ES2052545T3 - (n-piperidinil)-metil- y (n-piperazinil)metilazoles sustituidos con arilo que tienen propiedades antipsicoticas. - Google Patents
(n-piperidinil)-metil- y (n-piperazinil)metilazoles sustituidos con arilo que tienen propiedades antipsicoticas.Info
- Publication number
- ES2052545T3 ES2052545T3 ES87200296T ES87200296T ES2052545T3 ES 2052545 T3 ES2052545 T3 ES 2052545T3 ES 87200296 T ES87200296 T ES 87200296T ES 87200296 T ES87200296 T ES 87200296T ES 2052545 T3 ES2052545 T3 ES 2052545T3
- Authority
- ES
- Spain
- Prior art keywords
- piperazinyl
- piperidinyl
- substituted
- aryl
- methylazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A NUEVOS (N-PIPERIDIL) METIL- Y (N-PIPERACINIL) METILAZOLES ARIL-SUSTITUIDOS QUE TIENEN PROPIEDADES FARMACOLOGICAS, EN ESPECIAL, ANTIPSICOTICOS. LOS COMPUESTOS PUEDEN PREPARARSE EN LA FORMA YA CONOCIDA PARA LA SINTESIS DE COMPUESTOS ANALOGOS Y PROCESARSE PARA OBTENER COMPOSICIONES DE ACUERDO CON METODOS CONOCIDOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8600488 | 1986-02-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2052545T3 true ES2052545T3 (es) | 1994-07-16 |
Family
ID=19847632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87200296T Expired - Lifetime ES2052545T3 (es) | 1986-02-27 | 1987-02-24 | (n-piperidinil)-metil- y (n-piperazinil)metilazoles sustituidos con arilo que tienen propiedades antipsicoticas. |
Country Status (15)
Country | Link |
---|---|
US (2) | US4772604A (es) |
EP (1) | EP0241053B1 (es) |
JP (1) | JPH0798800B2 (es) |
AT (1) | ATE82281T1 (es) |
AU (1) | AU585131B2 (es) |
CA (1) | CA1279645C (es) |
DE (1) | DE3782525T2 (es) |
DK (1) | DK93087A (es) |
ES (1) | ES2052545T3 (es) |
GR (1) | GR3006689T3 (es) |
IE (1) | IE61724B1 (es) |
IL (1) | IL81669A (es) |
NZ (1) | NZ219380A (es) |
PH (1) | PH22783A (es) |
ZA (1) | ZA871335B (es) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3782525T2 (de) * | 1986-02-27 | 1993-05-27 | Duphar Int Res | Aryl-substituierte(n-piperidinyl)methyl und (n-piperazinyl)methylazole mit antipsychotischer wirkung. |
US4992441A (en) * | 1987-10-14 | 1991-02-12 | Mcneilab, Inc. | 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia |
FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
GB9021453D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
US5159083A (en) * | 1990-12-28 | 1992-10-27 | Neurogen Corporation | Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands |
FR2673628B1 (fr) * | 1991-03-07 | 1993-07-09 | Esteve Labor Dr | Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles. |
NZ240863A (en) * | 1991-09-11 | 1995-04-27 | Mcneilab Inc | Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof |
US5569659A (en) * | 1991-09-11 | 1996-10-29 | Mcneilab, Inc. | 4-arylpiperazines and 4-arylpiperidines |
JPH05255089A (ja) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
NZ254784A (en) * | 1992-08-06 | 1996-11-26 | Smithkline Beecham Plc | Substituted 5-phenyl pyrrole derivatives and medicaments |
US5314885A (en) * | 1992-09-11 | 1994-05-24 | Mcneilab, Inc. | Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents |
GB9305644D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
GB9306578D0 (en) * | 1993-03-30 | 1993-05-26 | Merck Sharp & Dohme | Therapeutic agents |
GB9307400D0 (en) * | 1993-04-08 | 1993-06-02 | Smithkline Beecham Plc | Compounds |
EP0705259B1 (en) * | 1993-06-25 | 1998-02-25 | Smithkline Beecham Plc | Phenyrrole derivatives and their use as dopamine d3 antagonists |
GB9315800D0 (en) * | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
GB9315801D0 (en) * | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
GB9320855D0 (en) * | 1993-10-09 | 1993-12-01 | Smithkline Beecham Plc | Compounds |
GB9325827D0 (en) * | 1993-12-17 | 1994-02-23 | Smithkline Beecham Plc | Compounds |
GB9402197D0 (en) * | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Compounds |
GB9403199D0 (en) * | 1994-02-19 | 1994-04-13 | Smithkline Beecham Plc | Compounds |
US5478934A (en) * | 1994-11-23 | 1995-12-26 | Yuan; Jun | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands |
WO1996016057A1 (en) * | 1994-11-23 | 1996-05-30 | Neurogen Corporation | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives; novel dopamine receptor subtype specific ligands |
GB9512129D0 (en) * | 1995-06-15 | 1995-08-16 | Smithkline Beecham Plc | Compounds |
WO1997003067A1 (en) * | 1995-07-13 | 1997-01-30 | Knoll Aktiengesellschaft | Piperazine derivatives as therapeutic agents |
AU708053B2 (en) * | 1996-03-29 | 1999-07-29 | Duphar International Research B.V. | Piperazine and piperidine compounds |
AU730224B2 (en) | 1996-12-23 | 2001-03-01 | Du Pont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
EA002101B1 (ru) * | 1997-01-27 | 2001-12-24 | Дайити Фармасьютикал Ко., Лтд. | Производные пиразола |
US6169086B1 (en) | 1997-01-27 | 2001-01-02 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives |
TW530054B (en) * | 1997-09-24 | 2003-05-01 | Duphar Int Res | New piperazine and piperidine compounds |
DE60132032T2 (de) | 2000-07-04 | 2008-12-18 | Kyoyu Agri Co., Ltd., Kawasaki | Benzoxazol-Derivative, Verfahren zu ihrer Herstellung und Herbizide |
DK1408976T5 (da) | 2001-07-20 | 2011-01-10 | Psychogenics Inc | Behandling af ADHD (Attention deficit hyperactivity disorder) |
US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
EP1531822B1 (en) | 2002-06-12 | 2009-08-05 | ChemoCentryx Inc | 1-aryl-4-substituted piperazine derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders |
US7589199B2 (en) * | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
EP1720545B1 (en) * | 2004-03-03 | 2014-10-29 | ChemoCentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
BRPI0405418A (pt) * | 2004-09-02 | 2006-05-02 | Univ Rio De Janeiro | uso de derivados n-fenilperazìnicos e composições farmacêuticas contendo os mesmos |
TW200800946A (en) * | 2005-08-15 | 2008-01-01 | Astrazeneca Ab | Substituted piperazines as metabotropic glutamate receptor antagonists |
KR100654328B1 (ko) | 2005-08-26 | 2006-12-08 | 한국과학기술연구원 | 피페라지닐알킬피라졸계 t-타입 칼슘 채널 억제 화합물 및이의 제조방법 |
US9066903B2 (en) | 2006-02-28 | 2015-06-30 | The United States Of America As Represented By The Department Of Veterans Affairs | Pharmacological treatment of Parkinson's disease |
CN103570705B (zh) * | 2012-07-18 | 2017-01-25 | 中国医学科学院医药生物技术研究所 | 取代的n‑((1',3'‑杂唑‑4'‑基)‑甲基)‑4‑苯甲酰基六氢吡啶类化合物及其用途 |
MX2016008130A (es) | 2013-12-20 | 2016-10-13 | Esteve Labor Dr | Derivados de piperidina con actividad multimodal contra el dolor. |
ES2806408T3 (es) * | 2013-12-20 | 2021-02-17 | Esteve Pharmaceuticals Sa | Compuestos piperidínicos con actividad multimodal contra el dolor |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3407199A (en) * | 1966-01-18 | 1968-10-22 | Endo Lab | Tertiaryamino ethyl or propyl pyrrol-2-yl ketones |
DE2261351A1 (de) * | 1972-12-15 | 1974-06-20 | Merck Patent Gmbh | Pyrazolderivate und verfahren zu ihrer herstellung |
DE2526469A1 (de) * | 1975-06-13 | 1976-12-30 | Bayer Ag | 1-substituierte pyrazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4032526A (en) * | 1975-10-02 | 1977-06-28 | American Cyanamid Company | 1,2-dimethyl-3 or 5-piperazinyl-pyrazolium salts |
US4123529A (en) * | 1976-04-23 | 1978-10-31 | Lilly Industries Limited | Phenylpiperazine derivatives |
DE2747531A1 (de) * | 1977-10-22 | 1979-04-26 | Basf Ag | Substituierte 3-aminopyrazole |
FR2537133A1 (fr) * | 1982-12-07 | 1984-06-08 | Rhone Poulenc Sante | Nouveaux derives de la (piperazinyl-1)-5 pyrrolidine, leur preparation et les medicaments qui les contiennent |
DK169601B1 (da) * | 1983-10-17 | 1994-12-19 | Duphar Int Res | Piperazinderivater og farmaceutisk præparat indeholdende et sådant derivat, samt piperazinderivater med mellemproduktanvendelse |
US4562189A (en) * | 1984-10-09 | 1985-12-31 | American Cyanamid Company | Pyrazolylpiperazines |
DE3442860A1 (de) * | 1984-11-24 | 1986-05-28 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE3782525T2 (de) * | 1986-02-27 | 1993-05-27 | Duphar Int Res | Aryl-substituierte(n-piperidinyl)methyl und (n-piperazinyl)methylazole mit antipsychotischer wirkung. |
-
1987
- 1987-02-24 DE DE8787200296T patent/DE3782525T2/de not_active Expired - Fee Related
- 1987-02-24 IL IL81669A patent/IL81669A/xx not_active IP Right Cessation
