PT87523A - Mischkristalle aus insulin und insulinderivaten verfahren zur herstellung dieser mischkristalle diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus - Google Patents

Mischkristalle aus insulin und insulinderivaten verfahren zur herstellung dieser mischkristalle diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus

Info

Publication number: PT87523A
Authority: PT; Portugal
Prior art keywords: mischkristalle; insulin; und; diabetes mellitus; insulinderivaten
Prior art date: 1987-05-22

Application number

PT87523A

Other languages

English (en)

Other versions

PT87523B (pt

Inventor

Michael Dorschug

Rainer Obermeier

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-22

Filing date

1988-05-19

Publication date

1989-05-31

1988-05-19 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-05-31 Publication of PT87523A publication Critical patent/PT87523A/pt

1992-09-30 Publication of PT87523B publication Critical patent/PT87523B/pt

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Emergency Medicine (AREA)
Toxicology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

PT87523A 1987-05-22 1988-05-19 Processo para a preparacao de cristais mistos de insulina e derivados da insulina, e de composicoes farmaceuticas que os contem PT87523B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19873717370 DE3717370A1 (de)	1987-05-22	1987-05-22	Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus

Publications (2)

Publication Number	Publication Date
PT87523A true PT87523A (pt)	1989-05-31
PT87523B PT87523B (pt)	1992-09-30

Family

ID=6328227

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT87523A PT87523B (pt)	1987-05-22	1988-05-19	Processo para a preparacao de cristais mistos de insulina e derivados da insulina, e de composicoes farmaceuticas que os contem

Country Status (20)

Country	Link
US (1)	US5028587A (pt)
EP (1)	EP0291863B1 (pt)
JP (1)	JPS63303930A (pt)
KR (1)	KR880013572A (pt)
AT (1)	ATE71842T1 (pt)
AU (1)	AU601280B2 (pt)
CA (1)	CA1335924C (pt)
DE (2)	DE3717370A1 (pt)
DK (1)	DK278088A (pt)
ES (1)	ES2032896T3 (pt)
FI (1)	FI93797C (pt)
GR (1)	GR3004344T3 (pt)
HU (1)	HU203840B (pt)
IE (1)	IE60649B1 (pt)
IL (1)	IL86452A (pt)
NO (1)	NO175641C (pt)
NZ (1)	NZ224715A (pt)
PH (1)	PH25587A (pt)
PT (1)	PT87523B (pt)
ZA (1)	ZA883599B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
AU9172991A (en)	1990-12-07	1992-07-08	Cnc Development, Inc.	Catalytic chemical reactor
ATE157010T1 (de) *	1991-05-24	1997-09-15	Amylin Pharmaceuticals Inc	Amylin oder amylinanaloga enthaltende zusammensetzung, welche auch wahlweise insulin enthält, zur behandlung von anorexie und verwandten zuständen
DK72793D0 (da) *	1993-06-21	1993-06-21	Novo Nordisk As	Nyt produkt
US5461031A (en) *	1994-06-16	1995-10-24	Eli Lilly And Company	Monomeric insulin analog formulations
US5474978A (en) *	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
US5504188A (en) *	1994-06-16	1996-04-02	Eli Lilly And Company	Preparation of stable zinc insulin analog crystals
US5547929A (en) *	1994-09-12	1996-08-20	Eli Lilly And Company	Insulin analog formulations
US5597893A (en) *	1994-10-31	1997-01-28	Eli Lilly And Company	Preparation of stable insulin analog crystals
US6004549A (en) *	1994-12-14	1999-12-21	Schering Corporation	Crystalline protein controlled release compositions
CO4970787A1 (es) *	1997-12-23	2000-11-07	Lilly Co Eli	Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
DE19903125B4 (de) *	1999-01-27	2006-01-05	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga
CN1125081C (zh)	1999-09-08	2003-10-22	中国科学院上海生物化学研究所	重组天然和新型人胰岛素及其制备方法
HUP0500733A3 (en) *	2001-02-09	2010-01-28	Genentech Inc	Crystallization of igf-1
US7396936B1 (en)	2004-11-09	2008-07-08	Kemia, Inc.	Modulators of calcitonin and amylin receptor activity
EP2101735A2 (en) *	2006-11-28	2009-09-23	Marinus Pharmaceuticals, Inc.	Nanoparticulate formulations and methods for the making and use thereof
WO2015084694A2 (en)	2013-12-04	2015-06-11	Merck Sharp & Dohme Corp.	Method for preparing crystalline insulin
WO2016032869A1 (en)	2014-08-26	2016-03-03	Merck Sharp & Dohme Corp.	Method for preparing crystalline insulin or insulin analog compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2538018A (en) *	1944-04-04	1951-01-16	Nordisk Insulinlab	Crystalline product of insulin and alkaline protein and process of making it
EG12098A (en) *	1974-04-13	1980-12-31	Hoechst Ag	New pharmaceutical insulin preparations having antidiabetic activity and process for their manufacture
DE3326472A1 (de) *	1983-07-22	1985-02-14	Hoechst Ag, 6230 Frankfurt	Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3326473A1 (de) *	1983-07-22	1985-01-31	Hoechst Ag, 6230 Frankfurt	Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3333640A1 (de) *	1983-09-17	1985-04-25	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung

1987
- 1987-05-22 DE DE19873717370 patent/DE3717370A1/de not_active Withdrawn
1988
- 1988-05-13 DE DE8888107667T patent/DE3867903D1/de not_active Expired - Fee Related
- 1988-05-13 EP EP88107667A patent/EP0291863B1/de not_active Expired - Lifetime
- 1988-05-13 ES ES198888107667T patent/ES2032896T3/es not_active Expired - Lifetime
- 1988-05-13 AT AT88107667T patent/ATE71842T1/de not_active IP Right Cessation
- 1988-05-19 FI FI882354A patent/FI93797C/fi not_active IP Right Cessation
- 1988-05-19 PT PT87523A patent/PT87523B/pt not_active IP Right Cessation
- 1988-05-20 PH PH36954A patent/PH25587A/en unknown
- 1988-05-20 JP JP63122211A patent/JPS63303930A/ja active Pending
- 1988-05-20 AU AU16487/88A patent/AU601280B2/en not_active Ceased
- 1988-05-20 HU HU882597A patent/HU203840B/hu not_active IP Right Cessation
- 1988-05-20 IE IE152288A patent/IE60649B1/en not_active IP Right Cessation
- 1988-05-20 IL IL86452A patent/IL86452A/xx unknown
- 1988-05-20 DK DK278088A patent/DK278088A/da not_active Application Discontinuation
- 1988-05-20 US US07/196,530 patent/US5028587A/en not_active Expired - Fee Related
- 1988-05-20 NO NO882207A patent/NO175641C/no unknown
- 1988-05-20 KR KR1019880005946A patent/KR880013572A/ko not_active Application Discontinuation
- 1988-05-20 ZA ZA883599A patent/ZA883599B/xx unknown
- 1988-05-20 CA CA000567377A patent/CA1335924C/en not_active Expired - Fee Related
- 1988-05-20 NZ NZ224715A patent/NZ224715A/en unknown
1992
- 1992-04-15 GR GR920400389T patent/GR3004344T3/el unknown

