ES2157443T3 - Particulas polimericas magneticas a base de alcohol polivinilico, proceso para su fabricacion y utilizacion. - Google Patents
Particulas polimericas magneticas a base de alcohol polivinilico, proceso para su fabricacion y utilizacion.Info
- Publication number
- ES2157443T3 ES2157443T3 ES96918662T ES96918662T ES2157443T3 ES 2157443 T3 ES2157443 T3 ES 2157443T3 ES 96918662 T ES96918662 T ES 96918662T ES 96918662 T ES96918662 T ES 96918662T ES 2157443 T3 ES2157443 T3 ES 2157443T3
- Authority
- ES
- Spain
- Prior art keywords
- polyvinyl alcohol
- particles
- polymer particles
- hydroxyl groups
- magnetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/14—Powdering or granulating by precipitation from solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/005—Pretreatment specially adapted for magnetic separation
- B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F16/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
- C08F16/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
- C08F16/04—Acyclic compounds
- C08F16/06—Polyvinyl alcohol ; Vinyl alcohol
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F261/00—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00
- C08F261/02—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols
- C08F261/04—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols on to polymers of vinyl alcohol
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/16—Powdering or granulating by coagulating dispersions
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K9/00—Use of pretreated ingredients
- C08K9/08—Ingredients agglomerated by treatment with a binding agent
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
- C08L51/003—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
- H01F1/44—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2329/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
- C08J2329/02—Homopolymers or copolymers of unsaturated alcohols
- C08J2329/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/815—Enzyme separation or purification by sorption
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
- Y10S530/816—Attached to the carrier via a bridging agent
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Power Engineering (AREA)
- Dispersion Chemistry (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Soft Magnetic Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Polymerisation Methods In General (AREA)
Abstract
LA INVENCION TRATA DE VEHICULOS DE POLIVINILALCOHOL MAGNETICOS Y EN FORMA DE PERLA, QUE SE FABRICAN MEDIANTE SUSPENSION DE UNA FASE POLIMERA QUE CONTIENE UN COLOIDE MAGNETICO EN UNA FASE ORGANICA QUE CONTIENE UNA MEZCLA ESPECIAL DE EMULSIONANTE. SE OBTIENEN PARTICULAS CON UN TAMAÑO DE GRANO DE 1 Y QUE PUEDEN LIGAR QUIMICAMENTE LOS LIGANDOS. LOS VEHICULOS PUEDEN EMPLEARSE EN EL AISLAMIENTO Y DETECCION DE BIOMOLECULAS, CELULAS, ANTICUERPOS Y ACIDOS NUCLEICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19528029A DE19528029B4 (de) | 1995-07-31 | 1995-07-31 | Magnetische Polymerpartikel auf der Basis von Polyvinylalkohol, Verfahren für ihre Herstellung und Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2157443T3 true ES2157443T3 (es) | 2001-08-16 |
Family
ID=7768276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96918662T Expired - Lifetime ES2157443T3 (es) | 1995-07-31 | 1996-06-03 | Particulas polimericas magneticas a base de alcohol polivinilico, proceso para su fabricacion y utilizacion. |
