FI952961A - Dolostatiinianalogeja - Google Patents

Dolostatiinianalogeja Download PDF

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Publication number
FI952961A
FI952961A FI952961A FI952961A FI952961A FI 952961 A FI952961 A FI 952961A FI 952961 A FI952961 A FI 952961A FI 952961 A FI952961 A FI 952961A FI 952961 A FI952961 A FI 952961A
Authority
FI
Finland
Prior art keywords
dolostatiinianalogeja
novel
chdcheco
formula
preparation
Prior art date
Application number
FI952961A
Other languages
English (en)
Swedish (sv)
Other versions
FI952961A0 (fi
Inventor
Andreas Haupt
Bernd Janssen
Kurt Ritter
Dagmar Klinge
Gerhard Keilhauer
Cynthia Romerdahl
Teresa Barlozzari
Xiao-Dong Qian
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of FI952961A0 publication Critical patent/FI952961A0/fi
Publication of FI952961A publication Critical patent/FI952961A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Window Of Vehicle (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI952961A 1992-12-16 1995-06-15 Dolostatiinianalogeja FI952961A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99130992A 1992-12-16 1992-12-16
PCT/EP1993/003410 WO1994013695A1 (en) 1992-12-16 1993-12-04 Dolostatin analog

Publications (2)

Publication Number Publication Date
FI952961A0 FI952961A0 (fi) 1995-06-15
FI952961A true FI952961A (fi) 1995-06-15

Family

ID=25537082

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952961A FI952961A (fi) 1992-12-16 1995-06-15 Dolostatiinianalogeja

Country Status (24)

Country Link
US (1) US5502032A (fi)
EP (1) EP0674652B1 (fi)
JP (1) JPH08504415A (fi)
CN (1) CN1057095C (fi)
AT (1) ATE196296T1 (fi)
AU (1) AU679479B2 (fi)
BR (1) BR1100019A (fi)
CA (1) CA2151953A1 (fi)
CZ (1) CZ286752B6 (fi)
DE (1) DE69329425T2 (fi)
ES (1) ES2151921T3 (fi)
FI (1) FI952961A (fi)
HR (1) HRP931504B1 (fi)
HU (1) HUT72067A (fi)
IL (1) IL107987A (fi)
NO (1) NO952366L (fi)
NZ (1) NZ258882A (fi)
PL (1) PL178766B1 (fi)
RU (1) RU2132334C1 (fi)
SG (1) SG67935A1 (fi)
SI (1) SI9300661A (fi)
TW (1) TW400335B (fi)
WO (1) WO1994013695A1 (fi)
ZA (1) ZA939389B (fi)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599902A (en) * 1994-11-10 1997-02-04 Arizona Board Of Regents Acting On Behalf Of Arizona State University Cancer inhibitory peptides
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US5939527A (en) * 1996-07-30 1999-08-17 Basf Aktiengesellschaft Tetrapeptides as antitumor agents
US5741892A (en) * 1996-07-30 1998-04-21 Basf Aktiengesellschaft Pentapeptides as antitumor agents
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
US5985837A (en) * 1998-07-08 1999-11-16 Basf Aktiengesellschaft Dolastatin 15 derivatives
WO2000047207A1 (en) 1999-02-09 2000-08-17 Bristol-Myers Squibb Company LACTAM INHIBITORS OF FXa AND METHOD
US6323315B1 (en) 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
US6511973B2 (en) 2000-08-02 2003-01-28 Bristol-Myers Squibb Co. Lactam inhibitors of FXa and method
JP2004518688A (ja) 2001-01-30 2004-06-24 ブリストル−マイヤーズ　スクイブ　カンパニー ファクターＸａ阻害剤のスルホンアミドラクタムおよびその方法
JP2005509616A (ja) * 2001-10-16 2005-04-14 センジェント・セラピューティクス・インク チロシンホスファターゼに対する有機硫黄阻害剤
US7087604B2 (en) 2002-03-08 2006-08-08 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
CA2524511A1 (en) * 2003-05-12 2004-11-18 Pfizer Products Inc. Isoxazole and isothiazole compounds for the treatment of neurodegenerative disorders
US20060135773A1 (en) * 2004-06-17 2006-06-22 Semple Joseph E Trisubstituted nitrogen modulators of tyrosine phosphatases
JP2008505916A (ja) * 2004-07-09 2008-02-28 メタバシス・セラピューティクス・インコーポレイテッド チロシンホスファターゼの酸素／窒素複素環阻害剤
EP1841749A1 (en) * 2004-09-02 2007-10-10 Metabasis Therapeutics, Inc. Derivatives of thiazole and thiadiazole inhibitors of tyrosine phosphatases
JP5171621B2 (ja) * 2005-07-07 2013-03-27 シアトル ジェネティックス， インコーポレイテッド フェニルアラニン側鎖修飾をｃ末端に有するモノメチルバリン化合物
JP5926374B2 (ja) 2011-06-10 2016-05-25 メルサナ セラピューティクス，インコーポレイティド タンパク質−高分子−薬剤コンジュゲート
WO2014093379A1 (en) 2012-12-10 2014-06-19 Mersana Therapeutics, Inc. Auristatin compounds and conjugates thereof
MY174813A (en) 2013-03-15 2020-05-16 Zymeworks Inc Cytotoxic and anti-mitotic compounds, and methods of using the same
CN106255513B (zh) 2013-12-27 2022-01-14 酵活有限公司 用于药物偶联物的含磺酰胺连接***
JP6615115B2 (ja) 2013-12-27 2019-12-04 ザイムワークス インコーポレイティド Ｖａｒ２ｃｓａ−薬物コンジュゲート
AU2015318556C1 (en) 2014-09-17 2021-01-07 Zymeworks Bc Inc. Cytotoxic and anti-mitotic compounds, and methods of using the same
US10517958B2 (en) 2016-10-04 2019-12-31 Zymeworks Inc. Compositions and methods for the treatment of platinum-drug resistant cancer
CN118119409A (zh) 2021-09-03 2024-05-31 东丽株式会社 癌的治疗和/或预防用药物组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3540495A1 (de) * 1985-11-15 1987-05-21 Merck Patent Gmbh Aminosaeurederivate
DE3787403D1 (de) * 1986-05-09 1993-10-21 Pulverer Gerhard Verwendung von spezifischen Monosacchariden zur Herstellung eines Arzneimittels zur Verhinderung von Metastasen maligner Tumore.
JP2714402B2 (ja) * 1988-07-13 1998-02-16 日清製粉株式会社 癌転移抑制剤
EP0357332A3 (en) * 1988-08-24 1991-07-31 Merck & Co. Inc. Renin inhibitors useful for the treatment of aids by inhibition of hiv protease
US4978744A (en) * 1989-01-27 1990-12-18 Arizona Board Of Regents Synthesis of dolastatin 10
US5138036A (en) * 1989-11-13 1992-08-11 Arizona Board Of Regents Acting On Behalf Of Arizona State University Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
SG87056A1 (en) * 1991-08-09 2002-03-19 Teikoku Hormone Mfg Co Ltd Novel tetrapeptide derivative