Also Published As

Publication number	Publication date
NO175641B (pt)	1994-08-01
ES2032896T3 (es)	1993-03-01
FI93797C (fi)	1995-06-12
HUT46546A (en)	1988-11-28
DK278088A (da)	1988-11-23
FI882354A (fi)	1988-11-23
DE3717370A1 (de)	1988-12-01
NZ224715A (en)	1990-04-26
AU1648788A (en)	1988-11-24
EP0291863A3 (en)	1990-04-04
IL86452A (en)	1993-02-21
US5028587A (en)	1991-07-02
FI93797B (fi)	1995-02-28
ATE71842T1 (de)	1992-02-15
KR880013572A (ko)	1988-12-21
JPS63303930A (ja)	1988-12-12
NO175641C (no)	1994-11-09
FI882354A0 (fi)	1988-05-19
EP0291863A2 (de)	1988-11-23
IE881522L (en)	1988-11-22
DK278088D0 (da)	1988-05-20
CA1335924C (en)	1995-06-13
GR3004344T3 (pt)	1993-03-31
IL86452A0 (en)	1988-11-15
EP0291863B1 (de)	1992-01-22
PT87523B (pt)	1992-09-30
PH25587A (en)	1991-08-08
AU601280B2 (en)	1990-09-06
NO882207L (no)	1988-11-23
NO882207D0 (no)	1988-05-20
DE3867903D1 (de)	1992-03-05
IE60649B1 (en)	1994-08-10
ZA883599B (en)	1989-01-25
HU203840B (en)	1991-10-28

Legal Events

Date

Code

Title

Description

1992-09-30

FG3A

Patent granted, date of granting

Effective date: 19920311

1998-01-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19970930

Publication	Publication Date	Title
PT87523A (pt)	1989-05-31	Mischkristalle aus insulin und insulinderivaten verfahren zur herstellung dieser mischkristalle diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus
DK393288D0 (da)	1988-07-14	Praeparat til saarheling og knogleregenerering
ATE29729T1 (de)	1987-10-15	Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus.
DE3768286D1 (de)	1991-04-11	Substituierte pyridinsulfonamidverbindungen, diese enthaltende herbizide zusammensetzungen und verfahren zur herstellung dieser verbindungen.
FI875533A0 (fi)	1987-12-16	Insulinpreparat foer non-parenteral dosering.
DE69033040D1 (de)	1999-05-12	Verfahren zur Herstellung von biologisch aktivem Protein (z.B. TGF)
ATE31625T1 (de)	1988-01-15	Pharmazeutisches mittel zur behandlung des diabetes mellitus.
DE3784693D1 (de)	1993-04-15	Verwendung von fluticasonpropionat zur herstellung eines praeparats zur behandlung von darmerkrankungen.
DE3782028D1 (de)	1992-11-05	Verwendung von ketonderivaten zur behandlung von bewusstseinsstoerungen.
DE68924714D1 (de)	1995-12-07	Verwendung von essentiellen fettsäuren zur herstellung eines medikaments zur behandlung von ekzemen.
ES2059588T3 (es)	1994-11-16	Factor xiii para la prevencion de una hemorragia intraventricular.
PT83309B (de)	1988-01-11	Neue pyrrolo-benzimidazole pyrrolo-benzoxazole und pyrrolo-benzthiazole verfahren zu ihrer herstellung und diese verbindungen enthaltende arneimittel
DE69007065D1 (de)	1994-04-07	Verwendung von Diadenosin-5',5'''-p1,p4-tetraphosphat zur Herstellung eines Arzneimittels zur Behandlung von Herzkrankheiten.
DE3885818D1 (de)	1994-01-05	Trinatriumsalz des 2,4,6-Trimercapto-s-triazin-nonahydrats und Verfahren zur Herstellung.
DE3781667D1 (de)	1992-10-15	Verwendung von 24,25-dihydroxycholecalciferol zur verhuetung des knochenalterns.
DE69809785D1 (de)	2003-01-09	Verwendung eines retinoidids zur in vivo erhöhung der entkopplung des ucp2 proteins
ATE135702T1 (de)	1996-04-15	Aryl- oder heteroaryl-1-alkyl-pyrrol-2- carbonsäure-derivate, zur behandlung von durch interleukin-1 hervorgerufenen erkrankungen
DE69014747D1 (de)	1995-01-19	Verfahren zur Herstellung von Kaliumtitanarsenat-Einkristallen.
DE68926222D1 (de)	1996-05-15	Verwendung von 1,2,3,4-Tetrahydroacridinen zur Behandlung von AIDS, sowie Verbindungen
DE68905479D1 (de)	1993-04-22	Transdermate magensafthemmende wirkstoffe zur behandlung von magen-darm-erkrankungen.