ES2176322T3 - Nuevos peptidos opioides para el tratamiento de dolores y su utilizacion. - Google Patents
Nuevos peptidos opioides para el tratamiento de dolores y su utilizacion.Info
- Publication number
- ES2176322T3 ES2176322T3 ES95910838T ES95910838T ES2176322T3 ES 2176322 T3 ES2176322 T3 ES 2176322T3 ES 95910838 T ES95910838 T ES 95910838T ES 95910838 T ES95910838 T ES 95910838T ES 2176322 T3 ES2176322 T3 ES 2176322T3
- Authority
- ES
- Spain
- Prior art keywords
- peptides
- pain
- treatment
- opioid
- opioid peptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA INVENCION SE REFIERE A UNA SERIE DE NUEVOS PEPTIDOS OPIOIDE PARA EL TRATAMIENTO DEL DOLOR Y COMPOSICIONES FARMACEUTICAMENTE ACEPTABLES QUE CONTIENEN DICHOS PEPTIDOS.LA INVENCION TAMBIEN ENSEÑA METODOS PARA CONTROLAR EL DOLOR EN PACIENTES USANDO LAS COMPOSICIONES DE LA INVENCION.LOS PEPTIDOS DE LA INVENCION TIENEN UN ALTO GRADO DE SELECTIVIDAD PARA LOS RECEPTORES {MU}-OPIOIDE. ESTOS PEPTIDOS SON ALTAMENTE LIPOFILICOS.A PESAR DE SU CARACTER LIPOFILICO, NO ATRAVIESAN LA BARRERA DE SANGRE DEL CEREBRO (BBB).LOS PEPTIDOS DE LA INVENCION ESTAN PARTICULARMENTE BIEN PREPARADOS COMO AGENTES ANALGESICOS ACTUANDO SUBSTANCIALMENTE SOBRE LOS RECEPTORES {MU}-OPIOIDE PERIFERICOS, DEBIDO A QUE ESTOS PEPTIDOS ACTUAN PERIFERICAMENTE, EVITAN LA PRODUCCION DE EFECTOS LATERALES NORMALMENTE ASOCIADOS CON LA ACCION ANALGESICA CENTRAL.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9403263A GB9403263D0 (en) | 1994-02-21 | 1994-02-21 | Novel opiod peptides |
GB9408179A GB9408179D0 (en) | 1994-02-21 | 1994-04-25 | Novel opioid peptides for the treatment of pain and use thereof |
SE9401519A SE9401519D0 (sv) | 1994-05-03 | 1994-05-03 | Novel opioid peptides for the tratment of pain and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2176322T3 true ES2176322T3 (es) | 2002-12-01 |
Family
ID=27267061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95910838T Expired - Lifetime ES2176322T3 (es) | 1994-02-21 | 1995-02-15 | Nuevos peptidos opioides para el tratamiento de dolores y su utilizacion. |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0746567B1 (es) |
JP (1) | JPH09509168A (es) |
AT (1) | ATE217011T1 (es) |
BR (1) | BR9506847A (es) |
CA (1) | CA2181367A1 (es) |
CZ (1) | CZ288523B6 (es) |
DE (1) | DE69526577T2 (es) |
EE (1) | EE03265B1 (es) |
ES (1) | ES2176322T3 (es) |
FI (1) | FI963252A (es) |
HR (1) | HRP950413A2 (es) |
HU (1) | HUT74731A (es) |
IS (1) | IS4261A (es) |
MX (1) | MX9603489A (es) |
NO (1) | NO963464L (es) |
NZ (1) | NZ281742A (es) |
PL (1) | PL181092B1 (es) |
SK (1) | SK93596A3 (es) |
TW (1) | TW408131B (es) |
WO (1) | WO1995022557A1 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9503924D0 (sv) | 1995-08-18 | 1995-11-07 | Astra Ab | Novel opioid peptides |
CA2223428A1 (en) * | 1995-06-07 | 1996-12-19 | Torrey Pines Institute For Molecular Studies | Novel mu opioid receptor ligands: agonists and antagonists |
GB9516994D0 (en) * | 1995-08-18 | 1995-10-18 | Iaf Biochem Int | Solution synthesis of peripheral acting analgestic opioid tetrapeptides |
MX9709494A (es) * | 1996-12-04 | 1998-07-31 | Pfizer | Compuestos peptidicos ciclicos, procedimiento para su produccion, composiciones que los contienen y uso de los mismos. |
US5885958A (en) * | 1997-03-25 | 1999-03-23 | Administrators Of The Tulane Educational Fund | Mu-opiate receptor peptides |
WO1999065932A1 (en) * | 1998-06-18 | 1999-12-23 | Sepracor, Inc. | Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors |
SE9900961D0 (sv) * | 1999-03-16 | 1999-03-16 | Astra Ab | Novel compounds |
AU2001239896A1 (en) | 2000-03-16 | 2001-10-03 | Sepracor, Inc. | Peptidomimetic ligands for cellular receptors and ion channels |
WO2002005748A2 (en) * | 2000-07-18 | 2002-01-24 | Cornell Research Foundation, Inc. | Medicinal uses of mu-opioid receptor agonists |
AU2004209663B2 (en) | 2003-02-04 | 2009-01-15 | Clinical Research Institute Of Montreal | Methods for preventing mitochondrial permeability transition |
EP2604621B1 (en) | 2003-05-01 | 2015-10-21 | Cornell Research Foundation, Inc. | Method and carrier complexes for delivering molecules to cells |
CA2971931C (en) | 2004-01-23 | 2019-01-08 | Cornell Research Foundation, Inc. | Methods for reducing oxidative damage |
BRPI0609879A2 (pt) | 2005-04-28 | 2010-05-11 | Pfizer Ltd | derivados de aminoácidos |
US7541340B2 (en) | 2005-09-16 | 2009-06-02 | Cornell Research Foundation, Inc. | Methods for reducing CD36 expression |
EP1782819A1 (en) | 2005-11-03 | 2007-05-09 | Cognis IP Management GmbH | Oligopeptides and their use |
MY148144A (en) | 2006-11-10 | 2013-03-15 | Cara Therapeutics Inc | Synthetic peptide amides |
US8236766B2 (en) | 2006-11-10 | 2012-08-07 | Cara Therapeutics, Inc. | Uses of synthetic peptide amides |
US7842662B2 (en) | 2006-11-10 | 2010-11-30 | Cara Therapeutics, Inc. | Synthetic peptide amide dimers |
US7713937B2 (en) | 2006-11-10 | 2010-05-11 | Cara Therapeutics, Inc. | Synthetic peptide amides and dimeric forms thereof |
US8906859B2 (en) | 2006-11-10 | 2014-12-09 | Cera Therapeutics, Inc. | Uses of kappa opioid synthetic peptide amides |
CN102127151B (zh) * | 2007-06-11 | 2012-07-04 | 北京大学 | 抗阿片肽的拮抗肽与该拮抗肽的应用 |
CN102127152B (zh) * | 2007-06-11 | 2012-07-04 | 北京大学 | 一种抗阿片肽的拮抗肽与该拮抗肽的应用 |
CN101805396B (zh) * | 2007-06-28 | 2011-09-14 | 北京大学 | 抗阿片肽的拮抗肽与该拮抗肽的应用 |
CN101817877B (zh) * | 2007-06-28 | 2011-09-14 | 北京大学 | 一种抗阿片肽的活性片段 |
WO2009100363A2 (en) | 2008-02-07 | 2009-08-13 | Cornell University | Methods for preventing or treating insulin resistance |
CN101951936A (zh) | 2008-02-26 | 2011-01-19 | 康奈尔大学 | 用于防止和治疗急性肾损伤的方法 |
CN112469729A (zh) * | 2018-05-31 | 2021-03-09 | 悉尼大学 | 镇痛剂及其使用方法 |
