ES2183340T3 - Procedimiento para la preparcion de compuestos de 4-bromometil-bifenilo. - Google Patents
Procedimiento para la preparcion de compuestos de 4-bromometil-bifenilo.Info
- Publication number
- ES2183340T3 ES2183340T3 ES98913755T ES98913755T ES2183340T3 ES 2183340 T3 ES2183340 T3 ES 2183340T3 ES 98913755 T ES98913755 T ES 98913755T ES 98913755 T ES98913755 T ES 98913755T ES 2183340 T3 ES2183340 T3 ES 2183340T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- bromometil
- bifenilo
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000031709 bromination Effects 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
Abstract
La invención se refiere a compuestos de fórmula (I) en la que R es tal y como se define en la descripción, que se preparan por bromación de compuestos de fórmula (II) por medio de Br{sub,2} o HBr en presencia de H{sub,2}O{sub,2}.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97MI000846A IT1291551B1 (it) | 1997-04-11 | 1997-04-11 | Processo per la preparazione di composti 4-bromometil bifenilici |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2183340T3 true ES2183340T3 (es) | 2003-03-16 |
Family
ID=11376859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98913755T Expired - Lifetime ES2183340T3 (es) | 1997-04-11 | 1998-04-06 | Procedimiento para la preparcion de compuestos de 4-bromometil-bifenilo. |
Country Status (8)
Country | Link |
---|---|
US (1) | US6111114A (es) |
EP (1) | EP0973729B1 (es) |
JP (1) | JP2001518904A (es) |
AU (1) | AU6832898A (es) |
DE (1) | DE69807859T2 (es) |
ES (1) | ES2183340T3 (es) |
IT (1) | IT1291551B1 (es) |
WO (1) | WO1998046562A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2771090B1 (fr) * | 1997-11-17 | 2000-02-04 | Sanofi Sa | Procede de preparation de derives de bromomethyl-biphenyle |
DE19757995A1 (de) * | 1997-12-29 | 1999-07-08 | Great Lakes Chem Konstanz Gmbh | Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen |
EP1535901B8 (en) * | 2002-06-12 | 2008-09-24 | Sumitomo Chemical Company, Limited | Process for producing 4'-bromomethyl-2-cyanobiphenyl |
JP4537678B2 (ja) * | 2003-09-04 | 2010-09-01 | 住友化学株式会社 | 2’−(1h−テトラゾール−5−イル)ビフェニル−4−カルボアルデヒド結晶およびその製造方法 |
US20060074117A1 (en) * | 2004-09-02 | 2006-04-06 | Lilach Hedvati | Purification of olmesartan medoxomil |
JP4511550B2 (ja) * | 2004-09-02 | 2010-07-28 | テバ ファーマシューティカル インダストリーズ リミティド | オルメサルタンメドキソミルの調製法 |
US20070054948A1 (en) * | 2004-09-02 | 2007-03-08 | Lilach Hedvati | Purification of olmesartan medoxomil |
KR20080112424A (ko) * | 2004-10-15 | 2008-12-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | 텔미사르탄의 제조 방법 |
WO2006073518A1 (en) * | 2004-12-30 | 2006-07-13 | Teva Pharmaceutical Industries Ltd. | Process for preparing olmesartan medoxomil at ph higher than 2.5 |
US20060258727A1 (en) * | 2005-01-03 | 2006-11-16 | Lilach Hedvati | Olmesartan medoxomil with reduced levels of impurities |
CA2592160A1 (en) * | 2005-01-03 | 2006-07-13 | Teva Pharmaceutical Industries Ltd. | Olmesartan medoxomil with reduced levels of impurities |
US7968727B2 (en) | 2005-04-01 | 2011-06-28 | Lek Pharmaceuticals, D.D. | Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists |
WO2008078340A1 (en) * | 2006-12-27 | 2008-07-03 | Calyx Chemicals And Pharmaceuticals Ltd. | Process for the separation of 4-bromomethyl-2'-substituted biphenyls from 4,4,-dibromomethyl-2'-substituted biphenyls |
HUP0900788A2 (en) * | 2009-12-16 | 2011-11-28 | Sanofi Aventis | Process for producing 4-bromomethyl-biphenyl derivatives |
CN108947870B (zh) * | 2018-07-23 | 2021-03-19 | 湖北宇阳药业有限公司 | 一种溴代沙坦联苯的制备方法 |
CN112010831A (zh) * | 2020-09-08 | 2020-12-01 | 上海生农生化制品股份有限公司 | 一种绿色高效的苯醚缩酮溴化合成方法 |
CN112851549A (zh) * | 2021-03-11 | 2021-05-28 | 安徽云帆药业有限公司 | 一种溴化钠套用实验方法 |
