DK0552041T3 - Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fr - Google Patents

Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fr

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Publication number
DK0552041T3
DK0552041T3 DK93300241T DK93300241T DK0552041T3 DK 0552041 T3 DK0552041 T3 DK 0552041T3 DK 93300241 T DK93300241 T DK 93300241T DK 93300241 T DK93300241 T DK 93300241T DK 0552041 T3 DK0552041 T3 DK 0552041T3
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Denmark
Prior art keywords
intermediates
cleavage
compounds useful
enzymatic methods
enantiomeric mixtures
Prior art date
Application number
DK93300241T
Other languages
English (en)
Inventor
Ramesh N Patel
Laszlo J Szarka
Richard A Partyka
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Application granted granted Critical
Publication of DK0552041T3 publication Critical patent/DK0552041T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK93300241T 1992-01-15 1993-01-15 Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fr DK0552041T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82201592A 1992-01-15 1992-01-15

Publications (1)

Publication Number Publication Date
DK0552041T3 true DK0552041T3 (da) 2000-10-09

Family

ID=25234887

Family Applications (2)

Application Number Title Priority Date Filing Date
DK93300241T DK0552041T3 (da) 1992-01-15 1993-01-15 Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fr
DK99124119T DK1001036T3 (da) 1992-01-15 1993-01-15 Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fremstillingen af taxaner

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK99124119T DK1001036T3 (da) 1992-01-15 1993-01-15 Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fremstillingen af taxaner

Country Status (11)

Country Link
US (2) US5567614A (da)
EP (2) EP1001036B1 (da)
JP (1) JP3184350B2 (da)
AT (2) ATE280240T1 (da)
CA (2) CA2434312A1 (da)
DE (2) DE69333675T2 (da)
DK (2) DK0552041T3 (da)
ES (2) ES2149800T3 (da)
GR (1) GR3034942T3 (da)
HK (1) HK1027130A1 (da)
PT (2) PT552041E (da)

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US6521660B2 (en) 1991-09-23 2003-02-18 Florida State University 3′-alkyl substituted taxanes and pharmaceutical compositions containing them
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US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
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US5602272A (en) * 1994-06-21 1997-02-11 Bristol-Myers Squibb Company Reduction and resolution methods for the preparation of compounds useful as intemediates for preparing taxanes
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US5523233A (en) * 1995-05-03 1996-06-04 Merck & Co., Inc. Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
EP1308519B1 (en) * 1997-01-24 2006-04-19 Sumitomo Chemical Company, Limited Process for improving optical purity of azetidine-2-carboxylic acid
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EP0933360A1 (en) 1997-12-22 1999-08-04 Pharmachemie B.V. Synthesis of new beta-lactams
US5919672A (en) * 1998-10-02 1999-07-06 Schering Corporation Resolution of trans-2-(alkoxycarbonylethyl)-lactams useful in the synthesis of 1-(4-fluoro-phenyl)-3(R)- (S)-hydroxy-3-(4-fluorophenyl)-propyl!-4(S)-(4-hydroxyphenyl)-2-azetidinone
KR100567108B1 (ko) * 1999-07-16 2006-03-31 에스케이 주식회사 효소적 방법에 의한 트랜스-(1ｓ,2ｓ)-1-아지도 2-인단올 및 트랜스-(1ｒ,2ｒ)-1-아지도 2-인다닐 아세테이트의 제조방법
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US6548293B1 (en) * 1999-10-18 2003-04-15 Fsu Research Foundation, Inc. Enzymatic process for the resolution of enantiomeric mixtures of β-lactams
CZ20013405A3 (cs) 2000-02-02 2002-03-13 Florida State University Research Foundation, Inc. C10 karbonátem substituované taxany jako protinádorová činidla
CZ20013521A3 (cs) * 2000-02-02 2002-03-13 Florida State University Research Foundation, Inc. C7 karbamoyloxy substituované taxany jako protinádorové látky
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
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AR030188A1 (es) 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
JP2003522169A (ja) * 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ７ヘテロ置換アセテートタキサン
CN1362876A (zh) 2000-02-02 2002-08-07 佛罗里达州立大学研究基金有限公司 C10杂取代的乙酸基紫衫烷抗肿瘤剂
HUP0200756A3 (en) 2000-02-02 2005-02-28 Univ Florida State Res Found C7 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them
DE10004926A1 (de) * 2000-02-04 2001-08-09 Gruenenthal Gmbh Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten
AU3144801A (en) * 2000-02-11 2001-08-20 Shire Biochem Inc. Stereoselective synthesis of nucleoside analogues
WO2002070512A1 (fr) * 2001-03-07 2002-09-12 Daiichi Pharmaceutical Co, Ltd. Procede de fabrication d'un derive d'azetidinone-2
US6653501B2 (en) 2001-06-27 2003-11-25 Napro Biotherapeutics, Inc. Chiral resolution method for producing compounds useful in the synthesis of taxanes
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WO2003047508A2 (en) 2001-11-30 2003-06-12 Bristol-Myers Squibb Company Paclitaxel solvates
KR100433633B1 (ko) * 2002-04-18 2004-05-31 학교법인 포항공과대학교 무용매 이상계 시스템을 이용한 효소적 광학분할 방법
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
PE20050693A1 (es) * 2004-02-13 2005-09-27 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
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US20060189679A1 (en) * 2005-02-14 2006-08-24 Florida State University Research Foundation, Inc. C10 cyclopropyl ester substituted taxane compositions
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DK0552041T3 (da) * 1992-01-15 2000-10-09 Squibb & Sons Inc Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fr
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Also Published As

Publication number Publication date
ATE280240T1 (de) 2004-11-15
DE69333675T2 (de) 2006-02-02
ATE195973T1 (de) 2000-09-15
DE69329304T2 (de) 2001-01-04
EP1001036A2 (en) 2000-05-17
PT1001036E (pt) 2005-01-31
EP0552041B1 (en) 2000-08-30
DK1001036T3 (da) 2004-11-29
DE69333675D1 (de) 2004-11-25
DE69329304D1 (de) 2000-10-05
ES2149800T3 (es) 2000-11-16
EP1001036B1 (en) 2004-10-20
ES2230790T3 (es) 2005-05-01
JP3184350B2 (ja) 2001-07-09
EP0552041A2 (en) 1993-07-21
EP0552041A3 (en) 1994-10-05
US5567614A (en) 1996-10-22
PT552041E (pt) 2000-12-29
CA2434312A1 (en) 1993-07-16
HK1027130A1 (en) 2001-01-05
GR3034942T3 (en) 2001-02-28
US5811292A (en) 1998-09-22
JPH05308996A (ja) 1993-11-22
EP1001036A3 (en) 2000-08-02
CA2087359A1 (en) 1993-07-16

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