ES2068404T3 - Un metodo para aislar el factor viii. - Google Patents
Un metodo para aislar el factor viii.Info
- Publication number
- ES2068404T3 ES2068404T3 ES90917201T ES90917201T ES2068404T3 ES 2068404 T3 ES2068404 T3 ES 2068404T3 ES 90917201 T ES90917201 T ES 90917201T ES 90917201 T ES90917201 T ES 90917201T ES 2068404 T3 ES2068404 T3 ES 2068404T3
- Authority
- ES
- Spain
- Prior art keywords
- factor viii
- isolating
- proteins
- plasma
- practically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229960000301 factor viii Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 210000002381 plasma Anatomy 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Amplifiers (AREA)
- Cephalosporin Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Networks Using Active Elements (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Separation By Low-Temperature Treatments (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE PRESENTA UN METODO PARA AISLAR EL FACTOR VIII DE OTRAS PROTEINAS DISUELTAS EN EL PLASMA SANGUINEO, EN DONDE EL PLASMA SE SOMETE A UNA FILTRACION EN GEL BAJO CONDICIONES DE SEPARACION DEL GRUPO CON LO QUE SE OBTIENE UNA FRACCION QUE CONTIENE EL FACTOR VIII EN UN RENDIMIENTO MUY ELEVADO Y PRACTICAMENTE SIN OTRAS PROTEINAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK562189A DK162233C (da) | 1989-11-09 | 1989-11-09 | Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2068404T3 true ES2068404T3 (es) | 1995-04-16 |
Family
ID=8144000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90917201T Expired - Lifetime ES2068404T3 (es) | 1989-11-09 | 1990-11-05 | Un metodo para aislar el factor viii. |
Country Status (26)
Country | Link |
---|---|
US (1) | US5245014A (es) |
EP (1) | EP0524172B1 (es) |
JP (1) | JP2509407B2 (es) |
CN (1) | CN1044121C (es) |
AT (1) | ATE118508T1 (es) |
AU (1) | AU631471B2 (es) |
BG (1) | BG61231B1 (es) |
CA (1) | CA2073012C (es) |
CZ (1) | CZ537190A3 (es) |
DE (1) | DE69017050T2 (es) |
DK (1) | DK162233C (es) |
ES (1) | ES2068404T3 (es) |
FI (1) | FI103510B (es) |
HU (1) | HU214905B (es) |
IE (1) | IE66836B1 (es) |
IL (1) | IL96277A (es) |
NO (1) | NO180741C (es) |
NZ (1) | NZ236004A (es) |
PL (1) | PL164894B1 (es) |
PT (1) | PT95830B (es) |
RU (1) | RU2055593C1 (es) |
SK (1) | SK537190A3 (es) |
UA (1) | UA29421C2 (es) |
WO (1) | WO1991007438A1 (es) |
YU (1) | YU47524B (es) |
ZA (1) | ZA908599B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0399321B1 (en) * | 1989-05-24 | 1993-06-23 | Miles Inc. | Gel filtration of heat treated factor viii |
US5888974A (en) * | 1992-04-07 | 1999-03-30 | Emory University | Hybrid human/animal factor VIII |
US6180371B1 (en) | 1996-06-26 | 2001-01-30 | Emory University | Modified factor VIII |
US5859204A (en) * | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
US5659017A (en) * | 1995-11-07 | 1997-08-19 | Alpha Therapeutic Corporation | Anion exchange process for the purification of Factor VIII |
US7560107B2 (en) | 1996-06-26 | 2009-07-14 | Emory University | Modified factor VIII |
US6458563B1 (en) | 1996-06-26 | 2002-10-01 | Emory University | Modified factor VIII |
US6531577B1 (en) * | 1997-12-15 | 2003-03-11 | Hemasure Denmark A/S | von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations |
US6290527B1 (en) * | 1998-07-03 | 2001-09-18 | Nippon Telegraph And Telephone Corp. | Nippon telegraph and telephone corporation |
BR0008405B1 (pt) | 1999-02-22 | 2014-04-22 | Baxter Int | Composição de fator viii formulada sem a adição de albumina, uso de uma composição de fator viii, e, método de liofilizar uma formulação farmacêutica aquosa |