Country Status (16)
Country | Link |
---|---|
US (2) | US6204033B1 (es) |
EP (1) | EP0843591B1 (es) |
JP (1) | JP3164585B2 (es) |
KR (1) | KR100355006B1 (es) |
CN (1) | CN1104276C (es) |
AT (1) | ATE199503T1 (es) |
AU (1) | AU717433B2 (es) |
CA (1) | CA2227608C (es) |
DE (2) | DE19528029B4 (es) |
DK (1) | DK0843591T3 (es) |
ES (1) | ES2157443T3 (es) |
GR (1) | GR3035993T3 (es) |
IL (1) | IL123061A (es) |
PT (1) | PT843591E (es) |
RU (1) | RU2160154C2 (es) |
WO (1) | WO1997004862A1 (es) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2290364A1 (en) | 1996-04-25 | 2011-03-02 | BioArray Solutions Ltd. | Light-controlled electrokinetic assembly of particles near surfaces |
EP2241537A1 (en) * | 1999-02-19 | 2010-10-20 | Japan Science And Technology Agency | Apparatus with magnetic sludge for use in wastewater treatment |
EP1203240A2 (de) * | 1999-08-09 | 2002-05-08 | Bilatec Gesellschaft Zur Entwicklung Biotechnologischer Systeme MBH | Labor-roboter und verfahren und reagenzienkit zur isolierung von nukleinsäuren |
FR2800636A1 (fr) * | 1999-11-05 | 2001-05-11 | Bio Merieux | Particules composites, conjugues derives, leur procede de preparation et utilisations |
GB0001450D0 (en) | 2000-01-21 | 2000-03-08 | Genpoint As | Cell isolation method |
DE10013995A1 (de) | 2000-03-22 | 2001-09-27 | Chemagen Biopolymer Technologi | Magnetische, silanisierte Trägermaterialien auf Basis von Polyvinylalkohol |
AU2001272993B2 (en) * | 2000-06-21 | 2005-03-10 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis |
US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
WO2002016528A1 (fr) * | 2000-08-21 | 2002-02-28 | National Institute Of Advanced Industrial Science And Technology | Particules magnetiques et procede de fabrication correspondant |
US6649419B1 (en) * | 2000-11-28 | 2003-11-18 | Large Scale Proteomics Corp. | Method and apparatus for protein manipulation |
US7262063B2 (en) * | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
GB0116358D0 (en) * | 2001-07-04 | 2001-08-29 | Genovision As | Preparation of polymer particles |
GB0116359D0 (en) * | 2001-07-04 | 2001-08-29 | Genovision As | Preparation of polymer particles |
DE10136375A1 (de) * | 2001-07-26 | 2003-02-13 | Cellgenix Technologie Transfer | Verfahren zur Anreicherung von Zellen |
JP4072994B2 (ja) * | 2001-10-11 | 2008-04-09 | 学校法人日本大学 | 磁性粒子 |
KR20040068122A (ko) | 2001-10-15 | 2004-07-30 | 바이오어레이 솔루션스 리미티드 | 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석 |
US6797782B2 (en) * | 2002-03-25 | 2004-09-28 | Jsr Corporation | Process for producing particles for diagnostic reagent |
US7282540B2 (en) * | 2002-03-25 | 2007-10-16 | Jsr Corporation | Process for producing particles for diagnostic reagent |
US20030219753A1 (en) * | 2002-05-22 | 2003-11-27 | Quinn John G. | Biosensor and method |
DE10224352A1 (de) * | 2002-06-01 | 2003-12-11 | Mueller Schulte Detlef | Thermosensitive Polymerträger mit veränderbarer physikalischer Struktur für die biochemische Analytik, Diagnostik und Therapie |
GB0214947D0 (en) * | 2002-06-28 | 2002-08-07 | Secr Defence | Assay |
GB0216197D0 (en) * | 2002-07-12 | 2002-08-21 | Univ Strathclyde | Serrs active particles |
DE10235302A1 (de) * | 2002-08-01 | 2004-02-12 | Henkel Kgaa | Verfahren zur Herstellung perl- bzw. kugelförmiger magnetischer Partikel auf Acrylsäuresbasis zur Aufreinigung biologischer Substanzen |
AU2002951240A0 (en) * | 2002-08-23 | 2002-09-19 | Royal Women's Hospital | Depletion of plasma proteins |
US7306809B2 (en) * | 2002-09-13 | 2007-12-11 | Lipo Chemicals, Inc. | Optically activated particles for use in cosmetic compositions |
AU2003298655A1 (en) | 2002-11-15 | 2004-06-15 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
DE10256085A1 (de) * | 2002-11-29 | 2004-06-17 | Henkel Kgaa | Magnetische Mikrobizide |
GB0228914D0 (en) * | 2002-12-11 | 2003-01-15 | Dynal Biotech Asa | Particles |
GB0229696D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Biosciences Ab | Separation medium |
AU2003900335A0 (en) * | 2003-01-22 | 2003-02-13 | Sirtex Medical Limited | Microparticles for selectively targeted hyperthermia |
DE10331254B4 (de) | 2003-07-10 | 2006-05-04 | Chemagen Biopolymer-Technologie Aktiengesellschaft | Vorrichtung und Verfahren zum Abtrennen von magnetischen oder magnetisierbaren Partikeln aus einer Flüssigkeit |
WO2005029705A2 (en) * | 2003-09-18 | 2005-03-31 | Bioarray Solutions, Ltd. | Number coding for identification of subtypes of coded types of solid phase carriers |
ATE532066T1 (de) * | 2003-09-22 | 2011-11-15 | Bioarray Solutions Ltd | Oberflächenimmobilisierter polyelektrolyt mit mehreren, zur kovalenten bindung an biomoleküle fähigen funktionellen gruppen |
NZ547492A (en) * | 2003-10-28 | 2009-12-24 | Bioarray Solutions Ltd | Optimization of gene expression analysis using immobilized capture probes of different lengths and densities |
DE10350248A1 (de) * | 2003-10-28 | 2005-06-16 | Magnamedics Gmbh | Thermosensitive, biokompatible Polymerträger mit veränderbarer physikalischer Struktur für die Therapie, Diagnostik und Analytik |
WO2005045059A2 (en) * | 2003-10-28 | 2005-05-19 | Bioarray Solutions Ltd. | Allele assignment and probe selection in multiplexed assays of polymorphic targets |
WO2005045060A2 (en) | 2003-10-29 | 2005-05-19 | Bioarray Solutions, Ltd. | Multiplexed nucleic acid analysis by fragmentation of double-stranded dna |
DE10355409A1 (de) | 2003-11-25 | 2005-06-30 | Magnamedics Gmbh | Sphärische, magnetische Silicagel-Träger mit vergrößerter Oberfläche für die Aufreinigung von Nukleinsäuren |
US9267167B2 (en) | 2004-06-28 | 2016-02-23 | Becton, Dickinson And Company | Dissolvable films and methods including the same |
US7363170B2 (en) * | 2004-07-09 | 2008-04-22 | Bio Array Solutions Ltd. | Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products |
US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
GB2420976B (en) * | 2004-11-19 | 2006-12-20 | Zvi Finkelstein | Therapeutic implant |
TWI277632B (en) * | 2004-12-14 | 2007-04-01 | Nat Univ Chung Cheng | Magnetic polymer microbeads and a method for preparing the same |
DE102005004664B4 (de) * | 2005-02-02 | 2007-06-21 | Chemagen Biopolymer-Technologie Aktiengesellschaft | Vorrichtung und Verfahren und Verwendung zum Abtrennen von magnetischen oder magnetisierbaren Partikeln aus einer Flüssigkeit sowie deren Verwendungen |
US7897257B2 (en) * | 2005-04-18 | 2011-03-01 | Ge Healthcare Bio-Sciences Ab | Magnetic beads comprising an outer coating of hydrophilic porous polymer and method of making thereof |
US8486629B2 (en) | 2005-06-01 | 2013-07-16 | Bioarray Solutions, Ltd. | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
