ES2187518T3 - 3-(aminoalquilamino)-1-2-benzisoxazoles sustituidos y compuestos relacionados. - Google Patents
3-(aminoalquilamino)-1-2-benzisoxazoles sustituidos y compuestos relacionados.Info
- Publication number
- ES2187518T3 ES2187518T3 ES94902374T ES94902374T ES2187518T3 ES 2187518 T3 ES2187518 T3 ES 2187518T3 ES 94902374 T ES94902374 T ES 94902374T ES 94902374 T ES94902374 T ES 94902374T ES 2187518 T3 ES2187518 T3 ES 2187518T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- benzisoxazols
- aminoalquilamino
- substituted
- related compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
ESTA APLICACION SE REFIERE A COMPUESTOS DE LA FORMULA (I) EN DONDE R1, X, Y Y N SON COMO SE DEFINE EN LA ESPECIFICACION; Y A SALES DE ADICION DEL MISMO ACEPTABLES FARMACEUTICAMENTE Y A MEZCLAS DE ISOMEROS OPTICOS, GEOMETRICOS O RACEMICOS DEL MISMO; CUYOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE VARIAS DISFUNCIONES DE LA MEMORIA CARACTERIZADAS POR UNA DISMINUCION DE LA FUNCION COLINERGICA TALES COMO LA ENFERMEDAD DE ALZHEIMER. LOS COMPUESTOS DE ESTE INVENTO TAMBIEN INHIBEN LA OXIDASA MONOAMINA Y POR LO TANTO SON UTILES COMO ANTIDEPRESIVOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98002192A | 1992-11-23 | 1992-11-23 | |
US08/150,301 US5494908A (en) | 1992-11-23 | 1993-11-12 | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2187518T3 true ES2187518T3 (es) | 2003-06-16 |
Family
ID=26847521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94902374T Expired - Lifetime ES2187518T3 (es) | 1992-11-23 | 1993-11-22 | 3-(aminoalquilamino)-1-2-benzisoxazoles sustituidos y compuestos relacionados. |
Country Status (14)
Country | Link |
---|---|
US (2) | US6046203A (es) |
EP (1) | EP0669920B1 (es) |
JP (1) | JP3462501B2 (es) |
AT (1) | ATE232529T1 (es) |
AU (1) | AU690529B2 (es) |
CA (1) | CA2149918A1 (es) |
DE (1) | DE69332691T2 (es) |
DK (1) | DK0669920T3 (es) |
ES (1) | ES2187518T3 (es) |
FI (1) | FI952481A (es) |
MX (1) | MX9307332A (es) |
NO (1) | NO304980B1 (es) |
NZ (1) | NZ258747A (es) |
PT (1) | PT669920E (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5494908A (en) * | 1992-11-23 | 1996-02-27 | Hoechst-Roussel Pharmaceutical Incorporated | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
AU5919001A (en) * | 2000-04-28 | 2001-11-12 | Acadia Pharm Inc | Muscarinic agonists |
AU2005308523B2 (en) * | 2004-11-29 | 2010-01-07 | Warner-Lambert Company Llc | Therapeutic pyrazolo[3,4-b] pyridines and indazoles |
DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
CA2788656A1 (en) * | 2010-02-16 | 2011-08-25 | Pfizer Inc. | (r)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2h-pyran-4-ol, a partial agonist of 5-ht4 receptors |
CN104024251B (zh) | 2011-10-31 | 2017-08-11 | 克赛农制药股份有限公司 | 苯磺酰胺化合物及其作为治疗剂的用途 |
US9481677B2 (en) | 2011-10-31 | 2016-11-01 | Xenon Pharmaceuticals Inc. | Biaryl ether sulfonamides and their use as therapeutic agents |
TW201400446A (zh) | 2012-05-22 | 2014-01-01 | Genentech Inc | N-取代之苯甲醯胺及其使用方法 |
KR101663436B1 (ko) | 2012-07-06 | 2016-10-06 | 제넨테크, 인크. | N-치환된 벤즈아미드 및 이의 사용 방법 |
BR112015022488A2 (pt) | 2013-03-14 | 2017-07-18 | Genentech Inc | triazolopiridinas substituídas e métodos de uso das mesmas |
BR112015023397A2 (pt) | 2013-03-15 | 2017-07-18 | Genentech Inc | benzoxazois substituídos e métodos de uso dos mesmos |
CN105492430B (zh) * | 2013-03-15 | 2017-10-10 | 基因泰克公司 | 取代的苯并噁唑及其使用方法 |
CR20160296A (es) | 2013-11-27 | 2016-09-20 | Genentech Inc | Benzamidas sustituidas y métodos para usarlas |
WO2016007534A1 (en) | 2014-07-07 | 2016-01-14 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
EP3297989A1 (en) | 2015-05-22 | 2018-03-28 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
WO2017035271A1 (en) | 2015-08-27 | 2017-03-02 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
