ES2141085T3 - Analogos del factor liberador de la hormona del crecimiento. - Google Patents

Analogos del factor liberador de la hormona del crecimiento.

Info

Publication number
ES2141085T3
ES2141085T3 ES91303507T ES91303507T ES2141085T3 ES 2141085 T3 ES2141085 T3 ES 2141085T3 ES 91303507 T ES91303507 T ES 91303507T ES 91303507 T ES91303507 T ES 91303507T ES 2141085 T3 ES2141085 T3 ES 2141085T3
Authority
ES
Spain
Prior art keywords
growth hormone
analogs
compounds
release factor
grf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91303507T
Other languages
English (en)
Inventor
Gerald Stephen Brooke
Richard Dennis Dimarchi
Mark Louis Heiman
Hansen Maxwell Hsiung
David Lee Smiley
Dennis Paul Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2141085T3 publication Critical patent/ES2141085T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Slot Machines And Peripheral Devices (AREA)
  • Pens And Brushes (AREA)
  • Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

ESTA INVENCION APORTA NUEVOS ANALOGOS DEL FACTOR DE LIBERACION DE LA HORMONA DEL CRECIMIENTO (FLC). LAS VERSIONES MODIFICADAS QUIMICAMENTE DE ESTAS MOLECULAS TAMBIEN SE PROPONE COMO COMPUESTOS DE ADN QUE CODIFICAN ANALOGOS DE FLC. ALGUNOS DE LOS COMPUESTOS DE POLIPEPTIDOS PUEDEN SER OBTENIDOS EN GRANDES PROPORCIONES MEDIANTE LA PRODUCCION DE LOS COMPUESTOS EN E. COLI. LA INVENCION TAMBIEN SE REFIERE A COMPOSICIONES FARMACEUTICAS Y METODOS PARA EL ESTIMULO DE LA LIBERACION DE LA HORMONA DEL CRECIMIENTO.
ES91303507T 1990-04-24 1991-04-19 Analogos del factor liberador de la hormona del crecimiento. Expired - Lifetime ES2141085T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51373090A 1990-04-24 1990-04-24
US58732390A 1990-09-24 1990-09-24

Publications (1)

Publication Number Publication Date
ES2141085T3 true ES2141085T3 (es) 2000-03-16

Family

ID=27057991

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91303507T Expired - Lifetime ES2141085T3 (es) 1990-04-24 1991-04-19 Analogos del factor liberador de la hormona del crecimiento.

Country Status (18)

Country Link
EP (1) EP0454367B1 (es)
JP (1) JPH04305598A (es)
KR (1) KR910018546A (es)
CN (1) CN1066345C (es)
AT (1) ATE186570T1 (es)
AU (1) AU643773B2 (es)
CA (1) CA2040649A1 (es)
DE (1) DE69131771T2 (es)
DK (1) DK0454367T3 (es)
ES (1) ES2141085T3 (es)
FI (1) FI911961A (es)
GR (1) GR3032384T3 (es)
HU (1) HUT60634A (es)
IE (1) IE911358A1 (es)
IL (1) IL97885A0 (es)
NO (1) NO911609L (es)
NZ (1) NZ237857A (es)
PT (1) PT97414A (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5973114A (en) * 1992-06-23 1999-10-26 The University Of Virginia Patent Foundation Isolation and characterization of the growth hormone releasing hormone receptor
CN103547591A (zh) * 2011-04-21 2014-01-29 瑟瑞技术公司 生长激素释放因子(grf)类似物及其用途
CN109180800B (zh) * 2018-08-01 2019-07-12 广东药科大学 新型生长激素释放激素类似肽二聚体及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728609A (en) 1983-01-10 1988-03-01 Hoffmann-La-Roche Inc. Recombinant growth hormone releasing factor
US4617149A (en) 1983-09-21 1986-10-14 Eli Lilly And Company Growth hormone release factor analogs
IT1234977B (it) 1985-03-22 1992-06-09 Serono Ist Farm Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita
US4734399A (en) * 1985-08-06 1988-03-29 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
PT83613B (en) * 1985-10-28 1988-11-21 Lilly Co Eli Process for the selective chemical removal of a protein amino-terminal residue
IL86102A (en) * 1987-05-11 1994-04-12 Univ Tulane Alkylated peptides that release growth hormone and their use
DK470689A (da) * 1988-09-30 1990-03-31 Lilly Co Eli Hidtil ukendte dna-sekvenser, der koder for protein-derivater, som tillader hoej udtrykkelse af rekombinante proteiner med ringe molekylevaegt

Also Published As

Publication number Publication date
NZ237857A (en) 1992-05-26
GR3032384T3 (en) 2000-04-27
EP0454367A2 (en) 1991-10-30
CN1057784A (zh) 1992-01-15
HU911358D0 (en) 1991-10-28
DE69131771T2 (de) 2000-04-06
FI911961A (fi) 1991-10-25
JPH04305598A (ja) 1992-10-28
CN1066345C (zh) 2001-05-30
IE911358A1 (en) 1991-11-06
DE69131771D1 (de) 1999-12-16
EP0454367A3 (en) 1992-07-29
ATE186570T1 (de) 1999-11-15
CA2040649A1 (en) 1991-10-25
NO911609D0 (no) 1991-04-23
HUT60634A (en) 1992-10-28
NO911609L (no) 1991-10-25
FI911961A0 (fi) 1991-04-23
EP0454367B1 (en) 1999-11-10
KR910018546A (ko) 1991-11-30
IL97885A0 (en) 1992-06-21
DK0454367T3 (da) 2000-03-27
PT97414A (pt) 1992-01-31
AU643773B2 (en) 1993-11-25
AU7525091A (en) 1991-11-07

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