JP7437578B2 (ja) * | 2019-03-20 | 2024-02-26 | 国立大学法人東北大学 | 新規オピオイドペプチド、その糖鎖付加体及びそれらを含む医薬組成物 |
CN113968902B (zh) * | 2020-07-25 | 2023-05-26 | 兰州大学 | 亮氨酸-脑啡肽类似物及其制备方法和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8005121A (nl) * | 1979-09-20 | 1981-03-24 | Erba Farmitalia | Biologisch actieve peptiden. |
ATE235911T1 (de) * | 1992-11-12 | 2003-04-15 | Sod Conseils Rech Applic | Opioidpeptide |
SE9300012D0 (sv) * | 1993-01-05 | 1993-01-05 | Astra Ab | New peptides |
-
1995
- 1995-02-13 IS IS4261A patent/IS4261A/is unknown
- 1995-02-15 EP EP95910838A patent/EP0746567B1/en not_active Expired - Lifetime
- 1995-02-15 MX MX9603489A patent/MX9603489A/es unknown
- 1995-02-15 SK SK935-96A patent/SK93596A3/sk unknown
- 1995-02-15 EE EE9600071A patent/EE03265B1/xx not_active IP Right Cessation
- 1995-02-15 JP JP7521753A patent/JPH09509168A/ja not_active Abandoned
- 1995-02-15 NZ NZ281742A patent/NZ281742A/en unknown
- 1995-02-15 CZ CZ19962391A patent/CZ288523B6/cs not_active IP Right Cessation
- 1995-02-15 AT AT95910838T patent/ATE217011T1/de not_active IP Right Cessation
- 1995-02-15 PL PL95315947A patent/PL181092B1/pl unknown
- 1995-02-15 WO PCT/SE1995/000158 patent/WO1995022557A1/en active IP Right Grant
- 1995-02-15 HU HU9602281A patent/HUT74731A/hu unknown
- 1995-02-15 DE DE69526577T patent/DE69526577T2/de not_active Expired - Fee Related
- 1995-02-15 BR BR9506847A patent/BR9506847A/pt not_active Application Discontinuation
- 1995-02-15 CA CA002181367A patent/CA2181367A1/en not_active Abandoned
- 1995-02-15 ES ES95910838T patent/ES2176322T3/es not_active Expired - Lifetime
- 1995-02-16 TW TW084101429A patent/TW408131B/zh not_active IP Right Cessation
- 1995-07-19 HR HR9401519-5A patent/HRP950413A2/hr not_active Application Discontinuation
-
1996
- 1996-08-20 NO NO963464A patent/NO963464L/no not_active Application Discontinuation
- 1996-08-20 FI FI963252A patent/FI963252A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
CA2181367A1 (en) | 1995-08-24 |
FI963252A0 (fi) | 1996-08-20 |
ATE217011T1 (de) | 2002-05-15 |
BR9506847A (pt) | 1997-09-30 |
SK93596A3 (en) | 1997-05-07 |
WO1995022557A1 (en) | 1995-08-24 |
JPH09509168A (ja) | 1997-09-16 |
HUT74731A (en) | 1997-02-28 |
HU9602281D0 (en) | 1996-10-28 |
NZ281742A (en) | 1997-06-24 |
AU690648B2 (en) | 1998-04-30 |
TW408131B (en) | 2000-10-11 |
EP0746567B1 (en) | 2002-05-02 |
MX9603489A (es) | 1997-03-29 |
FI963252A (fi) | 1996-08-20 |
DE69526577T2 (de) | 2003-01-02 |
NO963464L (no) | 1996-08-20 |
HRP950413A2 (en) | 1997-10-31 |
EP0746567A1 (en) | 1996-12-11 |
EE03265B1 (et) | 2000-04-17 |
CZ288523B6 (cs) | 2001-07-11 |
IS4261A (is) | 1995-08-22 |
PL315947A1 (en) | 1996-12-09 |
DE69526577D1 (de) | 2002-06-06 |
AU1865195A (en) | 1995-09-04 |
PL181092B1 (pl) | 2001-05-31 |
CZ239196A3 (en) | 1996-12-11 |
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