US20080283792A1 (en) * | 2005-10-28 | 2008-11-20 | Ge Healthcare Bio-Sciences Ab | Separation Medium with Various Functionalities |
DE102005058979A1 (de) * | 2005-12-09 | 2007-06-21 | Qiagen Gmbh | Magnetische Polymerpartikel |
WO2007126151A1 (ja) * | 2006-04-28 | 2007-11-08 | Hitachi Maxell, Ltd. | 機能性粒子およびそれを用いた標的物質の分離方法 |
KR100823684B1 (ko) * | 2006-12-06 | 2008-04-21 | 한국전자통신연구원 | 바코드 dna를 이용한 생물학적 표적 물질의 검출 방법 |
DE102007039899B3 (de) * | 2007-08-23 | 2009-04-09 | Siemens Ag | Sensor zum Ermöglichen des Nachweises einer Substanz im Körper eines Lebewesens |
JP5628037B2 (ja) * | 2007-10-12 | 2014-11-19 | フィオ コーポレイション | 濃縮されたミクロビーズを形成するためのフローフォーカシング方法及びシステム、並びにそのシステムに形成されたミクロビーズ |
EP2067867A1 (en) | 2007-12-03 | 2009-06-10 | Siemens Aktiengesellschaft | Process for concentrating nucleic acid molecules |
DE102007059939A1 (de) | 2007-12-12 | 2009-06-18 | Müller-Schulte, Detlef, Dr. | Auflösbare, magnetische und unmagnetische Polymerträger zur Abtrennung und Wiedergewinnung von Zellen und Biosubstanzen |
DE102008015365A1 (de) | 2008-03-20 | 2009-09-24 | Merck Patent Gmbh | Magnetische Nanopartikel und Verfahren zu deren Herstellung |
CN102046285B (zh) * | 2008-05-30 | 2015-03-25 | 默克专利股份公司 | 在不含羟基的聚合物之上Ce(Ⅳ)-引发的接枝聚合 |
US8669354B2 (en) | 2009-01-26 | 2014-03-11 | The Hong Kong Polytechnic University | Removal of endotoxin using amphiphilic core-shell nanosorbents |
US8404347B2 (en) * | 2009-01-26 | 2013-03-26 | Hong Kong Polytechnic University | Method of synthesis of amphiphilic magnetic composite particles |
WO2010089098A1 (de) * | 2009-02-05 | 2010-08-12 | Deklatec Gmbh | Verfahren und mittel für die tuberkulose diagnostik |
WO2010149150A2 (de) | 2009-06-22 | 2010-12-29 | Deklatec Gmbh | Farblose, magnetische polymerpartikel für den hochempfindlichen nachweis von biologischen substanzen und pathogenen im rahmen der bioanalytik und diagnostik |
JP5980127B2 (ja) * | 2011-02-15 | 2016-08-31 | 協和メデックス株式会社 | ストレプトアビジン結合磁性粒子及びその製造方法 |
CN102516563B (zh) * | 2011-11-24 | 2013-06-12 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | 微磁载体制备方法、微磁载体及其活性污泥固定化方法 |
WO2013106948A1 (zh) | 2012-01-18 | 2013-07-25 | 芮宝生医股份有限公司 | 磁性微粒复合物的制作方法 |
DE102012014536B4 (de) | 2012-07-21 | 2016-11-24 | Perkinelmer Chemagen Technologie Gmbh | Sphärische, magnetisierbare Polyvinylalkohol-Mikropartikel, Verfahren für deren Herstellung sowie deren Verwendung |
RU2507155C1 (ru) * | 2012-12-28 | 2014-02-20 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Национальный исследовательский технологический университет "МИСиС" | Способ получения наночастиц магнетита, стабилизированных поливиниловым спиртом |
GB201301631D0 (en) | 2013-01-30 | 2013-03-13 | Ge Healthcare Ltd | Separation of substances using magnetic beads |
CN103435762B (zh) * | 2013-09-06 | 2017-07-07 | 复旦大学 | 一种富含硼酯的核壳式磁性复合微球的制备方法及其应用 |
US10151672B2 (en) | 2014-02-11 | 2018-12-11 | Wallac Oy | Device and a method for managing a sample to be analyzed and a solid sample carrier and liquid sample carrier |
EP3210216A1 (en) | 2014-10-23 | 2017-08-30 | Corning Incorporated | Polymer-encapsulated magnetic nanoparticles |
EP3288912A4 (en) | 2015-05-01 | 2018-11-07 | Biolegend, Inc. | Stable nanomagnetic particle dispersions |
US10465049B2 (en) * | 2015-09-04 | 2019-11-05 | Sabic Global Technologies B.V. | Process for the manufacture of thermoplastic polymer particles with improved process yield |
US11421102B2 (en) | 2015-11-24 | 2022-08-23 | Jsr Corporation | Method for manufacturing porous particles, porous particles, carrier, column, and method for separating target substance |
US10640580B2 (en) * | 2015-12-22 | 2020-05-05 | Ddp Specialty Electronic Materials Us 8, Llc | Method of suspension polymerization of droplets distributed in an aqueous medium |
US11608489B2 (en) | 2016-04-30 | 2023-03-21 | BioLegend, Inc. | Compositions and methods for performing magnetibuoyant separations |
US11020752B2 (en) * | 2016-10-05 | 2021-06-01 | Khalifa University of Science and Technology | Process for heat stable salts removal from solvents |
DE102016121483B4 (de) | 2016-11-09 | 2020-06-18 | Axagarius Gmbh & Co. Kg | Partikelförmiges Feststoff-Kompositmaterial zur Nukleinsäureaufreinigung, enthaltend magnetische Nanopartikel , Verfahren zu dessen Herstellung und dessen Verwendung |
EP3610262A1 (en) * | 2017-04-13 | 2020-02-19 | Roche Diagnostics GmbH | Superparamagnetic and highly porous polymer particles for diagnostic applications |
WO2019141779A1 (en) | 2018-01-18 | 2019-07-25 | F. Hoffmann-La Roche Ag | Hypercrosslinking with diamine crosslinkers |
CN110308287A (zh) * | 2019-07-31 | 2019-10-08 | 宁波奥丞生物科技有限公司 | 一种胎盘生长因子的化学发光试剂盒的制备方法 |
CN111426659B (zh) * | 2020-03-24 | 2023-06-06 | 深圳唯公生物科技有限公司 | 磁性荧光编码微球及其制备方法 |
DE102020125278A1 (de) | 2020-09-28 | 2022-03-31 | Bundesrepublik Deutschland, Vertreten Durch Das Bundesministerium Für Wirtschaft Und Energie, Dieses Vertreten Durch Den Präsidenten Der Physikalischen Bundesanstalt | 3D-Druckverfahren, Messverfahren zum Bestimmen der Magnetisierbarkeit eines Druckteils, das Nanopartikel enthält, und 3D-Drucker |
CN112871097A (zh) * | 2021-01-19 | 2021-06-01 | 苏州为度生物技术有限公司 | 基于超声雾化法制备的超亲水磁性微球 |
CN114307988A (zh) * | 2021-12-31 | 2022-04-12 | 苏州知益微球科技有限公司 | 一种用于纯化mRNA的微球的制备方法及应用 |
CN114289003A (zh) * | 2021-12-31 | 2022-04-08 | 苏州知益微球科技有限公司 | 一种用于纯化mRNA的磁性微球的制备方法及应用 |
CN115181215B (zh) * | 2022-07-07 | 2023-07-21 | 斯兰达生物科技(上海)有限公司 | 一种均一粒径免疫微米磁珠的制备方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2870740A (en) | 1955-12-07 | 1959-01-27 | Theodore B H Vogt | Crayon holders |
FR2115594A5 (es) | 1970-11-25 | 1972-07-07 | Inst Textile De France | |
US3843540A (en) | 1972-07-26 | 1974-10-22 | Us Interior | Production of magnetic fluids by peptization techniques |
US4106488A (en) | 1974-08-20 | 1978-08-15 | Robert Thomas Gordon | Cancer treatment method |
US4136683A (en) | 1976-03-25 | 1979-01-30 | Gordon Robert T | Intracellular temperature measurement |
US4070246A (en) | 1976-04-09 | 1978-01-24 | Abbott Laboratories | Reactive matrices |
US4115534A (en) | 1976-08-19 | 1978-09-19 | Minnesota Mining And Manufacturing Company | In vitro diagnostic test |
US4169804A (en) | 1976-08-19 | 1979-10-02 | Minnesota Mining And Manufacturing Company | Magnetically responsive composite microparticle |
US4357259A (en) | 1977-08-01 | 1982-11-02 | Northwestern University | Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres |
US4267234A (en) | 1978-03-17 | 1981-05-12 | California Institute Of Technology | Polyglutaraldehyde synthesis and protein bonding substrates |
US4230685A (en) | 1979-02-28 | 1980-10-28 | Northwestern University | Method of magnetic separation of cells and the like, and microspheres for use therein |
US4247406A (en) | 1979-04-23 | 1981-01-27 | Widder Kenneth J | Intravascularly-administrable, magnetically-localizable biodegradable carrier |
