FI945703A0 - 3,4,4-trisybstituoitujen piperidinyyli-N-alkyylikarboksylaattien ja välituotteiden valmistus - Google Patents

3,4,4-trisybstituoitujen piperidinyyli-N-alkyylikarboksylaattien ja välituotteiden valmistus

Info

Publication number
FI945703A0
FI945703A0 FI945703A FI945703A FI945703A0 FI 945703 A0 FI945703 A0 FI 945703A0 FI 945703 A FI945703 A FI 945703A FI 945703 A FI945703 A FI 945703A FI 945703 A0 FI945703 A0 FI 945703A0
Authority
FI
Finland
Prior art keywords
piperidinyl
intermediates
trisysubstituted
preparation
alkyl carboxylates
Prior art date
Application number
FI945703A
Other languages
English (en)
Swedish (sv)
Other versions
FI106455B (fi
FI945703A (fi
Inventor
Scott Alan Frank
Douglas Edward Prather
Jeffrey Alan Ward
John Arnold Werner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI945703A0 publication Critical patent/FI945703A0/fi
Publication of FI945703A publication Critical patent/FI945703A/fi
Application granted granted Critical
Publication of FI106455B publication Critical patent/FI106455B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI945703A 1993-12-08 1994-12-02 Menetelmä kiteisen (alfaS,3R,4R)-4-(3-hydroksifenyyli)-3,4-dimetyyli-alfa-(fenyylimetyyli)-1-piperidiinipropionihappomonohydraatin valmistamiseksi ja kiteiset välituotteet FI106455B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/164,074 US5434171A (en) 1993-12-08 1993-12-08 Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates
US16407493 1993-12-08

Publications (3)

Publication Number Publication Date
FI945703A0 true FI945703A0 (fi) 1994-12-02
FI945703A FI945703A (fi) 1995-06-09
FI106455B FI106455B (fi) 2001-02-15

Family

ID=22592858

Family Applications (2)

Application Number Title Priority Date Filing Date
FI945703A FI106455B (fi) 1993-12-08 1994-12-02 Menetelmä kiteisen (alfaS,3R,4R)-4-(3-hydroksifenyyli)-3,4-dimetyyli-alfa-(fenyylimetyyli)-1-piperidiinipropionihappomonohydraatin valmistamiseksi ja kiteiset välituotteet
FI20000353A FI106860B (fi) 1993-12-08 2000-02-17 Menetelmä kiteisen dihydraattiyhdisteen valmistamiseksi ja kiteinen välituote

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20000353A FI106860B (fi) 1993-12-08 2000-02-17 Menetelmä kiteisen dihydraattiyhdisteen valmistamiseksi ja kiteinen välituote

Country Status (31)

Country Link
US (1) US5434171A (fi)
EP (3) EP0657428B1 (fi)
JP (2) JP3834075B2 (fi)
KR (1) KR100356239B1 (fi)
CN (2) CN1057294C (fi)
AT (1) ATE200279T1 (fi)
AU (1) AU681198B2 (fi)
BR (1) BR9404842A (fi)
CA (1) CA2137221C (fi)
CO (1) CO4290427A1 (fi)
CZ (1) CZ290559B6 (fi)
DE (1) DE69427017T2 (fi)
DK (1) DK0657428T3 (fi)
ES (1) ES2155844T3 (fi)
FI (2) FI106455B (fi)
GR (1) GR3036136T3 (fi)
HK (1) HK1013826A1 (fi)
HU (1) HUT71489A (fi)
IL (1) IL111843A (fi)
MY (1) MY121543A (fi)
NO (1) NO302884B1 (fi)
NZ (1) NZ270039A (fi)
PE (1) PE41495A1 (fi)
PL (1) PL181734B1 (fi)
PT (1) PT657428E (fi)
RU (1) RU2145958C1 (fi)
SI (1) SI0657428T1 (fi)
TW (1) TW290540B (fi)
UA (1) UA52577C2 (fi)
YU (2) YU49312B (fi)
ZA (1) ZA949584B (fi)

