ES2084560A1 - Process for preparing indole derivatives - Google Patents
Process for preparing indole derivativesInfo
- Publication number
- ES2084560A1 ES2084560A1 ES09400481A ES9400481A ES2084560A1 ES 2084560 A1 ES2084560 A1 ES 2084560A1 ES 09400481 A ES09400481 A ES 09400481A ES 9400481 A ES9400481 A ES 9400481A ES 2084560 A1 ES2084560 A1 ES 2084560A1
- Authority
- ES
- Spain
- Prior art keywords
- image
- indole derivatives
- alkyl group
- preparing indole
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Process for preparing indole derivatives of formula (I): < IMAGE > where "Z" represents a ring selected from: < IMAGE > (II) in which n is 4, 5 or 6 < IMAGE > (III) < IMAGE > (IV) where R1 is hydrogen or an alkyl group and R2 is an alkyl, methoxy, benzyl or R3NHCO group, where R3 is an alkyl group, and < IMAGE > (V) where R4 is an alkyl group, and pharmaceutically acceptable salts of the same which comprises methylating an aminoethyl indole of formula (IX): < IMAGE > where "Z" is as defined above, including formaldehyde and a boron hydride complex.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9400481A ES2084560B1 (en) | 1994-03-09 | 1994-03-09 | EL INDOL DERIVATIVES PREPARATION PROCEDURE. |
BR9500821A BR9500821A (en) | 1994-03-09 | 1995-03-06 | Process for the preparation of an indole derivative |
CO95008919A CO4340738A1 (en) | 1994-03-09 | 1995-03-07 | PROCEDURE FOR THE PREPARATION OF INDOL DERIVATIVES |
FI951047A FI116837B (en) | 1994-03-09 | 1995-03-07 | A process for the preparation of indole derivatives |
EG17595A EG20611A (en) | 1994-03-09 | 1995-03-08 | Process for the production of indole derivatives |
UY23929A UY23929A1 (en) | 1994-03-09 | 1995-03-09 | PROCEDURE FOR THE PREPARATION OF INDEOL DERIVATIVES |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9400481A ES2084560B1 (en) | 1994-03-09 | 1994-03-09 | EL INDOL DERIVATIVES PREPARATION PROCEDURE. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2084560A1 true ES2084560A1 (en) | 1996-05-01 |
ES2084560B1 ES2084560B1 (en) | 1997-01-16 |
Family
ID=8285486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9400481A Expired - Fee Related ES2084560B1 (en) | 1994-03-09 | 1994-03-09 | EL INDOL DERIVATIVES PREPARATION PROCEDURE. |
Country Status (6)
Country | Link |
---|---|
BR (1) | BR9500821A (en) |
CO (1) | CO4340738A1 (en) |
EG (1) | EG20611A (en) |
ES (1) | ES2084560B1 (en) |
FI (1) | FI116837B (en) |
UY (1) | UY23929A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007013098A1 (en) * | 2005-07-25 | 2007-02-01 | Matrix Laboratories Limited | A process for the preparation of almotriptan |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2774605A1 (en) | 2013-02-06 | 2014-09-10 | Galenicum Health S.L. | Pharmaceutical composition comprising almotriptan malate having uniform drug distribution and potency |
CN106478484B (en) * | 2016-08-31 | 2017-11-10 | 重庆华森制药股份有限公司 | A kind of method for preparing almotriptan key intermediate |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8402268A1 (en) * | 1980-08-12 | 1984-01-16 | Glaxo Group Ltd | Indole-5-acetamides for treatment of migraine |
EP0147107A1 (en) * | 1983-12-06 | 1985-07-03 | Glaxo Group Limited | Indole derivates |
ES8801900A1 (en) * | 1984-08-01 | 1988-03-01 | Glaxo Group Ltd | Indole derivative |
ES2033577B1 (en) * | 1991-06-06 | 1995-01-16 | Quimica Sint S A Con El 50 | PROCEDURE FOR OBTAINING 2-CARBOXY-3- (2- (DIMETHYLAMINE) ETHYL) -N-METHYL-1H-INDOL-5-METHANOSULFONAMIDE AND ITS LOWER ALKYL ESTERS. |
ES2033578B1 (en) * | 1991-06-06 | 1995-01-16 | Quimica Sint S A Con El 50 | PROCEDURE FOR OBTAINING 3- (2- (DIMETHYLAMINE) ETHYL) -N-METHYL-1H-INDOL-5-METHANOSULFONAMIDE. |
-
1994
- 1994-03-09 ES ES9400481A patent/ES2084560B1/en not_active Expired - Fee Related
-
1995
- 1995-03-06 BR BR9500821A patent/BR9500821A/en not_active Application Discontinuation
- 1995-03-07 FI FI951047A patent/FI116837B/en not_active IP Right Cessation
- 1995-03-07 CO CO95008919A patent/CO4340738A1/en unknown
- 1995-03-08 EG EG17595A patent/EG20611A/en active
- 1995-03-09 UY UY23929A patent/UY23929A1/en not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8402268A1 (en) * | 1980-08-12 | 1984-01-16 | Glaxo Group Ltd | Indole-5-acetamides for treatment of migraine |
ES8500903A1 (en) * | 1980-08-12 | 1984-11-01 | Glaxo Group Ltd | Indole-5-acetamides for treatment of migraine |
EP0147107A1 (en) * | 1983-12-06 | 1985-07-03 | Glaxo Group Limited | Indole derivates |
ES8801900A1 (en) * | 1984-08-01 | 1988-03-01 | Glaxo Group Ltd | Indole derivative |
ES2033577B1 (en) * | 1991-06-06 | 1995-01-16 | Quimica Sint S A Con El 50 | PROCEDURE FOR OBTAINING 2-CARBOXY-3- (2- (DIMETHYLAMINE) ETHYL) -N-METHYL-1H-INDOL-5-METHANOSULFONAMIDE AND ITS LOWER ALKYL ESTERS. |
ES2033578B1 (en) * | 1991-06-06 | 1995-01-16 | Quimica Sint S A Con El 50 | PROCEDURE FOR OBTAINING 3- (2- (DIMETHYLAMINE) ETHYL) -N-METHYL-1H-INDOL-5-METHANOSULFONAMIDE. |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007013098A1 (en) * | 2005-07-25 | 2007-02-01 | Matrix Laboratories Limited | A process for the preparation of almotriptan |
US7943784B2 (en) * | 2005-07-25 | 2011-05-17 | Matrix Laboratories Limited | Process for the preparation of almotriptan |
Also Published As
Publication number | Publication date |
---|---|
FI951047A0 (en) | 1995-03-07 |
FI116837B (en) | 2006-03-15 |
UY23929A1 (en) | 1995-03-21 |
FI951047A (en) | 1995-09-10 |
CO4340738A1 (en) | 1996-07-30 |
EG20611A (en) | 1999-09-30 |
BR9500821A (en) | 1995-11-21 |
ES2084560B1 (en) | 1997-01-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19940309 Kind code of ref document: B1 Effective date: 19940309 |
|
TK9A | Correction |
Free format text: EN EL BOPI 010596 SE PUBLICA LA CLASIFICACION DEL EXPE0 DIENTE CON ERROR EN:C07D209/16//C07D401/12 (A61K 31/390 5)//C07D401/12,C07D209:16)C07D211:96 0 |
|
PC2A | Transfer of patent | ||
PC2A | Transfer of patent | ||
PC2A | Transfer of patent |
Owner name: ALMIRALL S.A. Effective date: 20130315 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20141120 |