RU2018115718A (ru) | 2015-09-28 | 2019-10-28 | Дженентек, Инк. | Терапевтические соединения и способы их применения |
CN108495851A (zh) | 2015-11-25 | 2018-09-04 | 基因泰克公司 | 取代的苯甲酰胺及其使用方法 |
WO2017172802A1 (en) | 2016-03-30 | 2017-10-05 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
AU2017347549A1 (en) | 2016-10-17 | 2019-05-02 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
JP2020511511A (ja) | 2017-03-24 | 2020-04-16 | ジェネンテック, インコーポレイテッド | ナトリウムチャネル阻害剤としての4−ピペリジン−n−(ピリミジン−4−イル)クロマン−7−スルホンアミド誘導体 |
WO2019165290A1 (en) | 2018-02-26 | 2019-08-29 | Genentech, Inc. | Pyridine-sulfonamide compounds and their use against pain and related conditions |
EP3774801A1 (en) | 2018-03-30 | 2021-02-17 | F. Hoffmann-La Roche AG | Fused ring hydro-pyrido compounds as sodium channel inhibitors |
CN112204017A (zh) * | 2018-04-27 | 2021-01-08 | 国立大学法人大阪大学 | 苯并异噁唑化合物 |
WO2021079962A1 (ja) * | 2019-10-24 | 2021-04-29 | 国立大学法人大阪大学 | 難聴の予防および/または治療用医薬組成物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0090972B1 (en) * | 1982-03-17 | 1990-05-30 | Asahi Kasei Kogyo Kabushiki Kaisha | Indazole derivatives |
US4590196A (en) * | 1984-08-23 | 1986-05-20 | Bristol-Myers Company | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
EP0302423A3 (en) * | 1987-08-07 | 1991-01-09 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments |
US5134236A (en) * | 1987-08-07 | 1992-07-28 | Hoechst-Roussel Pharmaceuticals Incorporated | Phenylhydrazones as intermediates 1-phenyl-3-(1-piperazenyl)-1H-indazoles |
US4999356A (en) * | 1987-08-07 | 1991-03-12 | Hoechst-Roussel Pharmaceuticals, Inc. | 1-phenyl-3-(1-piperazinyl)-1H-indazoles |
US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
FR2654104B1 (fr) * | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
US5147881A (en) * | 1990-11-14 | 1992-09-15 | Pfizer Inc | 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents |
DK0646115T3 (da) * | 1991-03-28 | 2003-04-22 | Eisai Co Ltd | Heterocykliske/cykliske aminderivater |
-
1993
- 1993-11-22 CA CA002149918A patent/CA2149918A1/en not_active Abandoned
- 1993-11-22 EP EP94902374A patent/EP0669920B1/en not_active Expired - Lifetime
- 1993-11-22 AU AU56765/94A patent/AU690529B2/en not_active Ceased
- 1993-11-22 JP JP51335294A patent/JP3462501B2/ja not_active Expired - Fee Related
- 1993-11-22 NZ NZ258747A patent/NZ258747A/en unknown
- 1993-11-22 AT AT94902374T patent/ATE232529T1/de not_active IP Right Cessation
- 1993-11-22 PT PT94902374T patent/PT669920E/pt unknown
- 1993-11-22 DK DK94902374T patent/DK0669920T3/da active
- 1993-11-22 DE DE69332691T patent/DE69332691T2/de not_active Expired - Fee Related
- 1993-11-22 ES ES94902374T patent/ES2187518T3/es not_active Expired - Lifetime
- 1993-11-23 MX MX9307332A patent/MX9307332A/es not_active Application Discontinuation
-
1995
- 1995-05-22 FI FI952481A patent/FI952481A/fi not_active IP Right Cessation
- 1995-05-22 NO NO952018A patent/NO304980B1/no not_active IP Right Cessation
- 1995-06-06 US US08/471,197 patent/US6046203A/en not_active Expired - Lifetime
- 1995-06-06 US US08/470,520 patent/US5580982A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK0669920T3 (da) | 2003-05-26 |
US5580982A (en) | 1996-12-03 |
DE69332691D1 (de) | 2003-03-20 |
NO304980B1 (no) | 1999-03-15 |
NZ258747A (en) | 1997-02-24 |
EP0669920A4 (en) | 1995-10-25 |
NO952018D0 (no) | 1995-05-22 |
EP0669920B1 (en) | 2003-02-12 |
JP3462501B2 (ja) | 2003-11-05 |
NO952018L (no) | 1995-05-22 |
US6046203A (en) | 2000-04-04 |
MX9307332A (es) | 1994-07-29 |
FI952481A0 (fi) | 1995-05-22 |
DE69332691T2 (de) | 2003-12-18 |
AU5676594A (en) | 1994-06-22 |
EP0669920A1 (en) | 1995-09-06 |
PT669920E (pt) | 2003-06-30 |
ATE232529T1 (de) | 2003-02-15 |
AU690529B2 (en) | 1998-04-30 |
JPH08506094A (ja) | 1996-07-02 |
CA2149918A1 (en) | 1994-06-09 |
FI952481A (fi) | 1995-05-22 |
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