ES2100125A1 - Process for the preparation of methanediol esters of dioxopenicillanic acid - Google Patents
Process for the preparation of methanediol esters of dioxopenicillanic acidInfo
- Publication number
- ES2100125A1 ES2100125A1 ES09501106A ES9501106A ES2100125A1 ES 2100125 A1 ES2100125 A1 ES 2100125A1 ES 09501106 A ES09501106 A ES 09501106A ES 9501106 A ES9501106 A ES 9501106A ES 2100125 A1 ES2100125 A1 ES 2100125A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- esters
- dioxopenicillanic acid
- atom
- amine group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Process for the preparation of methanediol esters of dioxopenicillanic acid 57 Process for the preparation of methandiol esters of 1,1-dioxopenicillanic acid and its pharmaceutically acceptable salts of formula I (Figure I) in which R1 is a hydrogen atom, a lower alkyl residue or with R2 comprises a 5 or 6 carbon ring. R2 is an atom of hydrogen, a lower alkyl, cycloalkenynl or aryl residue which may or may not be substituted by hydroxyl or lower alkoxyl residues and R3 is a free amine group. Compound II, in which R1 and R2 have the meanings above, R3 is a free or protected amine group and R4 is a bromine atom is obtained by hydrogenation in the presence of a noble metal catalyst. Useful in the treatment of bacterial infections. They combine a betalactam antibiotic with a betalactamase inhibitor in a single molecule. <IMAGE>
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9501106A ES2100125B1 (en) | 1995-06-02 | 1995-06-02 | PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9501106A ES2100125B1 (en) | 1995-06-02 | 1995-06-02 | PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2100125A1 true ES2100125A1 (en) | 1997-06-01 |
ES2100125B1 ES2100125B1 (en) | 1998-04-01 |
Family
ID=8290613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9501106A Expired - Fee Related ES2100125B1 (en) | 1995-06-02 | 1995-06-02 | PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2100125B1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2161602A1 (en) * | 1999-04-08 | 2001-12-01 | Astur Pharma Sa | SYNTHESIS OF 1,1-DIOXOPENICILLANOYLOXYMETHYL 6-[D-alpha-(BENZYLIDENEAMINOPHENYLACETAMIDO)-PENICILLINATE AND ITS ANALOGUE, AND NEW INTERMEDIATE IN SYNTHESIS OF SULTAMICILLIN |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8305767A1 (en) * | 1981-03-23 | 1983-04-16 | Pfizer | Process for preparing penicillanic acid 1,1-dioxide derivatives and certain intermediates useful therein. |
ES8403132A1 (en) * | 1981-03-23 | 1984-03-01 | Pfizer | Process and intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates. |
ES8504824A1 (en) * | 1982-12-06 | 1985-05-01 | Pfizer | Process and intermediates for sultamicillin and analogs. |
ES2039299A1 (en) * | 1991-10-04 | 1993-09-16 | Asturpharma S A | Process for obtaining 1,1-dioxopenicillanic acid esters and their salts |
-
1995
- 1995-06-02 ES ES9501106A patent/ES2100125B1/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8305767A1 (en) * | 1981-03-23 | 1983-04-16 | Pfizer | Process for preparing penicillanic acid 1,1-dioxide derivatives and certain intermediates useful therein. |
ES8403132A1 (en) * | 1981-03-23 | 1984-03-01 | Pfizer | Process and intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates. |
ES8504824A1 (en) * | 1982-12-06 | 1985-05-01 | Pfizer | Process and intermediates for sultamicillin and analogs. |
ES2039299A1 (en) * | 1991-10-04 | 1993-09-16 | Asturpharma S A | Process for obtaining 1,1-dioxopenicillanic acid esters and their salts |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2161602A1 (en) * | 1999-04-08 | 2001-12-01 | Astur Pharma Sa | SYNTHESIS OF 1,1-DIOXOPENICILLANOYLOXYMETHYL 6-[D-alpha-(BENZYLIDENEAMINOPHENYLACETAMIDO)-PENICILLINATE AND ITS ANALOGUE, AND NEW INTERMEDIATE IN SYNTHESIS OF SULTAMICILLIN |
Also Published As
Publication number | Publication date |
---|---|
ES2100125B1 (en) | 1998-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19970601 Kind code of ref document: A1 Effective date: 19970601 |
|
FD1A | Patent lapsed |
Effective date: 20050603 |