US4345588A (en) | 1979-04-23 | 1982-08-24 | Northwestern University | Method of delivering a therapeutic agent to a target capillary bed |
US4647447A (en) | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
NO155316C (no) | 1982-04-23 | 1987-03-11 | Sintef | Fremgangsmaate for fremstilling av magnetiske polymerpartikler. |
US4861705A (en) | 1983-01-31 | 1989-08-29 | Yeda Research And Development Company, Ltd. | Method for removing components of biological fluids |
US4735796A (en) | 1983-12-08 | 1988-04-05 | Gordon Robert T | Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease |
US4628037A (en) | 1983-05-12 | 1986-12-09 | Advanced Magnetics, Inc. | Binding assays employing magnetic particles |
US4693985A (en) * | 1984-08-21 | 1987-09-15 | Pall Corporation | Methods of concentrating ligands and active membranes used therefor |
US4827945A (en) | 1986-07-03 | 1989-05-09 | Advanced Magnetics, Incorporated | Biologically degradable superparamagnetic materials for use in clinical applications |
DE3811042A1 (de) | 1988-03-31 | 1989-10-19 | Merck Patent Gmbh | Ionenaustauscher |
ATE114507T1 (de) | 1988-12-28 | 1994-12-15 | Stefan Miltenyi | Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien. |
DE4127657B4 (de) * | 1991-08-21 | 2008-03-13 | Chemagen Biopolymer-Technologie Aktiengesellschaft | Perlförmige Polyvinylalkoholgele für die Aufreinigung und Auftrennung biologischer Flüssigkeiten, Verfahren zu ihrer Herstellung und Verwendung |
DE4201461A1 (de) * | 1992-01-21 | 1993-07-22 | Mueller Schulte Detlef Dr | Mittel fuer die selektive tumortherapie auf der basis ferromagnetischer partikel - verfahren zu ihrer herstellung und verwendung |
DE4412651A1 (de) * | 1994-04-13 | 1995-10-19 | Mueller Schulte Detlef Dr | Mittel zur selektiven AIDS Therapie sowie Verfahren zur Herstellung und Verwendung derselben |
-
1995
- 1995-07-31 DE DE19528029A patent/DE19528029B4/de not_active Expired - Lifetime
-
1996
- 1996-06-03 RU RU98103394/04A patent/RU2160154C2/ru not_active IP Right Cessation
- 1996-06-03 ES ES96918662T patent/ES2157443T3/es not_active Expired - Lifetime
- 1996-06-03 US US09/011,667 patent/US6204033B1/en not_active Expired - Lifetime
- 1996-06-03 PT PT96918662T patent/PT843591E/pt unknown
- 1996-06-03 AT AT96918662T patent/ATE199503T1/de active
- 1996-06-03 EP EP96918662A patent/EP0843591B1/de not_active Expired - Lifetime
- 1996-06-03 KR KR1019980700585A patent/KR100355006B1/ko not_active IP Right Cessation
- 1996-06-03 JP JP50713897A patent/JP3164585B2/ja not_active Expired - Lifetime
- 1996-06-03 CA CA002227608A patent/CA2227608C/en not_active Expired - Fee Related
- 1996-06-03 AU AU61243/96A patent/AU717433B2/en not_active Expired
- 1996-06-03 IL IL12306196A patent/IL123061A/en not_active IP Right Cessation
- 1996-06-03 WO PCT/EP1996/002398 patent/WO1997004862A1/de active IP Right Grant
- 1996-06-03 DE DE59606556T patent/DE59606556D1/de not_active Expired - Lifetime
- 1996-06-03 DK DK96918662T patent/DK0843591T3/da active
- 1996-06-03 CN CN96197315A patent/CN1104276C/zh not_active Expired - Lifetime
-
2000
- 2000-11-29 US US09/727,232 patent/US6514688B2/en not_active Expired - Lifetime
-
2001
- 2001-06-06 GR GR20010400846T patent/GR3035993T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0843591A1 (de) | 1998-05-27 |
US6514688B2 (en) | 2003-02-04 |
CN1198104A (zh) | 1998-11-04 |
