ES2057561T3 - Procedimiento para la preparacion de l-alfa-glicerilfosforilcolina y de l-alfa-glicerilfosforiletanolamina. - Google Patents

Procedimiento para la preparacion de l-alfa-glicerilfosforilcolina y de l-alfa-glicerilfosforiletanolamina.

Info

Publication number
ES2057561T3
ES2057561T3 ES90906950T ES90906950T ES2057561T3 ES 2057561 T3 ES2057561 T3 ES 2057561T3 ES 90906950 T ES90906950 T ES 90906950T ES 90906950 T ES90906950 T ES 90906950T ES 2057561 T3 ES2057561 T3 ES 2057561T3
Authority
ES
Spain
Prior art keywords
alpha
glycerylphosphorylethanolamine
glycerylphosphorylcholine
resin
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90906950T
Other languages
English (en)
Inventor
Giovanni Tronconi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Archimica SpA
Original Assignee
Prime European Therapeuticals SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11166558&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2057561(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Prime European Therapeuticals SpA filed Critical Prime European Therapeuticals SpA
Application granted granted Critical
Publication of ES2057561T3 publication Critical patent/ES2057561T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA LA PURIFICACION DE GLICERILFOSFORILCOLINA (GPC) Y DE GLICERILFOSFORILETANOLAMINA (GPE) DE MEZCLAS DESACILADAS BRUTAS OBTENIDAS MEDIANTE LA DESACILACION DE SOJA DESOLEATADAS O BRUTA O DE LECITINA DE HUEVO O DE EXTRACTOS ALCOHOLICOS DE LAS MISMAS QUE CONSISTE EN: A) LA ELUCION DE UNA RESINA CATIONICA EN FORMA ACIDA EQUILIBRADA EN SOLVENTE ANHIDRICO DE LAS SOLUCIONES BRUTAS DEL PASO DE DESACILACION; B) EL LAVADO DE LA RESINA CON ALCOHOLES O AGUA/ALCOHOLES; C) LA OBTENCION DE LA MEZCLA PURA DE NGPC + MGPE MEDIANTE EL LAVADO DE LA RESINA CON AGUA; D) LA SEPARACION DE LA MEZCLA DE NGPC + MGPE MEDIANTE LA ELUCION DE RESINAS BASICAS PARA OBTENER GPC Y GPE PURAS.
ES90906950T 1989-05-08 1990-05-04 Procedimiento para la preparacion de l-alfa-glicerilfosforilcolina y de l-alfa-glicerilfosforiletanolamina. Expired - Lifetime ES2057561T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8920413A IT1229238B (it) 1989-05-08 1989-05-08 Procedimento per la preparazione di l-alfa-glicerilfosforilcolina e l alfa glicerilfosforiletanolammina.

Publications (1)

Publication Number Publication Date
ES2057561T3 true ES2057561T3 (es) 1994-10-16

Family

ID=11166558

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90906950T Expired - Lifetime ES2057561T3 (es) 1989-05-08 1990-05-04 Procedimiento para la preparacion de l-alfa-glicerilfosforilcolina y de l-alfa-glicerilfosforiletanolamina.

Country Status (11)

