MX9603489A - Peptidos opiodes novedosos para el tratamiento del dolor y uso de los mismos. - Google Patents

Peptidos opiodes novedosos para el tratamiento del dolor y uso de los mismos.

Info

Publication number
MX9603489A
MX9603489A MX9603489A MX9603489A MX9603489A MX 9603489 A MX9603489 A MX 9603489A MX 9603489 A MX9603489 A MX 9603489A MX 9603489 A MX9603489 A MX 9603489A MX 9603489 A MX9603489 A MX 9603489A
Authority
MX
Mexico
Prior art keywords
peptides
pain
treatment
opioid
opioid peptides
Prior art date
Application number
MX9603489A
Other languages
English (en)
Inventor
William Brown
John Dimaio
Peter Schiller
Rene Martel
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9403263A external-priority patent/GB9403263D0/en
Priority claimed from SE9401519A external-priority patent/SE9401519D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of MX9603489A publication Critical patent/MX9603489A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Esta invencion se relaciona con una serie de péptidos opioides novedosos para el tratamiento del dolor y composiciones farmacéuticamente aceptables constituidas por estos péptidos. La invencion también describe métodos para controlar el dolor en pacientes mediante la utilizacion de las composiciones de la invencion. Los péptidos de esta invencion tienen un alto grado de selectividad por el receptor æ-opiode. Estos péptidos son altamente lipofílicos. Pese a su carácter lipofílico no atraviesan con facilidad la barrera hematoencefálica (BBB). Los péptidos de la presente invencion son particularmente adecuados como agentes analgésicos que actuan sustancialmente sobre los receptores æ-opioides periféricos. Debido a que estos péptidos actuan de manera periférica, sustancialmente evitan la produccion de efectos colaterales normalmente asociados con la accion analgésica central.
MX9603489A 1994-02-21 1995-02-15 Peptidos opiodes novedosos para el tratamiento del dolor y uso de los mismos. MX9603489A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9403263A GB9403263D0 (en) 1994-02-21 1994-02-21 Novel opiod peptides
GB9408179A GB9408179D0 (en) 1994-02-21 1994-04-25 Novel opioid peptides for the treatment of pain and use thereof
SE9401519A SE9401519D0 (sv) 1994-05-03 1994-05-03 Novel opioid peptides for the tratment of pain and use thereof
PCT/SE1995/000158 WO1995022557A1 (en) 1994-02-21 1995-02-15 Novel opioid peptides for the treatment of pain and use thereof

Publications (1)

Publication Number Publication Date
MX9603489A true MX9603489A (es) 1997-03-29

Family

ID=27267061

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9603489A MX9603489A (es) 1994-02-21 1995-02-15 Peptidos opiodes novedosos para el tratamiento del dolor y uso de los mismos.

Country Status (20)