CN112898182A (zh) * | 2021-03-11 | 2021-06-04 | 安徽云帆药业有限公司 | 一种制备4`-溴甲基-2-氰基联苯的合成方法 |
CN114426501A (zh) * | 2021-12-23 | 2022-05-03 | 山东艾孚特科技有限公司 | 基于水相反应的溴代沙坦联苯的制备方法 |
CN114436833A (zh) * | 2021-12-27 | 2022-05-06 | 南京红太阳医药研究院有限公司 | 一种替米沙坦关键中间体4′-甲基联苯-2-羧酸酯的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2688657B2 (ja) * | 1989-02-23 | 1997-12-10 | 三光化学工業株式会社 | 芳香核に結合するメチル基の臭素化方法 |
US5312958A (en) * | 1992-01-31 | 1994-05-17 | Takeda Chemical Industries, Ltd. | Process for producing 4-bromomethylbiphenyl compounds |
DE59303357D1 (de) * | 1992-10-29 | 1996-09-05 | Hoechst Ag | Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen |
-
1997
- 1997-04-11 IT IT97MI000846A patent/IT1291551B1/it active IP Right Grant
-
1998
- 1998-04-06 AU AU68328/98A patent/AU6832898A/en not_active Abandoned
- 1998-04-06 DE DE69807859T patent/DE69807859T2/de not_active Expired - Fee Related
- 1998-04-06 US US09/402,667 patent/US6111114A/en not_active Expired - Fee Related
- 1998-04-06 JP JP54343398A patent/JP2001518904A/ja not_active Ceased
- 1998-04-06 ES ES98913755T patent/ES2183340T3/es not_active Expired - Lifetime
- 1998-04-06 WO PCT/EP1998/001992 patent/WO1998046562A1/en active IP Right Grant
- 1998-04-06 EP EP98913755A patent/EP0973729B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0973729A1 (en) | 2000-01-26 |
JP2001518904A (ja) | 2001-10-16 |
DE69807859T2 (de) | 2003-05-22 |
US6111114A (en) | 2000-08-29 |
WO1998046562A1 (en) | 1998-10-22 |
IT1291551B1 (it) | 1999-01-11 |
ITMI970846A1 (it) | 1998-10-11 |
AU6832898A (en) | 1998-11-11 |
DE69807859D1 (de) | 2002-10-17 |
EP0973729B1 (en) | 2002-09-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2183340T3 (es) | Procedimiento para la preparcion de compuestos de 4-bromometil-bifenilo. | |
ES2162198T3 (es) | Agentes estrogenos. | |
TR200000782T2 (tr) | Resorsinol türevleri. | |
GT199900055A (es) | Nuevas dihidropirimidinas2 heterocìclicamente sustituidas. | |
ES2184070T3 (es) | Derivados de oximas sustituidas utiles como antagonistas de la neuroquinina. | |
BR0114630A (pt) | Secretagogos de hormÈnio do crescimento | |
BR9805706A (pt) | Conjunto de assento para veículo que possui um banco amovível montado sobre corrediças. | |
NO961377L (no) | Distamycin A-analoger som antitumor eller antivirale midler | |
FI971489A (fi) | Uusia bentsoksatsoleja | |
ES2103751T3 (es) | Procedimiento para la obtencion de oxetanonas. | |
MY126559A (en) | Fungicidal 2-methoxybenzophenones | |
ZA991569B (en) | Derivatives of GLP-1 analogs. | |
HN1998000118A (es) | 2 - aminopiridinas que contienen sustituyentes de anillos condensados. | |
GT199800197A (es) | Proceso para la sintesis de 1,3-dioles. | |
BR9915938A (pt) | Derivados de pirimidina substituìdos por arila e heterociclila como anticoagulantes | |
ATE263157T1 (de) | Nematizide trifluorbutene | |
ID24845A (id) | Prostaglandin tetrahidro tersubstitusi c16-c20 aromatik yang berguna sebagai agonis fp | |
KR960702830A (ko) | 방사선 보호제로서의 N-알킬티오 폴리아민 유도체(N-Alkylthio polyaine derivatives as radioprotective agents) | |
DK0956033T3 (da) | Totalsyntese af amino-Hip-analogen af didemnin A | |
SV1999000060A (es) | Procedimiento para la preparacion de (s,s)-bencil-2,8-diazabiciclo 4.3.0 nonano ref. 32965-sv | |
AR006058A1 (es) | Procedimientos para preparar compuestos de dicianoacetato y de 1,2-pirazol-5-amino-3-substituido | |
BR9901378A (pt) | Processo de purificação de uma solução aquosa em relação a compostos orgânicos.. | |
TR200002932T2 (tr) | Azabisayklik 5HT1 Alıcı liganolları | |
BR9807988A (pt) | Processo para a preparação de um composto, e, composto. | |
TR199800543A2 (xx) | Benziloksi ikame edilen, aniliye edilmi� N-heterosiklik bile�ikler. |