ES2038602T3 - Metodo para la produccion de proteinas por medio de sistemas de expresion inducible en celulas-huesped en carioticas geneticamente modificadas multiplicadas in-vivo. - Google Patents

Metodo para la produccion de proteinas por medio de sistemas de expresion inducible en celulas-huesped en carioticas geneticamente modificadas multiplicadas in-vivo.

Info

Publication number
ES2038602T3
ES2038602T3 ES198686810455T ES86810455T ES2038602T3 ES 2038602 T3 ES2038602 T3 ES 2038602T3 ES 198686810455 T ES198686810455 T ES 198686810455T ES 86810455 T ES86810455 T ES 86810455T ES 2038602 T3 ES2038602 T3 ES 2038602T3
Authority
ES
Spain
Prior art keywords
proteins
cells
production
vivo
cariotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686810455T
Other languages
English (en)
Inventor
Peter Bromley
Michel Dreano
Michel Fischbah
Xavier Fouillet
Prudent Padieu
Richard Voellmy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Battelle Memorial Institute Inc
Original Assignee
Battelle Memorial Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute Inc filed Critical Battelle Memorial Institute Inc
Application granted granted Critical
Publication of ES2038602T3 publication Critical patent/ES2038602T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Una preparación para curar heridas que comprende 50 90% en peso de un azúcar no reductor, 0,5 10% en peso de povidona yodo, 1 20% en peso de agua y un tampón para ajustar el pH de la preparación a 3,5 6 en una cantidad suciente para mantener el pH en el citado intervalo.
ES198686810455T 1986-10-15 1986-10-15 Metodo para la produccion de proteinas por medio de sistemas de expresion inducible en celulas-huesped en carioticas geneticamente modificadas multiplicadas in-vivo. Expired - Lifetime ES2038602T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP86810455A EP0263908B1 (en) 1986-10-15 1986-10-15 Method for the production of proteins by means of inducible expression systems in genetically modified eukaryotic host-cells multiplicated in-vivo

Publications (1)

Publication Number Publication Date
ES2038602T3 true ES2038602T3 (es) 1993-08-01

Family

ID=8196470

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686810455T Expired - Lifetime ES2038602T3 (es) 1986-10-15 1986-10-15 Metodo para la produccion de proteinas por medio de sistemas de expresion inducible en celulas-huesped en carioticas geneticamente modificadas multiplicadas in-vivo.

Country Status (12)

Country Link
US (1) US5614381A (es)
EP (2) EP0263908B1 (es)
JP (1) JP2509271B2 (es)
AT (1) ATE67787T1 (es)
AU (1) AU612607B2 (es)
CA (1) CA1319631C (es)
DE (1) DE3681738D1 (es)
DK (1) DK320888A (es)
ES (1) ES2038602T3 (es)
NO (1) NO882469D0 (es)
WO (1) WO1988002778A1 (es)
ZA (1) ZA877656B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85728A (en) * 1987-03-25 1993-01-14 Bio Mega Inc Fluorine containing atrial natriuretic peptides, their preparation and pharmaceutical compositions containing them
JP2796547B2 (ja) * 1987-09-11 1998-09-10 ジェネンテク，インコーポレイテッド 組換え細胞培養中でのポリペプチド発現の増大法
AU2900389A (en) * 1987-12-15 1989-07-19 Trustees Of Princeton University, The Transgenic testing systems for mutagens and carcinogens
ZA892518B (en) * 1988-04-08 1989-12-27 Intracel Corp Method for the in-vivo production and testing of proteins by recombinant gene expression in selected host-cells
EP0386185A1 (fr) * 1988-07-29 1990-09-12 IntraCel Corporation Procede d'expression genetique de proteines heterologues par des cellules transfectees in vivo
GB8928884D0 (en) * 1989-12-21 1990-02-28 Feldmann Marc Transformed cell lines
GB9003791D0 (en) * 1990-02-20 1990-04-18 Ludwig Inst Cancer Res Transgenic animals,cell lines therefrom,and their use
US5866759A (en) * 1991-02-20 1999-02-02 Ludwig Institute For Cancer Research Transgenic mice expressing TSSV40 large T antigen
US5877398A (en) * 1993-01-29 1999-03-02 University Of British Columbia Biological systems incorporating stress-inducible genes and reporter constructs for environmental biomonitoring and toxicology
DE69738640T2 (de) 1996-08-15 2009-07-16 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Räumliche und temporäre kontrolle der genexpression mittels eines hitzeschockproteinpromotors in kombination mit lokaler hitze
IT1294450B1 (it) * 1997-08-28 1999-03-25 Consiglio Nazionale Ricerche Animali transgenici per lo studio di agenti tossici chimici fisici o biologici
US6709858B1 (en) * 1997-11-03 2004-03-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
US7098191B2 (en) * 1997-11-03 2006-08-29 The Arizona Board Of Reagents Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
US7279565B2 (en) * 1998-05-05 2007-10-09 Richard Voellmy Molecular regulatory circuits to achieve sustained activation of genes of interest by a single stress
AUPQ233799A0 (en) 1999-08-19 1999-09-09 Minister For Agriculture, Minister For Land And Water Conservation For And On Behalf Of The State Of New South Wales Recombinant sub-unit vaccine
US20030044398A1 (en) * 2001-03-20 2003-03-06 Robl James M. Methods for producing antibodies in mammals
CA2349506C (en) * 2001-06-14 2009-12-08 Duke University A method for selective expression of therapeutic genes by hyperthermia
CA2580515C (en) * 2004-10-04 2017-05-02 National Research Council Of Canada Expression system, components thereof and methods of use
US7935788B2 (en) * 2004-10-04 2011-05-03 National Research Council Of Canada Reverse cumate repressor mutant

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
JPS5729294A (en) * 1980-07-30 1982-02-17 Hayashibara Biochem Lab Inc Preparation of human insulin
JPS5852634B2 (ja) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 ウロキナ−ゼの製造法
DK172882B1 (da) * 1983-02-07 1999-09-06 Rothwell Property Ltd DNA indeholdende udtrykkelseskontrolregion fra et eukaryot varmechokproteingen, vektor og eukaryot celle indeholdende DNA'e
AU7280487A (en) * 1986-04-04 1987-10-20 Battelle Memorial Institute Methods and compositions for expression of competent eukaryotic gene products
PT85828B (pt) * 1986-09-30 1990-08-31 Smithkline Beecham Corp Profcesso de producao de uma linha de ceculas de mamifero, recombinante, linha de celulas assim obtida e processo de preparacao de um gene
DE3855681T2 (de) * 1987-05-01 1997-05-28 The General Hospital Corp., Boston, Mass. Transkaryotische Einpflanzung

Also Published As

Publication number Publication date
DK320888D0 (da) 1988-06-13
EP0263908B1 (en) 1991-09-25
DK320888A (da) 1988-06-13
ATE67787T1 (de) 1991-10-15
WO1988002778A1 (en) 1988-04-21
DE3681738D1 (es) 1991-10-31
ZA877656B (en) 1988-04-18
EP0263908A1 (en) 1988-04-20
NO882469L (no) 1988-06-03
AU612607B2 (en) 1991-07-18
US5614381A (en) 1997-03-25
AU8078487A (en) 1988-05-06
EP0285642A1 (en) 1988-10-12
JPH01501439A (ja) 1989-05-25
CA1319631C (en) 1993-06-29
NO882469D0 (no) 1988-06-03
JP2509271B2 (ja) 1996-06-19

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