ATE242220T1 - Benzimidazolderivate mit dopaminerger wirkung - Google Patents
Benzimidazolderivate mit dopaminerger wirkungInfo
- Publication number
- ATE242220T1 ATE242220T1 AT95917441T AT95917441T ATE242220T1 AT E242220 T1 ATE242220 T1 AT E242220T1 AT 95917441 T AT95917441 T AT 95917441T AT 95917441 T AT95917441 T AT 95917441T AT E242220 T1 ATE242220 T1 AT E242220T1
- Authority
- AT
- Austria
- Prior art keywords
- benzimidazole derivatives
- dopaminergic effects
- dopaminergic
- effects
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28657694A | 1994-08-05 | 1994-08-05 | |
US29800594A | 1994-08-30 | 1994-08-30 | |
PCT/IB1995/000378 WO1996004250A1 (en) | 1994-08-05 | 1995-05-18 | Benzimidazole derivatives having dopaminergic activity |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE242220T1 true ATE242220T1 (de) | 2003-06-15 |
Family
ID=26963924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95917441T ATE242220T1 (de) | 1994-08-05 | 1995-05-18 | Benzimidazolderivate mit dopaminerger wirkung |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0775118B1 (de) |
JP (1) | JP3004727B2 (de) |
KR (1) | KR970704698A (de) |
AT (1) | ATE242220T1 (de) |
AU (1) | AU703431B2 (de) |
BR (1) | BR9503572A (de) |
CA (1) | CA2196769C (de) |
CO (1) | CO4410330A1 (de) |
DE (1) | DE69530988T2 (de) |
DK (1) | DK0775118T3 (de) |
ES (1) | ES2201105T3 (de) |
FI (1) | FI970469A (de) |
IL (1) | IL114754A0 (de) |
MX (1) | MX9700959A (de) |
NZ (1) | NZ284851A (de) |
PE (1) | PE35796A1 (de) |
PT (1) | PT775118E (de) |
TR (1) | TR199500956A2 (de) |
TW (1) | TW306920B (de) |
WO (1) | WO1996004250A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR199801161T2 (xx) * | 1995-12-21 | 1998-10-21 | Pfizer Inc. | 2,7-�kame edilmi� oktahidro-pirdo (1,2-A) pirazin t�revleri. |
EP0953567A3 (de) | 1998-04-29 | 2003-04-02 | Pfizer Products Inc. | Bizyklisch substituierte Piperazin-, Piperidin- und Tetrahydropyridin Derivate, deren Herstellung und deren Verwendung als Mittel mit zentraler dopaminerger (Dopamin D4 Rezeptor) Aktivität |
NZ519692A (en) * | 1999-12-30 | 2004-05-28 | H | Phenylpiperazinyl, -piperidinyl or -tetrahydropyridinyl derivatives |
EP1177792A3 (de) * | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamin-d4-ligande zur behandlung von gaudi-suchenden krankheiten |
CA2429383A1 (en) * | 2000-11-22 | 2002-05-30 | Abbott Laboratories | Selective dopamine d4 receptor agonists for treating sexual dysfunction |
US7432304B2 (en) | 2001-05-30 | 2008-10-07 | The Regents Of The University Of Michigan | Small molecule antagonists of Bcl-2 family proteins |
WO2002100350A2 (en) * | 2001-06-13 | 2002-12-19 | The Regents Of University Of Michigan | Dopamine receptor ligands and therapeutic methods based thereon |
US7354928B2 (en) | 2001-11-01 | 2008-04-08 | The Regents Of The University Of Michigan | Small molecule inhibitors targeted at Bcl-2 |
WO2003078420A2 (en) * | 2002-03-12 | 2003-09-25 | Wyeth | Process for making chiral 1,4-disubstituted piperazines |
JP2004123562A (ja) * | 2002-09-30 | 2004-04-22 | Japan Science & Technology Corp | 神経細胞死抑制作用を有する化合物を用いた医薬 |
KR20060129023A (ko) * | 2004-02-23 | 2006-12-14 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 신규한 헤테로환 화합물 |
JP2007530568A (ja) | 2004-03-25 | 2007-11-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ゴシポール共結晶およびその使用 |
