ES2151921T3 - Analogo de dolastatina. - Google Patents

Analogo de dolastatina.

Info

Publication number
ES2151921T3
ES2151921T3 ES94902676T ES94902676T ES2151921T3 ES 2151921 T3 ES2151921 T3 ES 2151921T3 ES 94902676 T ES94902676 T ES 94902676T ES 94902676 T ES94902676 T ES 94902676T ES 2151921 T3 ES2151921 T3 ES 2151921T3
Authority
ES
Spain
Prior art keywords
dolastatine
analog
new
anthineoplastic
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94902676T
Other languages
English (en)
Inventor
Andreas Haupt
Bernd Janssen
Kurt Ritter
Dagmar Klinge
Gerhard Keilhauer
Cynthia Romerdahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2151921T3 publication Critical patent/ES2151921T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Window Of Vehicle (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN NUEVOS PEPTIDOS DE FORMULA (I) EN LA QUE R1, R2, X, A, R3, B, D, E, R7, M, Q, A, B Y D SON TALES COMO SE DESCRIBEN EN LA DESCRIPCION, Y SU PREPARACION. LAS NUEVAS SUSTANCIAS TIENEN UN EFECTO ANTINEOPLASTICO.
ES94902676T 1992-12-16 1993-12-04 Analogo de dolastatina. Expired - Lifetime ES2151921T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99130992A 1992-12-16 1992-12-16

Publications (1)

Publication Number Publication Date
ES2151921T3 true ES2151921T3 (es) 2001-01-16

Family

ID=25537082

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94902676T Expired - Lifetime ES2151921T3 (es) 1992-12-16 1993-12-04 Analogo de dolastatina.

Country Status (24)