JP2002348300A (ja) * | 1999-04-12 | 2002-12-04 | Fujimori Kogyo Co Ltd | 血液凝固第viii因子および血液凝固第viii因子/フォン・ビルブラント因子複合体の精製方法 |
AUPR638801A0 (en) * | 2001-07-13 | 2001-08-09 | Life Therapeutics Limited | Factor viii separation |
PL1750733T3 (pl) | 2004-05-03 | 2014-05-30 | Univ Emory | Sposób podawania świńskiego czynnika krzepnięcia VIII pozbawionego domeny B |
WO2006021584A2 (en) * | 2004-08-27 | 2006-03-02 | Novo Nordisk Health Care Ag | Purification of factor xiii polypeptides from biological materials |
US20060226086A1 (en) * | 2005-04-08 | 2006-10-12 | Robinson Thomas C | Centrifuge for blood processing systems |
US20100168018A1 (en) * | 2008-11-07 | 2010-07-01 | Baxter International Inc. | Factor viii formulations |
DK3133157T3 (da) * | 2010-03-30 | 2019-08-12 | Octapharma Ag | Fremgangsmåde til oprensning af vitamin k-afhængige proteiner |
RU2445974C2 (ru) * | 2010-04-26 | 2012-03-27 | Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН | Способ получения концентрата фактора viii из плазмы крови человека |
EP2635297B1 (en) | 2010-11-05 | 2019-02-27 | Baxalta GmbH | A new variant of antihemophilic factor viii having increased specific activity |
WO2012082933A1 (en) | 2010-12-15 | 2012-06-21 | Baxter International, Inc. | Eluate collection using conductivity gradient |
CN103506080A (zh) * | 2012-06-19 | 2014-01-15 | 汪志友 | 一种用于分离纯化凝血因子viii的介质及其制备方法 |
US11078518B2 (en) * | 2012-09-28 | 2021-08-03 | Chugai Seiyaku Kabushiki Kaisha | Method for evaluating blood coagulation reaction |
US9663553B2 (en) * | 2014-01-29 | 2017-05-30 | Hemarus Therapeutics Limited | Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4495175A (en) * | 1982-08-05 | 1985-01-22 | University Of Rochester | Preparation of highly purified human antihemophilic factor |
US4543210A (en) * | 1984-10-04 | 1985-09-24 | Miles Laboratories, Inc. | Process for producing a high purity antihemophilic factor concentrate |
DK525384D0 (da) * | 1984-11-05 | 1984-11-05 | Nordisk Insulinlab | Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat |
US4847362A (en) * | 1985-02-01 | 1989-07-11 | New York University | Method for purifying antihemophilic factor |
US4675385A (en) * | 1985-03-27 | 1987-06-23 | Alpha Therapeutic Corporation | Isolation of human plasma procoagulant protein factor VIII from biological factors |
US4758657A (en) * | 1985-07-11 | 1988-07-19 | Armour Pharmaceutical Company | Method of purifying Factor VIII:C |
AT391808B (de) * | 1986-11-03 | 1990-12-10 | Immuno Ag | Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion |
EP0321835B1 (en) * | 1987-12-21 | 1994-09-28 | Miles Inc. | Gel filteration of factor VIII |
WO1989009784A1 (en) * | 1988-04-08 | 1989-10-19 | Commonwealth Serum Laboratories Commission | Production of heat-stable factor viii concentrate |
EP0399321B1 (en) * | 1989-05-24 | 1993-06-23 | Miles Inc. | Gel filtration of heat treated factor viii |
-
1989
- 1989-11-09 DK DK562189A patent/DK162233C/da not_active IP Right Cessation
-
1990
- 1990-10-26 ZA ZA908599A patent/ZA908599B/xx unknown
- 1990-11-01 SK SK5371-90A patent/SK537190A3/sk unknown
- 1990-11-01 CZ CS905371A patent/CZ537190A3/cs unknown
- 1990-11-05 WO PCT/DK1990/000279 patent/WO1991007438A1/en active IP Right Grant
- 1990-11-05 DE DE69017050T patent/DE69017050T2/de not_active Expired - Fee Related
- 1990-11-05 EP EP90917201A patent/EP0524172B1/en not_active Expired - Lifetime
- 1990-11-05 AU AU67470/90A patent/AU631471B2/en not_active Ceased
- 1990-11-05 RU SU905052211A patent/RU2055593C1/ru active
- 1990-11-05 JP JP3500067A patent/JP2509407B2/ja not_active Expired - Lifetime
