ES2095317T3 - Inhibidor de enfermedades hepaticas. - Google Patents

Inhibidor de enfermedades hepaticas.

Info

Publication number
ES2095317T3
ES2095317T3 ES91908176T ES91908176T ES2095317T3 ES 2095317 T3 ES2095317 T3 ES 2095317T3 ES 91908176 T ES91908176 T ES 91908176T ES 91908176 T ES91908176 T ES 91908176T ES 2095317 T3 ES2095317 T3 ES 2095317T3
Authority
ES
Spain
Prior art keywords
glutathione
substd
opt
lower alkyl
hepatic disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91908176T
Other languages
English (en)
Inventor
Shinji Ohmori
Kazumi Ogata
Takahiro Sakaue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Original Assignee
Senju Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2095317T3 publication Critical patent/ES2095317T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN INHIBIDOR DE DESORDENES HEPATICOS QUE CONTIENE COMO INGREDIENTE ACTIVO UN DERIVADO DE GLUTATIONA SUSTITUIDO POR ACIDO ALIFATICO INFERIOR DE S QUE TIENE LA FORMULA GENERAL (I) O SU SAL, EN DONDE R SUB 1 Y R SUB 3 PUEDEN SER IGUALES O DIFERENTES ENTRE SI Y CADA UNO REPRESENTA HIDROGENO O ALQUILO INFERIOR SUSTITUIDO DE MANERA OPTIMA; R SUB 4 REPRESENTA HIDROXI , ALQUILO INFERIOR SUSTITUIDO DE MANERA OPTIMA O AMINO SUSTITUIDO DE MANERA OPTIMA; N ES 0 O 1; Y CUANDO N ES 1, R SUB 2 REPRESENTA HIDROGENO , ALQUILO INFERIOR SUSTITUIDO DE MANERA OPTIMA O FENILO SUSTITUIDO DE MANERA OPTIMA.
ES91908176T 1990-04-26 1991-04-25 Inhibidor de enfermedades hepaticas. Expired - Lifetime ES2095317T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11226090 1990-04-26

Publications (1)

Publication Number Publication Date
ES2095317T3 true ES2095317T3 (es) 1997-02-16

Family

ID=14582257

Family Applications (3)

Application Number Title Priority Date Filing Date
ES91908176T Expired - Lifetime ES2095317T3 (es) 1990-04-26 1991-04-25 Inhibidor de enfermedades hepaticas.
ES91908175T Expired - Lifetime ES2093098T3 (es) 1990-04-26 1991-04-25 Derivado de glutation sustituido en s-acido graso inferior.
ES91908790T Expired - Lifetime ES2092565T3 (es) 1990-04-26 1991-04-26 Derivado de glutation con sustitucion en s-acido graso inferior.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES91908175T Expired - Lifetime ES2093098T3 (es) 1990-04-26 1991-04-25 Derivado de glutation sustituido en s-acido graso inferior.
ES91908790T Expired - Lifetime ES2092565T3 (es) 1990-04-26 1991-04-26 Derivado de glutation con sustitucion en s-acido graso inferior.

Country Status (10)