EP1634598A1 (de) * | 2004-09-07 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Verwendung von Piperazinderivaten und Analogen zur Behandlung oder Prophylaxe von Essstörungen |
EP2924033B1 (de) * | 2012-11-26 | 2019-02-27 | Shenyang Haiwang Biotechnology Co., Ltd | Verwendung von benzo-fünfgliedrigen heterocyclischen piperazin- oder piperidinderivaten aus stickstoff |
JP2016500084A (ja) * | 2012-11-26 | 2016-01-07 | リアオニン エミー バイオロジカル ファーマシューティカル カンパニー リミテッドLiaoning Emmy Biological Pharmaceutical Co.,Ltd | 含窒素ベンゾ複素五員環基ピペリジン又はピペラジン誘導体及びその作製方法並びに薬剤組成物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3647790A (en) * | 1969-04-08 | 1972-03-07 | American Home Prod | Ouinoxalinyl-oxazolidines and -oxazines |
FR2579596B1 (fr) * | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
IT1251144B (it) * | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
-
1995
- 1995-05-18 AT AT95917441T patent/ATE242220T1/de not_active IP Right Cessation
- 1995-05-18 ES ES95917441T patent/ES2201105T3/es not_active Expired - Lifetime
- 1995-05-18 WO PCT/IB1995/000378 patent/WO1996004250A1/en active IP Right Grant
- 1995-05-18 DE DE69530988T patent/DE69530988T2/de not_active Expired - Fee Related
- 1995-05-18 AU AU23510/95A patent/AU703431B2/en not_active Ceased
- 1995-05-18 PT PT95917441T patent/PT775118E/pt unknown
- 1995-05-18 NZ NZ284851A patent/NZ284851A/en unknown
- 1995-05-18 JP JP7524233A patent/JP3004727B2/ja not_active Expired - Fee Related
- 1995-05-18 MX MX9700959A patent/MX9700959A/es not_active IP Right Cessation
- 1995-05-18 KR KR1019970700749A patent/KR970704698A/ko not_active Application Discontinuation
- 1995-05-18 EP EP95917441A patent/EP0775118B1/de not_active Expired - Lifetime
- 1995-05-18 CA CA002196769A patent/CA2196769C/en not_active Expired - Fee Related
- 1995-05-18 DK DK95917441T patent/DK0775118T3/da active
- 1995-07-17 TW TW084107371A patent/TW306920B/zh active
- 1995-07-27 IL IL11475495A patent/IL114754A0/xx unknown
- 1995-08-02 PE PE1995275146A patent/PE35796A1/es not_active Application Discontinuation
- 1995-08-04 CO CO95035006A patent/CO4410330A1/es unknown
- 1995-08-04 TR TR95/00956A patent/TR199500956A2/xx unknown
- 1995-08-07 BR BR9503572A patent/BR9503572A/pt not_active Application Discontinuation
-
1997
- 1997-02-04 FI FI970469A patent/FI970469A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
CA2196769C (en) | 2002-10-08 |
DK0775118T3 (da) | 2003-09-29 |
DE69530988D1 (de) | 2003-07-10 |
CO4410330A1 (es) | 1997-01-09 |
PE35796A1 (es) | 1996-10-01 |
NZ284851A (en) | 1998-07-28 |
JPH09510706A (ja) | 1997-10-28 |
MX9700959A (es) | 1997-05-31 |
PT775118E (pt) | 2003-10-31 |
FI970469A (fi) | 1997-04-04 |
IL114754A0 (en) | 1995-11-27 |
AU2351095A (en) | 1996-03-04 |
EP0775118B1 (de) | 2003-06-04 |
WO1996004250A1 (en) | 1996-02-15 |
ES2201105T3 (es) | 2004-03-16 |
TR199500956A2 (tr) | 1996-07-21 |
AU703431B2 (en) | 1999-03-25 |
CA2196769A1 (en) | 1996-02-15 |
TW306920B (de) | 1997-06-01 |
DE69530988T2 (de) | 2003-12-04 |
FI970469A0 (fi) | 1997-02-04 |
BR9503572A (pt) | 1996-04-30 |
KR970704698A (ko) | 1997-09-06 |
JP3004727B2 (ja) | 2000-01-31 |
EP0775118A1 (de) | 1997-05-28 |
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Legal Events
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UEP | Publication of translation of european patent specification |
Ref document number: 0775118 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |