ES2053609T3 - Derivados de urea inhibidores de lipoxigenasa. - Google Patents
Derivados de urea inhibidores de lipoxigenasa.Info
- Publication number
- ES2053609T3 ES2053609T3 ES88106373T ES88106373T ES2053609T3 ES 2053609 T3 ES2053609 T3 ES 2053609T3 ES 88106373 T ES88106373 T ES 88106373T ES 88106373 T ES88106373 T ES 88106373T ES 2053609 T3 ES2053609 T3 ES 2053609T3
- Authority
- ES
- Spain
- Prior art keywords
- lipoxigenasa
- urea
- inhibitors
- derivatives
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Abstract
COMPUESTOS DE FORMULA (I) DONDE R1 Y R2, R3 Y R4, TIENEN EL SIGNIFICADO QUE SE DETALLA EN LA INVENCION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4249187A | 1987-04-24 | 1987-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2053609T3 true ES2053609T3 (es) | 1994-08-01 |
Family
ID=21922212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88106373T Expired - Lifetime ES2053609T3 (es) | 1987-04-24 | 1988-04-21 | Derivados de urea inhibidores de lipoxigenasa. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0292699B1 (es) |
JP (1) | JPS63284155A (es) |
CA (1) | CA1336099C (es) |
DE (1) | DE3888574T2 (es) |
ES (1) | ES2053609T3 (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5084575A (en) * | 1987-07-31 | 1992-01-28 | American Home Products Corporation | Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents |
US5068251A (en) * | 1988-12-16 | 1991-11-26 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
GB8830427D0 (en) * | 1988-12-30 | 1989-03-01 | Fujisawa Pharmaceutical Co | New hydroxylamine derivatives,a process for the preparation thereof and pharmaceutical composition comprising the same |
US5096919A (en) * | 1989-01-05 | 1992-03-17 | Ciba-Geigy Corporation | Pyrrolylphenyl-substituted hydroxamic acid derivatives |
US5175183A (en) * | 1989-02-01 | 1992-12-29 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
EP0456760A4 (en) * | 1989-02-01 | 1992-01-08 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
MC2091A1 (fr) * | 1989-02-03 | 1991-02-15 | Wellcome Found | Procedes pour la preparation de composes a action anti-inflammatoire et de formulations pharmaceutiques les contenant |
US4960787A (en) * | 1989-02-06 | 1990-10-02 | Ciba-Geigy Corporation | Certain pyrrolyl-substituted hydroxamic acid derivatives |
EP0588785A1 (en) * | 1989-03-30 | 1994-03-30 | Abbott Laboratories | Urea based lipoxygenase inhibiting compounds |
US5112846A (en) * | 1989-05-26 | 1992-05-12 | Warner-Lambert Company | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents |
US4981865A (en) * | 1989-05-26 | 1991-01-01 | Warner-Lambert Co. | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents |
US5075330A (en) * | 1989-05-26 | 1991-12-24 | Warner-Lambert Co. | N-hydroxyamide, N-hydroxythioamide, N-hydroxyurea, and N-hydroxythiourea derivatives of selected NSAIDS as antiinflammatory agents |
US5155130A (en) * | 1989-08-11 | 1992-10-13 | Ciba-Geigy Corporation | Certain benzopyran and benzothiopyran derivatives |
US5120752A (en) * | 1989-12-28 | 1992-06-09 | Abbott Laboratories | Cyclopropyl derivative lipoxygenase inhibitors |
US5220059A (en) * | 1990-04-19 | 1993-06-15 | Abbott Laboratories | Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids |
KR900016822A (ko) * | 1990-04-20 | 1990-11-14 | 하라 레이노스께 | 슬라이드 프로젝터 |
GB9012252D0 (en) * | 1990-06-01 | 1990-07-18 | Lilly Industries Ltd | Pharmaceutical compounds |
DK0540673T3 (da) * | 1990-07-25 | 1997-03-24 | Abbott Lab | Acetylen-derivater med lipoxygenaseinhiberende virkning |
US5476873A (en) * | 1990-07-25 | 1995-12-19 | Abbott Laboratories | Acetylene derivatives having lipoxygenase inhibitory activity |
DE4023742A1 (de) * | 1990-07-26 | 1992-01-30 | Gruenenthal Gmbh | Substituierte phenylacetylene, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel |
JP3007138B2 (ja) | 1990-11-27 | 2000-02-07 | ファイザー製薬株式会社 | 新規なヒドロキサム酸とn―ヒドロキシ尿素誘導体およびそれらの組成物 |
JP2528741B2 (ja) * | 1991-01-09 | 1996-08-28 | ファイザー製薬株式会社 | オキサゾ―ル、チアゾ―ルおよびイミダゾ―ル化合物 |
