UY23929A1 - PROCEDURE FOR THE PREPARATION OF INDEOL DERIVATIVES - Google Patents
PROCEDURE FOR THE PREPARATION OF INDEOL DERIVATIVESInfo
- Publication number
- UY23929A1 UY23929A1 UY23929A UY23929A UY23929A1 UY 23929 A1 UY23929 A1 UY 23929A1 UY 23929 A UY23929 A UY 23929A UY 23929 A UY23929 A UY 23929A UY 23929 A1 UY23929 A1 UY 23929A1
- Authority
- UY
- Uruguay
- Prior art keywords
- indole
- preparation
- derivatives
- aminoethyl
- boron hydride
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion se refiere a un nuevo procedimiento de preparacion de derivados del indol de formula (I) (figura 1) y sales farmacéuticamente aceptables de los mismos, donde Z representa a un anillo, el cual comprende: metilar un aminoetil-indol con formaldehído y un hidruro complejo de boro (como hidruro de boro y sodio o cianoborohidruro de sodio). También es de alcance un procedimiento para la obtención del aminoetil-indol mencionado a partir de una hidrazina con 4-clorobutiraldehído o un derivado reactivo delmismo para formar una hidrazona (para luego ser calentada). Ejemplo no limitante: 1-[[3-(2-dimetilaminoetil)-5-indolil]metanosulfonil]pirrolidina. Los productos de la invención son adecuados para el tratamiento o prevención de la migraña y otros dolores asociados con trastornos vasculares, depresión, ansiedad, trastornos del equilibrio.The present invention refers to a new process for the preparation of indole derivatives of formula (I) (figure 1) and pharmaceutically acceptable salts thereof, where Z represents a ring, which comprises: methylating an aminoethyl-indole with formaldehyde and a complex boron hydride (such as sodium boron hydride or sodium cyanoborohydride). A process for obtaining the aforementioned aminoethyl-indole from a hydrazine with 4-chlorobutyraldehyde or a reactive derivative thereof to form a hydrazone (to later be heated) is also within reach. Non-limiting example: 1 - [[3- (2-dimethylaminoethyl) -5-indolyl] methanesulfonyl] pyrrolidine. The products of the invention are suitable for the treatment or prevention of migraine headaches and other pain associated with vascular disorders, depression, anxiety, balance disorders.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9400481A ES2084560B1 (en) | 1994-03-09 | 1994-03-09 | EL INDOL DERIVATIVES PREPARATION PROCEDURE. |
Publications (1)
Publication Number | Publication Date |
---|---|
UY23929A1 true UY23929A1 (en) | 1995-03-21 |
Family
ID=8285486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY23929A UY23929A1 (en) | 1994-03-09 | 1995-03-09 | PROCEDURE FOR THE PREPARATION OF INDEOL DERIVATIVES |
Country Status (6)
Country | Link |
---|---|
BR (1) | BR9500821A (en) |
CO (1) | CO4340738A1 (en) |
EG (1) | EG20611A (en) |
ES (1) | ES2084560B1 (en) |
FI (1) | FI116837B (en) |
UY (1) | UY23929A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7943784B2 (en) * | 2005-07-25 | 2011-05-17 | Matrix Laboratories Limited | Process for the preparation of almotriptan |
EP2774605A1 (en) | 2013-02-06 | 2014-09-10 | Galenicum Health S.L. | Pharmaceutical composition comprising almotriptan malate having uniform drug distribution and potency |
CN106478484B (en) * | 2016-08-31 | 2017-11-10 | 重庆华森制药股份有限公司 | A kind of method for preparing almotriptan key intermediate |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3131728A1 (en) * | 1980-08-12 | 1982-03-11 | Glaxo Group Ltd., London | INDOLDE COMPOUNDS, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
GB8332437D0 (en) * | 1983-12-06 | 1984-01-11 | Glaxo Group Ltd | Chemical compounds |
GB8419575D0 (en) * | 1984-08-01 | 1984-09-05 | Glaxo Group Ltd | Chemical compounds |
ES2033578B1 (en) * | 1991-06-06 | 1995-01-16 | Quimica Sint S A Con El 50 | PROCEDURE FOR OBTAINING 3- (2- (DIMETHYLAMINE) ETHYL) -N-METHYL-1H-INDOL-5-METHANOSULFONAMIDE. |
ES2033577B1 (en) * | 1991-06-06 | 1995-01-16 | Quimica Sint S A Con El 50 | PROCEDURE FOR OBTAINING 2-CARBOXY-3- (2- (DIMETHYLAMINE) ETHYL) -N-METHYL-1H-INDOL-5-METHANOSULFONAMIDE AND ITS LOWER ALKYL ESTERS. |
-
1994
- 1994-03-09 ES ES9400481A patent/ES2084560B1/en not_active Expired - Fee Related
-
1995
- 1995-03-06 BR BR9500821A patent/BR9500821A/en not_active Application Discontinuation
- 1995-03-07 FI FI951047A patent/FI116837B/en not_active IP Right Cessation
- 1995-03-07 CO CO95008919A patent/CO4340738A1/en unknown
- 1995-03-08 EG EG17595A patent/EG20611A/en active
- 1995-03-09 UY UY23929A patent/UY23929A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI951047A0 (en) | 1995-03-07 |
FI116837B (en) | 2006-03-15 |
FI951047A (en) | 1995-09-10 |
CO4340738A1 (en) | 1996-07-30 |
EG20611A (en) | 1999-09-30 |
ES2084560A1 (en) | 1996-05-01 |
BR9500821A (en) | 1995-11-21 |
ES2084560B1 (en) | 1997-01-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
VENC | Patent expired |
Effective date: 20141115 |