AU2900389A - Transgenic testing systems for mutagens and carcinogens - Google Patents

Transgenic testing systems for mutagens and carcinogens

Info

Publication number
AU2900389A
AU2900389A AU29003/89A AU2900389A AU2900389A AU 2900389 A AU2900389 A AU 2900389A AU 29003/89 A AU29003/89 A AU 29003/89A AU 2900389 A AU2900389 A AU 2900389A AU 2900389 A AU2900389 A AU 2900389A
Authority
AU
Australia
Prior art keywords
mutagens
carcinogens
testing systems
transgenic
transgenic testing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU29003/89A
Inventor
Arnold J. Levine
Thomas E. Shenk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Princeton University filed Critical Princeton University
Publication of AU2900389A publication Critical patent/AU2900389A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/30—Animal model comprising expression system for selective cell killing, e.g. toxins, enzyme dependent prodrug therapy using ganciclovir
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
AU29003/89A 1987-12-15 1988-12-08 Transgenic testing systems for mutagens and carcinogens Abandoned AU2900389A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13238387A 1987-12-15 1987-12-15
US132383 1987-12-15

Publications (1)

Publication Number Publication Date
AU2900389A true AU2900389A (en) 1989-07-19

Family

ID=22453778

Family Applications (1)

Application Number Title Priority Date Filing Date
AU29003/89A Abandoned AU2900389A (en) 1987-12-15 1988-12-08 Transgenic testing systems for mutagens and carcinogens

Country Status (5)

Country Link
EP (1) EP0390857A4 (en)
JP (1) JPH03502882A (en)
KR (1) KR900700621A (en)
AU (1) AU2900389A (en)
WO (1) WO1989005864A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015116A1 (en) * 1990-03-30 1991-10-17 Amrad Corporation Limited Doubly transgenic animals

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370813A3 (en) * 1988-11-25 1991-06-19 Exemplar Corporation Rapid screening mutagenesis and teratogenesis assay
US5174986A (en) * 1989-07-05 1992-12-29 Genpharm International, Inc. Method for determining oncogenic potential of a chemical compound
DE69027683T2 (en) * 1989-12-01 1997-02-13 Pharming Bv PRODUCTION OF RECOMBINANT POLYPEPTIDES BY CATTLE AND TRANSGENIC METHODS
GB9003791D0 (en) * 1990-02-20 1990-04-18 Ludwig Inst Cancer Res Transgenic animals,cell lines therefrom,and their use
AU1236092A (en) * 1991-01-04 1992-08-17 Baylor College Of Medicine Tumor susceptible non-human animals
US5569824A (en) * 1991-01-04 1996-10-29 Baylor College Of Medicine Transgenic mice containing a disrupted p53 gene
US5866759A (en) * 1991-02-20 1999-02-02 Ludwig Institute For Cancer Research Transgenic mice expressing TSSV40 large T antigen
GB9113097D0 (en) * 1991-06-18 1991-08-07 Boehringer Ingelheim Int Chimeric gene
AU3777693A (en) * 1992-02-27 1993-09-13 Ohio University Mutagenicity testing using reporter genes with modified methylation frequencies
AU4240293A (en) * 1992-05-08 1993-12-13 Exemplar Corporation Anti-neoplastic in vivo drug screen
DE19525285C2 (en) * 1995-06-28 1999-04-15 Inst Pflanzengenetik & Kultur In vitro test procedure for the detection of chemical-induced embryotoxic / teratogenic effects
GB9707141D0 (en) * 1997-04-08 1997-05-28 Inst Of Food Research Biological assay
US6063359A (en) * 1997-09-26 2000-05-16 Washington University Method for determining oncogenic activity of a substance
DE19818422A1 (en) * 1998-04-24 1999-10-28 Stefan Harjes Method for determining absolute mutagenicity and error rate of polymerases in amplification reactions
WO2001090339A2 (en) * 2000-05-23 2001-11-29 Warner-Lambert Company Methods and compositions to activate genes in cells

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1466256A (en) * 1973-06-20 1977-03-02 Grindstedvaerket As 2,5-substituted furans and their production
US4302535A (en) * 1979-09-27 1981-11-24 Massachusetts Institute Of Technology Assay for mutagenesis in heterozygous diploid human lymphoblasts
IL62479A (en) * 1981-03-25 1984-11-30 Yeda Res & Dev Assay for the determination of carcinogenicity
US4792520A (en) * 1984-02-16 1988-12-20 University Of Cincinnati Methods and kits for identifying mutagenic agents and molecular mutations in DNA in mammalian cells
US4736866A (en) * 1984-06-22 1988-04-12 President And Fellows Of Harvard College Transgenic non-human mammals
ATE67787T1 (en) * 1986-10-15 1991-10-15 Battelle Memorial Institute METHOD FOR PRODUCING PROTEINS USING INDUCIBLE EXPRESSION SYSTEMS IN IN VIVIVUM-PROPULAR GENETICALLY MODIFIED EUKARYOTIC HOST CELLS.
ATE132266T1 (en) * 1987-05-01 1996-01-15 Stratagene Inc MUTAGENEOSIS TESTING USING NON-HUMAN LIVING BEINGS CONTAINING TEST DNA SEQUENCES
WO1989009272A1 (en) * 1988-03-22 1989-10-05 Chemical Industry Institute Of Toxicology A transgenic mouse for measurement and characterization of mutation induction in vivo
ZA892518B (en) * 1988-04-08 1989-12-27 Intracel Corp Method for the in-vivo production and testing of proteins by recombinant gene expression in selected host-cells
EP0370813A3 (en) * 1988-11-25 1991-06-19 Exemplar Corporation Rapid screening mutagenesis and teratogenesis assay

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015116A1 (en) * 1990-03-30 1991-10-17 Amrad Corporation Limited Doubly transgenic animals

Also Published As

Publication number Publication date
WO1989005864A1 (en) 1989-06-29
KR900700621A (en) 1990-08-16
EP0390857A4 (en) 1991-04-17
JPH03502882A (en) 1991-07-04
EP0390857A1 (en) 1990-10-10

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