IL123061A0 (en) | 1998-09-24 |
DK0843591T3 (da) | 2001-07-09 |
ATE199503T1 (de) | 2001-03-15 |
US6204033B1 (en) | 2001-03-20 |
EP0843591B1 (de) | 2001-03-07 |
CA2227608C (en) | 2006-11-14 |
CN1104276C (zh) | 2003-04-02 |
DE19528029A1 (de) | 1997-02-06 |
IL123061A (en) | 2004-06-01 |
DE19528029B4 (de) | 2008-01-10 |
GR3035993T3 (en) | 2001-09-28 |
US20010014468A1 (en) | 2001-08-16 |
DE59606556D1 (de) | 2001-04-12 |
KR100355006B1 (ko) | 2002-11-18 |
RU2160154C2 (ru) | 2000-12-10 |
JP3164585B2 (ja) | 2001-05-08 |
AU717433B2 (en) | 2000-03-23 |
AU6124396A (en) | 1997-02-26 |
CA2227608A1 (en) | 1997-02-13 |
PT843591E (pt) | 2001-08-30 |
JPH11510836A (ja) | 1999-09-21 |
KR19990035924A (ko) | 1999-05-25 |
WO1997004862A1 (de) | 1997-02-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2157443T3 (es) | Particulas polimericas magneticas a base de alcohol polivinilico, proceso para su fabricacion y utilizacion. | |
RU98103394A (ru) | Магнитные полимерные частицы на основе поливинилового спирта, способы их получения и применение | |
Ugelstad et al. | Preparation and biochemical and biomedical applications of new monosized polymer particles | |
US4552812A (en) | Process for the production of polyacrolein microspheres and grafted microspheres | |
US4438239A (en) | Microsphere coated substrate containing reactive aldehyde groups | |
US20090099342A1 (en) | Process for Preparing Composite Particles, Composite Particles Obtained, and Their Use in a Diagnostic Test | |
US5773488A (en) | Hydrophilization of hydrophobic polymers | |
CN104031201B (zh) | 一种用于生物蛋白分离的磁性微球的制备方法及其应用 | |
AU7567800A (en) | New molecularly imprinted polymers grafted on solid supports | |
US7122381B2 (en) | Selective affinity material, preparation thereof by molecular imprinting, and use of the same | |
US20130164761A1 (en) | Carrier polymer particle, process for producing the same, magnetic particle for specific trapping, and process for producing the same | |
CN102532408B (zh) | 一种温敏型磁性蛋白质印迹纳米球的制备方法 | |
Wang et al. | Modification of poly (glycidyl methacrylate–divinylbenzene) porous microspheres with polyethylene glycol and their adsorption property of protein | |
Basinska | Hydrophilic Core‐Shell Microspheres: A Suitable Support for Controlled Attachment of Proteins and Biomedical Diagnostics | |
JPH10505630A (ja) | 校正単分散磁化性微小球の新規なラテックス、その製法および化学または生物学でのラテックスの用途 | |
CN106565908B (zh) | 一种单分散大粒径聚合物微球的制备方法 | |
Sarobe et al. | Functionalized monodisperse particles with chloromethyl groups for the covalent coupling of proteins | |
CN103333299B (zh) | 甲基丙烯酸缩水甘油酯和聚(乙二醇)甲基丙烯酸酯共聚物微球及其制备方法和应用 | |
Sankarakumar et al. | Protein adsorption behavior in batch and competitive conditions with nanoparticle surface imprinting | |
Yang et al. | Surface functionalization and characterization of magnetic polystyrene microbeads | |
CN108329509B (zh) | 一种羧基化多孔聚苯乙烯微球及其制备方法 | |
Pichot et al. | Polymer colloids for biomedical and pharmaceutical applications | |
Bergström et al. | Microemulsions as reaction media for immobilization of proteins to hydrophilized surfaces | |
Guo et al. | Magnetic polymer microspheres with azidocarbonyl groups: synthesis, characterization and application in protein immobilization | |
Yao et al. | Recognition of Staphylococcus enterotoxin via molecularly imprinted beads |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 843591 Country of ref document: ES |