Also Published As

Publication number Publication date
CZ286752B6 (en) 2000-06-14
RU2132334C1 (ru) 1999-06-27
CN1057095C (zh) 2000-10-04
DE69329425T2 (de) 2001-01-18
ES2151921T3 (es) 2001-01-16
WO1994013695A1 (en) 1994-06-23
NZ258882A (en) 1997-06-24
IL107987A (en) 1999-10-28
BR1100019A (pt) 2000-07-25
NO952366D0 (no) 1995-06-15
FI952961A0 (fi) 1995-06-15
HRP931504A2 (en) 1997-02-28
DE69329425D1 (de) 2000-10-19
CN1095724A (zh) 1994-11-30
HU9501754D0 (en) 1995-08-28
AU679479B2 (en) 1997-07-03
SI9300661A (en) 1994-06-30
AU5695994A (en) 1994-07-04
ATE196296T1 (de) 2000-09-15
RU95115135A (ru) 1997-06-10
JPH08504415A (ja) 1996-05-14
HUT72067A (en) 1996-03-28
US5502032A (en) 1996-03-26
HRP931504B1 (en) 2001-04-30
ZA939389B (en) 1995-06-15
EP0674652B1 (en) 2000-09-13
IL107987A0 (en) 1994-04-12
TW400335B (en) 2000-08-01
PL178766B1 (pl) 2000-06-30
CZ157595A3 (en) 1996-01-17
EP0674652A1 (en) 1995-10-04
SG67935A1 (en) 1999-10-19
PL309353A1 (en) 1995-10-02
NO952366L (no) 1995-06-15
CA2151953A1 (en) 1994-06-23

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