- 1990-11-05 ES ES90917201T patent/ES2068404T3/es not_active Expired - Lifetime
- 1990-11-05 UA UA94020494A patent/UA29421C2/uk unknown
- 1990-11-05 HU HU9201551A patent/HU214905B/hu unknown
- 1990-11-05 AT AT90917201T patent/ATE118508T1/de not_active IP Right Cessation
- 1990-11-05 CA CA002073012A patent/CA2073012C/en not_active Expired - Lifetime
- 1990-11-07 NZ NZ236004A patent/NZ236004A/xx unknown
- 1990-11-07 US US07/610,480 patent/US5245014A/en not_active Expired - Lifetime
- 1990-11-07 YU YU210590A patent/YU47524B/sh unknown
- 1990-11-08 IL IL9627790A patent/IL96277A/en not_active IP Right Cessation
- 1990-11-08 IE IE402290A patent/IE66836B1/en not_active IP Right Cessation
- 1990-11-08 PT PT95830A patent/PT95830B/pt not_active IP Right Cessation
- 1990-11-09 PL PL90287703A patent/PL164894B1/pl unknown
- 1990-11-09 CN CN90109030A patent/CN1044121C/zh not_active Expired - Lifetime
-
1992
- 1992-05-08 NO NO921839A patent/NO180741C/no not_active IP Right Cessation
- 1992-05-08 FI FI922105A patent/FI103510B/fi active
- 1992-05-08 BG BG96316A patent/BG61231B1/bg unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2068404T3 (es) | Un metodo para aislar el factor viii. | |
AR240990A2 (es) | Procedimiento para la separacion de moleculas de intweres biologico,de una mezcla que las contiene." | |
IT8867767A0 (it) | Metodo di separazione centrifuga del sangue | |
IT8720689A0 (it) | Procedimento e impianto per la separazione di sostanze leggere da miscele di substrati. | |
NO880866D0 (no) | Apparat for separasjon av blodbestanddeler. | |
DE69017826D1 (de) | Membranverfahren zum Trennen von organischen Flüssigkeiten. | |
CY1105206T1 (el) | Διαδικασια για την εκχυλιση και χρησιμοποιηση υγρου επωασης απο σολομο του ατλαντικου | |
ES8504246A1 (es) | Un metodo para la preparacion de las proteasas fibrinoliticamente activas | |
DE3851400D1 (de) | Raffinierungsverfahren von Äthylenglycol. | |
ES2054612T3 (es) | Secuencias de adn que codifican para proteinas con actividad biologica de los inhibidores husi tipo-i y procedimientos tecnologicos geneticos para la preparacion de estas proteinas. | |
ES2148890T3 (es) | Procedimiento para la preparacion de tamices moleculares con contenido en titanio. | |
IT8619893A0 (it) | Procedimento per la estrazione di paraffine da miscele delle stesse con acidi alcansolfonici. | |
MY113294A (en) | A process for the preparation of a virus inactivated fraction containing factor viii by means of chromatographic methods | |
IT8221059A0 (it) | Procedimento per la separazione delle miscele di idrocarburi aromatici nei singoli componenti. | |
ATE66931T1 (de) | Verfahren zur scheidung und isolierung von nosiheptid. | |
SU1175872A1 (ru) | Способ выделени оксотетрахлорида вольфрама | |
DE3785852D1 (de) | Verfahren zur chromatographischen trennung von metallionen. | |
IT8441665A0 (it) | Metodo di separazione di policarbonato aromatico da una sua soluzione. | |
IT8622246A0 (it) | Processo per la debromurazione di derivati del naftalene. | |
ATE93545T1 (de) | Extraktion von probesubstanzen. | |
IT8621545A0 (it) | Procedimento per la raffinazione di oli vegetali. | |
ATE74365T1 (de) | Dipeptid-derivate von fettsaeure, verfahren zu ihrer herstellung, heilmittel, das sie enthaelt und anwendung. | |
ATE80142T1 (de) | Verfahren zur herstellung von alpha,betaunges|ttigten aldehyden. | |
IT8719685A0 (it) | Lamiera raspante per l'estrazione di olii essenziali dalla scorza di frutti interi, particolarmente di agrumi interi. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 524172 Country of ref document: ES |