ES2142089T3 - Derivados de quinolein-2(1h)-ona, su preparacion y su aplicacion en terapeutica. - Google Patents
Derivados de quinolein-2(1h)-ona, su preparacion y su aplicacion en terapeutica.Info
- Publication number
- ES2142089T3 ES2142089T3 ES96931112T ES96931112T ES2142089T3 ES 2142089 T3 ES2142089 T3 ES 2142089T3 ES 96931112 T ES96931112 T ES 96931112T ES 96931112 T ES96931112 T ES 96931112T ES 2142089 T3 ES2142089 T3 ES 2142089T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- quinolein
- therapeutics
- derivatives
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
COMPUESTOS DE FORMULA (I) EN LA CUAL A REPRSENTA UN GRUPO 4 (TIENO[3,2 - C]PIRIDIN - 4 - IL)PIPERACIN - 1 - ILO O 4 - (4 FLUOROBENZOIL)PIPERIDIN - 1 IL); R 1 Y R 2 REPRESENTAN, CADA UNO DE FORMA INDEPENDIENTE, UN ATOMO DE HIDROGENO O DE HALOGENO, O UN GRUPO AMINO, HIDROXI, NITRO, CIANO, (C 1 C 6 )ALQUILO, (C 1 - C 6 )ALCOXI, TRIFLUOROMETILO, TRIFLUOROMETOXI, - COOH, - COOR 4 , - CONH 2 , CONHR SUB,4 , - CONR 4 R 5 , - SR 4 , SO 2 R 4 , - NHCOR 4 , - NHSO 2 R 4 , N(R 4 ) 2 , DONDE R 4 Y R 5 SON CADA UNO UN GRUPO (C 1 - C 4 )ALQUILO, R 3 REPRESENTA BIEN UN ATOMO DE HIDROGENO O BIEN UN GRUPO (C 1 - C 4 )ALQUILO, - (CH 2 ) P OH, - (CH 2 ) P NH 2 , (CH 2 ) N COOH, (CH 2 ) N COOR 4 , (CH 2 ) N CONH 2 , - (CH 2 ) N CONHOH, (CH 2 ) P SH, - (CH 2 ) N SO 3 H, (CH 2 ) N SO 2 NH 2 , (CH 2 ) N SO 2 NHR 4 , (CH 2 ) N SO 2 NR 4 R 5 , (CH 2 ) N CONHR 4 , (CH 2 ) N CONR 4 R 5 , (CH 2 ) P NHSO2 , (CH 2 ) P NHCOR 4 , - (CH 2 ) P OCOR4 , DONDE R 4 Y R 5 SON CADA UNO UN GRUPO (C 1 C 4 )ALQUIL, N ES IGUAL A 1, 2, 3 O 4, P ES IGUAL A 2, 3 O 4 Y M ES IGUAL A 2, 3 O 4. APLICACION TERAPEUTICA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9510815A FR2738822B1 (fr) | 1995-09-15 | 1995-09-15 | Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique |
| FR9511083A FR2739100B1 (fr) | 1995-09-21 | 1995-09-21 | Derives de 4-(omega-(4-(4-fluorobenzoyl)piperidin-1-yl)- alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2142089T3 true ES2142089T3 (es) | 2000-04-01 |
Family
ID=26232206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96931112T Expired - Lifetime ES2142089T3 (es) | 1995-09-15 | 1996-09-12 | Derivados de quinolein-2(1h)-ona, su preparacion y su aplicacion en terapeutica. |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5958924A (es) |
| EP (1) | EP0850235B1 (es) |
| JP (1) | JP3335362B2 (es) |
| KR (1) | KR100422850B1 (es) |
| CN (1) | CN1094490C (es) |
| AR (1) | AR003996A1 (es) |
| AT (1) | ATE187172T1 (es) |
| AU (1) | AU715879B2 (es) |
| BG (1) | BG63779B1 (es) |
| BR (1) | BR9610579A (es) |
| CA (1) | CA2228038C (es) |
| CO (1) | CO4750663A1 (es) |
| CZ (1) | CZ288149B6 (es) |
| DE (1) | DE69605430T2 (es) |
| DK (1) | DK0850235T3 (es) |
| EE (1) | EE04116B1 (es) |
| ES (1) | ES2142089T3 (es) |
| GR (1) | GR3032618T3 (es) |
| HK (1) | HK1014868A1 (es) |
| HU (1) | HU222745B1 (es) |
| IL (1) | IL123600A (es) |
| NO (1) | NO323841B1 (es) |
| NZ (1) | NZ318436A (es) |
| PL (1) | PL184808B1 (es) |
| RU (1) | RU2167874C2 (es) |
| SI (1) | SI0850235T1 (es) |
| SK (1) | SK282222B6 (es) |
| TR (1) | TR199800464T1 (es) |
| UA (1) | UA44332C2 (es) |
| WO (1) | WO1997010238A1 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3335362B2 (ja) * | 1995-09-15 | 2002-10-15 | サノフィ―サンテラボ | キノレイン−２（１ｈ）−オン誘導体セロトニンアンタゴニスト |
| FR2761071B1 (fr) * | 1997-03-20 | 1999-12-03 | Synthelabo | Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique |
| FR2761067B1 (fr) * | 1997-03-20 | 1999-04-23 | Synthelabo | Derives de quinolein-2-(1h)-one, leur preparation et leur application en therapeutique |
| FR2797874B1 (fr) * | 1999-08-27 | 2002-03-29 | Adir | Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| ATE327230T1 (de) | 2000-01-20 | 2006-06-15 | Eisai Co Ltd | Piperidinverbindungen und diese enthaltenden medikamente |
