ES2100125A1 - Process for the preparation of methanediol esters of dioxopenicillanic acid - Google Patents

Process for the preparation of methanediol esters of dioxopenicillanic acid

Info

Publication number
ES2100125A1
ES2100125A1 ES09501106A ES9501106A ES2100125A1 ES 2100125 A1 ES2100125 A1 ES 2100125A1 ES 09501106 A ES09501106 A ES 09501106A ES 9501106 A ES9501106 A ES 9501106A ES 2100125 A1 ES2100125 A1 ES 2100125A1
Authority
ES
Spain
Prior art keywords
preparation
esters
dioxopenicillanic acid
atom
amine group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09501106A
Other languages
Spanish (es)
Other versions
ES2100125B1 (en
Inventor
Pinilla Paloma Esteban
Simon Jose Fernandez
Martin Juan Antonio Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AsturPharma SA
Original Assignee
AsturPharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AsturPharma SA filed Critical AsturPharma SA
Priority to ES9501106A priority Critical patent/ES2100125B1/en
Publication of ES2100125A1 publication Critical patent/ES2100125A1/en
Application granted granted Critical
Publication of ES2100125B1 publication Critical patent/ES2100125B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Process for the preparation of methanediol esters of dioxopenicillanic acid 57 Process for the preparation of methandiol esters of 1,1-dioxopenicillanic acid and its pharmaceutically acceptable salts of formula I (Figure I) in which R1 is a hydrogen atom, a lower alkyl residue or with R2 comprises a 5 or 6 carbon ring. R2 is an atom of hydrogen, a lower alkyl, cycloalkenynl or aryl residue which may or may not be substituted by hydroxyl or lower alkoxyl residues and R3 is a free amine group. Compound II, in which R1 and R2 have the meanings above, R3 is a free or protected amine group and R4 is a bromine atom is obtained by hydrogenation in the presence of a noble metal catalyst. Useful in the treatment of bacterial infections. They combine a betalactam antibiotic with a betalactamase inhibitor in a single molecule. <IMAGE>
ES9501106A 1995-06-02 1995-06-02 PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID. Expired - Fee Related ES2100125B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9501106A ES2100125B1 (en) 1995-06-02 1995-06-02 PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9501106A ES2100125B1 (en) 1995-06-02 1995-06-02 PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID.

Publications (2)

Publication Number Publication Date
ES2100125A1 true ES2100125A1 (en) 1997-06-01
ES2100125B1 ES2100125B1 (en) 1998-04-01

Family

ID=8290613

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9501106A Expired - Fee Related ES2100125B1 (en) 1995-06-02 1995-06-02 PROCEDURE FOR THE PREPARATION OF METHANODIOL ESTERS OF DIOXOPENICILANIC ACID.

Country Status (1)

Country Link
ES (1) ES2100125B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2161602A1 (en) * 1999-04-08 2001-12-01 Astur Pharma Sa SYNTHESIS OF 1,1-DIOXOPENICILLANOYLOXYMETHYL 6-[D-alpha-(BENZYLIDENEAMINOPHENYLACETAMIDO)-PENICILLINATE AND ITS ANALOGUE, AND NEW INTERMEDIATE IN SYNTHESIS OF SULTAMICILLIN

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8305767A1 (en) * 1981-03-23 1983-04-16 Pfizer Process for preparing penicillanic acid 1,1-dioxide derivatives and certain intermediates useful therein.
ES8403132A1 (en) * 1981-03-23 1984-03-01 Pfizer Process and intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates.
ES8504824A1 (en) * 1982-12-06 1985-05-01 Pfizer Process and intermediates for sultamicillin and analogs.
ES2039299A1 (en) * 1991-10-04 1993-09-16 Asturpharma S A Process for obtaining 1,1-dioxopenicillanic acid esters and their salts

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8305767A1 (en) * 1981-03-23 1983-04-16 Pfizer Process for preparing penicillanic acid 1,1-dioxide derivatives and certain intermediates useful therein.
ES8403132A1 (en) * 1981-03-23 1984-03-01 Pfizer Process and intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates.
ES8504824A1 (en) * 1982-12-06 1985-05-01 Pfizer Process and intermediates for sultamicillin and analogs.
ES2039299A1 (en) * 1991-10-04 1993-09-16 Asturpharma S A Process for obtaining 1,1-dioxopenicillanic acid esters and their salts

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2161602A1 (en) * 1999-04-08 2001-12-01 Astur Pharma Sa SYNTHESIS OF 1,1-DIOXOPENICILLANOYLOXYMETHYL 6-[D-alpha-(BENZYLIDENEAMINOPHENYLACETAMIDO)-PENICILLINATE AND ITS ANALOGUE, AND NEW INTERMEDIATE IN SYNTHESIS OF SULTAMICILLIN

Also Published As

Publication number Publication date
ES2100125B1 (en) 1998-04-01

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