Country Link
US (1) US5250719A (es)
EP (1) EP0471706B1 (es)
JP (1) JP2883202B2 (es)
AT (1) ATE109785T1 (es)
AU (1) AU5550490A (es)
CA (1) CA2055503C (es)
DE (1) DE69011516T2 (es)
DK (1) DK0471706T3 (es)
ES (1) ES2057561T3 (es)
IT (1) IT1229238B (es)
WO (1) WO1990013552A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE158295T1 (de) * 1991-07-04 1997-10-15 Asta Medica Ag Verfahren zur herstellung von alkylphosphocholinen und reinherstellung derselben
GB9201371D0 (en) * 1992-01-22 1992-03-11 Enzymatix Ltd Crystallisation process
IT1254991B (it) * 1992-06-24 1995-10-11 Chemi Spa Procedimento per la preparazione di glicerofosfolipidi
US5917068A (en) * 1995-12-29 1999-06-29 Eastman Chemical Company Polyunsaturated fatty acid and fatty acid ester mixtures free of sterols and phosphorus compounds
US6063946A (en) * 1996-01-26 2000-05-16 Eastman Chemical Company Process for the isolation of polyunsaturated fatty acids and esters thereof from complex mixtures which contain sterols and phosphorus compounds
US6200624B1 (en) 1996-01-26 2001-03-13 Abbott Laboratories Enteral formula or nutritional supplement containing arachidonic and docosahexaenoic acids
US5883273A (en) * 1996-01-26 1999-03-16 Abbott Laboratories Polyunsaturated fatty acids and fatty acid esters free of sterols and phosphorus compounds
US8835665B2 (en) * 2008-06-02 2014-09-16 University Of Saskatchewan Recovery of multiple compounds and recyclable water from thin stillage
US8658401B2 (en) * 2011-03-24 2014-02-25 Jiannan University Method for preparing high purity L-α glycerylphosphorylcholine
ITVI20120063A1 (it) * 2012-03-22 2013-09-23 Fortom Chimica S R L Procedimento per l'estrazione e raffinazione di fosfatidilcolina e altri fosfolipidi da lecitine vegetali
CN102875592A (zh) * 2012-09-29 2013-01-16 常熟富士莱医药化工有限公司 天然的L-α-甘油磷脂酰胆碱的制备方法
CN103172659A (zh) * 2013-03-29 2013-06-26 山东罗欣药业股份有限公司 L-α-甘油磷酰胆碱晶型化合物
WO2015108355A1 (ko) * 2014-01-15 2015-07-23 지준홍 글리세릴 포스포릴 콜린 결정 및 이의 제조 방법
KR101616945B1 (ko) 2014-02-10 2016-04-29 엔자이텍 주식회사 라세믹 또는 광학적으로 활성이 있는 α―글리세로포스포릴 콜린의 제조방법
CN106459107B (zh) 2014-06-10 2019-09-27 凯米股份公司 用于纯化L-α-甘油磷酰胆碱的工艺
RU2685238C1 (ru) * 2016-07-01 2019-04-17 Общество с ограниченной ответственностью "ФАРМАЦЕЛЬ" Способ получения кристаллического глицерофосфатидилхолина
RU2635665C1 (ru) * 2017-02-16 2017-11-15 Общество с ограниченной ответственностью "БИОН" Способ получения l-a-глицерофосфорилхолина фармакопейного качества
WO2023026449A1 (ja) * 2021-08-26 2023-03-02 協和発酵バイオ株式会社 シチジン－５'－ジリン酸化合物の製造方法
CN114106036A (zh) * 2021-11-08 2022-03-01 云南开放大学(云南国防工业职业技术学院) 一种L-α-甘油磷脂酰胆碱的分离提取方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1543722A1 (de) * 1966-08-25 1969-09-11 Knoll Ag Verfahren zur Gewinnung von reinen natuerlichen Cholinphosphorsaeurediglyceridestern
FR2587574B1 (fr) * 1985-09-18 1987-10-30 Commissariat Energie Atomique Resistor pour le traitement de materiaux
IT1201477B (it) * 1985-10-04 1989-02-02 Istituto Chemioterapico Procedimento per la preparazione di l-alfa-glicerilfosforilcolina,l-alfa-glicerilfosforiletanolommina e l-alfa-glicerilfosforilinositolo da lecitine grezze e/o deoleate

Also Published As

Publication number Publication date
IT8920413A0 (it) 1989-05-08
DK0471706T3 (da) 1994-11-21
WO1990013552A1 (en) 1990-11-15
JP2883202B2 (ja) 1999-04-19
US5250719A (en) 1993-10-05
IT1229238B (it) 1991-07-26
DE69011516T2 (de) 1994-12-08
EP0471706A1 (en) 1992-02-26
EP0471706B1 (en) 1994-08-10
CA2055503C (en) 2000-01-18
DE69011516D1 (de) 1994-09-15
ATE109785T1 (de) 1994-08-15
CA2055503A1 (en) 1990-11-09
JPH04505013A (ja) 1992-09-03
AU5550490A (en) 1990-11-29

Similar Documents

Publication Publication Date Title
ES2057561T3 (es) Procedimiento para la preparacion de l-alfa-glicerilfosforilcolina y de l-alfa-glicerilfosforiletanolamina.
JPS53149181A (en) Semipermeable membrane
IT1181462B (it) Procedimento per la separazione dell'arsenico da soluzioni acide che lo contengono
MY106624A (en) Preparation of monoepoxides
GB1385368A (en) Nitration process and apparatus therefor
ATE48411T1 (de) Herstellungsverfahren von aethyltrifluoracetat.
ATE29874T1 (de) Verfahren zur herstellung von dihydroxybenzolen.
GB1256203A (en) Racemization of optically active transcyclopropane-mono-carboxylic acids and their derivatives
JPS51136607A (en) Process for purification of aqueous glycerine solution
SE7714689L (sv) Forfarande for framstellning av fluorvete fran en vattenlosning av fluorvete och svavelsyra
JPS5659716A (en) Separating method of gamma-globulin aggregate with membrane
ATE29484T1 (de) Verfahren zur selektiven herstellung von dihydroxybenzolen.
JPS5344528A (en) Separation of dihalogenobenzenes
JPS56104866A (en) Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt
JPS5427507A (en) Preparation of tertiary butyl alcohol
JPS5212988A (en) Purification of glutamic acid
ES452056A1 (es) Procedimiento para la obtencion de acido fluorhidrico con- centrado altamente puro.
JPS53124205A (en) Preparation of diol and its manufacture
JPS5581825A (en) Production of tertiary butyl alcohol
JPS5742633A (en) Production of blood preparation
JPS57207624A (en) Production of cation exchanging fiber
SU768863A1 (ru) Осадительна ванна дл получени вискозных волокон и нитей
SU833530A1 (ru) Способ концентрировани свинца
JPS5339399A (en) Preparation of silicon polyme or oligomer
JPS57144297A (en) Purifying method of glycyrrhizin

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 471706

Country of ref document: ES