| FR2812548B1 (fr) * | 2000-08-01 | 2002-09-20 | Sanofi Synthelabo | Utilisation de derives de quinolein-2(1h)-one ou un de leurs sels pharmaceutiquement acceptable pour la preparation d'un medicament destine au traitement de l'insuffisance renale |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| FR2909670B1 (fr) * | 2006-12-12 | 2010-07-30 | Sanofi Aventis | Derive fluore de quinoleine-2(1h)-one,son procede de preparation et son utilisation comme intermediaire de synthese |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| EA019085B1 (ru) | 2007-09-14 | 2014-01-30 | Янссен Фармасьютикалз, Инк. | 1',3-двузамещенные 4-(арил-х-фенил)-1н-пиридин-2-оны |
| US9114138B2 (en) | 2007-09-14 | 2015-08-25 | Janssen Pharmaceuticals, Inc. | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′] bipyridinyl-2′-ones |
| WO2010025890A1 (en) | 2008-09-02 | 2010-03-11 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| NZ592008A (en) * | 2008-10-02 | 2011-12-22 | Taisho Pharmaceutical Co Ltd | 7-piperidinoalkyl-3,4-dihydroquinolone derivative |
| AU2009319387B2 (en) | 2008-11-28 | 2012-05-10 | Addex Pharma S.A. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| JP5634506B2 (ja) | 2009-05-12 | 2014-12-03 | ジャンセン ファーマシューティカルズ， インコーポレイテッド | １，２，３−トリアゾロ［４，３−ａ］ピリジン誘導体ならびに神経障害および精神障害の治療または予防のためのその使用 |
| CA2760259C (en) | 2009-05-12 | 2018-05-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| JP5852665B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
| ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| JP5852666B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| LT3096790T (lt) | 2014-01-21 | 2019-10-10 | Janssen Pharmaceutica, N.V. | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
| WO2015110435A1 (en) | 2014-01-21 | 2015-07-30 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| MA44007A (fr) | 2016-02-05 | 2018-12-19 | Denali Therapeutics Inc | Inhibiteurs du récepteur interagissant avec protéine kinase 1 |
| LT3552017T (lt) | 2016-12-09 | 2022-05-10 | Denali Therapeutics Inc. | Junginiai, naudotini kaip ripk1 inhibitoriai |
| CN108707109A (zh) * | 2018-08-29 | 2018-10-26 | 常州沃腾化工科技有限公司 | 一种2-甲氧基-4-三氟甲基吡啶-3-磺酰氯的制备方法 |
| WO2023137035A1 (en) | 2022-01-12 | 2023-07-20 | Denali Therapeutics Inc. | Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1278792C (en) * | 1985-05-06 | 1991-01-08 | Joseph P. Yevich | Antipsychotic fused-ring pyridinylpiperazine derivatives |
| KR910006138B1 (ko) * | 1986-09-30 | 1991-08-16 | 에자이 가부시끼가이샤 | 환상아민 유도체 |
| FR2644786B1 (fr) * | 1989-03-21 | 1993-12-31 | Adir Cie | Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| JP3335362B2 (ja) * | 1995-09-15 | 2002-10-15 | サノフィ―サンテラボ | キノレイン−２（１ｈ）−オン誘導体セロトニンアンタゴニスト |
-
1996
- 1996-09-12 JP JP51170797A patent/JP3335362B2/ja not_active Expired - Fee Related
- 1996-09-12 SI SI9630151T patent/SI0850235T1/xx unknown
- 1996-09-12 NZ NZ318436A patent/NZ318436A/xx not_active IP Right Cessation
- 1996-09-12 KR KR10-1998-0701920A patent/KR100422850B1/ko not_active IP Right Cessation
- 1996-09-12 DK DK96931112T patent/DK0850235T3/da active
- 1996-09-12 CA CA002228038A patent/CA2228038C/en not_active Expired - Fee Related
- 1996-09-12 AU AU69919/96A patent/AU715879B2/en not_active Ceased
- 1996-09-12 IL IL12360096A patent/IL123600A/en not_active IP Right Cessation
- 1996-09-12 PL PL96325467A patent/PL184808B1/pl not_active IP Right Cessation
- 1996-09-12 DE DE69605430T patent/DE69605430T2/de not_active Expired - Lifetime
- 1996-09-12 CO CO96048698A patent/CO4750663A1/es unknown
- 1996-09-12 HU HU9802940A patent/HU222745B1/hu not_active IP Right Cessation