US5120758A (en) * | 1991-02-08 | 1992-06-09 | Ciba-Geigy Corporation | Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors |
US5132319A (en) * | 1991-03-28 | 1992-07-21 | Merck Frosst Canada, Inc. | 1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis |
US5128364A (en) * | 1991-03-28 | 1992-07-07 | Merck Frosst Canada, Inc. | Pyrrolo[1,2-a]indole hydroxylamine derivatives as inhibitors of leukotriene biosynthesis |
US5130485A (en) * | 1991-04-23 | 1992-07-14 | Eli Lilly And Company | N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas useful as 5-lipoxygenase inhibiting agents |
JPH07100687B2 (ja) * | 1991-06-13 | 1995-11-01 | ファイザー製薬株式会社 | 新規なn−ヒドロキシ尿素化合物および組成物 |
JPH0717612B2 (ja) * | 1991-06-28 | 1995-03-01 | ファイザー製薬株式会社 | 新規なテトラヒドロベンズアゼピン誘導体 |
DE4124345A1 (de) * | 1991-07-23 | 1993-01-28 | Gruenenthal Gmbh | Substituierte 3,4-dihydronaphthaline, diese verbindungen enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel |
US5350761A (en) * | 1991-07-30 | 1994-09-27 | Ciba-Geigy Corporation | Indolyl substituted hydroxylamine derivatives |
US5260316A (en) * | 1991-07-30 | 1993-11-09 | Ciba-Geigy Corporation | Isoquinolyl substituted hydroxylamine derivatives |
US5334600A (en) * | 1991-07-30 | 1994-08-02 | Ciba-Geigy Corporation | Isoquinolyl substituted hydroxylamine derivatives |
US5183818A (en) * | 1991-08-27 | 1993-02-02 | Abbott Laboratories | Arylalkylether and arylalkylthioether inhibitors of lipoxygenase enzyme activity |
DE4204686A1 (de) * | 1992-02-17 | 1993-08-19 | Gruenenthal Gmbh | Imidazolylphenolderivate, diese enthaltende arzneimittel sowie ein verfahren zur herstellung dieser verbindungen und arzneimitteln |
US5169854A (en) * | 1992-02-26 | 1992-12-08 | Abbott Laboratories | N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity |
DE4210332C1 (es) * | 1992-03-30 | 1993-07-15 | Gruenenthal Gmbh, 5100 Aachen, De | |
DE4308535A1 (de) * | 1992-03-30 | 1993-10-07 | Volkswagen Ag | Brennkraftmaschine mit einem desaktivierbaren Ladungswechselventil |
EP0679396A1 (en) * | 1994-03-02 | 1995-11-02 | Pfizer Inc. | Use of 3-substituted-2-oxidole-1-carboxamides for the manufacture of a medicament in the treatment and prevention of ischemia induced myocardial injury and cytokine mediated myocardial injury |
US5612377A (en) * | 1994-08-04 | 1997-03-18 | Minnesota Mining And Manufacturing Company | Method of inhibiting leukotriene biosynthesis |
US5578576A (en) * | 1994-09-02 | 1996-11-26 | Dalhousie University | Method and composition for treating intestinal wounds or ulcers |
WO1996023772A1 (fr) * | 1995-02-02 | 1996-08-08 | Nikken Chemicals Co., Ltd. | Derives de n-hydroxyuree |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS608243A (ja) * | 1983-06-29 | 1985-01-17 | Showa Denko Kk | α,αジメチルベンジルヒドロキシルアミン誘導体及び除草剤 |
DK117986A (da) * | 1985-03-16 | 1986-09-17 | Wellcome Found | Arylderivater, fremgangsmaader til deres fremstilling og deres anvendelse |
US4897422A (en) * | 1987-02-10 | 1990-01-30 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
DE3882732T2 (de) * | 1987-02-10 | 1993-12-02 | Abbott Lab | Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen. |
US4769387A (en) * | 1987-11-13 | 1988-09-06 | Abbott Laboratories | Dibenzofuran lipoxygenase inhibiting compounds, compositions and use |
-
1988
- 1988-04-21 ES ES88106373T patent/ES2053609T3/es not_active Expired - Lifetime
- 1988-04-21 EP EP88106373A patent/EP0292699B1/en not_active Expired - Lifetime
- 1988-04-21 DE DE3888574T patent/DE3888574T2/de not_active Expired - Fee Related
- 1988-04-21 CA CA000564751A patent/CA1336099C/en not_active Expired - Fee Related
- 1988-04-22 JP JP63101192A patent/JPS63284155A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA1336099C (en) | 1995-06-27 |
DE3888574D1 (de) | 1994-04-28 |
DE3888574T2 (de) | 1994-06-30 |
JPS63284155A (ja) | 1988-11-21 |
EP0292699A2 (en) | 1988-11-30 |
EP0292699B1 (en) | 1994-03-23 |
EP0292699A3 (en) | 1990-02-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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