Country Link
US (2) US5232913A (es)
EP (3) EP0480061B1 (es)
KR (3) KR970008108B1 (es)
AT (3) ATE144531T1 (es)
CA (2) CA2060209A1 (es)
DE (3) DE69122831T2 (es)
ES (3) ES2095317T3 (es)
RU (1) RU2046798C1 (es)
TW (1) TW203060B (es)
WO (3) WO1991016337A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030950A (en) * 1987-07-09 2000-02-29 Ohlenschlaeger; Gerhard Pharmaceutical therapeutic use of glutathione derivative
US5599903A (en) * 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
US5679643A (en) * 1987-10-13 1997-10-21 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
EP0469156B1 (en) * 1990-02-17 1996-10-23 Senju Pharmaceutical Co., Ltd. Glutathione derivative
US5786336A (en) * 1991-04-29 1998-07-28 Terrapin Technologies, Inc. Target-selective protocols based on mimics
US5955432A (en) * 1992-04-03 1999-09-21 Terrapin Technologies, Inc. Metabolic effects of certain glutathione analogs
CA2099346A1 (en) * 1992-07-17 1994-01-18 Shinji Ohmori Lipid metabolism improving composition
US5427425A (en) * 1994-08-05 1995-06-27 Droesch; Joaquin C. Pickup tailgate mounting assembly
ES2147162B1 (es) 1999-01-27 2001-03-16 Lacer Sa "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias".
US6596870B2 (en) 2000-07-13 2003-07-22 Brandeis University Asymmetric synthetic methods based on phase transfer catalysis
US7172905B2 (en) * 2001-08-07 2007-02-06 The University Of Chicago Polypeptide immobilization
EP1521961A2 (en) * 2002-07-05 2005-04-13 The University of Chicago Characterization of biochips containing self-assembled monolayers with maldi-tof-ms
US20100021398A1 (en) * 2008-01-18 2010-01-28 Skinner Keith K Compositions and methods for lightening skin and protecting skin from ultraviolet radiation with glutathione
US9017477B2 (en) * 2008-05-28 2015-04-28 Nagoya City University Process for producing colloidal crystal and colloidal crystal
JP5267096B2 (ja) * 2008-12-12 2013-08-21 住友化学株式会社 Ｎ，Ｓ−ジ−ｔｅｒｔ−ブトキシカルボニルグルタチオン蛍光誘導体及びそれを中間体として用いるグルタチオン蛍光誘導体の製造方法
WO2012027455A1 (en) * 2010-08-24 2012-03-01 The University Of Toledo Glutathione-lanthionine compounds and methods related thereto
US9676818B2 (en) 2013-01-17 2017-06-13 University Of Kansas Toll-like receptor 2-agonistic lipopeptides, and method of making the same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60104018A (ja) * 1983-11-11 1985-06-08 Kyowa Hakko Kogyo Co Ltd Ν−メチルホルムアミド肝毒性の軽減剤
US4879370A (en) * 1983-12-02 1989-11-07 Cornell Research Foundation, Inc. Glutathione delivery system
JPS60123497A (ja) * 1983-12-02 1985-07-02 コ−ネル・リサ−チ・フアウンデ−シヨン，インコ−ポレイテツド グルタチオン伝達系
JPS61249997A (ja) * 1985-04-22 1986-11-07 コ−ネル・リサ−チ・フアウンデ−シヨン・インコ−ポレイテツド グルタチオンアルキルエステルおよびその用途
JPS60237963A (ja) * 1984-05-02 1985-11-26 Ajinomoto Co Inc こく味調味料またはこく味の増強された食品の製造法
ATE53991T1 (de) * 1985-04-19 1990-07-15 Smithkline Beecham Corp Leukotrien-antagonisten.
JPS638337A (ja) * 1986-06-30 1988-01-14 Senjiyu Seiyaku Kk 抗血液凝固剤
DE3784905T2 (de) * 1986-07-07 1993-08-05 Teijin Ltd Gamma-l-glutamyl-l-cysteinethylester und arzneimittel, die dieses als aktives mittel enthalten.
JPS6463525A (en) * 1987-05-08 1989-03-09 Yamanouchi Pharma Co Ltd Alcoholic liver triglyceride increase-suppressing agent
DE3722647A1 (de) * 1987-07-09 1989-01-19 Gerhard Ohlenschlaeger Galenische verwendung eines tripeptids als arzneimittel
JPH02255624A (ja) * 1989-03-29 1990-10-16 Senjiyu Seiyaku Kk 血小板凝集抑制剤
US5102871A (en) * 1989-04-24 1992-04-07 Kyowa Hakko Kogyo Co., Ltd. Nutrient composition
US5093478A (en) * 1989-07-14 1992-03-03 Cornell Research Foundation, Inc. Preparing glutathione monoesters
JP2815179B2 (ja) * 1989-07-14 1998-10-27 千寿製薬株式会社 抗炎症および／または抗アレルギー剤
JP2919867B2 (ja) * 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
JP2919870B2 (ja) * 1989-09-29 1999-07-19 千寿製薬株式会社 肝障害抑制剤
EP0469156B1 (en) * 1990-02-17 1996-10-23 Senju Pharmaceutical Co., Ltd. Glutathione derivative

Also Published As

Publication number Publication date
DE69123428T2 (de) 1997-05-15
CA2060210A1 (en) 1991-10-27
ES2093098T3 (es) 1996-12-16
EP0480071A1 (en) 1992-04-15
DE69122466D1 (de) 1996-11-07
DE69122831T2 (de) 1997-03-27
ES2092565T3 (es) 1996-12-01
EP0480060A1 (en) 1992-04-15
KR970008108B1 (ko) 1997-05-21
KR920701143A (ko) 1992-08-11
CA2060209A1 (en) 1991-10-27
US5232913A (en) 1993-08-03
EP0480060B1 (en) 1996-10-23
RU2046798C1 (ru) 1995-10-27
EP0480071B1 (en) 1996-10-02
WO1991016337A1 (en) 1991-10-31
DE69122466T2 (de) 1997-03-20
WO1991016065A1 (en) 1991-10-31
KR920701142A (ko) 1992-08-11
EP0480061B1 (en) 1996-12-04
DE69123428D1 (de) 1997-01-16
ATE145919T1 (de) 1996-12-15
EP0480061A1 (en) 1992-04-15
WO1991016338A1 (en) 1991-10-31
ATE144531T1 (de) 1996-11-15
TW203060B (es) 1993-04-01
EP0480071A4 (en) 1993-06-30
EP0480061A4 (en) 1993-07-21
KR970002904B1 (ko) 1997-03-12
EP0480060A4 (en) 1993-07-14
DE69122831D1 (de) 1996-11-28
KR970002905B1 (ko) 1997-03-12
KR920701141A (ko) 1992-08-11
ATE143670T1 (de) 1996-10-15
US5274177A (en) 1993-12-28

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