ES2064374T3 - Escision especifica de enlaces peptidicos mediante fosfinas organicas que tienen cadenas laterales nucleofilas. - Google Patents

Escision especifica de enlaces peptidicos mediante fosfinas organicas que tienen cadenas laterales nucleofilas.

Info

Publication number
ES2064374T3
ES2064374T3 ES89103906T ES89103906T ES2064374T3 ES 2064374 T3 ES2064374 T3 ES 2064374T3 ES 89103906 T ES89103906 T ES 89103906T ES 89103906 T ES89103906 T ES 89103906T ES 2064374 T3 ES2064374 T3 ES 2064374T3
Authority
ES
Spain
Prior art keywords
nucleophylal
peptidic
links
side chains
organic phosphines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89103906T
Other languages
English (en)
Inventor
Lois M Hinman
Libby S Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meda Pharmaceuticals Inc
Original Assignee
Carter Wallace Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carter Wallace Inc filed Critical Carter Wallace Inc
Application granted granted Critical
Publication of ES2064374T3 publication Critical patent/ES2064374T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5004—Acyclic saturated phosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/128—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general sequencing

Abstract

NUEVOS ORGANOFOSFUROS TERCIARIOS NUCLEOFILICOS Y LA ROTURA ESPECIFICA DE PEPTIDO DEBIDA A ORGANOFOSFUROS TERCIARIOS NUCLEOFILICOS. ESTA INVENCION ES DE PARTICULAR UTILIDAD PROVEIENDO AGENTES QUIMICOS PARA USAR EN LA ROTURA DE PROTEINAS Y LA DETERMINACION DE LA SECUENCIA DE AMINO ACIDOS DE LAS PROTEINAS.
ES89103906T 1988-04-01 1989-03-06 Escision especifica de enlaces peptidicos mediante fosfinas organicas que tienen cadenas laterales nucleofilas. Expired - Lifetime ES2064374T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17657188A 1988-04-01 1988-04-01
US17657388A 1988-04-01 1988-04-01

Publications (1)

Publication Number Publication Date
ES2064374T3 true ES2064374T3 (es) 1995-02-01

Family

ID=26872381

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89103906T Expired - Lifetime ES2064374T3 (es) 1988-04-01 1989-03-06 Escision especifica de enlaces peptidicos mediante fosfinas organicas que tienen cadenas laterales nucleofilas.

Country Status (6)

Country Link
EP (1) EP0339217B1 (es)
JP (1) JPH0215092A (es)
AT (1) ATE111918T1 (es)
CA (1) CA1330800C (es)
DE (1) DE68918323T2 (es)
ES (1) ES2064374T3 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL213309B1 (pl) 2006-02-09 2013-02-28 Polska Akademia Nauk Inst Biochemii I Biofizyki Sposób hydrolizy wiazania peptydowego
JP5501439B2 (ja) 2009-04-02 2014-05-21 ロシュ グリクアート アクチェンゲゼルシャフト 完全長抗体と単鎖Ｆａｂフラグメントとを含む多重特異的抗体
CN104945509A (zh) 2009-09-16 2015-09-30 弗·哈夫曼-拉罗切有限公司 包含卷曲螺旋和/或系链的蛋白质复合体及其用途
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
CN103068846B9 (zh) 2010-08-24 2016-09-28 弗·哈夫曼-拉罗切有限公司 包含二硫键稳定性Fv片段的双特异性抗体
EP2655413B1 (en) 2010-12-23 2019-01-16 F.Hoffmann-La Roche Ag Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
BR112014019579A2 (pt) 2012-02-10 2019-10-15 Genentech, Inc Anticorpo de cadeia única, polinucleotídeo, vetor, célula hospedeira, método de produção de um anticorpo de cadeia única, heteromultímero e método de produção do heteromultímero
RU2639287C2 (ru) 2012-06-27 2017-12-20 Ф. Хоффманн-Ля Рош Аг Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения
WO2014001325A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
ES2764111T3 (es) 2014-12-03 2020-06-02 Hoffmann La Roche Anticuerpos multiespecíficos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3628910A (en) * 1966-05-02 1971-12-21 American Cyanamid Co Compositions for the deformation of keratin
FR1574239A (es) * 1967-07-12 1969-07-11
US3754035A (en) * 1970-01-29 1973-08-21 American Cyanamid Co Tertiary organophosphines
US3970532A (en) * 1975-01-16 1976-07-20 Borg-Warner Corporation 2-Hydroxyethylphosphines

Also Published As

Publication number Publication date
EP0339217A3 (en) 1990-01-03
ATE111918T1 (de) 1994-10-15
DE68918323T2 (de) 1995-05-18
DE68918323D1 (de) 1994-10-27
JPH0215092A (ja) 1990-01-18
CA1330800C (en) 1994-07-19
EP0339217B1 (en) 1994-09-21
EP0339217A2 (en) 1989-11-02

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