UY23929A1 - PROCEDURE FOR THE PREPARATION OF INDEOL DERIVATIVES - Google Patents

PROCEDURE FOR THE PREPARATION OF INDEOL DERIVATIVES

Info

Publication number
UY23929A1
UY23929A1 UY23929A UY23929A UY23929A1 UY 23929 A1 UY23929 A1 UY 23929A1 UY 23929 A UY23929 A UY 23929A UY 23929 A UY23929 A UY 23929A UY 23929 A1 UY23929 A1 UY 23929A1
Authority
UY
Uruguay
Prior art keywords
indole
preparation
derivatives
aminoethyl
boron hydride
Prior art date
Application number
UY23929A
Other languages
Spanish (es)
Inventor
Duran Carles Puig
Forner Dolors Fernandez
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of UY23929A1 publication Critical patent/UY23929A1/en

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a un nuevo procedimiento de preparacion de derivados del indol de formula (I) (figura 1) y sales farmacéuticamente aceptables de los mismos, donde Z representa a un anillo, el cual comprende: metilar un aminoetil-indol con formaldehído y un hidruro complejo de boro (como hidruro de boro y sodio o cianoborohidruro de sodio). También es de alcance un procedimiento para la obtención del aminoetil-indol mencionado a partir de una hidrazina con 4-clorobutiraldehído o un derivado reactivo delmismo para formar una hidrazona (para luego ser calentada). Ejemplo no limitante: 1-[[3-(2-dimetilaminoetil)-5-indolil]metanosulfonil]pirrolidina. Los productos de la invención son adecuados para el tratamiento o prevención de la migraña y otros dolores asociados con trastornos vasculares, depresión, ansiedad, trastornos del equilibrio.The present invention refers to a new process for the preparation of indole derivatives of formula (I) (figure 1) and pharmaceutically acceptable salts thereof, where Z represents a ring, which comprises: methylating an aminoethyl-indole with formaldehyde and a complex boron hydride (such as sodium boron hydride or sodium cyanoborohydride). A process for obtaining the aforementioned aminoethyl-indole from a hydrazine with 4-chlorobutyraldehyde or a reactive derivative thereof to form a hydrazone (to later be heated) is also within reach. Non-limiting example: 1 - [[3- (2-dimethylaminoethyl) -5-indolyl] methanesulfonyl] pyrrolidine. The products of the invention are suitable for the treatment or prevention of migraine headaches and other pain associated with vascular disorders, depression, anxiety, balance disorders.

UY23929A 1994-03-09 1995-03-09 PROCEDURE FOR THE PREPARATION OF INDEOL DERIVATIVES UY23929A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9400481A ES2084560B1 (en) 1994-03-09 1994-03-09 EL INDOL DERIVATIVES PREPARATION PROCEDURE.

Publications (1)

Publication Number Publication Date
UY23929A1 true UY23929A1 (en) 1995-03-21

Family

ID=8285486

Family Applications (1)

Application Number Title Priority Date Filing Date
UY23929A UY23929A1 (en) 1994-03-09 1995-03-09 PROCEDURE FOR THE PREPARATION OF INDEOL DERIVATIVES

Country Status (6)

Country Link
BR (1) BR9500821A (en)
CO (1) CO4340738A1 (en)
EG (1) EG20611A (en)
ES (1) ES2084560B1 (en)
FI (1) FI116837B (en)
UY (1) UY23929A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7943784B2 (en) * 2005-07-25 2011-05-17 Matrix Laboratories Limited Process for the preparation of almotriptan
EP2774605A1 (en) 2013-02-06 2014-09-10 Galenicum Health S.L. Pharmaceutical composition comprising almotriptan malate having uniform drug distribution and potency
CN106478484B (en) * 2016-08-31 2017-11-10 重庆华森制药股份有限公司 A kind of method for preparing almotriptan key intermediate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3131728A1 (en) * 1980-08-12 1982-03-11 Glaxo Group Ltd., London INDOLDE COMPOUNDS, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
ES2033578B1 (en) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 PROCEDURE FOR OBTAINING 3- (2- (DIMETHYLAMINE) ETHYL) -N-METHYL-1H-INDOL-5-METHANOSULFONAMIDE.
ES2033577B1 (en) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 PROCEDURE FOR OBTAINING 2-CARBOXY-3- (2- (DIMETHYLAMINE) ETHYL) -N-METHYL-1H-INDOL-5-METHANOSULFONAMIDE AND ITS LOWER ALKYL ESTERS.

Also Published As

Publication number Publication date
FI951047A0 (en) 1995-03-07
FI116837B (en) 2006-03-15
FI951047A (en) 1995-09-10
CO4340738A1 (en) 1996-07-30
EG20611A (en) 1999-09-30
ES2084560A1 (en) 1996-05-01
BR9500821A (en) 1995-11-21
ES2084560B1 (en) 1997-01-16

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VENC Patent expired

Effective date: 20141115