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HN1999000149A (es) * 1998-09-09 2000-01-12 Pfizer Prod Inc Derivados de 4,4-biarilpiperidina
GB9912415D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912411D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912416D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912413D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912417D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912410D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
US6451806B2 (en) 1999-09-29 2002-09-17 Adolor Corporation Methods and compositions involving opioids and antagonists thereof
US6469030B2 (en) 1999-11-29 2002-10-22 Adolor Corporation Methods for the treatment and prevention of ileus
AU2002314967B2 (en) * 2001-06-05 2007-09-20 University Of Chicago Use of methylnaltrexone to treat immune suppression
US20030068829A1 (en) * 2001-06-25 2003-04-10 Symyx Technologies, Inc. High throughput crystallographic screening of materials
US7056500B2 (en) 2001-10-18 2006-06-06 Nektar Therapeutics Al, Corporation Polymer conjugates of opioid antagonists
US6794510B2 (en) * 2002-08-08 2004-09-21 Adolor Corporation Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
US7381721B2 (en) * 2003-03-17 2008-06-03 Adolor Corporation Substituted piperidine compounds
MXPA05010819A (es) * 2003-04-08 2006-03-30 Progenics Pharm Inc Uso de antagonistas de opioide perifericos, especialmente metilnaltrexona para tratar sindrome de intestino irritable.
PT1615646E (pt) 2003-04-08 2015-02-12 Progenics Pharm Inc Formulações farmacêuticas com metilnaltrexona
US6992090B2 (en) * 2003-06-16 2006-01-31 Adolor Corporation Substituted piperidine compounds and methods of their use
FR2861304B1 (fr) * 2003-10-23 2008-07-18 Univ Grenoble 1 Modulateurs des canaux cftr
US20050148630A1 (en) * 2003-12-02 2005-07-07 Carpenter Randall L. Methods of preventing and treating non-opioid induced gastrointestinal dysfunction
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EA018427B1 (ru) * 2003-12-16 2013-07-30 Нектар Терапьютикс Химически модифицированный налоксон
US20060182692A1 (en) * 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
US7087749B2 (en) * 2004-03-11 2006-08-08 Adolor Corporation Substituted piperidine compounds and methods of their use
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KR101380200B1 (ko) * 2004-08-12 2014-04-01 헬신 세라퓨틱스 (유.에스.) 인크. 성장 호르몬 분비촉진제를 이용하여 위장관계의 운동성을촉진하는 방법
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US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
US20060211733A1 (en) * 2005-03-04 2006-09-21 Adolor Corporation Methods of preventing and treating opioid bowel dysfunction
CN101171010B (zh) * 2005-03-07 2014-09-17 芝加哥大学 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
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CN101426481B (zh) 2006-04-21 2012-12-05 帝斯曼知识产权资产管理有限公司 阿片受体拮抗剂的用途
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JP5469593B2 (ja) 2007-03-29 2014-04-16 ワイス・エルエルシー 末梢性オピオイド受容体アンタゴニストおよびその使用
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US5250542A (en) * 1991-03-29 1993-10-05 Eli Lilly And Company Peripherally selective piperidine carboxylate opioid antagonists

Also Published As

Publication number Publication date
CN1111239A (zh) 1995-11-08
AU7917094A (en) 1995-06-15
JP3834075B2 (ja) 2006-10-18
GR3036136T3 (en) 2001-09-28
FI106455B (fi) 2001-02-15
RU94042903A (ru) 1996-10-27
PT657428E (pt) 2001-07-31
KR100356239B1 (ko) 2002-12-26
CA2137221C (en) 2011-02-22
HUT71489A (en) 1995-11-28
BR9404842A (pt) 1995-08-08
EP1607387A3 (en) 2007-01-03
FI945703A (fi) 1995-06-09
EP0657428B1 (en) 2001-04-04
JPH07215937A (ja) 1995-08-15
NO302884B1 (no) 1998-05-04
YU82304A (sh) 2006-03-03
DE69427017D1 (de) 2001-05-10
PE41495A1 (es) 1995-11-28
RU2145958C1 (ru) 2000-02-27
MY121543A (en) 2006-02-28
HK1013826A1 (en) 1999-09-10
SI0657428T1 (en) 2001-08-31
EP0984004A3 (en) 2003-10-15
NO944644L (no) 1995-06-09
PL306068A1 (en) 1995-06-12
US5434171A (en) 1995-07-18
JP2006070042A (ja) 2006-03-16
UA52577C2 (uk) 2003-01-15
EP1607387A2 (en) 2005-12-21
NO944644D0 (no) 1994-12-02
KR950017957A (ko) 1995-07-22
YU70294A (sh) 1997-07-31
CA2137221A1 (en) 1995-06-09
ZA949584B (en) 1996-06-03
NZ270039A (en) 1996-08-27
IL111843A (en) 2000-02-29
PL181734B1 (pl) 2001-09-28
IL111843A0 (en) 1995-03-15
FI106860B (fi) 2001-04-30
HU9403466D0 (en) 1995-02-28
DK0657428T3 (da) 2001-05-07
EP0984004A2 (en) 2000-03-08
FI20000353A (fi) 2000-02-17
EP0657428A1 (en) 1995-06-14
TW290540B (fi) 1996-11-11
CN1121387C (zh) 2003-09-17
CN1223257A (zh) 1999-07-21
CO4290427A1 (es) 1996-04-17
YU49312B (sh) 2005-06-10
ATE200279T1 (de) 2001-04-15
CN1057294C (zh) 2000-10-11
CZ290559B6 (cs) 2002-08-14
DE69427017T2 (de) 2001-09-06
AU681198B2 (en) 1997-08-21
ES2155844T3 (es) 2001-06-01
CZ299294A3 (en) 1995-10-18

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