ES2088870T3 - Un derivado de benzoxazinorrifamicina sustituida, un procedimiento para preparar el mismo y un agente antibacteriano que contiene el mismo. - Google Patents

Un derivado de benzoxazinorrifamicina sustituida, un procedimiento para preparar el mismo y un agente antibacteriano que contiene el mismo.

Info

Publication number
ES2088870T3
ES2088870T3 ES89104620T ES89104620T ES2088870T3 ES 2088870 T3 ES2088870 T3 ES 2088870T3 ES 89104620 T ES89104620 T ES 89104620T ES 89104620 T ES89104620 T ES 89104620T ES 2088870 T3 ES2088870 T3 ES 2088870T3
Authority
ES
Spain
Prior art keywords
same
derivative
group
benzoxazinorrifamicina
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89104620T
Other languages
English (en)
Inventor
Fumihiko Kanoo
Takehiko Yamane
Hideo Kondo
Takuji Hashizume
Katsuji Yamashita
Kazunori Hosoe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Application granted granted Critical
Publication of ES2088870T3 publication Critical patent/ES2088870T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN DERIVADO DE RIFAMICINA CON LA FORMULA (I) DONDE R EXP1 ES UN ATOMO DE HIDROGENO, GRUPO METILO O ETILO, R (AL CUADRADO) ES UN GRUPO ALQUILO CON 1 A 4 ATOMOS DE CARBONO, Y A ES UN GRUPO CON LA FORMULA (II), EN LA QUE N ES UN NUMERO ENTERO DE 3 A 5 O UN GRUPO CON LA FORMULA (III) EN LA QUE R EXP3 ES UN GRUPO ALQUILO CON 1 A 5 ATOMOS DE CARBONO O UNA SAL DE ESTO. EL DERIVADO DE RIFAMICINA (I) MUESTRA UNA FUERTE ACTIVIDAD ANTIBACTERIANA FRENTE A BACTERIAS GRAM - POSITIVAS Y BACTERIAS, TAMBIEN MUESTRA UNA FUERTE ACTIVIDAD ANTIBACTERIANA CONTRA TUBERCLE BACILLI.
ES89104620T 1988-03-18 1989-03-15 Un derivado de benzoxazinorrifamicina sustituida, un procedimiento para preparar el mismo y un agente antibacteriano que contiene el mismo. Expired - Lifetime ES2088870T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6701488 1988-03-18
JP63239288 1988-09-24

Publications (1)

Publication Number Publication Date
ES2088870T3 true ES2088870T3 (es) 1996-10-01

Family

ID=26408219

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89104620T Expired - Lifetime ES2088870T3 (es) 1988-03-18 1989-03-15 Un derivado de benzoxazinorrifamicina sustituida, un procedimiento para preparar el mismo y un agente antibacteriano que contiene el mismo.

Country Status (6)

Country Link
US (1) US4965261A (es)
EP (1) EP0333176B1 (es)
CN (1) CN1020610C (es)
CA (1) CA1293503C (es)
DE (1) DE68924722T2 (es)
ES (1) ES2088870T3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756466A (en) 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
CA2465846A1 (en) * 2001-11-21 2003-06-05 Activbiotics, Inc. Targeted therapeutics and uses thereof
WO2003051299A2 (en) * 2001-12-13 2003-06-26 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
CA2536378A1 (en) * 2003-08-22 2005-03-10 Activbiotics, Inc. Rifamycin analogs and uses thereof
WO2005058231A2 (en) * 2003-12-10 2005-06-30 Activbiotics, Inc. Rifamycin analogs and uses thereof
AU2004308399A1 (en) * 2003-12-23 2005-07-14 Activbiotics, Inc. Rifamycin analogs and uses thereof
US7202246B2 (en) * 2004-06-09 2007-04-10 Cumbre Pharmaceuticals Inc. Spiro-rifamycin derivatives targeting RNA polymerase
CN101031572B (zh) * 2004-07-22 2010-12-08 坎布里Ip风险投资有限合伙公司 (r/s)利福霉素衍生物，它们的制备和药物组合物
CA2632028A1 (en) 2005-12-14 2007-06-21 Activbiotics, Inc. Rifamycin analogs and uses thereof
WO2008008480A2 (en) * 2006-07-12 2008-01-17 Cumbre Pharmaceuticals Inc. Nitroheteroaryl-containing rifamycin derivatives
US7884099B2 (en) 2007-11-16 2011-02-08 Cumbre Ip Ventures, L.P. Quinolone carboxylic acid-substituted rifamycin derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL130099C (es) * 1963-10-11
US4005077A (en) * 1965-08-24 1977-01-25 Ciba-Geigy Corporation Antibiotically active compounds
US4690919A (en) * 1984-01-04 1987-09-01 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Benzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same
JPS63183587A (ja) * 1985-02-05 1988-07-28 Kanegafuchi Chem Ind Co Ltd ベンゾキサジノリフアマイシン誘導体
JP2544375B2 (ja) * 1986-07-14 1996-10-16 鐘淵化学工業株式会社 アルキル置換ベンゾキサジノリフアマイシン誘導体

Also Published As

Publication number Publication date
DE68924722T2 (de) 1996-04-18
US4965261A (en) 1990-10-23
CN1020610C (zh) 1993-05-12
EP0333176A2 (en) 1989-09-20
DE68924722D1 (de) 1995-12-14
EP0333176A3 (en) 1991-03-20
CN1036576A (zh) 1989-10-25
EP0333176B1 (en) 1995-11-08
CA1293503C (en) 1991-12-24

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