- 1987-02-24 DK DK093087A patent/DK93087A/da not_active Application Discontinuation
- 1987-02-24 US US07/018,164 patent/US4772604A/en not_active Expired - Lifetime
- 1987-02-24 NZ NZ219380A patent/NZ219380A/xx unknown
- 1987-02-24 PH PH34901A patent/PH22783A/en unknown
- 1987-02-24 ES ES87200296T patent/ES2052545T3/es not_active Expired - Lifetime
- 1987-02-24 IE IE46687A patent/IE61724B1/en not_active IP Right Cessation
- 1987-02-24 EP EP87200296A patent/EP0241053B1/en not_active Expired - Lifetime
- 1987-02-24 AT AT87200296T patent/ATE82281T1/de not_active IP Right Cessation
- 1987-02-24 CA CA000530424A patent/CA1279645C/en not_active Expired - Lifetime
- 1987-02-24 ZA ZA871335A patent/ZA871335B/xx unknown
- 1987-02-25 JP JP62040530A patent/JPH0798800B2/ja not_active Expired - Lifetime
- 1987-02-25 AU AU69247/87A patent/AU585131B2/en not_active Ceased
-
1988
- 1988-07-01 US US07/214,310 patent/US4874770A/en not_active Expired - Lifetime
-
1992
- 1992-12-28 GR GR920403153T patent/GR3006689T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA1279645C (en) | 1991-01-29 |
JPS62205058A (ja) | 1987-09-09 |
JPH0798800B2 (ja) | 1995-10-25 |
DE3782525D1 (de) | 1992-12-17 |
EP0241053A1 (en) | 1987-10-14 |
DK93087D0 (da) | 1987-02-24 |
GR3006689T3 (es) | 1993-06-30 |
NZ219380A (en) | 1990-06-26 |
EP0241053B1 (en) | 1992-11-11 |
AU585131B2 (en) | 1989-06-08 |
ZA871335B (en) | 1987-09-30 |
AU6924787A (en) | 1987-09-03 |
IE870466L (en) | 1987-08-27 |
IL81669A (en) | 1990-11-29 |
PH22783A (en) | 1988-12-12 |
ATE82281T1 (de) | 1992-11-15 |
DK93087A (da) | 1987-08-28 |
DE3782525T2 (de) | 1993-05-27 |
US4874770A (en) | 1989-10-17 |
US4772604A (en) | 1988-09-20 |
IL81669A0 (en) | 1987-09-16 |
IE61724B1 (en) | 1994-11-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2052545T3 (es) | (n-piperidinil)-metil- y (n-piperazinil)metilazoles sustituidos con arilo que tienen propiedades antipsicoticas. | |
DE3781509D1 (de) | Stabilisierte zusammensetzungen mit gehalt an egf. | |
BR8802017A (pt) | Composicao estabilizada | |
FI904851A0 (fi) | Radiomaerkta antikoagulantpeptider. | |
DE69018412D1 (de) | Verfahren zur Verminderung des Gehaltes von Siloxanoligomere in geformten Polyorganosiloxanmassen. | |
DE3873126D1 (de) | Rohoel- oder heizoel-zusammensetzungen. | |
EP0192988A3 (en) | Process for solubilization, purification and characterization of protein from insoluble protein aggregates or complexes and compositions of matter therefrom | |
DE59010370D1 (de) | Stabilisierte chlorhaltige Polymerzusammensetzungen | |
DE3788676D1 (de) | Härtbare Organopolysiloxanzusammensetzungen. | |
DE3777239D1 (de) | Mit aminoxyalkylaminen stabilisierte zusammensetzungen. | |
DE3750192D1 (de) | Mit Aminoxysilanen stabilisierte Zusammensetzungen. | |
IT8848573A0 (it) | Composizioni polimere | |
DE3854179D1 (de) | Vulkanisierbare Fluorkautschukzusammensetzung. | |
DE69208387D1 (de) | Herstellung von feuchtigkeitshärtenden Organosiloxanzusammensetzungen | |
DE3870723D1 (de) | Herstellung von ascorbinsaeure-6-estern. | |
EP0325719A3 (en) | Melt stable polyetherimide-poly-carbonate blends | |
IT1197462B (it) | Composizioni poliolefiniche stabilizzate e composti stabilizzanti adatti allo scopo | |
DE3852248D1 (de) | Harzzusammensetzungen. | |
ES2021383B3 (es) | Procedimiento de conversion termica de fracciones pesadas de petroleo y de residuos de refinado, en presencia de compuestos oxigenados del azufre o del nitrogeno y composiciones que contienen estos compuestos. | |
DE69012882D1 (de) | Herstellung von Stickstoffzusammensetzungen. | |
AU4434289A (en) | Single-component rtv compositions which can be stored with the exclusion of moisture | |
DE3861262D1 (de) | Verfahren zur herstellung von polysulfurierten olefin-zusammensetzungen mit hohem schwefel-und sehr niedrigem chlorgehalt. | |
DE68920358D1 (de) | Verfahren zur Herstellung von Schwefelwasserstoff. | |
IT8705102A0 (it) | Derivati di prolina. | |
DE3878776D1 (de) | Hohe feststoffgehalte enthaltende ueberzugszusammensetzungen. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 241053 Country of ref document: ES |