
JP2005538925A (ja)	2005-12-22
EP1453820A1 (fr)	2004-09-08
CA2470105A1 (fr)	2003-06-26
AU2002357184A1 (en)	2003-06-30

Publication	Publication Date	Title
US20060074128A1 (en)	2006-04-06	Substituted 2-phenyl benzofurans as estrogenic agents
ES2277273T3 (es)	2007-07-01	Derivados de oxima de aril-carbaldehido, y su utilizacion como agentes estrogenicos.
ES2289538T3 (es)	2008-02-01	Derivados de la oxima del hidroxibifenilcarbaldehido y su uso como agentes estrogenicos.
US6835745B2 (en)	2004-12-28	Phenyl substituted thiophenes as estrogenic agents
CA2470109C (fr)	2010-12-21	Naphthalenes de phenyle substitues en tant qu'agents oestrogeniques
US7531564B2 (en)	2009-05-12	Substituted benzoxazoles as estrogenic agents
ES2240856T3 (es)	2005-10-16	6h- dibenzo (c,h) cromen0s sustituidos, como agentes estrogenicos.
US20050272786A1 (en)	2005-12-08	Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents
MX2007002251A (es)	2007-04-20	Benzoxazoles sustituidos con profarmaco como agentes estrogenicos.
US20050159465A1 (en)	2005-07-21	Phenyl benzisoxazoles as estrogenic agents
US6903238B2 (en)	2005-06-07	Substituted indenones as estrogenic agents
US7235539B2 (en)	2007-06-26	6-Hydroxyequilenins as estrogenic agents