Country Link
US (1) US5502032A (es)
EP (1) EP0674652B1 (es)
JP (1) JPH08504415A (es)
CN (1) CN1057095C (es)
AT (1) ATE196296T1 (es)
AU (1) AU679479B2 (es)
BR (1) BR1100019A (es)
CA (1) CA2151953A1 (es)
CZ (1) CZ286752B6 (es)
DE (1) DE69329425T2 (es)
ES (1) ES2151921T3 (es)
FI (1) FI952961A (es)
HR (1) HRP931504B1 (es)
HU (1) HUT72067A (es)
IL (1) IL107987A (es)
NO (1) NO952366D0 (es)
NZ (1) NZ258882A (es)
PL (1) PL178766B1 (es)
RU (1) RU2132334C1 (es)
SG (1) SG67935A1 (es)
SI (1) SI9300661A (es)
TW (1) TW400335B (es)
WO (1) WO1994013695A1 (es)
ZA (1) ZA939389B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599902A (en) * 1994-11-10 1997-02-04 Arizona Board Of Regents Acting On Behalf Of Arizona State University Cancer inhibitory peptides
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
US5741892A (en) * 1996-07-30 1998-04-21 Basf Aktiengesellschaft Pentapeptides as antitumor agents
US5939527A (en) * 1996-07-30 1999-08-17 Basf Aktiengesellschaft Tetrapeptides as antitumor agents
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) * 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
US5985837A (en) * 1998-07-08 1999-11-16 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6297233B1 (en) 1999-02-09 2001-10-02 Bristol-Myers Squibb Company Lactam inhibitors of FXa and method
US6323315B1 (en) 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6511973B2 (en) 2000-08-02 2003-01-28 Bristol-Myers Squibb Co. Lactam inhibitors of FXa and method
HUP0304058A2 (hu) * 2001-01-30 2004-04-28 Bristol-Myers Squibb Company Xa faktor szulfonamid-laktám inhibitorok és alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
JP2005509616A (ja) * 2001-10-16 2005-04-14 センジェント・セラピューティクス・インク チロシンホスファターゼに対する有機硫黄阻害剤
WO2003075853A2 (en) 2002-03-08 2003-09-18 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
MXPA05012196A (es) * 2003-05-12 2006-02-08 Pfizer Prod Inc Compuestos de isoxazol e isotiazol para el tratamiento de trastornos neurodegenerativos.
WO2006009876A2 (en) * 2004-06-17 2006-01-26 Cengent Therapeutics, Inc. Trisubstituted nitrogen modulators of tyrosine phosphatases
EP1786421A2 (en) * 2004-07-09 2007-05-23 Cengent Therapeutics, Inc. Oxygen/nitrogen heterocycle inhibitors of tyrosine phosphatases
EP1841749A1 (en) * 2004-09-02 2007-10-10 Metabasis Therapeutics, Inc. Derivatives of thiazole and thiadiazole inhibitors of tyrosine phosphatases
ES2708763T3 (es) * 2005-07-07 2019-04-11 Seattle Genetics Inc Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
TWI603741B (zh) 2011-06-10 2017-11-01 梅爾莎納醫療公司 蛋白質-聚合物-藥物共軛體
EP2928503B1 (en) 2012-12-10 2019-02-20 Mersana Therapeutics, Inc. Conjugates of auristatin compounds
ES2741207T3 (es) 2013-03-15 2020-02-10 Zymeworks Inc Compuestos citotóxicos y antimitóticos, y métodos de uso de los mismos
AU2014373574B2 (en) 2013-12-27 2020-07-16 Zymeworks Bc Inc. Sulfonamide-containing linkage systems for drug conjugates
WO2015095952A1 (en) 2013-12-27 2015-07-02 The Centre For Drug Research And Development Var2csa-drug conjugates
MX2017003476A (es) 2014-09-17 2017-08-02 Zymeworks Inc Compuestos citotoxicos y anti-mitoticos, y metodos para usar los mismos.
US10517958B2 (en) 2016-10-04 2019-12-31 Zymeworks Inc. Compositions and methods for the treatment of platinum-drug resistant cancer
KR20240051956A (ko) 2021-09-03 2024-04-22 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3540495A1 (de) * 1985-11-15 1987-05-21 Merck Patent Gmbh Aminosaeurederivate
DE3787403D1 (de) * 1986-05-09 1993-10-21 Pulverer Gerhard Verwendung von spezifischen Monosacchariden zur Herstellung eines Arzneimittels zur Verhinderung von Metastasen maligner Tumore.
JP2714402B2 (ja) * 1988-07-13 1998-02-16 日清製粉株式会社 癌転移抑制剤
EP0357332A3 (en) * 1988-08-24 1991-07-31 Merck & Co. Inc. Renin inhibitors useful for the treatment of aids by inhibition of hiv protease
US4978744A (en) * 1989-01-27 1990-12-18 Arizona Board Of Regents Synthesis of dolastatin 10
US5138036A (en) * 1989-11-13 1992-08-11 Arizona Board Of Regents Acting On Behalf Of Arizona State University Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
ES2172069T3 (es) * 1991-08-09 2002-09-16 Teikoku Hormone Mfg Co Ltd Derivado tetrapeptidico.

Also Published As

Publication number Publication date
CN1057095C (zh) 2000-10-04
CZ286752B6 (en) 2000-06-14
SI9300661A (en) 1994-06-30
IL107987A (en) 1999-10-28
IL107987A0 (en) 1994-04-12
FI952961A0 (fi) 1995-06-15
PL309353A1 (en) 1995-10-02
CA2151953A1 (en) 1994-06-23
AU679479B2 (en) 1997-07-03
NO952366L (no) 1995-06-15
FI952961A (fi) 1995-06-15
HUT72067A (en) 1996-03-28
DE69329425D1 (de) 2000-10-19
TW400335B (en) 2000-08-01
HRP931504B1 (en) 2001-04-30
SG67935A1 (en) 1999-10-19
PL178766B1 (pl) 2000-06-30
RU2132334C1 (ru) 1999-06-27
US5502032A (en) 1996-03-26
EP0674652B1 (en) 2000-09-13
WO1994013695A1 (en) 1994-06-23
DE69329425T2 (de) 2001-01-18
RU95115135A (ru) 1997-06-10
JPH08504415A (ja) 1996-05-14
BR1100019A (pt) 2000-07-25
AU5695994A (en) 1994-07-04
EP0674652A1 (en) 1995-10-04
HU9501754D0 (en) 1995-08-28
CZ157595A3 (en) 1996-01-17
ATE196296T1 (de) 2000-09-15
NO952366D0 (no) 1995-06-15
ZA939389B (en) 1995-06-15
CN1095724A (zh) 1994-11-30
NZ258882A (en) 1997-06-24
HRP931504A2 (en) 1997-02-28

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