Country Link
EP (1) EP0746567B1 (es)
JP (1) JPH09509168A (es)
AT (1) ATE217011T1 (es)
BR (1) BR9506847A (es)
CA (1) CA2181367A1 (es)
CZ (1) CZ288523B6 (es)
DE (1) DE69526577T2 (es)
EE (1) EE03265B1 (es)
ES (1) ES2176322T3 (es)
FI (1) FI963252A0 (es)
HR (1) HRP950413A2 (es)
HU (1) HUT74731A (es)
IS (1) IS4261A (es)
MX (1) MX9603489A (es)
NO (1) NO963464L (es)
NZ (1) NZ281742A (es)
PL (1) PL181092B1 (es)
SK (1) SK93596A3 (es)
TW (1) TW408131B (es)
WO (1) WO1995022557A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9503924D0 (sv) * 1995-08-18 1995-11-07 Astra Ab Novel opioid peptides
EP0853484B1 (en) * 1995-06-07 2002-09-11 Torrey Pines Institute For Molecular Studies Novel mu opioid receptor ligands: agonists and antagonists
GB9516994D0 (en) * 1995-08-18 1995-10-18 Iaf Biochem Int Solution synthesis of peripheral acting analgestic opioid tetrapeptides
MX9709494A (es) * 1996-12-04 1998-07-31 Pfizer Compuestos peptidicos ciclicos, procedimiento para su produccion, composiciones que los contienen y uso de los mismos.
US5885958A (en) * 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
US6548637B1 (en) 1998-06-18 2003-04-15 Sepracor, Inc. Ligands for opioid receptors
SE9900961D0 (sv) 1999-03-16 1999-03-16 Astra Ab Novel compounds
US7115664B2 (en) 2000-03-16 2006-10-03 Sepracor Inc. Peptidomimetic ligands for cellular receptors and ion channels
EP1303186B1 (en) 2000-07-18 2011-01-26 Cornell Research Foundation, Inc. Medicinal uses of mu-opioid receptor agonists
EP2491943B1 (en) 2003-02-04 2018-10-10 Cornell Research Foundation, Inc. Methods for preventing mitochondrial permeability transition
EP3167935B1 (en) 2003-05-01 2018-07-18 Cornell Research Foundation, Inc. Method and carrier complexes for delivering molecules to cells
RU2376028C2 (ru) 2004-01-23 2009-12-20 Корнелл Рисеч Фаундейшн, Инк. Способ уменьшения окислительного повреждения (варианты)
EP1879567A1 (en) 2005-04-28 2008-01-23 Pfizer Limited Amino acid derivatives
CA2622911C (en) 2005-09-16 2016-12-06 Cornell Research Foundation, Inc. Methods for reducing cd36 expression
EP1782819A1 (en) 2005-11-03 2007-05-09 Cognis IP Management GmbH Oligopeptides and their use
WO2008057608A2 (en) 2006-11-10 2008-05-15 Cara Therapeutics, Inc. Synthetic peptide amides
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US8236766B2 (en) 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
CN102127152B (zh) * 2007-06-11 2012-07-04 北京大学 一种抗阿片肽的拮抗肽与该拮抗肽的应用
CN102127151B (zh) * 2007-06-11 2012-07-04 北京大学 抗阿片肽的拮抗肽与该拮抗肽的应用
CN101805396B (zh) * 2007-06-28 2011-09-14 北京大学 抗阿片肽的拮抗肽与该拮抗肽的应用
CN101817877B (zh) * 2007-06-28 2011-09-14 北京大学 一种抗阿片肽的活性片段
ES2458870T3 (es) 2008-02-07 2014-05-07 Cornell University Procedimientos para prevenir o tratar la resistencia a la insulina
EP3741381B1 (en) 2008-02-26 2024-04-24 Cornell University A peptide for use for prevention and treatment of acute renal injury
CN112469729A (zh) * 2018-05-31 2021-03-09 悉尼大学 镇痛剂及其使用方法
JP7437578B2 (ja) * 2019-03-20 2024-02-26 国立大学法人東北大学 新規オピオイドペプチド、その糖鎖付加体及びそれらを含む医薬組成物
CN113968902B (zh) * 2020-07-25 2023-05-26 兰州大学 亮氨酸-脑啡肽类似物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8005121A (nl) * 1979-09-20 1981-03-24 Erba Farmitalia Biologisch actieve peptiden.
CZ168194A3 (en) * 1992-11-12 1994-12-15 Biomeasure Opioid peptides
SE9300012D0 (sv) * 1993-01-05 1993-01-05 Astra Ab New peptides

Also Published As

Publication number Publication date
WO1995022557A1 (en) 1995-08-24
EE03265B1 (et) 2000-04-17
PL181092B1 (pl) 2001-05-31
PL315947A1 (en) 1996-12-09
ATE217011T1 (de) 2002-05-15
TW408131B (en) 2000-10-11
DE69526577D1 (de) 2002-06-06
BR9506847A (pt) 1997-09-30
AU1865195A (en) 1995-09-04
HUT74731A (en) 1997-02-28
HRP950413A2 (en) 1997-10-31
JPH09509168A (ja) 1997-09-16
NZ281742A (en) 1997-06-24
CZ288523B6 (cs) 2001-07-11
EP0746567B1 (en) 2002-05-02
FI963252A (fi) 1996-08-20
DE69526577T2 (de) 2003-01-02
HU9602281D0 (en) 1996-10-28
SK93596A3 (en) 1997-05-07
CZ239196A3 (en) 1996-12-11
EP0746567A1 (en) 1996-12-11
AU690648B2 (en) 1998-04-30
IS4261A (is) 1995-08-22
CA2181367A1 (en) 1995-08-24
ES2176322T3 (es) 2002-12-01
FI963252A0 (fi) 1996-08-20
NO963464L (no) 1996-08-20

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