ES2085462T3 - Combinacion anticoagulante de laci y de polisacaridos sulfatados. - Google Patents

Combinacion anticoagulante de laci y de polisacaridos sulfatados.

Info

Publication number
ES2085462T3
ES2085462T3 ES91870132T ES91870132T ES2085462T3 ES 2085462 T3 ES2085462 T3 ES 2085462T3 ES 91870132 T ES91870132 T ES 91870132T ES 91870132 T ES91870132 T ES 91870132T ES 2085462 T3 ES2085462 T3 ES 2085462T3
Authority
ES
Spain
Prior art keywords
laci
combination
polysaccharides
sulphate
anticoagulant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91870132T
Other languages
English (en)
Inventor
Tze-Chein Wun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2085462T3 publication Critical patent/ES2085462T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE EXPONE AQUI UNA COMBINACION DE UN INHIBIDOR DE COAGULACION ASOCIADO CON LAS LIPOPROTEINAS (LACI) Y POLISACARIDOS SULFATADOS, POR EJ: HEPARINA , QUE EJERCE UNA ACCION ANTICOAGULANTE SINERGISTICA EN TODO EL PLASMA.
ES91870132T 1990-08-27 1991-08-26 Combinacion anticoagulante de laci y de polisacaridos sulfatados. Expired - Lifetime ES2085462T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57308390A 1990-08-27 1990-08-27

Publications (1)

Publication Number Publication Date
ES2085462T3 true ES2085462T3 (es) 1996-06-01

Family

ID=24290576

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91870132T Expired - Lifetime ES2085462T3 (es) 1990-08-27 1991-08-26 Combinacion anticoagulante de laci y de polisacaridos sulfatados.

Country Status (10)

Country Link
EP (1) EP0473564B1 (es)
JP (1) JPH0733336B2 (es)
AT (1) ATE135585T1 (es)
CA (1) CA2049873C (es)
DE (1) DE69118056T2 (es)
DK (1) DK0473564T3 (es)
ES (1) ES2085462T3 (es)
GR (1) GR3020312T3 (es)
IE (1) IE913004A1 (es)
PT (1) PT98779B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US20030171292A1 (en) 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
CA2194443A1 (en) * 1994-07-07 1996-01-25 Dana R. Abendschein Method of attenuating arterial stenosis
ATE226249T1 (de) * 1994-08-05 2002-11-15 Chiron Corp Herstellung des inhibitors fuer die komplexbildung des gewebefaktors
US5589359A (en) 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
PT1602667E (pt) * 1995-06-07 2007-07-13 Searle Llc Formulação aquosa que compreende tfpi e agentes de solubilização
AU759412B2 (en) * 1995-06-07 2003-04-17 G.D. Searle & Co. Method of solubilizing, purifying and refolding protein and compositions comprising proteins and solubilizing agents
AU2003200506B2 (en) * 1995-06-07 2007-01-18 G.D. Searle Llc Method of solubilizing, purifying and refolding protein and compositions comprising proteins and solubilizing agents
US5772629A (en) * 1995-10-23 1998-06-30 Localmed, Inc. Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels
WO1997022347A1 (en) * 1995-12-18 1997-06-26 Stichting Sanquin Bloedvoorziening Potentiation of complement and coagulation inhibitory properties of c1-inhibitor.
KR20040040489A (ko) 2001-10-15 2004-05-12 카이론 코포레이션 조직 인자 경로 억제제（ｔｆｐｉ）의 저용량 투여에 의한패혈증의 치료
EP1654283B1 (en) 2003-08-13 2011-07-13 Novartis Vaccines and Diagnostics, Inc. Improved method of purifying tfpi and tfpi analogs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87172A (en) * 1987-07-23 1994-12-29 Univ Washington A method of inhibiting the isolation of a purer tissue factor
IL87171A (en) * 1987-11-23 1995-08-31 Monsanto Co ANDC of human tissue factor inhibitor
ATE135044T1 (de) * 1990-01-25 1996-03-15 Univ Washington Faktor x-laci-hybridprotein

Also Published As

Publication number Publication date
JPH04257524A (ja) 1992-09-11
CA2049873C (en) 2001-12-04
ATE135585T1 (de) 1996-04-15
JPH0733336B2 (ja) 1995-04-12
EP0473564A1 (en) 1992-03-04
DE69118056D1 (de) 1996-04-25
PT98779A (pt) 1992-07-31
PT98779B (pt) 1999-06-30
DK0473564T3 (da) 1996-04-15
GR3020312T3 (en) 1996-09-30
IE913004A1 (en) 1992-03-11
DE69118056T2 (de) 1996-10-24
EP0473564B1 (en) 1996-03-20
CA2049873A1 (en) 1992-02-28

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