- 1996-09-12 BR BR9610579A patent/BR9610579A/pt not_active Application Discontinuation
- 1996-09-12 SK SK346-98A patent/SK282222B6/sk not_active IP Right Cessation
- 1996-09-12 EE EE9800089A patent/EE04116B1/xx not_active IP Right Cessation
- 1996-09-12 TR TR1998/00464T patent/TR199800464T1/xx unknown
- 1996-09-12 WO PCT/FR1996/001401 patent/WO1997010238A1/fr active IP Right Grant
- 1996-09-12 AR ARP960104322A patent/AR003996A1/es active IP Right Grant
- 1996-09-12 US US09/011,482 patent/US5958924A/en not_active Expired - Lifetime
- 1996-09-12 CZ CZ1998786A patent/CZ288149B6/cs not_active IP Right Cessation
- 1996-09-12 UA UA98031235A patent/UA44332C2/uk unknown
- 1996-09-12 RU RU98106501/04A patent/RU2167874C2/ru not_active IP Right Cessation
- 1996-09-12 CN CN96198333A patent/CN1094490C/zh not_active Expired - Fee Related
- 1996-09-12 AT AT96931112T patent/ATE187172T1/de active
- 1996-09-12 EP EP96931112A patent/EP0850235B1/fr not_active Expired - Lifetime
- 1996-09-12 ES ES96931112T patent/ES2142089T3/es not_active Expired - Lifetime
-
1998
- 1998-03-11 BG BG102316A patent/BG63779B1/bg unknown
- 1998-03-13 NO NO19981141A patent/NO323841B1/no not_active IP Right Cessation
- 1998-12-30 HK HK98119241A patent/HK1014868A1/xx not_active IP Right Cessation
-
2000
- 2000-02-09 GR GR20000400317T patent/GR3032618T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2142089T3 (es) | Derivados de quinolein-2(1h)-ona, su preparacion y su aplicacion en terapeutica. | |
| EA199700209A1 (ru) | ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-a]ПИРИДИНА | |
| NO965125D0 (no) | Heterosykliske forbindelser med tachykininreseptor-antagonistaktivitet, deres fremstilling og anvendelse | |
| EA199800908A1 (ru) | Производные индола, полезные в качестве антагонистов рецептора эндотелина | |
| PT856001E (pt) | Derivados de pirimidina enquanto antagonistas do receptor 5ht2c | |
| TR199900308T2 (xx) | Tiyenopirimidinler | |
| NO20001624L (no) | Tablettformulering med vedvarende frigivelse for behandling av Parkinsons sykdom | |
| NO941679D0 (no) | Gallesyrederivater, fremgangsmåte for fremstilling og deres anvendelse | |
| EE200200118A (et) | Terapeutilised kinasoliini derivaadid, nende valmistamise meetod ning kasutamine | |
| RU98106501A (ru) | Производные-хинолин-2(1н)-она в качестве антагонистов серотонина | |
| UA49089C2 (uk) | Похідні вуглеводів та фармацевтична композиція на їх основі | |
| ATE389655T1 (de) | Pyrimidinderivate | |
| PL331740A1 (en) | Derivatives of acylamino alkenylamide as nk1 and nk2 antagonists | |
| EE200200185A (et) | NK1 retseptori antagonisti ja GABA struktuurse analoogi sünergistilised kombinatsioonid | |
| ATE90348T1 (de) | Pyrido(2,3-d>pyrimidin-derivate. | |
| ES539654A0 (es) | Un procedimiento para la preparacion de nuevos derivados de triazina | |
| TR200001941T1 (tr) | TNF ve PDE-IV önleyici aktiviteye sahip heterosiklik bileşiklerin N-oksitleri. | |
| DK1025101T3 (da) | Naphtho-imidazo[1,2-a]pyridinderivater, deres fremstilling og deres anvendelse ved behandlingen af sygdomme i centralnervesystemet | |
| KR880005134A (ko) | 인돌로-피라지노-벤조 디아제민 유도체 | |
| MX9709465A (es) | Derivados de bencimidazol 2-sustituidos como inhibidores de la proliferacion de celulas del musculo liso. | |
| HUP9801889A1 (hu) | Új karbamidszármazékok | |
| KR950700225A (ko) | Cck-수용체 길항제로써 유용한 벤조디아제핀 유도체(benzodiazepin derivatives useful as cck-receptor antagonists) | |
| DE69617420D1 (de) | 2-substituierte benzimidazolderivate als inhibitoren der glatten muskelzellenproliferation | |
| NO20040113L (no) | Variolinderivater og deres anvendelse som antitumormidler | |
| TR200003572T2 (tr) | Siyanoiminokuinoksalin Türevleri |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 850235 Country of ref document: ES |