DE69118056D1 - Anticoagulatorische Zusammensetzung aus LACI und sulfatierten Polysacchariden - Google Patents

Anticoagulatorische Zusammensetzung aus LACI und sulfatierten Polysacchariden

Info

Publication number
DE69118056D1
DE69118056D1 DE69118056T DE69118056T DE69118056D1 DE 69118056 D1 DE69118056 D1 DE 69118056D1 DE 69118056 T DE69118056 T DE 69118056T DE 69118056 T DE69118056 T DE 69118056T DE 69118056 D1 DE69118056 D1 DE 69118056D1
Authority
DE
Germany
Prior art keywords
laci
sulfated polysaccharides
anticoagulant composition
anticoagulant
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69118056T
Other languages
English (en)
Other versions
DE69118056T2 (de
Inventor
Tze-Chein Wun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of DE69118056D1 publication Critical patent/DE69118056D1/de
Application granted granted Critical
Publication of DE69118056T2 publication Critical patent/DE69118056T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69118056T 1990-08-27 1991-08-26 Anticoagulatorische Zusammensetzung aus LACI und sulfatierten Polysacchariden Expired - Lifetime DE69118056T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57308390A 1990-08-27 1990-08-27

Publications (2)

Publication Number Publication Date
DE69118056D1 true DE69118056D1 (de) 1996-04-25
DE69118056T2 DE69118056T2 (de) 1996-10-24

Family

ID=24290576

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69118056T Expired - Lifetime DE69118056T2 (de) 1990-08-27 1991-08-26 Anticoagulatorische Zusammensetzung aus LACI und sulfatierten Polysacchariden

Country Status (10)

Country Link
EP (1) EP0473564B1 (de)
JP (1) JPH0733336B2 (de)
AT (1) ATE135585T1 (de)
CA (1) CA2049873C (de)
DE (1) DE69118056T2 (de)
DK (1) DK0473564T3 (de)
ES (1) ES2085462T3 (de)
GR (1) GR3020312T3 (de)
IE (1) IE913004A1 (de)
PT (1) PT98779B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US20030171292A1 (en) 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
CA2194443A1 (en) * 1994-07-07 1996-01-25 Dana R. Abendschein Method of attenuating arterial stenosis
ATE226249T1 (de) * 1994-08-05 2002-11-15 Chiron Corp Herstellung des inhibitors fuer die komplexbildung des gewebefaktors
US5589359A (en) 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
PT1602667E (pt) * 1995-06-07 2007-07-13 Searle Llc Formulação aquosa que compreende tfpi e agentes de solubilização
AU759412B2 (en) * 1995-06-07 2003-04-17 G.D. Searle & Co. Method of solubilizing, purifying and refolding protein and compositions comprising proteins and solubilizing agents
AU2003200506B2 (en) * 1995-06-07 2007-01-18 G.D. Searle Llc Method of solubilizing, purifying and refolding protein and compositions comprising proteins and solubilizing agents
US5772629A (en) * 1995-10-23 1998-06-30 Localmed, Inc. Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels
WO1997022347A1 (en) * 1995-12-18 1997-06-26 Stichting Sanquin Bloedvoorziening Potentiation of complement and coagulation inhibitory properties of c1-inhibitor.
KR20040040489A (ko) 2001-10-15 2004-05-12 카이론 코포레이션 조직 인자 경로 억제제（ｔｆｐｉ）의 저용량 투여에 의한패혈증의 치료
EP1654283B1 (de) 2003-08-13 2011-07-13 Novartis Vaccines and Diagnostics, Inc. Verbessertes verfahren zur reinigung von tfpi und tfpi-analogen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87172A (en) * 1987-07-23 1994-12-29 Univ Washington A method of inhibiting the isolation of a purer tissue factor
IL87171A (en) * 1987-11-23 1995-08-31 Monsanto Co ANDC of human tissue factor inhibitor
ATE135044T1 (de) * 1990-01-25 1996-03-15 Univ Washington Faktor x-laci-hybridprotein

Also Published As

Publication number Publication date
JPH04257524A (ja) 1992-09-11
CA2049873C (en) 2001-12-04
ATE135585T1 (de) 1996-04-15
JPH0733336B2 (ja) 1995-04-12
EP0473564A1 (de) 1992-03-04
PT98779A (pt) 1992-07-31
PT98779B (pt) 1999-06-30
DK0473564T3 (da) 1996-04-15
GR3020312T3 (en) 1996-09-30
IE913004A1 (en) 1992-03-11
DE69118056T2 (de) 1996-10-24
ES2085462T3 (es) 1996-06-01
EP0473564B1 (de) 1996-03-20
CA2049873A1 (en) 1992-02-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition